Back to resultsOligodendrocyte Progenitor Cell Culture From Human Brain
Primary Purpose
Demyelinating Diseases
Status
Completed
Phase
Phase 1
Locations
Thailand
Study Type
Interventional
Intervention
Oligodendrocyte progenitor cell culture/craniotomy
Sponsored by
About this trial
This is an interventional basic science trial for Demyelinating Diseases focused on measuring All selective craniotomy
Eligibility Criteria
Inclusion Criteria: Male or female 20-65 years of age Informed consent Has elective craniotomy surgery Exclusion Criteria: HIV, hepatitis, and other central nervous system (CNS) infections Dementia, Alzheimer disease, and neurodegenerative disease
Sites / Locations
- Assistant Professor Subsai Kongsaengdao
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
A
Arm Description
Progenitor cells from the patinets with Craniotomy with V-P Shunt or ventriculostomy will be collected and cultured.
Outcomes
Primary Outcome Measures
Number of oligodendrocyte progenitor cell differentiation
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT00283023
Brief Title
Oligodendrocyte Progenitor Cell Culture From Human Brain
Official Title
Phase 1: Oligodendrocyte Progenitor Cell Culture From Human Brain
Study Type
Interventional
2. Study Status
Record Verification Date
October 2020
Overall Recruitment Status
Completed
Study Start Date
December 2007 (Actual)
Primary Completion Date
December 2010 (Actual)
Study Completion Date
December 2010 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
Rajavithi Hospital
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
Recent developments in the understanding of stem- and progenitor cell differentiation raises hopes that brain damage in chronic neurological diseases may become repaired by systemic or focal transplantation of such cells. Clinical trials of stem- or progenitor cell transplantation in multiple sclerosis are currently premature. The researchers developed a protocol for human oligodendrocyte progenitor cell culture from human brain for the treatment of demyelinating disease.
Detailed Description
Oligodendrocyte progenitor cell line were cultures and will be transplanted into the patient with Multiple sclerosis.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Demyelinating Diseases
Keywords
All selective craniotomy
7. Study Design
Primary Purpose
Basic Science
Study Phase
Phase 1
Interventional Study Model
Single Group Assignment
Model Description
Cell culture
Masking
None (Open Label)
Allocation
N/A
Enrollment
5 (Actual)
8. Arms, Groups, and Interventions
Arm Title
A
Arm Type
Experimental
Arm Description
Progenitor cells from the patinets with Craniotomy with V-P Shunt or ventriculostomy will be collected and cultured.
Intervention Type
Procedure
Intervention Name(s)
Oligodendrocyte progenitor cell culture/craniotomy
Other Intervention Name(s)
Rajavithi Oligodendrocyte progenitor cell culture protocol
Intervention Description
Oligodendrocyte progenitor cell culture protocol of Rajavithi Hospital will be apply
Primary Outcome Measure Information:
Title
Number of oligodendrocyte progenitor cell differentiation
Time Frame
one month
10. Eligibility
Sex
All
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Male or female 20-65 years of age
Informed consent
Has elective craniotomy surgery
Exclusion Criteria:
HIV, hepatitis, and other central nervous system (CNS) infections
Dementia, Alzheimer disease, and neurodegenerative disease
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Subsai Kongsaengdao, M.D.
Organizational Affiliation
Division of Neurology, Department of Medicine, Rajavithi Hospital : Thailand
Official's Role
Principal Investigator
Facility Information:
Facility Name
Assistant Professor Subsai Kongsaengdao
City
Bangkok
ZIP/Postal Code
10400
Country
Thailand
12. IPD Sharing Statement
Learn more about this trial
Oligodendrocyte Progenitor Cell Culture From Human Brain
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