Omega 3 Lipid Emulsions and Liver Transplantation (OTLT)
Ischemia Re-perfusion Injury
About this trial
This is an interventional supportive care trial for Ischemia Re-perfusion Injury focused on measuring Omega 3 lipid emulsions, Liver transplantation, Ischemia reperfusion injury, graft function
Eligibility Criteria
Inclusion Criteria:
- All liver transplant recipients
Exclusion Criteria:
- Budd chiari
- Previous upper abdominal surgery
- Re-transplantation
- Known allergy to the study emulsion
Sites / Locations
- Liver transplantation program - Gastroenterology surgical center - Mansoura universityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Placebo Comparator
Active Comparator
Active Comparator
Control
OMEGA_PRE
OMEGA_POST
38 patients Will receive standard oral diet 3 days before the operation will receive similar volume of 10% glucose solution Will receive same solution for 5 days postoperatively
38 patients Will receive standard oral diet 3 days before the operation will receive lipid supplementation 2 days before the operation with omega 3 enriched lipid emulsion (SMOFlipid) Will receive omega 3 enriched lipid emulsion (SMOFlipid) supplementation for 5 days postoperatively
38 patients Will receive standard oral diet 3 days before the operation will receive glucose 10% solution 2 days before the operation Will receive omega 3 enriched lipid emulsion (SMOFlipid 20%) supplementation for 5 days postoperatively