Optimal Nutrition for Prevention of Hypertension in Pregnancy (OptiPREG)
Blood Pressure, Pregnancy
About this trial
This is an interventional prevention trial for Blood Pressure focused on measuring Pregnancy, Maternal blood pressure, MTHFR 677TT genotype, Riboflavin, 5-methyltetrahydrofolate, Offspring blood pressure
Eligibility Criteria
Inclusion Criteria:
• Women with a singleton pregnancy who are in their first trimester of pregnancy
Exclusion Criteria:
- Patients who have a high risk pregnancy, a previous pregnancy with a neural tube defect (NTD) or are the first degree relative of a woman who had a pregnancy affected by NTD or are themselves a sufferer of an NTD
- Women who are taking medication known to interfere with B-vitamin metabolism
Sites / Locations
- Letterkenny University HospitalRecruiting
- Northern Health and Social Care TrustRecruiting
- Western Health and Social Care TrustRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Experimental
Placebo Comparator
Active Comparator
Experimental
Placebo Comparator
TT genotype active comparator group
TT genotype experimental group
TT genotype placebo group
CT genotype active comparator group
CT genotype experimental group
CT genotype placebo group
5mg riboflavin per day from 16th gestational week
5mg riboflavin + 400µg 5-methyltetrahydrofolate per day from 16th gestational week
Placebo supplement from 16th gestational week
5mg riboflavin per day from 16th gestational week
5mg riboflavin + 400µg 5-methyltetrahydrofolate per day from 16th gestational week
Placebo supplement from 16th gestational week