Back to resultsOptimized Antiplatelet Therapy in Patients With CHD After Implantation of NeoVas™ BRS System
Primary Purpose
Coronary Heart Disease
Status
Not yet recruiting
Phase
Not Applicable
Locations
China
Study Type
Interventional
Intervention
Single anti-platelet therapy
Dual anti-platelet therapy
Sponsored by
About this trial
This is an interventional treatment trial for Coronary Heart Disease focused on measuring Bioabsorbable Coronary Artery Rapamycin-eluting Stent System, Optimized Antiplatelet Therapy, Coronary Heart Disease, Randomized Controlled Trial
Eligibility Criteria
Inclusion Criteria:
- Age 18 or above, male or non-pregnant female.
- Evidence of myocardial ischemia (e.g., stable angina, unstable angina, medium-low risk NSTEMI, STEMI with onset more than 1 week, old myocardial infarction or asymptomatic myocardial ischemia), and suitable for PCI surgery.
- The target lesion is in-situ coronary artery lesion, the total length of single lesion is no more than 40mm (the total length of stent is no more than 48mm), and the diameter of the target lesion is between 2.75mm and 3.75mm (visual measurement).
- The diameter stenosis of target lesion is ≥70% in visual (or ≥50% with clinical evidence of myocardial ischemia in that range), and the TIMI blood flow is greater than grade 1.
- The stent with diameter more than 3.0mm is allowed to overlap with another stent once, the overlapping methods could be edge to edge or at most 1mm overlap. The total number of stents per patient is no more than 4, with a maximum of 2 stents per vessel (the 2.75mm diameter stent is not allowed to overlap).
- Patient with indications for coronary artery bypass surgery.
- Aspirin and clopidogrel could be used continuously during the study.
- Patient who can understand the purpose of this trial, is willing to participate in the trial and to conduct clinical follow-up as required by the study protocol.
Exclusion Criteria:
- Acute ST-segment elevation myocardial infarction within 1 week.
- Left main coronary artery disease, branch vessel diameter≥2.0mm, three-vessel coronary artery disease and bridge vessel disease; visible thrombus in the target vessel.
- Severe distortion, severe calcification that cannot be successfully predilated, and other lesions that are not suitable for stent delivery and deployment.
- Intra-stent restenosis.
- Severe heart failure (NYHA≥III or left ventricular ejection fraction<35%).
- Severe renal insufficiency, eGFR<30ml/min/1.73m2 or serum creatinine>2.5mg/dL (221μmol/L).
- Patients with bleeding tendency, active gastrointestinal ulcer, history of cerebral hemorrhage or subarachnoid hemorrhage, history of stroke within half a year, fundus hemorrhage affecting vision, antiplatelet agents and anticoagulant treatment contraindications who cannot receive antithrombotic therapy.
- Patients requiring long-term oral anticoagulants during the study period.
- Patients who are pregnant, breastfeeding, or planning to become pregnant during the study period.
- Patients with malignancies, organ transplants, or drug addiction that can seriously affect study compliance.
- Patients with contraindications to aspirin, clopidogrel or ticagrelor.
- Known allergy to aspirin, clopidogrel, ticagrelor, heparin, contrast agent, polylactic acid polymer and rapamycin.
- Thrombosis occurred during previous clopidogrel treatment.
- Life expectancy is less than 36 months.
- Participated in clinical trials of other drugs or medical devices before enrollment and failed to meet the time limit of the primary end point.
- Patients who will have elective surgery within a year and need to discontinue aspirin, clopidogrel or ticagrelor.
- Subjects are deemed unsuitable for enrollment by investigators.
Sites / Locations
- The First Affiliated Hospital of Bengbu Medical College
- The First Affiliated Hospital with Anhui Medical University
- The First Affiliated Hospital of Wannan Medical College
- Peking Union Medical College Hospital
- Beijing Chaoyang Hospital, Capital Medical University
- Beijing Anzhen Hospital, Capital Medical University-12 Ward
- Beijing Anzhen Hospital, Capital Medical University-28 Ward
- Beijing Anzhen Hospital, Capital Medical University-33 Ward
- Beijing Shijitan Hospital, Capital Medical University
- Beijing Friendship Hospital, Capital Medical University
- Xuan Wu Hospital, Capital Medical University
- Peking University Third Hospital
- Beijing Luhe Hospital, Capital Medical University
- Beijing Jingmei Group General Hospital
- The First Affiliated Hospital of Chongqing Medical University
- The Second Affiliated Hospital of Chongqing Medical University
- Gansu Provincial Hospital
- The First Hospital of Lanzhou University
- Lanzhou University Second Hospital
- Foshan First People's Hospital
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- The Third Affiliated Hospital of Guangdong Medical University
- Shantou Central Hospital
- The First Affiliated Hospital of Shantou University Medical College
- The Second Affiliated Hospital of Shantou University Medical College
- Shenzhen University General Hospital
- Zhanjiang Central People's Hospital
- The Fifth Affiliated Hospital of Sun Yat-sen University
- Guilin People's Hospital
- Liuzhou People's Hospital
- Liuzhou Worker's Hospital
- The First Affiliated Hospital of Guangxi Medical University
- The First People's Hospital of Nanning
- Yulin First People's Hospital
- Guizhou Provincial People's Hospital
- Haikou People's Hospital
- The Second Affiliated Hospital of Hainan Medical University
- Sanya Central Hospital (Hainan Third People's Hospital)
- Cangzhou Central Hospital
- Hengshui People's Hospital
- Hebei General Hospital
- the 980th Hospital of Chinese People's Liberation Army Joint Logistics Support Force
- Xingtai People's Hospital
- The Fourth Hospital of Harbin Medical University
- The Second Hospital of Harbin Medical University
- Nanyang Central Hospital
- Nanyang Second General Hospital
- Xinxiang Central Hospital
- The First Affiliated Hospital of Xinxiang Medical University
- Zhengzhou Central Hospital
- Henan Provincial People's Hospital
- Henan Provincial Chest Hospital
- The Second Affiliated Hospital, Zhengzhou University
- The 7th People's Hospital of Zhengzhou
- The First Affiliated Hospital of Henan University of Science and Technology
- The First Affiliated Hospital, Zhengzhou University
- The First Affiliated Hospital of Henan University of Chinese Medicine
- Fuwai Central China Cardiovascular Hospital
- Jingzhou Central Hospital
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Fifth Hospital in Wuhan
- Renmin Hospital of Wuhan University
- Zhongnan Hospital of Wuhan University
- Xiangya Hospital, Central South University
- Xiangtan Central Hospital
- The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science
- Gynecology of Huai'an First People's Hospital, Nanjing Medical University
- Affiliated Lianyungang Hospital of Nanjing University of Chinese Medicine
- Zhongda Hospital Southeast University
- The First Affiliated Hospital with Nanjing Medical University
- Xuzhou Cancer Hospital
- The Affiliated Hospital of Xuzhou Medical University
- The First Affiliated Hospital of Gannan Medical College
- Jiangxi Provincial People's Hospital
- The First Affiliated Hospital of Nanchang University
- The Second Affiliated Hospital of Nanchang University
- Yingtan People's Hospital
- China-Japan Union Hospital of Jilin University
- The Second Hospital of Jilin University
- The First Bethune Hospital of Jilin University
- Affiliated Zhongshan Hospital of Dalian University
- Dalian Municipal Central Hospital Affiliated of Dalian Medical University
- The People's Hospital of Liaoning Province
- General Hospital of Northern Theater Command
- General Hospital of Ningxia Medical University
- Qilu Hospital of Shandong University
- The Affiliated Hospital of Qingdao University
- Weihai Central Hospital
- Yantai Yuhuangding Hospital
- Zibo Central Hospital
- Shanghai Changzheng Hospital
- Ruijin Hospital Affiliated to School of Medicine, Shanghai Jiaotong University
- Shanghai Chest Hospital
- Xinhua Hospital Affiliated to School of Medicine, Shanghai Jiaotong University
- Shanghai East Hospital
- Changhai Hospital
- Shanghai General Hospital
- Shanghai 6th People's Hospital
- Baoji Central Hospital
- Second Hospital of Shanxi Medical University
- Shanxi Cardiovascular Hospital
- The Second Affiliated Hospital of Xi'an Jiaotong University
- First Affiliated Hospital of the Fourth Military Medical University
- The First Affiliated Hospital of Xi'an Jiaotong University
- Shanxi Provincial Hospital
- Tangdu Hospital of the Fourth Military Medical University of the PLA
- Yan'an University Affiliated Hospital
- Tianjin Chest Hospital
- Teda International Cardiovascular Hospital
- People's Hospital of Xinjiang Uygur Autonomous Region
- Fuwai Yunnan Cardiovascular Hospital
- The First People's Hospital of Yunnan
- Sir Run Run Shaw Hospital, Zhejiang University
- The Second Affiliated Hospital of Zhejiang University School of Medicine
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
Poststent SAPT treatment cohort
Poststent DAPT treatment cohort
Arm Description
receiving the treatment with NeoVas™ Bioabsorbable Coronary Artery Rapamycin-eluting Stent System of Lepu Medical combined with SAPT strategy
receiving the treatment with NeoVas™ Bioabsorbable Coronary Artery Rapamycin-eluting Stent System of Lepu Medical combined with DAPT strategy
Outcomes
Primary Outcome Measures
Net adverse clinical event (NACE)
NACE includes POCE (including all-cause death, all non-fatal myocardial infarction (Universal Definition of Myocardial Infarction, 4th Edition), any revascularization, and stroke), and major bleeding events of grade 2, 3, and 5 as defined by BARC.
Secondary Outcome Measures
Target lesion failure (TLF)
Target lesion failure (TLF) includes cardiac death, target vessel myocardial infarction (TV-MI) and ischemic-driven target lesion revascularization (ID-TLR).
Comparison of net adverse clinical events
Bleeding events of grade 3 and 5 as defined by BARC
Bleeding events of grade 2, 3 and 5 as defined by BARC
Bleeding events of grade 1, 2, 3 and 5 as defined by BARC
Comparison of target lesion failures
Patient-oriented composite endpoint (PoCE)
Patient-oriented composite endpoint (PoCE) includes all-cause death, all MI, any revascularization, and stroke.
Ischemic-driven target lesion revascularization (iTLR)
Ischemic-driven target vessel revascularization (iTVR)
All cardiac revascularization
All cardiac revascularization includes PCI and CABG.
Two types of stent thrombosis events as defined by BRS_ARC2
Full Information
NCT ID
NCT04995159
First Posted
July 29, 2021
Last Updated
July 29, 2021
Sponsor
Lepu Medical Technology (Beijing) Co., Ltd.
1. Study Identification
Unique Protocol Identification Number
NCT04995159
Brief Title
Optimized Antiplatelet Therapy in Patients With CHD After Implantation of NeoVas™ BRS System
Official Title
Evaluate the Safety and Efficacy of Optimized Antiplatelet Therapy in Patients With Coronary Heart Disease After Implantation of NeoVas™ Bioabsorbable Coronary Artery Rapamycin-eluting Stent System.
Study Type
Interventional
2. Study Status
Record Verification Date
July 2021
Overall Recruitment Status
Not yet recruiting
Study Start Date
September 2021 (Anticipated)
Primary Completion Date
January 2026 (Anticipated)
Study Completion Date
January 2028 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Lepu Medical Technology (Beijing) Co., Ltd.
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
5. Study Description
Brief Summary
This study is designed to verify the safety and efficacy of Lepu® NeoVas™ Bioabsorbable Coronary Artery Rapamycin-eluting Stent System combined with different antiplatelet therapies in the treatment of coronary heart disease.
Detailed Description
A total of 2150 subjects are planned to be enrolled in this trial. Subjects meeting the inclusion criteria and without exclusion criteria are implanted with NeoVas™ stents and randomly assigned to the experimental group and the control group in a 1:1 ratio. Patients in both groups will receive aspirin in combination with a P2Y12 receptor antagonist in the first year after PCI (either clopidogrel or ticagrelor will be selected by investigators according to the degree of ischemia). Aspirin will be discontinued one year after surgery and clopidogrel will be continued until 5 years after surgery in the experimental group. The control group will continue to take dual antiplatelet (DAPT) drugs, including aspirin and clopidogrel, for 2 more years; then aspirin will be used alone from the 4th year to the 5th year.
Subjects will be followed up at 30 days, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years after surgery to observe whether the net adverse clinical events (NACEs) and other end points occur or not.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Coronary Heart Disease
Keywords
Bioabsorbable Coronary Artery Rapamycin-eluting Stent System, Optimized Antiplatelet Therapy, Coronary Heart Disease, Randomized Controlled Trial
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
2150 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Poststent SAPT treatment cohort
Arm Type
Experimental
Arm Description
receiving the treatment with NeoVas™ Bioabsorbable Coronary Artery Rapamycin-eluting Stent System of Lepu Medical combined with SAPT strategy
Arm Title
Poststent DAPT treatment cohort
Arm Type
Active Comparator
Arm Description
receiving the treatment with NeoVas™ Bioabsorbable Coronary Artery Rapamycin-eluting Stent System of Lepu Medical combined with DAPT strategy
Intervention Type
Drug
Intervention Name(s)
Single anti-platelet therapy
Other Intervention Name(s)
SAPT strategy
Intervention Description
Aspirin in combination with a P2Y12 receptor antagonist (either clopidogrel or ticagrelor will be selected by investigators according to the degree of ischemia) in the first year after PCI. Aspirin will be discontinued one year after surgery and clopidogrel will be continued until 5 years after surgery.
Intervention Type
Drug
Intervention Name(s)
Dual anti-platelet therapy
Other Intervention Name(s)
DAPT strategy
Intervention Description
Aspirin in combination with a P2Y12 receptor antagonist (either clopidogrel or ticagrelor will be selected by investigators according to the degree of ischemia) in the first year after PCI. Patients continue to take dual antiplatelet (DAPT) drugs, including aspirin and clopidogrel, for 2 more years; then aspirin will be used alone from the 4th year to the 5th year.
Primary Outcome Measure Information:
Title
Net adverse clinical event (NACE)
Description
NACE includes POCE (including all-cause death, all non-fatal myocardial infarction (Universal Definition of Myocardial Infarction, 4th Edition), any revascularization, and stroke), and major bleeding events of grade 2, 3, and 5 as defined by BARC.
Time Frame
3 years
Secondary Outcome Measure Information:
Title
Target lesion failure (TLF)
Description
Target lesion failure (TLF) includes cardiac death, target vessel myocardial infarction (TV-MI) and ischemic-driven target lesion revascularization (ID-TLR).
Time Frame
3 years
Title
Comparison of net adverse clinical events
Time Frame
30 days, 6 months, 1 year, 2 years, 4 years, and 5 years
Title
Bleeding events of grade 3 and 5 as defined by BARC
Time Frame
30 days, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years
Title
Bleeding events of grade 2, 3 and 5 as defined by BARC
Time Frame
30 days, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years
Title
Bleeding events of grade 1, 2, 3 and 5 as defined by BARC
Time Frame
30 days, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years
Title
Comparison of target lesion failures
Time Frame
30 days, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years
Title
Patient-oriented composite endpoint (PoCE)
Description
Patient-oriented composite endpoint (PoCE) includes all-cause death, all MI, any revascularization, and stroke.
Time Frame
30 days, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years
Title
Ischemic-driven target lesion revascularization (iTLR)
Time Frame
30 days, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years
Title
Ischemic-driven target vessel revascularization (iTVR)
Time Frame
30 days, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years
Title
All cardiac revascularization
Description
All cardiac revascularization includes PCI and CABG.
Time Frame
30 days, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years
Title
Two types of stent thrombosis events as defined by BRS_ARC2
Time Frame
30 days, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Age 18 or above, male or non-pregnant female.
Evidence of myocardial ischemia (e.g., stable angina, unstable angina, medium-low risk NSTEMI, STEMI with onset more than 1 week, old myocardial infarction or asymptomatic myocardial ischemia), and suitable for PCI surgery.
The target lesion is in-situ coronary artery lesion, the total length of single lesion is no more than 40mm (the total length of stent is no more than 48mm), and the diameter of the target lesion is between 2.75mm and 3.75mm (visual measurement).
The diameter stenosis of target lesion is ≥70% in visual (or ≥50% with clinical evidence of myocardial ischemia in that range), and the TIMI blood flow is greater than grade 1.
The stent with diameter more than 3.0mm is allowed to overlap with another stent once, the overlapping methods could be edge to edge or at most 1mm overlap. The total number of stents per patient is no more than 4, with a maximum of 2 stents per vessel (the 2.75mm diameter stent is not allowed to overlap).
Patient with indications for coronary artery bypass surgery.
Aspirin and clopidogrel could be used continuously during the study.
Patient who can understand the purpose of this trial, is willing to participate in the trial and to conduct clinical follow-up as required by the study protocol.
Exclusion Criteria:
Acute ST-segment elevation myocardial infarction within 1 week.
Left main coronary artery disease, branch vessel diameter≥2.0mm, three-vessel coronary artery disease and bridge vessel disease; visible thrombus in the target vessel.
Severe distortion, severe calcification that cannot be successfully predilated, and other lesions that are not suitable for stent delivery and deployment.
Intra-stent restenosis.
Severe heart failure (NYHA≥III or left ventricular ejection fraction<35%).
Severe renal insufficiency, eGFR<30ml/min/1.73m2 or serum creatinine>2.5mg/dL (221μmol/L).
Patients with bleeding tendency, active gastrointestinal ulcer, history of cerebral hemorrhage or subarachnoid hemorrhage, history of stroke within half a year, fundus hemorrhage affecting vision, antiplatelet agents and anticoagulant treatment contraindications who cannot receive antithrombotic therapy.
Patients requiring long-term oral anticoagulants during the study period.
Patients who are pregnant, breastfeeding, or planning to become pregnant during the study period.
Patients with malignancies, organ transplants, or drug addiction that can seriously affect study compliance.
Patients with contraindications to aspirin, clopidogrel or ticagrelor.
Known allergy to aspirin, clopidogrel, ticagrelor, heparin, contrast agent, polylactic acid polymer and rapamycin.
Thrombosis occurred during previous clopidogrel treatment.
Life expectancy is less than 36 months.
Participated in clinical trials of other drugs or medical devices before enrollment and failed to meet the time limit of the primary end point.
Patients who will have elective surgery within a year and need to discontinue aspirin, clopidogrel or ticagrelor.
Subjects are deemed unsuitable for enrollment by investigators.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Ting Zhang
Phone
+86-010-80120666
Email
ting_zhang@lepumedical.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Yaling Han
Organizational Affiliation
The General Hospital of Northern Theater Command
Official's Role
Study Chair
Facility Information:
Facility Name
The First Affiliated Hospital of Bengbu Medical College
City
Bengbu
State/Province
Anhui
ZIP/Postal Code
233099
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hongju Wang
Facility Name
The First Affiliated Hospital with Anhui Medical University
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230022
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xianhe Lin
Facility Name
The First Affiliated Hospital of Wannan Medical College
City
Wuhu
State/Province
Anhui
ZIP/Postal Code
241001
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shengxing Tang
Facility Name
Peking Union Medical College Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100005
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhicheng Jing
Facility Name
Beijing Chaoyang Hospital, Capital Medical University
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100020
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lefeng Wang
Facility Name
Beijing Anzhen Hospital, Capital Medical University-12 Ward
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100029
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yujie Zhou
Facility Name
Beijing Anzhen Hospital, Capital Medical University-28 Ward
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100029
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jinghua Liu
Facility Name
Beijing Anzhen Hospital, Capital Medical University-33 Ward
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100029
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiantao Song
Facility Name
Beijing Shijitan Hospital, Capital Medical University
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100038
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jianjun Peng
Facility Name
Beijing Friendship Hospital, Capital Medical University
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100050
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hongwei Li
Facility Name
Xuan Wu Hospital, Capital Medical University
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100053
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hengjian Hao
Facility Name
Peking University Third Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100191
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yida Tang
Facility Name
Beijing Luhe Hospital, Capital Medical University
City
Beijing
State/Province
Beijing
ZIP/Postal Code
101199
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jincheng Guo
Facility Name
Beijing Jingmei Group General Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
102399
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yu Wang
Facility Name
The First Affiliated Hospital of Chongqing Medical University
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400042
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kanghua Ma
Facility Name
The Second Affiliated Hospital of Chongqing Medical University
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400042
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yuehui Yin
Facility Name
Gansu Provincial Hospital
City
Lanzhou
State/Province
Gansu
ZIP/Postal Code
730000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ping Xie
Facility Name
The First Hospital of Lanzhou University
City
Lanzhou
State/Province
Gansu
ZIP/Postal Code
730000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ming Bai
Facility Name
Lanzhou University Second Hospital
City
Lanzhou
State/Province
Gansu
ZIP/Postal Code
730099
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xin Lin
Facility Name
Foshan First People's Hospital
City
Foshan
State/Province
Guangdong
ZIP/Postal Code
528000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xili Yang
Facility Name
Guangdong Provincial Hospital of Traditional Chinese Medicine
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Qiuxiong Chen
Facility Name
The Third Affiliated Hospital of Guangdong Medical University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510150
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ximing Chen
Facility Name
Shantou Central Hospital
City
Shantou
State/Province
Guangdong
ZIP/Postal Code
515041
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhixiong Cai
Facility Name
The First Affiliated Hospital of Shantou University Medical College
City
Shantou
State/Province
Guangdong
ZIP/Postal Code
515041
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bin Wang
Facility Name
The Second Affiliated Hospital of Shantou University Medical College
City
Shantou
State/Province
Guangdong
ZIP/Postal Code
515041
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jilin Li
Facility Name
Shenzhen University General Hospital
City
Shenzhen
State/Province
Guangdong
ZIP/Postal Code
518055
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Haiying Li
Facility Name
Zhanjiang Central People's Hospital
City
Zhanjiang
State/Province
Guangdong
ZIP/Postal Code
524000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jie Chen
Facility Name
The Fifth Affiliated Hospital of Sun Yat-sen University
City
Zhuhai
State/Province
Guangdong
ZIP/Postal Code
519000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jian Chen
Facility Name
Guilin People's Hospital
City
Guilin
State/Province
Guangxi
ZIP/Postal Code
541002
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yubin Wu
Facility Name
Liuzhou People's Hospital
City
Liuzhou
State/Province
Guangxi
ZIP/Postal Code
545006
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fangyong Jiang
Facility Name
Liuzhou Worker's Hospital
City
Liuzhou
State/Province
Guangxi
ZIP/Postal Code
545006
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hong Wang
Facility Name
The First Affiliated Hospital of Guangxi Medical University
City
Nanning
State/Province
Guangxi
ZIP/Postal Code
530021
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lang Li
Facility Name
The First People's Hospital of Nanning
City
Nanning
State/Province
Guangxi
ZIP/Postal Code
530022
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xianming Zhao
Facility Name
Yulin First People's Hospital
City
Yulin
State/Province
Guangxi
ZIP/Postal Code
537099
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ping Li
Facility Name
Guizhou Provincial People's Hospital
City
Guiyang
State/Province
Guizhou
ZIP/Postal Code
550000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Qiang Wu
Facility Name
Haikou People's Hospital
City
Haikou
State/Province
Hainan
ZIP/Postal Code
570208
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bo Xing
Facility Name
The Second Affiliated Hospital of Hainan Medical University
City
Haikou
State/Province
Hainan
ZIP/Postal Code
570216
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yuewu Chen
Facility Name
Sanya Central Hospital (Hainan Third People's Hospital)
City
Sanya
State/Province
Hainan
ZIP/Postal Code
571199
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiangqun Zhou
Facility Name
Cangzhou Central Hospital
City
Cangzhou
State/Province
Hebei
ZIP/Postal Code
061011
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jun Zhang
Facility Name
Hengshui People's Hospital
City
Hengshui
State/Province
Hebei
ZIP/Postal Code
053099
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Qun Zheng
Facility Name
Hebei General Hospital
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
050057
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaoyong Qi
Facility Name
the 980th Hospital of Chinese People's Liberation Army Joint Logistics Support Force
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
050082
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Leisheng Ru
Facility Name
Xingtai People's Hospital
City
Xingtai
State/Province
Hebei
ZIP/Postal Code
054001
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Qingmin Wei
Facility Name
The Fourth Hospital of Harbin Medical University
City
Harbin
State/Province
Heilongjiang
ZIP/Postal Code
150001
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wei Yang
Facility Name
The Second Hospital of Harbin Medical University
City
Harbin
State/Province
Heilongjiang
ZIP/Postal Code
150086
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bo Yu
Facility Name
Nanyang Central Hospital
City
Nanyang
State/Province
Henan
ZIP/Postal Code
473005
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gang Li
Facility Name
Nanyang Second General Hospital
City
Nanyang
State/Province
Henan
ZIP/Postal Code
473009
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Quanbao Shi
Facility Name
Xinxiang Central Hospital
City
Xinxiang
State/Province
Henan
ZIP/Postal Code
453099
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhifang Wang
Facility Name
The First Affiliated Hospital of Xinxiang Medical University
City
Xinxiang
State/Province
Henan
ZIP/Postal Code
453199
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Guo'an Zhao
Facility Name
Zhengzhou Central Hospital
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450001
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhichen Zhao
Facility Name
Henan Provincial People's Hospital
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450003
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lixia Wang
Facility Name
Henan Provincial Chest Hospital
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450008
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fengling Wang
Facility Name
The Second Affiliated Hospital, Zhengzhou University
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450014
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Daguo Wan
Facility Name
The 7th People's Hospital of Zhengzhou
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450016
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yujie Zhao
Facility Name
The First Affiliated Hospital of Henan University of Science and Technology
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450052
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xuming Yang
Facility Name
The First Affiliated Hospital, Zhengzhou University
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450052
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jinying Zhang
Facility Name
The First Affiliated Hospital of Henan University of Chinese Medicine
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450099
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yushan Chen
Facility Name
Fuwai Central China Cardiovascular Hospital
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
451460
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chuanyu Gao
Facility Name
Jingzhou Central Hospital
City
Jingzhou
State/Province
Hubei
ZIP/Postal Code
434020
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Keping Yang
Facility Name
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430022
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiang Cheng
Facility Name
Fifth Hospital in Wuhan
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430050
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lifeng Hong
Facility Name
Renmin Hospital of Wuhan University
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430060
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hong Jiang
Facility Name
Zhongnan Hospital of Wuhan University
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430071
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaorong Hu
Facility Name
Xiangya Hospital, Central South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410008
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zaixin Yu
Facility Name
Xiangtan Central Hospital
City
Xiangtan
State/Province
Hunan
ZIP/Postal Code
411199
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mingxing Wu
Facility Name
The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science
City
Baotou
State/Province
Inner Mongolia
ZIP/Postal Code
014017
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hanjun Pei
Facility Name
Gynecology of Huai'an First People's Hospital, Nanjing Medical University
City
Huai'an
State/Province
Jiangsu
ZIP/Postal Code
223300
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiwen Zhang
Facility Name
Affiliated Lianyungang Hospital of Nanjing University of Chinese Medicine
City
Lianyungang
State/Province
Jiangsu
ZIP/Postal Code
222000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xin Wang
Facility Name
Zhongda Hospital Southeast University
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210009
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Genshan Ma
Facility Name
The First Affiliated Hospital with Nanjing Medical University
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210029
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiangqing Kong
Facility Name
Xuzhou Cancer Hospital
City
Xuzhou
State/Province
Jiangsu
ZIP/Postal Code
221005
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yaojun Zhang
Facility Name
The Affiliated Hospital of Xuzhou Medical University
City
Xuzhou
State/Province
Jiangsu
ZIP/Postal Code
221006
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chunmei Qi
Facility Name
The First Affiliated Hospital of Gannan Medical College
City
Ganzhou
State/Province
Jiangxi
ZIP/Postal Code
341000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yongling Liao
Facility Name
Jiangxi Provincial People's Hospital
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lang Hong
Facility Name
The First Affiliated Hospital of Nanchang University
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaoping Peng
Facility Name
The Second Affiliated Hospital of Nanchang University
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yanqing Wu
Facility Name
Yingtan People's Hospital
City
Yingtan
State/Province
Jiangxi
ZIP/Postal Code
335000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jinying Tong
Facility Name
China-Japan Union Hospital of Jilin University
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130033
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yuquan He
Facility Name
The Second Hospital of Jilin University
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130041
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bin Liu
Facility Name
The First Bethune Hospital of Jilin University
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130061
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Qian Tong
Facility Name
Affiliated Zhongshan Hospital of Dalian University
City
Dalian
State/Province
Liaoning
ZIP/Postal Code
116001
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhenguo Zheng
Facility Name
Dalian Municipal Central Hospital Affiliated of Dalian Medical University
City
Dalian
State/Province
Liaoning
ZIP/Postal Code
116089
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaoqun Zheng
Facility Name
The People's Hospital of Liaoning Province
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110016
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhanquan Li
Facility Name
General Hospital of Northern Theater Command
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110066
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yaling Han
Facility Name
General Hospital of Ningxia Medical University
City
Yinchuan
State/Province
Ningxia
ZIP/Postal Code
750003
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shaobin Jia
Facility Name
Qilu Hospital of Shandong University
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250012
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jifu Li
Facility Name
The Affiliated Hospital of Qingdao University
City
Qingdao
State/Province
Shandong
ZIP/Postal Code
266000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shanglang Cai
Facility Name
Weihai Central Hospital
City
Weihai
State/Province
Shandong
ZIP/Postal Code
264400
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jianhua Zhou
Facility Name
Yantai Yuhuangding Hospital
City
Yantai
State/Province
Shandong
ZIP/Postal Code
264099
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lin Zhong
Facility Name
Zibo Central Hospital
City
Zibo
State/Province
Shandong
ZIP/Postal Code
255020
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jun Wang
Facility Name
Shanghai Changzheng Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200003
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chun Liang
Facility Name
Ruijin Hospital Affiliated to School of Medicine, Shanghai Jiaotong University
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200025
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ruiyan Zhang
Facility Name
Shanghai Chest Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200030
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ben He
Facility Name
Xinhua Hospital Affiliated to School of Medicine, Shanghai Jiaotong University
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200092
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Li Zhang
Facility Name
Shanghai East Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200120
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Qi Zhang
Facility Name
Changhai Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200433
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xianxian Zhao
Facility Name
Shanghai General Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200940
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wenyi Yang
Facility Name
Shanghai 6th People's Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
201306
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chengxing Shen
Facility Name
Baoji Central Hospital
City
Baoji
State/Province
Shanxi
ZIP/Postal Code
721008
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yuhu Chun
Facility Name
Second Hospital of Shanxi Medical University
City
Taiyuan
State/Province
Shanxi
ZIP/Postal Code
030001
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bin Yang
Facility Name
Shanxi Cardiovascular Hospital
City
Taiyuan
State/Province
Shanxi
ZIP/Postal Code
030024
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jian An
Facility Name
The Second Affiliated Hospital of Xi'an Jiaotong University
City
Xi'an
State/Province
Shanxi
ZIP/Postal Code
710004
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jie Deng
Facility Name
First Affiliated Hospital of the Fourth Military Medical University
City
Xi'an
State/Province
Shanxi
ZIP/Postal Code
710032
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ling Tao
Facility Name
The First Affiliated Hospital of Xi'an Jiaotong University
City
Xi'an
State/Province
Shanxi
ZIP/Postal Code
710061
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dongqi Wang
Facility Name
Shanxi Provincial Hospital
City
Xi'an
State/Province
Shanxi
ZIP/Postal Code
710068
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiling Shou
Facility Name
Tangdu Hospital of the Fourth Military Medical University of the PLA
City
Yanan
State/Province
Shanxi
ZIP/Postal Code
716000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yan Li
Facility Name
Yan'an University Affiliated Hospital
City
Yanan
State/Province
Shanxi
ZIP/Postal Code
716000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Feng Gao
Facility Name
Tianjin Chest Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300222
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hongliang Cong
Facility Name
Teda International Cardiovascular Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300457
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wenhua Lin
Facility Name
People's Hospital of Xinjiang Uygur Autonomous Region
City
Urumqi
State/Province
Xinjiang
ZIP/Postal Code
830001
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yining Yang
Facility Name
Fuwai Yunnan Cardiovascular Hospital
City
Kunming
State/Province
Yunnan
ZIP/Postal Code
650000
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiangbin Pan
Facility Name
The First People's Hospital of Yunnan
City
Kunming
State/Province
Yunnan
ZIP/Postal Code
650034
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hong Zhang
Facility Name
Sir Run Run Shaw Hospital, Zhejiang University
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310016
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Guosheng Fu
Facility Name
The Second Affiliated Hospital of Zhejiang University School of Medicine
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
311100
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hong Yuan
12. IPD Sharing Statement
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Optimized Antiplatelet Therapy in Patients With CHD After Implantation of NeoVas™ BRS System
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