Back to results

Orientation Agnosia: Clinical and Anatomical Study (AGNORIENT)

Primary Purpose

Cerebrovascular Disorders, Brain Lesions

Status

Completed

Phase

Not Applicable

Locations

France

Study Type

Interventional

Intervention

Neuropsychological testing

MRI

About this trial

This is an interventional screening trial for Cerebrovascular Disorders focused on measuring stroke, parietal lesions

Eligibility Criteria

18 Years - 80 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

age between 18 and 80 years
french language
right parietal lesion on cerebral imaging (CT-scan is sufficient), including stroke,arterial malformation, isolated tumoral lesion
informed consent

Exclusion Criteria:

previous neurological history except non complicated migraine and stabilized epilepsia without seizure since 5 years
previous psychiatric history except depression without hospitalization > one week or anxiety with maximum one anxiolytic treatment
drug or alcohol abuse
severe cranial traumatism
other severe chronic pathology
psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month
visual impairment
motor or sensory deficit sufficient to render impossible neuropsychological tests
patient without judicial or administrative liberty
measure of legal protection or no capable to express their consent
pregnancy or breastfeeding

Sites / Locations

CHU de Rouen - Hôpitaux de Rouen

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

patient with right parietal lesions

patient with left parietal lesions

Arm Description

Outcomes

Primary Outcome Measures

orientation agnosia evaluation

orientation agnosia test

Secondary Outcome Measures

associated clinical symptoms especially apraxia

Full Information

NCT ID

NCT01304576

First Posted

August 23, 2010

Last Updated

September 1, 2014

Sponsor

University Hospital, Rouen

1. Study Identification

Unique Protocol Identification Number

NCT01304576

Brief Title

Orientation Agnosia: Clinical and Anatomical Study

Acronym

AGNORIENT

Official Title

Orientation Agnosia: Neuropsychological Evaluation, Associated Symptoms, Clinical and Anatomical Correlations

Study Type

Interventional

2. Study Status

Record Verification Date

September 2014

Overall Recruitment Status

Completed

Study Start Date

September 2010 (undefined)

Primary Completion Date

December 2013 (Actual)

Study Completion Date

December 2013 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

University Hospital, Rouen

4. Oversight

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

The area of the brain responsible of visuospatial processing data and more specifically the orientation of an object or image is located in parietal lobe, especially on the right side. A dysfunction of this region would result in a disorder of recognition of the orientation of objects and images that the investigators call orientation agnosia. Several isolated cases are reported in the literature but to the investigators knowledge deficit has never been systematically searched, or put into perspective compared to other neuropsychological deficits. Moreover, the precise location of the lesion responsible for such a disorder remains uncertain. The objectives of this study are (1) detect the existence of orientation agnosia in case of right parietal lesion, and (2) to improve the understanding of such a deficit allowing better management of this disorder.

Detailed Description

Idem

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Cerebrovascular Disorders, Brain Lesions

Keywords

stroke, parietal lesions

7. Study Design

Primary Purpose

Screening

Study Phase

Not Applicable

Interventional Study Model

Parallel Assignment

Masking

None (Open Label)

Allocation

Non-Randomized

Enrollment

34 (Actual)

8. Arms, Groups, and Interventions

Arm Title

patient with right parietal lesions

Arm Type

Experimental

Arm Title

patient with left parietal lesions

Arm Type

Active Comparator

Intervention Type

Behavioral

Intervention Name(s)

Neuropsychological testing

Intervention Description

Experimental test about orientation agnosia and standard neuropsychological tests.

Intervention Type

Other

Intervention Name(s)

MRI

Intervention Description

Cerebral MRI

Primary Outcome Measure Information:

Title

orientation agnosia evaluation

Description

orientation agnosia test

Time Frame

1 week to 6 months (average)

Secondary Outcome Measure Information:

Title

associated clinical symptoms especially apraxia

Time Frame

1 week to 6 months (average)

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Maximum Age & Unit of Time

80 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: age between 18 and 80 years french language right parietal lesion on cerebral imaging (CT-scan is sufficient), including stroke,arterial malformation, isolated tumoral lesion informed consent Exclusion Criteria: previous neurological history except non complicated migraine and stabilized epilepsia without seizure since 5 years previous psychiatric history except depression without hospitalization > one week or anxiety with maximum one anxiolytic treatment drug or alcohol abuse severe cranial traumatism other severe chronic pathology psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month visual impairment motor or sensory deficit sufficient to render impossible neuropsychological tests patient without judicial or administrative liberty measure of legal protection or no capable to express their consent pregnancy or breastfeeding

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Olivier MARTINAUD, Doctor

Organizational Affiliation

Service de neurologie et centre mémoire de ressources et recherche

Official's Role

Principal Investigator

Facility Information:

Facility Name

CHU de Rouen - Hôpitaux de Rouen

City

Rouen

State/Province

Haute-Normandie

ZIP/Postal Code

76031

Country

France

12. IPD Sharing Statement

Learn more about this trial

Orientation Agnosia: Clinical and Anatomical Study

We'll reach out to this number within 24 hrs