Back to resultsOsteopathic Health Outcomes in Chronic Low Back Pain (OSTEOPATHIC) Trial
Primary Purpose
Low Back Pain
Status
Completed
Phase
Phase 3
Locations
United States
Study Type
Interventional
Intervention
A. Active OMT and active UST
B. Sham OMT and active UST
C. Active OMT and sham UST
D. Sham OMT and sham UST
Sponsored by
About this trial
This is an interventional treatment trial for Low Back Pain focused on measuring Randomized controlled trial, Low back pain, Spinal manipulative therapy, Spinal manipulation, Osteopathic manipulation, Osteopathic medicine, Physical therapy modalities
Eligibility Criteria
Inclusion Criteria: Must give a positive response to the question: "Have you had low back pain constantly or on most days for the last three months?" Must identify the low back as the primary site of pain Must agree to not receive any of the following outside of the study during the period of participation: osteopathic manipulative treatment, chiropractic adjustment (including "mobilization" or "manipulation"), physical therapy Women must not be pregnant or plan to become pregnant during the period of study participation (a negative pregnancy test and willingness to maintain an acceptable method of contraception will be required) Exclusion Criteria: History of any of the following conditions which may be underlying causes of low back symptoms: cancer, spinal osteomyelitis, spinal fracture, herniated disc, ankylosing spondylitis, cauda equina syndrome History of surgery involving the low back within the past year or planned low back surgery in the future History of receiving Workers' Compensation benefits within the past three months Involvement in current litigation relating to back problems Current pregnancy or plan to become pregnant during the course of participation in the study Any of the following that may limit a provider's choice of osteopathic manipulative treatment techniques or hamper compliance with the study protocol: angina or congestive heart failure symptoms that occur at rest or with minimal activity, history of a stroke or transient ischemic attack within the past year Any of the following that may represent potential contraindications to receiving ultrasound physical therapy: implantation of a cardiac pacemaker, implantation of artificial joints or other biomedical devices, active bleeding or infection in the low back, pregnancy Use of intravenous, intramuscular, or oral corticosteroids within the past month History of osteopathic manipulative treatment, chiropractic adjustment, or physical therapy within the past three months or on more than three occasions during the past year Practitioner or student of any of the following: osteopathic medicine (D.O.) allopathic medicine (M.D.), chiropractic (D.C.), physical therapy
Sites / Locations
- The Osteopathic Research Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm Type
Other
Other
Other
Other
Arm Label
A (Active OMT and active (UST)
B (Sham OMT and active UST)
C (Active OMT and sham UST)
D (Sham OMT and sham UST)
Arm Description
Subjects in this group received active osteopathic manipulation and active ultrasound physical therapy
Subjects in this group received sham osteopathic manipulation and active ultrasound physical therapy
Subjects in this group received active osteopathic manipulation and sham ultrasound physical therapy
Subjects in this group received sham osteopathic manipulation and sham ultrasound physical therapy
Outcomes
Primary Outcome Measures
Change in Visual Analogue Scale Score for Pain Over 12 Weeks (OMT vs Sham OMT)
Comparison of the number (proportion) of participants in each study group who achieve a substantial improvement in low back pain over 12 weeks as determined by at least a 40-mm reduction (-40 mm) on the visual analogue scale score for pain compared with the baseline score. Changes in the visual analogue scale scores for pain over 12 weeks may potentially range from a 100-mm reduction (-100 mm) to a 100-mm increase (+100). Any reduction (negative score) represents an improvement in low back pain (i.e., a "better" outcome), while any increase (positive score) represents a worsening of low back pain (i.e., a "worse" outcome). However, only those "better" outcomes represented by change scores less than or equal to -40 mm are considered to represent substantial improvement in low back pain, which is the primary outcome measure of this study. For analyses wherein floor effects are important, the 40-mm reduction threshold for substantial improvement may be replaced by 50% reduction (-50%).
Change in Visual Analogue Scale Score for Pain Over 12 Weeks (Active UST vs Sham UST)
Comparison of the number (proportion) of participants in each study group who achieve a substantial improvement in low back pain over 12 weeks as determined by at least a 40-mm reduction (-40 mm) on the visual analogue scale score for pain compared with the baseline score. Changes in the visual analogue scale scores for pain over 12 weeks may potentially range from a 100-mm reduction (-100 mm) to a 100-mm increase (+100). Any reduction (negative score) represents an improvement in low back pain (i.e., a "better" outcome), while any increase (positive score) represents a worsening of low back pain (i.e., a "worse" outcome). However, only those "better" outcomes represented by change scores less than or equal to -40 mm are considered to represent substantial improvement in low back pain, which is the primary outcome measure of this study. For analyses wherein floor effects are important, the 40-mm reduction threshold for substantial improvement may be replaced by 50% reduction (-50%).
Secondary Outcome Measures
Roland Morris Disability Questionnaire (OMT and Sham OMT - Week 4)
Overall scores range from 0 to 24, which higher scores representing greater deficits in back-specific functioning.
Roland Morris Disability Questionnaire (OMT and Sham OMT - Week 8)
Overall scores range from 0 to 24, which higher scores representing greater deficits in back-specific functioning.
Roland Morris Disability Questionnaire (OMT and Sham OMT - Week 12)
Overall scores range from 0 to 24, which higher scores representing greater deficits in back-specific functioning.
Roland Morris Disability Questionnaire (UST and Sham UST - Week 4)
Overall scores range from 0 to 24, which higher scores representing greater deficits in back-specific functioning.
Roland Morris Disability Questionnaire (UST and Sham UST - Week 8)
Overall scores range from 0 to 24, which higher scores representing greater deficits in back-specific functioning.
Roland Morris Disability Questionnaire (UST and Sham UST - Week 12)
Overall scores range from 0 to 24, which higher scores representing greater deficits in back-specific functioning.
Medical Outcomes Study SF-36 Health Survey (OMT and Sham OMT - Week 4)
The general health scale ranges from 0 to 100, with higher scores representing better general health.
Medical Outcomes Study SF-36 Health Survey (OMT and Sham OMT - Week 8)
The general health scale ranges from 0 to 100, with higher scores representing better general health.
Medical Outcomes Study SF-36 Health Survey (OMT and Sham OMT - Week 12)
The general health scale ranges from 0 to 100, with higher scores representing better general health.
Medical Outcomes Study SF-36 Health Survey (UST and Sham UST - Week 4)
The general health scale ranges from 0 to 100, with higher scores representing better general health.
Medical Outcomes Study SF-36 Health Survey (UST and Sham UST - Week 8)
The general health scale ranges from 0 to 100, with higher scores representing better general health.
Medical Outcomes Study SF-36 Health Survey (UST and Sham UST - Week 12)
The general health scale ranges from 0 to 100, with higher scores representing better general health.
Work Disability (OMT and Sham OMT - Week 4)
Number of participants who reported losing one or more work days in the past 4 weeks because of low back pain.
Work Disability (OMT and Sham OMT - Week 8)
Number of participants who reported losing one or more work days in the past 4 weeks because of low back pain.
Work Disability (OMT and Sham OMT - Week 12)
Number of participants who reported losing one or more work days in the past 4 weeks because of low back pain.
Work Disability (UST and Sham UST - Week 4)
Number of participants who reported losing one or more work days in the past 4 weeks because of low back pain.
Work Disability (UST and Sham UST - Week 8)
Number of participants who reported losing one or more work days in the past 4 weeks because of low back pain.
Work Disability (UST and Sham UST - Week 12)
Number of participants who reported losing one or more work days in the past 4 weeks because of low back pain.
Satisfaction With Back Care (OMT and Sham OMT - Week 4)
Subjects who reported being very satisfied with back care
Satisfaction With Back Care (OMT and Sham OMT - Week 8)
Subjects who reported being very satisfied with back care
Satisfaction With Back Care (OMT and Sham OMT - Week 12)
Subjects who reported being very satisfied with back care
Satisfaction With Back Care (UST and Sham UST - Week 4)
Subjects who reported being very satisfied with back care
Satisfaction With Back Care (UST and Sham UST - Week 8)
Subjects who reported being very satisfied with back care
Satisfaction With Back Care (UST and Sham UST - Week 12)
Subjects who reported being very satisfied with back care
Full Information
NCT ID
NCT00315120
First Posted
April 13, 2006
Last Updated
May 24, 2016
Sponsor
University of North Texas Health Science Center
Collaborators
National Institutes of Health (NIH), Osteopathic Heritage Foundations, National Center for Complementary and Integrative Health (NCCIH)
1. Study Identification
Unique Protocol Identification Number
NCT00315120
Brief Title
Osteopathic Health Outcomes in Chronic Low Back Pain (OSTEOPATHIC) Trial
Official Title
A Randomized Controlled Trial of Osteopathic Manipulative Treatment and Ultrasound Physical Therapy for Chronic Low Back Pain
Study Type
Interventional
2. Study Status
Record Verification Date
May 2016
Overall Recruitment Status
Completed
Study Start Date
August 2006 (undefined)
Primary Completion Date
January 2011 (Actual)
Study Completion Date
January 2011 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of North Texas Health Science Center
Collaborators
National Institutes of Health (NIH), Osteopathic Heritage Foundations, National Center for Complementary and Integrative Health (NCCIH)
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The purpose of this study is to determine whether osteopathic manipulative treatment (a type of spinal manipulative therapy used by osteopathic physicians) and ultrasound physical therapy are effective in the treatment of chronic low back pain.
Detailed Description
The purpose of this study is to determine whether osteopathic manipulative treatment (a type of spinal manipulative therapy used by osteopathic physicians) and ultrasound physical therapy are effective in the treatment of chronic low back pain. This study uses a 2X2 factorial design to test the hypotheses.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Low Back Pain
Keywords
Randomized controlled trial, Low back pain, Spinal manipulative therapy, Spinal manipulation, Osteopathic manipulation, Osteopathic medicine, Physical therapy modalities
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Factorial Assignment
Masking
ParticipantOutcomes Assessor
Allocation
Randomized
Enrollment
455 (Actual)
8. Arms, Groups, and Interventions
Arm Title
A (Active OMT and active (UST)
Arm Type
Other
Arm Description
Subjects in this group received active osteopathic manipulation and active ultrasound physical therapy
Arm Title
B (Sham OMT and active UST)
Arm Type
Other
Arm Description
Subjects in this group received sham osteopathic manipulation and active ultrasound physical therapy
Arm Title
C (Active OMT and sham UST)
Arm Type
Other
Arm Description
Subjects in this group received active osteopathic manipulation and sham ultrasound physical therapy
Arm Title
D (Sham OMT and sham UST)
Arm Type
Other
Arm Description
Subjects in this group received sham osteopathic manipulation and sham ultrasound physical therapy
Intervention Type
Procedure
Intervention Name(s)
A. Active OMT and active UST
Intervention Description
Active osteopathic manipulation (OMT) and active ultrasound physical therapy (UST)
Intervention Type
Procedure
Intervention Name(s)
B. Sham OMT and active UST
Intervention Description
Sham osteopathic manipulation (OMT) and active ultrasound physical therapy (UST)
Intervention Type
Procedure
Intervention Name(s)
C. Active OMT and sham UST
Intervention Description
Active osteopathic manipulation (OMT) and sham ultrasound physical therapy (UST)
Intervention Type
Procedure
Intervention Name(s)
D. Sham OMT and sham UST
Intervention Description
Sham osteopathic manipulation (OMT) and sham ultrasound physical therapy (UST)
Primary Outcome Measure Information:
Title
Change in Visual Analogue Scale Score for Pain Over 12 Weeks (OMT vs Sham OMT)
Description
Comparison of the number (proportion) of participants in each study group who achieve a substantial improvement in low back pain over 12 weeks as determined by at least a 40-mm reduction (-40 mm) on the visual analogue scale score for pain compared with the baseline score. Changes in the visual analogue scale scores for pain over 12 weeks may potentially range from a 100-mm reduction (-100 mm) to a 100-mm increase (+100). Any reduction (negative score) represents an improvement in low back pain (i.e., a "better" outcome), while any increase (positive score) represents a worsening of low back pain (i.e., a "worse" outcome). However, only those "better" outcomes represented by change scores less than or equal to -40 mm are considered to represent substantial improvement in low back pain, which is the primary outcome measure of this study. For analyses wherein floor effects are important, the 40-mm reduction threshold for substantial improvement may be replaced by 50% reduction (-50%).
Time Frame
12 weeks
Title
Change in Visual Analogue Scale Score for Pain Over 12 Weeks (Active UST vs Sham UST)
Description
Comparison of the number (proportion) of participants in each study group who achieve a substantial improvement in low back pain over 12 weeks as determined by at least a 40-mm reduction (-40 mm) on the visual analogue scale score for pain compared with the baseline score. Changes in the visual analogue scale scores for pain over 12 weeks may potentially range from a 100-mm reduction (-100 mm) to a 100-mm increase (+100). Any reduction (negative score) represents an improvement in low back pain (i.e., a "better" outcome), while any increase (positive score) represents a worsening of low back pain (i.e., a "worse" outcome). However, only those "better" outcomes represented by change scores less than or equal to -40 mm are considered to represent substantial improvement in low back pain, which is the primary outcome measure of this study. For analyses wherein floor effects are important, the 40-mm reduction threshold for substantial improvement may be replaced by 50% reduction (-50%).
Time Frame
12 weeks
Secondary Outcome Measure Information:
Title
Roland Morris Disability Questionnaire (OMT and Sham OMT - Week 4)
Description
Overall scores range from 0 to 24, which higher scores representing greater deficits in back-specific functioning.
Time Frame
4 weeks
Title
Roland Morris Disability Questionnaire (OMT and Sham OMT - Week 8)
Description
Overall scores range from 0 to 24, which higher scores representing greater deficits in back-specific functioning.
Time Frame
8 weeks
Title
Roland Morris Disability Questionnaire (OMT and Sham OMT - Week 12)
Description
Overall scores range from 0 to 24, which higher scores representing greater deficits in back-specific functioning.
Time Frame
12 weeks
Title
Roland Morris Disability Questionnaire (UST and Sham UST - Week 4)
Description
Overall scores range from 0 to 24, which higher scores representing greater deficits in back-specific functioning.
Time Frame
4 weeks
Title
Roland Morris Disability Questionnaire (UST and Sham UST - Week 8)
Description
Overall scores range from 0 to 24, which higher scores representing greater deficits in back-specific functioning.
Time Frame
8 weeks
Title
Roland Morris Disability Questionnaire (UST and Sham UST - Week 12)
Description
Overall scores range from 0 to 24, which higher scores representing greater deficits in back-specific functioning.
Time Frame
12 weeks
Title
Medical Outcomes Study SF-36 Health Survey (OMT and Sham OMT - Week 4)
Description
The general health scale ranges from 0 to 100, with higher scores representing better general health.
Time Frame
4 weeks
Title
Medical Outcomes Study SF-36 Health Survey (OMT and Sham OMT - Week 8)
Description
The general health scale ranges from 0 to 100, with higher scores representing better general health.
Time Frame
8 weeks
Title
Medical Outcomes Study SF-36 Health Survey (OMT and Sham OMT - Week 12)
Description
The general health scale ranges from 0 to 100, with higher scores representing better general health.
Time Frame
12 weeks
Title
Medical Outcomes Study SF-36 Health Survey (UST and Sham UST - Week 4)
Description
The general health scale ranges from 0 to 100, with higher scores representing better general health.
Time Frame
4 Weeks
Title
Medical Outcomes Study SF-36 Health Survey (UST and Sham UST - Week 8)
Description
The general health scale ranges from 0 to 100, with higher scores representing better general health.
Time Frame
8 Weeks
Title
Medical Outcomes Study SF-36 Health Survey (UST and Sham UST - Week 12)
Description
The general health scale ranges from 0 to 100, with higher scores representing better general health.
Time Frame
12 Weeks
Title
Work Disability (OMT and Sham OMT - Week 4)
Description
Number of participants who reported losing one or more work days in the past 4 weeks because of low back pain.
Time Frame
4 weeks
Title
Work Disability (OMT and Sham OMT - Week 8)
Description
Number of participants who reported losing one or more work days in the past 4 weeks because of low back pain.
Time Frame
8 weeks
Title
Work Disability (OMT and Sham OMT - Week 12)
Description
Number of participants who reported losing one or more work days in the past 4 weeks because of low back pain.
Time Frame
12 weeks
Title
Work Disability (UST and Sham UST - Week 4)
Description
Number of participants who reported losing one or more work days in the past 4 weeks because of low back pain.
Time Frame
4 weeks
Title
Work Disability (UST and Sham UST - Week 8)
Description
Number of participants who reported losing one or more work days in the past 4 weeks because of low back pain.
Time Frame
8 weeks
Title
Work Disability (UST and Sham UST - Week 12)
Description
Number of participants who reported losing one or more work days in the past 4 weeks because of low back pain.
Time Frame
12 weeks
Title
Satisfaction With Back Care (OMT and Sham OMT - Week 4)
Description
Subjects who reported being very satisfied with back care
Time Frame
4 weeks
Title
Satisfaction With Back Care (OMT and Sham OMT - Week 8)
Description
Subjects who reported being very satisfied with back care
Time Frame
8 weeks
Title
Satisfaction With Back Care (OMT and Sham OMT - Week 12)
Description
Subjects who reported being very satisfied with back care
Time Frame
12 weeks
Title
Satisfaction With Back Care (UST and Sham UST - Week 4)
Description
Subjects who reported being very satisfied with back care
Time Frame
4 weeks
Title
Satisfaction With Back Care (UST and Sham UST - Week 8)
Description
Subjects who reported being very satisfied with back care
Time Frame
8 weeks
Title
Satisfaction With Back Care (UST and Sham UST - Week 12)
Description
Subjects who reported being very satisfied with back care
Time Frame
12 weeks
10. Eligibility
Sex
All
Minimum Age & Unit of Time
21 Years
Maximum Age & Unit of Time
69 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Must give a positive response to the question: "Have you had low back pain constantly or on most days for the last three months?"
Must identify the low back as the primary site of pain
Must agree to not receive any of the following outside of the study during the period of participation: osteopathic manipulative treatment, chiropractic adjustment (including "mobilization" or "manipulation"), physical therapy
Women must not be pregnant or plan to become pregnant during the period of study participation (a negative pregnancy test and willingness to maintain an acceptable method of contraception will be required)
Exclusion Criteria:
History of any of the following conditions which may be underlying causes of low back symptoms: cancer, spinal osteomyelitis, spinal fracture, herniated disc, ankylosing spondylitis, cauda equina syndrome
History of surgery involving the low back within the past year or planned low back surgery in the future
History of receiving Workers' Compensation benefits within the past three months
Involvement in current litigation relating to back problems
Current pregnancy or plan to become pregnant during the course of participation in the study
Any of the following that may limit a provider's choice of osteopathic manipulative treatment techniques or hamper compliance with the study protocol: angina or congestive heart failure symptoms that occur at rest or with minimal activity, history of a stroke or transient ischemic attack within the past year
Any of the following that may represent potential contraindications to receiving ultrasound physical therapy: implantation of a cardiac pacemaker, implantation of artificial joints or other biomedical devices, active bleeding or infection in the low back, pregnancy
Use of intravenous, intramuscular, or oral corticosteroids within the past month
History of osteopathic manipulative treatment, chiropractic adjustment, or physical therapy within the past three months or on more than three occasions during the past year
Practitioner or student of any of the following: osteopathic medicine (D.O.) allopathic medicine (M.D.), chiropractic (D.C.), physical therapy
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
John C. Licciardone, DO, MS, MBA
Organizational Affiliation
The Osteopathic Research Center, University of North Texas Health Science Center at Fort Worth
Official's Role
Principal Investigator
Facility Information:
Facility Name
The Osteopathic Research Center
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76107
Country
United States
12. IPD Sharing Statement
Plan to Share IPD
No
Citations:
PubMed Identifier
16080794
Citation
Licciardone JC, Brimhall AK, King LN. Osteopathic manipulative treatment for low back pain: a systematic review and meta-analysis of randomized controlled trials. BMC Musculoskelet Disord. 2005 Aug 4;6:43. doi: 10.1186/1471-2474-6-43.
Results Reference
background
PubMed Identifier
18439282
Citation
Licciardone JC, King HH, Hensel KL, Williams DG. OSTEOPAThic Health outcomes in chronic low back pain: The OSTEOPATHIC Trial. Osteopath Med Prim Care. 2008 Apr 25;2:5. doi: 10.1186/1750-4732-2-5.
Results Reference
background
PubMed Identifier
21135197
Citation
Clinical Guideline Subcommittee on Low Back Pain; American Osteopathic Association. American Osteopathic Association guidelines for osteopathic manipulative treatment (OMT) for patients with low back pain. J Am Osteopath Assoc. 2010 Nov;110(11):653-66.
Results Reference
background
PubMed Identifier
24590092
Citation
Licciardone JC, Gatchel R, Dagenais S. Assessment and management of back pain. JAMA Intern Med. 2014 Mar;174(3):478-9. doi: 10.1001/jamainternmed.2013.13692. No abstract available.
Results Reference
background
PubMed Identifier
24133757
Citation
Licciardone JC. Osteopathic manual treatment and ultrasound therapy for chronic low back pain: an illustration of osteopathic semantic confusion. Author reply. J Am Osteopath Assoc. 2013 Sep;113(9):661-2. doi: 10.7556/jaoa.2013.031. No abstract available.
Results Reference
background
PubMed Identifier
23294676
Citation
Licciardone JC. Systematic review and meta-analysis conclusions relating to osteopathic manipulative treatment for low back pain remain valid and well accepted. J Bodyw Mov Ther. 2013 Jan;17(1):2-4. doi: 10.1016/j.jbmt.2012.10.003. Epub 2012 Nov 16. No abstract available.
Results Reference
background
PubMed Identifier
21494808
Citation
Licciardone JC. Osteopathic manipulative treatment in patients with low back pain. Clin Rheumatol. 2011 Jun;30(6):871-2; author reply 873. doi: 10.1007/s10067-011-1739-9. Epub 2011 Apr 15. No abstract available.
Results Reference
background
PubMed Identifier
23759340
Citation
Licciardone JC, Kearns CM, Minotti DE. Outcomes of osteopathic manual treatment for chronic low back pain according to baseline pain severity: results from the OSTEOPATHIC Trial. Man Ther. 2013 Dec;18(6):533-40. doi: 10.1016/j.math.2013.05.006. Epub 2013 Jun 10.
Results Reference
result
PubMed Identifier
23739758
Citation
Licciardone JC, Kearns CM, Hodge LM, Minotti DE. Osteopathic manual treatment in patients with diabetes mellitus and comorbid chronic low back pain: subgroup results from the OSTEOPATHIC Trial. J Am Osteopath Assoc. 2013 Jun;113(6):468-78.
Results Reference
result
PubMed Identifier
23508598
Citation
Licciardone JC, Minotti DE, Gatchel RJ, Kearns CM, Singh KP. Osteopathic manual treatment and ultrasound therapy for chronic low back pain: a randomized controlled trial. Ann Fam Med. 2013 Mar-Apr;11(2):122-9. doi: 10.1370/afm.1468.
Results Reference
result
PubMed Identifier
23212429
Citation
Licciardone JC, Gatchel RJ, Kearns CM, Minotti DE. Depression, somatization, and somatic dysfunction in patients with nonspecific chronic low back pain: results from the OSTEOPATHIC Trial. J Am Osteopath Assoc. 2012 Dec;112(12):783-91.
Results Reference
result
PubMed Identifier
22984233
Citation
Licciardone JC, Kearns CM, Hodge LM, Bergamini MV. Associations of cytokine concentrations with key osteopathic lesions and clinical outcomes in patients with nonspecific chronic low back pain: results from the OSTEOPATHIC Trial. J Am Osteopath Assoc. 2012 Sep;112(9):596-605. doi: 10.7556/jaoa.2012.112.9.596. Erratum In: J Am Osteopath Assoc. 2017 Jun 1;117(6):350.
Results Reference
result
PubMed Identifier
22802542
Citation
Licciardone JC, Kearns CM. Somatic dysfunction and its association with chronic low back pain, back-specific functioning, and general health: results from the OSTEOPATHIC Trial. J Am Osteopath Assoc. 2012 Jul;112(7):420-8.
Results Reference
result
PubMed Identifier
24361999
Citation
Licciardone JC. Short-term dosing of manual therapies for chronic low back pain. Spine J. 2014 Jun 1;14(6):1085-6. doi: 10.1016/j.spinee.2013.12.015. Epub 2013 Dec 20. No abstract available.
Results Reference
result
PubMed Identifier
24704126
Citation
Licciardone JC, Kearns CM, Crow WT. Changes in biomechanical dysfunction and low back pain reduction with osteopathic manual treatment: results from the OSTEOPATHIC Trial. Man Ther. 2014 Aug;19(4):324-30. doi: 10.1016/j.math.2014.03.004. Epub 2014 Mar 18.
Results Reference
result
PubMed Identifier
25002440
Citation
Licciardone JC. The OSTEOPATHIC trial demonstrates significant improvement in patients with chronic low back pain as manifested by decreased prescription rescue medication use. J Am Osteopath Assoc. 2014 Jul;114(7):528-9. doi: 10.7556/jaoa.2014.103. No abstract available.
Results Reference
result
PubMed Identifier
24965494
Citation
Licciardone JC, Aryal S. Clinical response and relapse in patients with chronic low back pain following osteopathic manual treatment: results from the OSTEOPATHIC Trial. Man Ther. 2014 Dec;19(6):541-8. doi: 10.1016/j.math.2014.05.012. Epub 2014 Jun 5.
Results Reference
result
PubMed Identifier
26927909
Citation
Licciardone JC, Gatchel RJ, Aryal S. Targeting Patient Subgroups With Chronic Low Back Pain for Osteopathic Manipulative Treatment: Responder Analyses From a Randomized Controlled Trial. J Am Osteopath Assoc. 2016 Mar;116(3):156-68. doi: 10.7556/jaoa.2016.032.
Results Reference
derived
PubMed Identifier
26927908
Citation
Licciardone JC, Gatchel RJ, Aryal S. Recovery From Chronic Low Back Pain After Osteopathic Manipulative Treatment: A Randomized Controlled Trial. J Am Osteopath Assoc. 2016 Mar;116(3):144-55. doi: 10.7556/jaoa.2016.031.
Results Reference
derived
Learn more about this trial
Osteopathic Health Outcomes in Chronic Low Back Pain (OSTEOPATHIC) Trial
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