Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery
Colorectal Cancer

About this trial
This is an interventional treatment trial for Colorectal Cancer focused on measuring adenocarcinoma of the colon, stage III colon cancer
Eligibility Criteria
Requirements for tumor parameters
- Histologically documented adenocarcinoma of the colon. The gross inferior (caudad) margin of the primary tumor must lie above the peritoneal reflection (i.e., patients with rectal cancer are not eligible). Surgeon confirmation that the entire tumor was above the peritoneal reflection is only required in cases where it is important to establish if the tumor is a rectal or colon primary.
- Tumors must have been completely resected. In patients with tumor adherent to adjacent structures, en bloc R0 resection must be documented in the operative report or otherwise confirmed by the surgeon. Near or positive radial margin are not exclusions as long as en bloc resection was performed. Positive proximal margin or distal margin is an exclusion.
- Node positive disease (N1 or N2) as designated in AJCC version 7. Either at least one pathologically confirmed positive lymph node or N1C (defined as tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastases). Patients with resected stage IV disease are not eligible.
- No evidence of residual involved lymph node disease or metastatic disease at the time of registration.
- Patients with synchronous colon cancers are eligible and staging for stratification will be based on higher N stage of the more advanced primary tumor. However, patients with synchronous colon and rectal primary tumors are not eligible.
NSAID use
Patients are ineligible if they plan on regular use of NSAIDs at any dose more than 2 times per week (on average) or aspirin at more than 325 mg at least three times per week, on average. Low-dose aspirin not exceeding 100 mg/day is permitted. Patients who agree to stop regular NSAIDs or higher dose aspirin are eligible and no was out period is required.
Patient history
- No previous or concurrent malignancy, except treated basal cell or squamous cell cancer of skin, treated in situ cervical cancer, treated lobular or ductal carcinoma in situ in one breast, or any other cancer for which the patient has been disease-free for at least 5 years.
- No neurosensory or neuromotor toxicity ≥ grade 2 at the time of registration.
- No known allergy to platinum compounds.
- No prior allergic reaction or hypersensitivity to sulfonamides, celecoxib or NSAIDs.
- No history of upper gastrointestinal ulceration, upper gastrointestinal bleeding, or upper gastrointestinal perforation within the past 3 years. Patients with ulceration, bleeding or perforation in the lower bowel are not excluded.
- No symptomatic pulmonary fibrosis or interstitial pneumonitis ≥ grade 2.
No cardiac risk factors including:
- Uncontrolled high blood pressure (systolic blood pressure > 150).
- Unstable angina.
- History of documented myocardial infarction or cerebrovascular accident.
- New York Heart Association class III or IV heart failure.
Pregancy/nursing status
Non-pregnant and not nursing. Men and women of childbearing potential must agree to employ adequate contraception for the duration of chemotherapy and for as many as 8 weeks after the completion of chemotherapy due to the unknown teratogenic effects of FOLFOX on the developing fetus.
Age and performance status
- ECOG performance status 0, 1 or 2.
- Age at least 18 years.
Required initial laboratory values
- Granulocytes ≥ 1,500/μL
- Platelet count ≥ 100,000/μL
- Creatinine ≤ 1.5 times upper limit of normal (ULN)
- Total Bilirubin ≤ 1.5 times ULN in the absence of Gilbert's disease
- Direct bilirubin ≤ 1.5 x upper limit of normal for patients with Gilbert's syndrome
Sites / Locations
- University of South Alabama Mitchell Cancer Institute
- Alaska Breast Care and Surgery LLC
- Alaska Women's Cancer Care
- Anchorage Oncology Centre
- Katmai Oncology Group
- Providence Alaska Medical Center
- Fairbanks Memorial Hospital
- Fowler Family Center for Cancer Care
- Sutter Cancer Centers Radiation Oncology Services-Auburn
- Alta Bates Summit Medical Center-Herrick Campus
- Providence Saint Joseph Medical Center-Disney Family Cancer Center
- Mills-Peninsula Hospitals
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
- John Muir Medical Center-Concord
- Sutter Davis Hospital
- City of Hope Comprehensive Cancer Center
- Epic Care-Dublin
- Bay Area Breast Surgeons Inc
- Epic Care Partners in Cancer Care
- Comprehensive Cancer Care and Research Institute of Colorado LLC
- University Oncology Associates
- California Cancer Center - North Fresno
- Marin Cancer Care Inc
- Marin General Hospital
- Kaiser Permanente Los Angeles Medical Center
- USC/Norris Comprehensive Cancer Center
- Los Angeles County-USC Medical Center
- Contra Costa Regional Medical Center
- Memorial Medical Center
- Palo Alto Medical Foundation-Camino Division
- Palo Alto Medical Foundation-Gynecologic Oncology
- Sutter Cancer Research Consortium
- Alta Bates Summit Medical Center - Summit Campus
- Bay Area Tumor Institute
- Hematology and Oncology Associates-Oakland
- Saint Joseph Hospital - Orange
- UC Irvine Health-Chao Family Comprehensive Cancer Center
- Desert Regional Medical Center
- Stanford Cancer Institute
- Palchak David MD
- Valley Medical Oncology Consultants
- Kaiser Permanente-Redwood City
- Kaiser Permanente-Richmond
- Kaiser Permanente-Riverside
- Kaiser Permanente-Roseville
- Sutter Cancer Centers Radiation Oncology Services-Roseville
- Sutter Roseville Medical Center
- Sutter General Hospital
- University of California Davis Comprehensive Cancer Center
- Saint Helena Hospital
- Salinas Valley Memorial Hospital
- Salinas Valley Memorial
- Kaiser Permanente-San Diego Zion
- Naval Medical Center-San Diego
- Kaiser Permanente-San Francisco
- UCSF Medical Center-Mount Zion
- California Pacific Medical Center-Pacific Campus
- Veterans Affairs Medical Center-San Francisco
- UCSF Medical Center-Mission Bay
- Kaiser Permanente-Santa Teresa-San Jose
- Santa Clara Valley Medical Center
- Kaiser Permanente San Leandro
- Kaiser Permanente-San Rafael
- Kaiser Permanente Medical Center-Santa Clara
- Palo Alto Medical Foundation-Santa Cruz
- Kaiser Permanente-Santa Rosa
- Sutter Pacific Medical Foundation
- Kaiser Permanente-South San Francisco
- Kaiser Permanente-Stockton
- Palo Alto Medical Foundation-Sunnyvale
- Sutter Cancer Centers Radiation Oncology Services-Vacaville
- Kaiser Permanente Medical Center-Vacaville
- Kaiser Permanente-Vallejo
- Sutter Solano Medical Center/Cancer Center
- Kaiser Permanente-Walnut Creek
- John Muir Medical Center-Walnut Creek
- Rocky Mountain Cancer Centers-Aurora
- The Medical Center of Aurora
- University of Colorado Cancer Center-Anschutz Cancer Pavilion
- Boulder Community Hospital
- Rocky Mountain Cancer Centers-Boulder
- Penrose-Saint Francis Healthcare
- Rocky Mountain Cancer Centers-Penrose
- Memorial Hospital Colorado Springs
- Porter Adventist Hospital
- Exempla Saint Joseph Hospital
- Presbyterian-Saint Lukes Medical Center-Health One
- Rocky Mountain Cancer Centers-Midtown
- Rocky Mountain Cancer Centers-Rose
- Rose Medical Center
- Colorado Cancer Research Program NCORP
- Colorado Blood Cancer Institute
- Mercy Medical Center
- Southwest Oncology PC
- Swedish Medical Center
- Poudre Valley Hospital
- Mountain Blue Cancer Care Center
- North Colorado Medical Center
- Rocky Mountain Cancer Centers-Greenwood Village
- Rocky Mountain Cancer Centers-Lakewood
- Saint Anthony Hospital
- Rocky Mountain Cancer Centers-Littleton
- Littleton Adventist Hospital
- Rocky Mountain Cancer Centers-Sky Ridge
- Sky Ridge Medical Center
- Longmont United Hospital
- Rocky Mountain Cancer Centers-Longmont
- McKee Medical Center
- Parker Adventist Hospital
- Rocky Mountain Cancer Centers-Parker
- Rocky Mountain Cancer Centers - Pueblo
- Rocky Mountain Cancer Centers-Thornton
- Exempla Lutheran Medical Center
- Hartford Hospital
- Saint Francis Hospital and Medical Center
- Midstate Medical Center
- The Hospital of Central Connecticut
- Norwalk Hospital
- Beebe Medical Center
- Christiana Gynecologic Oncology LLC
- Delaware Clinical and Laboratory Physicians PA
- Helen F Graham Cancer Center
- Medical Oncology Hematology Consultants PA
- Regional Hematology and Oncology PA
- Christiana Care Health System-Christiana Hospital
- Beebe Health Campus
- Nanticoke Memorial Hospital
- Christiana Care Health System-Wilmington Hospital
- MedStar Georgetown University Hospital
- MedStar Washington Hospital Center
- Sibley Memorial Hospital
- Veterans Affairs Medical Center - Washington, DC
- University of Florida-Gainesville
- Memorial Regional Hospital-Joe DiMaggio Children's Hospital
- Mayo Clinic in Florida
- Mount Sinai Medical Center
- Memorial Hospital West
- Robert and Carol Weissman Cancer Center at Martin Health
- Phoebe Putney Memorial Hospital
- Emory University/Winship Cancer Institute
- Atlanta VA Medical Center
- Dekalb Medical Center
- Northeast Georgia Medical Center
- Medical Center of Central Georgia
- Low Country Cancer Care Associates PC
- Pali Momi Medical Center
- Oncare Hawaii Inc - POB II
- Queen's Medical Center
- Straub Clinic and Hospital
- University of Hawaii Cancer Center
- Oncare Hawaii Inc-Kuakini
- The Cancer Center of Hawaii-Liliha
- Kaiser Permanente Moanalua Medical Center
- Kapiolani Medical Center for Women and Children
- Tripler Army Medical Center
- Saint Alphonsus Cancer Care Center-Boise
- Saint Luke's Mountain States Tumor Institute
- Saint Luke's Mountain States Tumor Institute - Fruitland
- Saint Joseph Regional Medical Center
- Saint Luke's Mountain States Tumor Institute - Meridian
- Saint Luke's Mountain States Tumor Institute - Nampa
- Saint Luke's Mountain States Tumor Institute-Twin Falls
- Rush Copley Medical Center
- Illinois CancerCare - Bloomington
- Saint Joseph Medical Center
- Illinois CancerCare - Canton
- Memorial Hospital of Carbondale
- Illinois CancerCare - Carthage
- Centralia Oncology Clinic
- Northwestern University
- John H. Stroger, Jr. Hospital of Cook County
- University of Illinois
- Weiss Memorial Hospital
- Advocate Illinois Masonic Medical Center
- Presence Saint Joseph Hospital-Chicago
- Carle on Vermilion
- Cancer Care Specialists of Central Illinois
- Decatur Memorial Hospital Cancer Care Institute
- Carle Physician Group-Effingham
- Crossroads Cancer Center
- Advocate Sherman Hospital
- Elmhurst Memorial Hospital
- Illinois CancerCare - Eureka
- Saint Francis Hospital
- Illinois CancerCare - Galesburg
- Western Illinois Cancer Treatment Center
- Ingalls Memorial Hospital
- Hematology Oncology Associates -Highland Park
- Presence Saint Mary's Hospital
- Illinois CancerCare - Kewanee Clinic
- NorthShore Hematology Oncology-Libertyville
- Illinois CancerCare - Macomb
- Carle Physician Group-Mattoon/Charleston
- Garneau, Stewart C MD (UIA Investigator)
- Spector, David MD (UIA Investigator)
- Trinity Medical Center
- Good Samaritan Regional Health Center
- Edward Hospital Cancer Center
- Hematology Oncology Consultants Ltd.
- Illinois Cancer Specialists-Niles
- Advocate Christ Medical Center
- Radiation Oncology of Northern Illinois
- Pekin Cancer Treatment Center
- Illinois CancerCare - Pekin
- Methodist Medical Center of Illinois
- OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
- Illinois CancerCare - Peru
- Valley Radiation Oncology
- Illinois CancerCare - Princeton
- Quincy Medical Group - Clinic
- Swedish American Hospital
- OSF Saint Anthony Medical Center
- Hematology Oncology Associates - Skokie
- Central Illinois Hematology Oncology Center
- Southern Illinois University School of Medicine
- Springfield Clinic
- Memorial Medical Center
- Cancer Care Specialists of Illinois-Swansea
- Carle Cancer Center
- The Carle Foundation Hospital
- Cadence Cancer Center in Warrenville
- Michiana Hematology Oncology PC-Crown Point
- Michiana Hematology Oncology PC-Elkhart
- IU Health Central Indiana Cancer Centers-Fishers
- Indiana University - Melvin and Bren Simon Cancer Center
- IU Health Methodist Hospital
- Sidney and Lois Eskenazi Hospital
- IU Health Central Indiana Cancer Centers-East
- IU Health Arnett Cancer Care
- Franciscan Saint Anthony Health-Michigan City
- Memorial Regional Cancer Center Day Road
- Michiana Hematology Oncology PC-Mishawaka
- Saint Joseph Regional Medical Center-Mishawaka
- Michiana Hematology Oncology PC-Plymouth
- Memorial Hospital of South Bend
- Michiana Hematology Oncology PC-South Bend
- Northern Indiana Cancer Research Consrtium
- Michiana Hematology Oncology PC-Westville
- Mary Greeley Medical Center
- McFarland Clinic PC-William R Bliss Cancer Center
- Constantinou, Costas L MD (UIA Investigator)
- Hematology Oncology Associates - Quad Cities
- McFarland Clinic PC-Boone
- Mercy Hospital
- Oncology Associates at Mercy Medical Center
- Physicians' Clinic of Iowa PC
- Medical Oncology and Hematology Associates - West Des Moines
- Mercy Cancer Center-West Lakes
- Alegent Health Mercy Hospital
- Genesis Medical Center - East Campus
- Iowa Methodist Medical Center
- Medical Oncology and Hematology Associates - Des Moines
- Medical Oncology and Hematology Associates-Laurel
- Mercy Medical Center - Des Moines
- Iowa Lutheran Hospital
- JCHC McCreery Cancer Center
- McFarland Clinic PC-Trinity Cancer Center
- McFarland Clinic PC-Jefferson
- McFarland Clinic PC-Marshalltown
- Mercy Medical Center - North Iowa
- Ottumwa Regional Health Center
- Siouxland Regional Cancer Center
- Mercy Medical Center-West Lakes
- Methodist West Hospital
- Cancer Center of Kansas - Chanute
- Cancer Center of Kansas - Dodge City
- Cancer Center of Kansas - El Dorado
- Cancer Center of Kansas - Fort Scott
- Hays Medical Center
- Cancer Center of Kansas - Independence
- Kansas City Cancer Centers - West
- Cancer Center of Kansas - Kingman
- Lawrence Memorial Hospital
- Cancer Center of Kansas - Liberal
- Cancer Center of Kansas - Newton
- Menorah Medical Center
- Kansas City Cancer Centers - Southwest
- Saint Luke's South Hospital
- Cancer Center of Kansas - Parsons
- Kansas City NCI Community Oncology Research Program
- Cancer Center of Kansas - Pratt
- Cancer Center of Kansas - Salina
- Stormont-Vail Regional Health Center
- Cancer Center of Kansas - Wellington
- Associates In Womens Health
- Cancer Center of Kansas - Wichita Medical Arts Tower
- Cancer Center of Kansas - Main Office
- Via Christi Regional Medical Center
- Cancer Center of Kansas - Winfield
- Flaget Memorial Hospital
- Commonwealth Cancer Center-Corbin
- Baptist Health Corbin
- Oncology Hematology Care Inc-Crestview
- Hardin Memorial Hospital
- Baptist Health Lexington
- Saint Joseph Radiation Oncology Resource Center
- Saint Joseph Hospital East
- Jewish Hospital
- The James Graham Brown Cancer Center at University of Louisville
- Baptist Health Louisville
- Saints Mary and Elizabeth Hospital
- Owensboro Health Mitchell Memorial Cancer Center
- LSU Health Baton Rouge-North Clinic
- Louisiana Hematology Oncology Associates LLC
- Mary Bird Perkins Cancer Center - Baton Rouge
- Ochsner Health Center - Covington
- East Jefferson General Hospital
- Louisiana State University Health Sciences Center - Monroe
- Interim LSU Public Hospital
- Louisiana State University Health Science Center
- Ochsner Medical Center Jefferson
- Louisiana State University Health Sciences Center - Shreveport
- Harold Alfond Center for Cancer Care
- Eastern Maine Medical Center
- Eastern Maine Medical Center Cancer Care
- Penobscot Bay Medical Center
- York Hospital
- Sinai Hospital of Baltimore
- Saint Agnes Hospital
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
- Western Maryland Regional Medical Center
- Frederick Memorial Hospital
- Kaiser Permanente - Gaithersburg Medical Center
- Meritus Medical Center
- Holy Cross Hospital
- Beverly Hospital
- Tufts Medical Center
- Massachusetts General Hospital Cancer Center
- Brigham and Women's Hospital
- Dana Farber Cancer Institute
- Lahey Hospital and Medical Center
- MetroWest Medical Center-Framingham Union Hospital
- Addison Gilbert Hospital
- Lowell General Hospital
- Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center
- Newton-Wellesley Hospital
- Berkshire Hematology Oncology, PC
- Dana-Farber/Brigham and Women's Cancer Center at South Shore
- University of Massachusetts Medical School
- Toledo Clinic Cancer Centers - Adrian
- Saint Joseph Mercy Hospital
- University of Michigan Comprehensive Cancer Center
- Bronson Battle Creek
- Oakwood Hospital and Medical Center
- Wayne State University/Karmanos Cancer Institute
- Saint John Hospital and Medical Center
- Green Bay Oncology-Escanaba
- Botsford Hospital
- Hurley Medical Center
- Spectrum Health at Butterworth Campus
- Green Bay Oncology-Iron Mountain
- Allegiance Health
- West Michigan Cancer Center
- Sparrow Hospital
- Saint Mary Mercy Hospital
- Toledo Clinic Cancer Centers-Monroe
- Lakeland Community Hospital
- Saint Joseph Mercy Oakland
- Saint Joseph Mercy Port Huron
- Spectrum Health Reed City Hospital
- Michigan Cancer Specialists
- Oakland Colon and Rectal Association
- Cancer Care Associates PC
- Comprehensive Medical Center PLLC
- Hematology Oncology Consultants PC-Royal Oak
- Oakland Medical Group
- William Beaumont Hospital-Royal Oak
- Saint Mary's of Michigan
- Marie Yeager Cancer Center
- Providence Hospital - Southfield
- Premier Hematology Oncology Care
- Mitchell Folbe MD PC
- Munson Medical Center
- Michigan Institute of Urology-Town Center
- Claudia BR Herke MD PC
- Hematology Oncology Consultants PC-Troy
- William Beaumont Hospital - Troy
- Saint John Macomb-Oakland Hospital
- Sanford Clinic North-Bemidji
- Fairview Ridges Hospital
- Mercy Hospital
- Essentia Health Cancer Center
- Essentia Health Saint Mary's Medical Center
- Miller-Dwan Hospital
- Fairview Southdale Hospital
- Unity Hospital
- Hutchinson Area Health Care
- Mayo Clinic Health Systems-Mankato
- Minnesota Oncology - Maplewood
- Saint John's Hospital - Healtheast
- Abbott-Northwestern Hospital
- Hennepin County Medical Center
- Minneapolis Veterans Medical Center
- Health Partners Inc
- New Ulm Medical Center
- North Memorial Medical Health Center
- Mayo Clinic Cancer Center
- Coborn Cancer Center at Saint Cloud Hospital
- Saint Cloud Hospital
- Park Nicollet Clinic - Saint Louis Park
- Regions Hospital
- United Hospital
- Saint Francis Regional Medical Center
- Lakeview Hospital
- Ridgeview Medical Center
- Rice Memorial Hospital
- Minnesota Oncology - Woodbury
- Gulfport Memorial Hospital
- University of Mississippi Medical Center
- Singing River Hospital
- Central Care Cancer Center - Carrie J Babb Cancer Center
- Parkland Health Center-Bonne Terre
- Cox Cancer Center Branson
- Saint Francis Medical Center
- Southeast Cancer Center
- University of Missouri - Ellis Fischel
- Centerpoint Medical Center LLC
- Capital Region Medical Center-Goldschmidt Cancer Center
- Freeman Health System
- Mercy Hospital-Joplin
- Truman Medical Center
- Saint Luke's Hospital of Kansas City
- North Kansas City Hospital
- Heartland Hematology Oncology Associates, Incorporated
- Kansas City Cancer Centers - South
- Research Medical Center
- Kansas City Cancer Centers - North
- Saint Luke's East - Lee's Summit
- Liberty Radiation Oncology Center
- Mercy Clinic-Rolla-Cancer and Hematology
- Phelps County Regional Medical Center
- Lakeland Hospital
- Heartland Regional Medical Center
- Saint Louis Cancer and Breast Institute - South City
- Washington University School of Medicine
- Missouri Baptist Medical Center
- Barnes-Jewish West County Hospital
- Mercy Hospital Saint Louis
- Siteman Cancer Center - Saint Peters
- Sainte Genevieve County Memorial Hospital
- Mercy Hospital Springfield
- Cox Health South Hospital
- Missouri Baptist Sullivan Hospital
- Missouri Baptist Outpatient Center-Sunset Hills
- Montana Cancer Consortium NCORP
- Saint Vincent Healthcare
- Billings Clinic Cancer Center
- Bozeman Deaconess Hospital
- Saint James Community Hospital and Cancer Treatment Center
- Benefis Healthcare - Sletten Cancer Institute
- Saint Peter's Community Hospital
- Kalispell Regional Medical Center
- Saint Patrick Hospital - Community Hospital
- CHI Health Saint Francis
- Heartland Hematology and Oncology
- CHI Health Good Samaritan
- Nebraska Cancer Research Center
- Saint Elizabeth Regional Medical Center
- Great Plains Regional Medical Center
- Missouri Valley Cancer Consortium CCOP
- Nebraska Methodist Hospital
- Oncology Hematology West, P.C.
- Alegent Health Immanuel Medical Center
- Hematology and Oncology Consultants PC
- Alegent Health Bergan Mercy Medical Center
- Alegent Health Lakeside Hospital
- Creighton University Cancer Center
- University of Nebraska Medical Center
- Midlands Community Hospital
- 21st Century Oncology-Henderson
- University Medical Center of Southern Nevada
- Cancer and Blood Specialists-Henderson
- 21st Century Oncology
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
- Cancer Therapy and Integrative Medicine
- 21st Century Oncology-Vegas Tenaya
- Cancer and Blood Specialists-Shadow
- Cancer and Blood Specialists-Tenaya
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
- 21st Century Oncology-Fort Apache
- Cancer and Blood Specialists-Fort Apache
- New Hampshire Oncology Hematology PA-Concord
- Wentworth Douglass Hospital
- New Hampshire Oncology-Hematology, PA - Hooksett
- LRGHealthcare-Lakes Region General Hospital
- Dartmouth Hitchcock Medical Center
- Norris Cotton Cancer Center-Manchester
- Cooper Hospital University Medical Center
- Veterans Administration New Jersey Health Care System
- Saint Barnabas Medical Center
- Monmouth Medical Center
- Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County
- Newark Beth Israel Medical Center
- Robert Wood Johnson University Hospital Somerset
- Inspira Medical Center Vineland
- Virtua West Jersey Hospital Voorhees
- Inspira Medical Center Woodbury
- Lovelace Medical Center - Downtown
- University of New Mexico Cancer Center
- Lovelace Medical Center at Lovelace Sandia Health System
- Memorial Medical Center-Las Cruces
- Albert Einstein College of Medicine
- Montefiore Medical Center - Moses Campus
- Elmhurst Hospital Center
- Arnot Ogden Medical Center/Falck Cancer Center
- Glens Falls Hospital
- Queens Hospital Center
- North Shore University Hospital
- North Shore-LIJ Health System/Center for Advanced Medicine
- Beth Israel Medical Center
- Saint Luke's Roosevelt Hospital Center - Saint Luke's Division
- Weill Medical College of Cornell University
- Rochester General Hospital
- University of Rochester
- Staten Island University Hospital
- Stony Brook University Medical Center
- State University of New York - Upstate Medical University
- Faxton-Saint Luke's Healthcare
- Randolph Hospital
- Cancer Care of Western North Carolina
- Mission Hospital-Memorial Campus
- Mountain Radiation Oncology
- Hope Women's Cancer Centers-Asheville
- Transylvania Regional Hospital
- University of North Carolina at Chapel Hill
- Carolinas Medical Center/Levine Cancer Institute
- Southeastern Medical Oncology Center-Clinton
- Duke University Medical Center
- Angel Medical Center
- Southeastern Medical Oncology Center-Goldsboro
- Wayne Memorial Hospital
- Margaret R Pardee Memorial Hospital
- Park Ridge Health
- Maria Parham Medical Center
- Onslow Memorial Hospital
- Southeastern Medical Oncology Center-Jacksonville
- Kinston Medical Specialists PA
- Southeastern Regional Medical Center
- McDowell Hospital
- Rex Cancer Center
- Duke Raleigh Hospital
- Rex Cancer Center of Wakefield
- Annie Penn Memorial Hospital
- Blue Ridge Regional Hospital
- Iredell Memorial Hospital
- New Hanover Regional Medical Center
- Wake Forest University Health Sciences
- Sanford Bismarck Medical Center
- Sanford Clinic North-Fargo
- Sanford Medical Center-Fargo
- Sanford Roger Maris Cancer Center
- Trinity Cancer Care Center
- Summa Akron City Hospital/Cooper Cancer Center
- Akron General Medical Center
- Summa Barberton Hospital
- Cleveland Clinic Cancer Center Beachwood
- Strecker Cancer Center-Belpre
- Aultman Health Foundation
- Miami Valley Hospital South
- Adena Regional Medical Center
- Oncology Hematology Care Inc-Eden Park
- Oncology Hematology Care Inc-Mercy West
- Good Samaritan Hospital - Cincinnati
- Oncology Hematology Care Inc-Anderson
- Oncology Hematology Care Inc-Kenwood
- Bethesda North Hospital
- Oncology Hematology Care Inc-Blue Ash
- TriHealth Cancer Institute-Westside
- TriHealth Cancer Institute-Anderson
- University of Cincinnati
- Case Western Reserve Center
- MetroHealth Medical Center
- Cleveland Clinic Cancer Center at Fairview Hospital
- Cleveland Clinic Foundation
- Ohio State University Comprehensive Cancer Center
- Mount Carmel Hospital East
- Columbus Oncology and Hematology Associates Inc
- Riverside Methodist Hospital
- Columbus NCI Community Oncology Research Program
- Grant Medical Center
- The Mark H Zangmeister Center
- Doctors Hospital
- Good Samaritan Hospital - Dayton
- Miami Valley Hospital
- Dayton NCI Community Oncology Research Program
- Veteran Affairs Medical Center
- Delaware Health Center-Grady Cancer Center
- Delaware Radiation Oncology
- Grady Memorial Hospital
- Oncology Hematology Care Inc-Healthplex
- Blanchard Valley Hospital
- Atrium Medical Center-Middletown Regional Hospital
- Wayne Hospital
- Cleveland Clinic Cancer Center Independence
- Kettering Medical Center
- Fairfield Medical Center
- Cleveland Clinic Cancer Center Mansfield
- Marietta Memorial Hospital
- Toledo Clinic Cancer Centers-Maumee
- Toledo Radiation Oncology at Northwest Ohio Oncology Center
- Hillcrest Hospital Cancer Center
- Knox Community Hospital
- Newark Radiation Oncology
- Saint Charles Hospital
- Southern Ohio Medical Center
- North Coast Cancer Care
- Springfield Regional Medical Center
- Trinity's Tony Teramana Cancer Center
- Cleveland Clinic Foundation - Strongsville
- Flower Hospital
- Toledo Clinic Cancer Centers-Toledo
- Upper Valley Medical Center
- South Pointe Hospital
- Saint Ann's Hospital
- UHHS Westlake Medical Center
- Cleveland Clinic - Wooster Specialty Center
- Genesis Healthcare System Cancer Care Center
- Mercy Clinic Oklahoma Communities Inc-Norman
- University of Oklahoma Health Sciences Center
- Mercy Hospital Oklahoma City
- Tulsa Cancer Institute
- Saint Charles Health System
- Clackamas Radiation Oncology Center
- Providence Oncology and Hematology Care Southeast
- Legacy Mount Hood Medical Center
- Providence Newberg Medical Center
- Providence Willamette Falls Medical Center
- Legacy Good Samaritan Hospital and Medical Center
- Providence Portland Medical Center
- Providence Saint Vincent Medical Center
- Oregon Health and Science University
- Legacy Meridian Park Hospital
- Abington Memorial Hospital
- Lehigh Valley Hospital-Cedar Crest
- UPMC-Heritage Valley Health System Beaver
- Saint Luke's University Hospital-Bethlehem Campus
- Lehigh Valley Hospital - Muhlenberg
- Bryn Mawr Hospital
- Geisinger Medical Center
- Easton Hospital
- Adams Cancer Center
- UPMC Cancer Centers - Arnold Palmer Pavilion
- Cherry Tree Cancer Center
- PinnacleHealth Regional Cancer Center at Polyclinic Hospital
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
- Lewistown Hospital
- UPMC Cancer Center at UPMC McKeesport
- Forbes Hospital
- UPMC-Coraopolis/Heritage Valley Radiation Oncology
- Paoli Memorial Hospital
- Allegheny General Hospital
- UPMC-Magee Womens Hospital
- UPMC-Presbyterian Hospital
- UPMC-Saint Margaret
- West Penn Hospital
- University of Pittsburgh Cancer Institute (UPCI)
- UPMC-Shadyside Hospital
- UPMC Jefferson Regional Radiation Oncology
- UPMC-Passavant Hospital
- UPMC-Saint Clair Hospital Cancer Center
- Pottstown Memorial Regional Cancer Center
- Geisinger Medical Oncology-Pottsville
- Scranton Hematology-Oncology
- Grand View Hospital
- UPMC Cancer Center at UPMC Northwest
- Geisinger Medical Group
- Mount Nittany Medical Center
- UPMC Uniontown Hospital Radiation Oncology
- UPMC Washington Hospital Radiation Oncology
- Chester County Hospital
- Jennersville Regional Hospital
- Reading Hospital
- Geisinger Wyoming Valley/Henry Cancer Center
- Susquehanna Cancer Center at Divine Providence Hospital
- Wellspan Health - York Cancer Center
- WellSpan Health-York Hospital
- Memorial Hospital of Rhode Island
- Rhode Island Hospital
- Miriam Hospital
- AnMed Health Cancer Center
- Medical University of South Carolina
- Greenville Health System Cancer Institute-Easley
- Greenville Health System Cancer Institute - Butternut
- Greenville Health System Cancer Institute-Faris
- Greenville Memorial Hospital
- Saint Francis Cancer Center
- Greenville Health System Cancer Institute-Eastside
- Greenville Health System Cancer Institute-Greer
- Gibbs Cancer Center-Pelham
- Carolina Blood and Cancer Care Associates, PA
- Carolina Blood and Cancer Care
- Greenville Health System Cancer Institute-Seneca
- Spartanburg Medical Center
- Greenville Health System Cancer Institute - Spartanburg
- Avera Saint Luke's Hospital and Cancer Center
- Rapid City Regional Hospital
- Sanford Cancer Center Oncology Clinic
- Avera Cancer Institute
- Sanford USD Medical Center - Sioux Falls
- Wellmont Medical Associates-Oncology and Hematology
- Pulmonary Medicine Center of Chattanooga-Hixson
- Wellmont Holston Valley Hospital and Medical Center
- Thompson Cancer Survival Center
- University of Tennessee - Knoxville
- Tennessee Oncology PLLC- Centennial Medical Center
- Memorial GYN Plus
- Lyndon Baines Johnson General Hospital
- Baylor College of Medicine
- Ben Taub General Hospital
- M D Anderson Cancer Center
- University of Texas Health Science Center at San Antonio
- University Hospital - San Antonio
- Scott and White Memorial Hospital
- Central Vermont Medical Center
- University of Vermont College of Medicine
- Norris Cotton Cancer Center-North
- White River Junction Veteran Administration Medical Center
- Medical Oncology Hematology Associates of Northern Virginia Limited
- Virginia Oncology Associates - Hampton
- Memorial Hospital Of Martinsville
- Bon Secours Saint Francis Medical Center
- Southwest VA Regional Cancer Center
- Bon Secours Saint Mary's Hospital
- Virginia Cancer Institute - West End
- Virginia Commonwealth University/Massey Cancer Center
- VCU Community Memorial Health Center
- Cancer Care Center at Island Hospital
- MultiCare Auburn Medical Center
- Virginia Mason Bainbridge Island Medical Center
- Overlake Hospital Medical Center
- PeaceHealth Saint Joseph Medical Center
- Harrison HealthPartners Hematology and Oncology-Bremerton
- Harrison Medical Center
- Highline Medical Center-Main Campus
- Swedish Medical Center-Edmonds
- Saint Elizabeth Hospital
- Providence Regional Cancer Partnership
- Virginia Mason Federal Way Medical Center
- Saint Francis Hospital
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
- MultiCare Gig Harbor Medical Park
- Swedish Cancer Institute-Issaquah
- Kadlec Clinic Hematology and Oncology
- Northwest Cancer Clinic
- Seattle Cancer Care Alliance at EvergreenHealth
- Saint Clare Hospital
- Saint John Medical Center
- Virginia Mason Lynnwood Medical Center
- Skagit Valley Hospital
- Harrison HealthPartners Hematology and Oncology-Poulsbo
- Peninsula Cancer Center
- MultiCare Good Samaritan Hospital
- Tacoma/Valley Radiation Oncology Centers-Puyallup
- Virginia Mason Medical Center
- Minor and James Medical PLLC
- Swedish Medical Center-Ballard Campus
- Seattle Cancer Care Alliance
- Group Health Cooperative-Seattle
- Swedish Medical Center-First Hill
- University of Washington Medical Center
- Cancer Care Northwest-North Spokane
- Cancer Care Northwest - Spokane South
- Cancer Care Northwest-Valley
- Evergreen Hematology and Oncology PS
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
- Franciscan Research Center - Northwest Medical Plaza
- Northwest Medical Specialties PLLC
- Northwest NCI Community Oncology Research Program
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
- Multicare Health System
- Madigan Army Medical Center - Tacoma
- PeaceHealth Southwest Medical Center
- Legacy Salmon Creek Hospital
- Wenatchee Valley Hospital and Clinics
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- Edwards Comprehensive Cancer Center
- Princeton Community Hospital
- Fox Valley Hematology and Oncology
- Aurora Cancer Care-Burlington
- Marshfield Clinic Cancer Center at Sacred Heart
- Mayo Clinic Health System-Eau Claire Clinic
- Mayo Clinic Health System Eau Claire Hospital-Luther Campus
- Aurora Cancer Care-Southern Lakes
- Aurora Cancer Care-Grafton
- Green Bay Oncology at Saint Vincent Hospital
- Saint Vincent Hospital
- Green Bay Oncology Limited at Saint Mary's Hospital
- Saint Mary's Hospital
- Aurora BayCare Medical Center
- UW Cancer Center Johnson Creek
- Aurora Cancer Care-Kenosha South
- University of Wisconsin Hospital and Clinics
- Holy Family Memorial Hospital
- Bay Area Medical Center
- Vince Lombardi Cancer Clinic - Marinette
- Marshfield Clinic
- Aurora Advanced Healthcare Inc-Menomonee Falls
- Aurora Cancer Care-Milwaukee
- Wheaton Franciscan Healthcare - St. Joseph
- Aurora Saint Luke's Medical Center
- Aurora Sinai Medical Center
- Marshfield Clinic-Minocqua Center
- D N Greenwald Center
- Westfields Hospital/Cancer Center of Western Wisconsin
- Oconomowoc Memorial Hospital-ProHealth Care Inc
- Green Bay Oncology - Oconto Falls
- Vince Lombardi Cancer Clinic - Oshkosh
- Aurora Cancer Care-Racine
- Marshfield Clinic at James Beck Cancer Center
- Marshfield Clinic-Rice Lake Center
- Saint Nicholas Hospital
- Vince Lombardi Cancer Clinic - Sheboygan
- Marshfield Clinic Cancer Care at Saint Michael's Hospital
- Green Bay Oncology - Sturgeon Bay
- Aurora Medical Center in Summit
- Vince Lombardi Cancer Clinic - Two Rivers
- Aurora Cancer Care-Waukesha
- Waukesha Memorial Hospital
- Aspirus Regional Cancer Center
- Aurora Cancer Care-Milwaukee West
- Aurora West Allis Medical Center
- Diagnostic and Treatment Center
- Marshfield Clinic - Weston Center
- Marshfield Clinic - Wisconsin Rapids Center
- Cheyenne Regional Medical Center-West
- Welch Cancer Center
- Cross Cancer Institute
- BCCA-Cancer Centre for the Southern Interior
- BCCA-Vancouver Cancer Centre
- Horizon Health Network-Saint John Regional Hospital
- Cambridge Memorial Hospital
- London Regional Cancer Program
- Niagara Health System-Saint Catharines General
- Health Sciences North
- Toronto East General Hospital
- Mount Sinai Hospital - Toronto
- PEI Cancer Treatment Centre-Queen Elizabeth Hospital
- McGill University Department of Oncology
- Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
- Allan Blair Cancer Centre
- Saskatoon Cancer Centre
- San Juan City Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Experimental
Active Comparator
Experimental
Arm A - FOLFOX and placebo (12 treatments)
Arm B - FOLFOX and celecoxib (12 treatments)
Arm C - FOLFOX and placebo (6 treatments)
Arm D - FOLFOX and celecoxib (6 treatments)
Patients receive FOLFOX every 2 weeks plus placebo every day for 12 treatments (24 weeks). Each 2-week period is called a cycle. FOLFOX includes oxaliplatin, leucovorin and 5-FU.Then, patients receive placebo alone every day for 3 years total.
Patients receive FOLFOX every 2 weeks plus celecoxib every day for 12 treatments (24 weeks). Each 2-week period is called a cycle. FOLFOX includes oxaliplatin, leucovorin and 5-FU.Then, patients receive celecoxib alone every day for 3 years total.
Patients receive FOLFOX every 2 weeks plus placebo every day for 6 treatments (12 weeks). Each 2-week period is called a cycle. FOLFOX includes oxaliplatin, leucovorin and 5-FU.Then, patients receive placebo alone every day for 3 years total.
Patients receive FOLFOX every 2 weeks plus celecoxib every day for 6 treatments (12 weeks). Each 2-week period is called a cycle. FOLFOX includes oxaliplatin, leucovorin and 5-FU.Then, patients receive celecoxib alone every day for 3 years total.