Oxidative Stress in Chronic Kidney Disease: Diet and Exercise
Chronic Kidney Disease
About this trial
This is an interventional treatment trial for Chronic Kidney Disease
Eligibility Criteria
Inclusion Criteria:
- Stage III-IV CKD measured by the MDRD equation with eGFR 15-60 ml/min/1.73m2;
- Age 18-75 years;
- BMI ≥ 25;
- Life expectancy ≥ 1 year;
- Ability to understand and provide informed consent.
Exclusion Criteria:
- Any acute inflammatory condition (including chronic infection requiring treatment, and collagen vascular disease including active gout);
- Pregnancy;
- Taking high-dose anti-oxidants (Vitamin E or C);
- Chronic use of anti-inflammatory medication except low dose (< 10mg/d) prednisone and aspirin (< 100 mg/day);
- Significant cardiac or vascular disease (symptomatic disease or CV event including congestive heart failure within 6 months);
- Significant occlusive atherosclerotic disease or ischemic disease (on non-invasive or invasive diagnostic procedures);
- Significant physical immobility or disabilities (joint replacement, muscular disorders);
- Type I diabetes mellitus, or Type II requiring insulin therapy;
- History of poor adherence to medical regimen;
- Those subjects who have a diagnosis of atrial fibrillation or a pacemaker will be allowed in the study but will not undergo Arterial Tonometry (PWV) studies.
Sites / Locations
- Springfield College
- Vanderbilt University Medical Center
- Kidney Research Institute
- Providence Sacred Heart Medical Research Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
No Intervention
caloric restriction
aerobic exercise
caloric restriction and aerobic exercise
usual diet and usual activity
10 to 15% reduction in total daily calories (300 to 500 kcal reduction) from the usual daily energy consumption for 4 months duration
supervised physical activity for a maximum of 30-45 minutes, 3 times per week for 4 months duration
10 to 15% reduction in total daily calories (300 to 500 kcal reduction) from the usual daily energy consumption for 4 months duration, and supervised physical activity for a maximum of 30-45 minutes, 3 times per week for 4 months duration
usual diet and usual activity