Paclitaxel Plus Radiation Therapy in Treating Women With Stage II or Stage III Breast Cancer
Breast Cancer
About this trial
This is an interventional treatment trial for Breast Cancer focused on measuring stage II breast cancer, stage IIIA breast cancer, stage IIIB breast cancer, stage IIIC breast cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Stage II or III invasive breast cancer Prior breast conserving surgery (lumpectomy or quadrantectomy) with ipsilateral axillary lymph node dissection required No prior contralateral breast cancer No metastatic disease Prior ductal carcinoma in situ or lobular carcinoma in situ of the breast allowed unless treated with radiation or chemotherapy Doxorubicin and cyclophosphamide adjuvant chemotherapy completed within past 3 weeks Candidate for definitive radiotherapy Hormone receptor status: Not specified PATIENT CHARACTERISTICS: Age: 18 and over Sex: Female Menopausal status: Not specified Performance status: ECOG 0-1 Life expectancy: Not specified Hematopoietic: WBC at least 3,000/mm3 Granulocyte count at least 2,000/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 times upper limit of normal (ULN) ALT/AST no greater than 1.5 times ULN Renal: Creatinine no greater than 1.5 mg/dL Cardiovascular: No concurrent poorly controlled ischemic heart disease or congestive heart failure LVEF at least 45% by MUGA scan or echocardiogram Pulmonary: No concurrent severe chronic obstructive or restrictive pulmonary disease Other: Not pregnant or nursing Fertile patients must use effective contraception No concurrent severe medical or psychiatric illness No concurrent severe diabetes mellitus No other prior malignancy within the past 5 years except nonmelanoma skin cancer or carcinoma in situ of the cervix treated with local excision PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent filgrastim (G-CSF) Chemotherapy: See Disease Characteristics Prior tamoxifen allowed No concurrent tamoxifen Endocrine therapy: Not specified Radiotherapy: No prior radiation to the breast Surgery: Recovered form prior surgery Other: No concurrent adjuvant therapy on another clinical trial
Sites / Locations
- UH-CantonMercy
- UH-Geauga
- University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center
- UH-Monarch
- UH-LUICC
- UH-Southwest
- UH-Chagrin Highlands
- UH-Green Road
- UH-Westlake