Parameters of Exercise to Prevent Osteoporosis (OSTEOPOROSISEX)
Osteoporosis, Postmenopausal
About this trial
This is an interventional basic science trial for Osteoporosis, Postmenopausal
Eligibility Criteria
Inclusion Criteria:
- Age 50 to 65 years if naturally post-menopausal, or age 47 if surgically postmenopausal
- Dual energy X-ray absorptiometry (DEXA) Z score above -1
- No endocrine or metabolic disease requiring medication except for hormonally corrected hypothyroidism
- No musculo-skeletal disabilities that would preclude treadmill walking
- Normal electrocardiogram (EKG) and heart health history
- BMI between 24 and 30
- Hematocrit above 32 %
- No hormone replacement therapy (HRT)
- Personal health provider's Release Letter
Exclusion Criteria:
- Age and BMI outside of the specified range
- Z score below -1
- Medication for presence of metabolic or endocrine disease
- Musculo-skeletal disabilities that would preclude treadmill walking
- Abnormal electrocardiogram (EKG) and heart health history
- Hematocrit below 32%
- Hormone replacement therapy
- Failure to conform to study protocol
Sites / Locations
- Michigan Clinical Research Unit United States
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Active Comparator
40 minute up trial
40 minute down trial
Two 20 minute up trials
Two 20 min down trials
Sedentary trial
Subjects were subjected to 40 minutes of treadmill exercise at a 6 degree incline and at 75% of maximal effort between 8:00 and 8:40 am. Isocaloric meals were provided at 7:00, 13:00. and 19:00 h.
Subjects were subjected to 40 minutes of treadmill exercise at a 6 degree decline and at 45% of maximal effort between 8:00 and 8:40 am. Isocaloric meals were provided at 7:00, 13:00. and 19:00 h.
Subjects were subjected to two 20 minutes of treadmill exercise separated by 7 h at a 6 degree incline and at 75% of maximal effort, the first one between 8:00 and 8:40 am and the second one between 15:00 and 15:20 h..Isocaloric meals were provided at 7:00, 13:00. and 19:00 h.
Subjects were subjected to two 20 minutes of treadmill exercise separated by 7 h at a 6 degree incline and at 45% of maximal effort , the first one between 8:00 and 8:40 am and the second one between 15:00 and 15:20 h. Isocaloric meals were provided at 7:00, 13:00. and 19:00 h.
No exercise day with isocaloric meals provided at 7:00, 13:00. and 19:00 h.