Pathophysiology of the Upper Airway in Patients With COPD and Concomitant OSA
Obstructive Sleep Apnea
About this trial
This is an interventional other trial for Obstructive Sleep Apnea focused on measuring Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Overlap syndrome, Pcrit, Critical closing pressure
Eligibility Criteria
Inclusion Criteria for COPD Subjects:
- Age range 40-70 years.
- Demonstrated moderate to severe COPD as determined by spirometry (post-bronchodilator spirometry FEV1/FVC < 0.70 for diagnosing CODP and FEV1<80% predicted for staging)
- Smoking history of ≥ 10 pack-years
Inclusion Criteria for Control Subjects
- Age range 40-70 years
- Demonstrated no COPD as determined by normal spirometry (post-bronchodilator spirometry FEV1/FVC > 0.70 for diagnosing CODP and FEV1<80% predicted for staging)
- No smoking history as defined by less than 100 cigarettes smoked in a lifetime
Exclusion Criteria for both COPD and Control Subjects:
- Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, metal projectile or metal weapon fragment (bullet, shrapnel, shotgun shot) or metal shoulder prosthesis
Subjects unable to perform spirometry due to:
- chest or abdominal surgery in the past three months
- a heart attack in the last three months
- detached retina or eye surgery in the past three months
- hospitalization for any other heart problem in the past month
- History of hypersensitivity to Afrin, Lidocaine or albuterol
- A psychiatric disorder, other than mild depression; e.g. schizophrenia, bipolar disorder, major depression, panic or anxiety disorders.
- More than 10 cups of beverages with caffeine (coffee, tea, soda/pop) per day
- Pregnancy or suspected pregnancy
Sites / Locations
- University of California, San Diego
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
COPD Group
Normal Control Group
Patients who were previously diagnosed of moderate to severe COPD as determined by spirometry. All patients will have sleep and pulmonary physiologic measurements.
Patients who are healthy, without major medical or sleep problems, and have normal spirometry. All patients will have sleep and pulmonary physiologic measurements.