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Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure (DIAMOND) (DIAMOND)

Primary Purpose

Hyperkalemia

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Patiromer
Placebos
Sponsored by
Vifor Pharma, Inc.
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Hyperkalemia focused on measuring treatment of hyperkalemia, chronic kidney disease, hypertension, hyperkalemia, potassium, spironolactone, heart failure, Renin Angiotensin-Aldosterone System Inhibitor (RAASi), RAASi, high potassium, eplerenone, reduced ejection fraction

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Age at least 18 years or greater
  • Symptomatic low ejection fraction heart failure (weak heart muscle)
  • Receiving any dose of a beta blocker for the treatment of HF (unless not able to tolerate)
  • Kidney function not more than mild or moderately impaired
  • High blood potassium (>5.0 mEq/L) currently while receiving medications for heart failure OR normal blood potassium currently but previously had high potassium in the12 months prior to screening which caused a permanent reduction or discontinuation of heart failure medications
  • Hospitalization for heart failure or treatment in an out patient setting with intravenous medications within the last 12 months before screening.

Exclusion Criteria:

  • Current acute decompensated HF, within 4 weeks before screening. Subjects with a discharge from a hospitalization for acute decompensation of HF longer than 4 weeks before screening may be included
  • Significant primary aortic or mitral valvular heart disease (except secondary mitral regurgitation due to left ventricular dilatation)
  • Heart transplantation or planned heart transplantation (i.e., currently on a heart transplant waiting list) during the study period

Sites / Locations

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Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

Group 1: Patiromer

Group 2: Placebo

Arm Description

Subjects will be randomized to receive a daily dose of patiromer with possible dose adjustments based on subsequent local serum potassium levels.

Subjects will be randomized to receive a daily dose of placebo with possible dose adjustments based on subsequent local serum potassium levels.

Outcomes

Primary Outcome Measures

Changes in Serum K+ Levels From Baseline
Adjusted mean changes in serum K+ from Baseline.

Secondary Outcome Measures

CIF Estimates of the Time to First Hyperkalemia Event With Serum K+ Level > 5.5 mEq/l Over Time
Cumulative incidence of the first event of hyperkalemia with a serum K+ value >5.5 mEq/l taking death as competing and calculated as CIF Estimates (95% CI) over time. Aalen-Johansen estimators of the cumulative incidence function with death as a competing event. CIF = cumulative incidence function; mEq/l = Milliequivalents Per Liter
CIF Estimates of the Reduction of the MRA Dose Below Target Dose Over Time
Cumulative incidence of the reduction of the MRA dose below target dose calculated as CIF Estimates (95% CI) over time. Note: The reduction below the MRA target dose must last for at least 14 days (orless if at the end of study) to confirm this endpoint. CIF = cumulative incidence function; mEq/l = Milliequivalents Per Liter
Investigator-reported Events of Hyperkalemia
Participant's follow-up is from the date of the first dose of randomized study medication up to the participant's end of study date or 24 Jun 2021, whichever comes first. Annualized event rate per 100 subject-years= The total number of events for all subjects in the treatment group divided by the total subject-years of follow-up in that treatment group multiplied by 100.
Hyperkalemia-related Hard Outcomes Endpoints
Analyzed using Win Ratio approach with the following hierarchical components: Time to CV death Total number of CV hospitalizations Total number of hyperkalemia toxicity events with serum K+ >6.5 mEq/l Total number of hyperkalemia events with serum K+ >6.0-6.5 mEq/l Total number of hyperkalemia events with serum K+ >5.0 mEq/l MHTE=More hyperkalemia toxicity events; MHE=More hyperkalemia events; CV=Cardiovascular
RAASi Use Score
RAASi use score (0 to 8 points) analyzed using the Win Ratio approach for each pair of participants with the following additive components: All-cause death Occurrence of a CV hospitalization HF medication use and dose for i) an ACEi/ARB/ARNi, ii) a MRA, and iii) a beta-blocker Each participant in each comparison can have 0-8 points and all participants are compared using this score at the respective appropriate follow-up time point. RAASi=renin-angiotensin-aldosterone system inhibitor; ACEi=angiotensin converting enzyme inhibitor; ARB=angiotensin receptor blocker; ARNi=angiotensin receptor/neprilysin inhibitor; MRA=mineralocorticoid receptor antagonist.

Full Information

First Posted
March 12, 2019
Last Updated
February 22, 2023
Sponsor
Vifor Pharma, Inc.
Collaborators
Syneos Health, LLC
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1. Study Identification

Unique Protocol Identification Number
NCT03888066
Brief Title
Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure (DIAMOND)
Acronym
DIAMOND
Official Title
A Multicenter, Double-blind, Placebo-controlled, Randomized Withdrawal, Parallel Group Study of Patiromer for the Management of Hyperkalemia in Subjects Receiving Renin Angiotensin Aldosterone System Inhibitor (RAASi) Medications for the Treatment of Heart Failure (DIAMOND)
Study Type
Interventional

2. Study Status

Record Verification Date
February 2023
Overall Recruitment Status
Completed
Study Start Date
April 24, 2019 (Actual)
Primary Completion Date
September 2, 2021 (Actual)
Study Completion Date
September 2, 2021 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Vifor Pharma, Inc.
Collaborators
Syneos Health, LLC

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The purpose of this study is to assess the effects of patiromer compared with placebo on serum K+ in HF patients.
Detailed Description
Prospective Phase 3b multinational, multicenter, double-blind, placebo-controlled, randomized withdrawal, parallel group study that includes screening and up to 12 weeks Run-in Phase (all subjects will have patiromer initiated and RAASi medications, including mineralocorticoid receptor antagonist (MRA) optimized) and a randomized withdrawal Blinded Treatment Phase. The study population includes subjects with heart failure (HF) with reduced ejection fraction (HFrEF) who are hyperkalemic (serum potassium [K+] > 5.0 mEq/L) while receiving treatment with renin angiotensin aldosterone system inhibitor (RAASi) medications or who are normokalemic (serum K+ 4.0 - 5.0 mEq/L) but have a history of hyperkalemia prior to screening with subsequent reduction or discontinuation of a RAASi medication. Each subject's participation includes a Run-in Phase (maximum 12 weeks) followed by the Treatment Phase (variable per subject). Study duration for individual subjects will vary, depending on their individual enrollment date. Subjects who prematurely discontinue patiromer/placebo will remain in the study for the collection of clinical events data and will receive usual care.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Hyperkalemia
Keywords
treatment of hyperkalemia, chronic kidney disease, hypertension, hyperkalemia, potassium, spironolactone, heart failure, Renin Angiotensin-Aldosterone System Inhibitor (RAASi), RAASi, high potassium, eplerenone, reduced ejection fraction

7. Study Design

Primary Purpose
Prevention
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Model Description
Prospective Phase 3b multinational, multicenter, double-blind, placebo-controlled, randomized withdrawal, parallel group study that includes screening and 12 weeks Run-in Phase and a randomized withdrawal Blinded Treatment Phase.
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
1195 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Group 1: Patiromer
Arm Type
Experimental
Arm Description
Subjects will be randomized to receive a daily dose of patiromer with possible dose adjustments based on subsequent local serum potassium levels.
Arm Title
Group 2: Placebo
Arm Type
Placebo Comparator
Arm Description
Subjects will be randomized to receive a daily dose of placebo with possible dose adjustments based on subsequent local serum potassium levels.
Intervention Type
Drug
Intervention Name(s)
Patiromer
Other Intervention Name(s)
Veltassa
Intervention Description
The starting dose of patiromer will be 1 packet/day and may be taken either with food or without food. Based upon the patiromer treatment algorithm patiromer may be increased by 1 packet per day in intervals of at least 1 week (± 3 days). For subjects who become hypokalemic, patiromer may be decreased to a minimum of 0 packets/day. Doses of patiromer will be 0 packets/day, 1 packet/day, 2 packets/day, and 3 packets/day (maximum dose).
Intervention Type
Drug
Intervention Name(s)
Placebos
Intervention Description
The starting dose of placebo will be 1 packet/day and may be taken either with food or without food. Based upon the placebo treatment algorithm placebo may be increased by 1 packet per day in intervals of at least 1 week (± 3 days). For subjects who become hypokalemic, placebo may be decreased to a minimum of 0 packets/day. Doses of placebo will be 0 packets/day, 1 packet/day, 2 packets/day, and 3 packets/day (maximum dose).
Primary Outcome Measure Information:
Title
Changes in Serum K+ Levels From Baseline
Description
Adjusted mean changes in serum K+ from Baseline.
Time Frame
Mean duration of exposure: 227.9 days for Patiromer and 234.5 days for Placebo
Secondary Outcome Measure Information:
Title
CIF Estimates of the Time to First Hyperkalemia Event With Serum K+ Level > 5.5 mEq/l Over Time
Description
Cumulative incidence of the first event of hyperkalemia with a serum K+ value >5.5 mEq/l taking death as competing and calculated as CIF Estimates (95% CI) over time. Aalen-Johansen estimators of the cumulative incidence function with death as a competing event. CIF = cumulative incidence function; mEq/l = Milliequivalents Per Liter
Time Frame
From Day 1/Baseline to week 90
Title
CIF Estimates of the Reduction of the MRA Dose Below Target Dose Over Time
Description
Cumulative incidence of the reduction of the MRA dose below target dose calculated as CIF Estimates (95% CI) over time. Note: The reduction below the MRA target dose must last for at least 14 days (orless if at the end of study) to confirm this endpoint. CIF = cumulative incidence function; mEq/l = Milliequivalents Per Liter
Time Frame
From Day 1/Baseline to week 102
Title
Investigator-reported Events of Hyperkalemia
Description
Participant's follow-up is from the date of the first dose of randomized study medication up to the participant's end of study date or 24 Jun 2021, whichever comes first. Annualized event rate per 100 subject-years= The total number of events for all subjects in the treatment group divided by the total subject-years of follow-up in that treatment group multiplied by 100.
Time Frame
Mean duration of exposure: 227.9 days for Patiromer and 234.5 days for Placebo
Title
Hyperkalemia-related Hard Outcomes Endpoints
Description
Analyzed using Win Ratio approach with the following hierarchical components: Time to CV death Total number of CV hospitalizations Total number of hyperkalemia toxicity events with serum K+ >6.5 mEq/l Total number of hyperkalemia events with serum K+ >6.0-6.5 mEq/l Total number of hyperkalemia events with serum K+ >5.0 mEq/l MHTE=More hyperkalemia toxicity events; MHE=More hyperkalemia events; CV=Cardiovascular
Time Frame
Mean duration of exposure: 227.9 days for Patiromer and 234.5 days for Placebo
Title
RAASi Use Score
Description
RAASi use score (0 to 8 points) analyzed using the Win Ratio approach for each pair of participants with the following additive components: All-cause death Occurrence of a CV hospitalization HF medication use and dose for i) an ACEi/ARB/ARNi, ii) a MRA, and iii) a beta-blocker Each participant in each comparison can have 0-8 points and all participants are compared using this score at the respective appropriate follow-up time point. RAASi=renin-angiotensin-aldosterone system inhibitor; ACEi=angiotensin converting enzyme inhibitor; ARB=angiotensin receptor blocker; ARNi=angiotensin receptor/neprilysin inhibitor; MRA=mineralocorticoid receptor antagonist.
Time Frame
Mean duration of exposure: 227.9 days for Patiromer and 234.5 days for Placebo

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Age at least 18 years or greater Symptomatic low ejection fraction heart failure (weak heart muscle) Receiving any dose of a beta blocker for the treatment of HF (unless not able to tolerate) Kidney function not more than mild or moderately impaired High blood potassium (>5.0 mEq/L) currently while receiving medications for heart failure OR normal blood potassium currently but previously had high potassium in the12 months prior to screening which caused a permanent reduction or discontinuation of heart failure medications Hospitalization for heart failure or treatment in an out patient setting with intravenous medications within the last 12 months before screening. Exclusion Criteria: Current acute decompensated HF, within 4 weeks before screening. Subjects with a discharge from a hospitalization for acute decompensation of HF longer than 4 weeks before screening may be included Significant primary aortic or mitral valvular heart disease (except secondary mitral regurgitation due to left ventricular dilatation) Heart transplantation or planned heart transplantation (i.e., currently on a heart transplant waiting list) during the study period
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Peter Szecsödy, MD
Organizational Affiliation
Vifor Pharma
Official's Role
Study Director
Facility Information:
Facility Name
Investigator Site 11-080
City
Alexander City
State/Province
Alabama
ZIP/Postal Code
35010
Country
United States
Facility Name
Investigator Site 11-041
City
Huntsville
State/Province
Alabama
ZIP/Postal Code
35801
Country
United States
Facility Name
Investigator Site 11-153
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85108
Country
United States
Facility Name
Investigator Site 11-097
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85724
Country
United States
Facility Name
Investigator Site 11-052
City
Bakersfield
State/Province
California
ZIP/Postal Code
93308
Country
United States
Facility Name
Investigator Site 11-174
City
Fremont
State/Province
California
ZIP/Postal Code
94538
Country
United States
Facility Name
Investigator Site 11-136
City
Fresno
State/Province
California
ZIP/Postal Code
93720
Country
United States
Facility Name
Investigator Site 11-102
City
Huntington Beach
State/Province
California
ZIP/Postal Code
92648
Country
United States
Facility Name
Investigator Site 11-162
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Investigator Site 11-048
City
La Mesa
State/Province
California
ZIP/Postal Code
91942
Country
United States
Facility Name
Investigator Site 11-111
City
Laguna Hills
State/Province
California
ZIP/Postal Code
92653
Country
United States
Facility Name
Investigator Site 11-017
City
Long Beach
State/Province
California
ZIP/Postal Code
90813
Country
United States
Facility Name
Investigator Site 11-128
City
Northridge
State/Province
California
ZIP/Postal Code
91324
Country
United States
Facility Name
Investigator Site 11-035
City
Pasadena
State/Province
California
ZIP/Postal Code
91105
Country
United States
Facility Name
Investigator Site 11-044
City
Sacramento
State/Province
California
ZIP/Postal Code
95816
Country
United States
Facility Name
Investigator Site 11-135
City
San Diego
State/Province
California
ZIP/Postal Code
92119
Country
United States
Facility Name
Investigator Site 11-086
City
San Diego
State/Province
California
ZIP/Postal Code
92161
Country
United States
Facility Name
Investigator Site 11-112
City
Santa Ana
State/Province
California
ZIP/Postal Code
92705
Country
United States
Facility Name
Investigator Site 11-101
City
Stockton
State/Province
California
ZIP/Postal Code
95204
Country
United States
Facility Name
Investigator Site 11-047
City
Thousand Oaks
State/Province
California
ZIP/Postal Code
91360
Country
United States
Facility Name
Investigator Site 11-057
City
Van Nuys
State/Province
California
ZIP/Postal Code
91401
Country
United States
Facility Name
Investigator Site 11-058
City
West Hills
State/Province
California
ZIP/Postal Code
91307
Country
United States
Facility Name
Investigator Site 11-095
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
Investigator Site 11-168
City
Altamonte Springs
State/Province
Florida
ZIP/Postal Code
32701
Country
United States
Facility Name
Investigator Site 11-106
City
Boynton Beach
State/Province
Florida
ZIP/Postal Code
33437
Country
United States
Facility Name
Investigator Site 11-028
City
Brandon
State/Province
Florida
ZIP/Postal Code
33511
Country
United States
Facility Name
Investigator Site 11-003
City
Doral
State/Province
Florida
ZIP/Postal Code
33166
Country
United States
Facility Name
Investigator Site 11-138
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32608
Country
United States
Facility Name
Investigator Site 11-164
City
Greenacres City
State/Province
Florida
ZIP/Postal Code
33467
Country
United States
Facility Name
Investigator Site 11-078
City
Homestead
State/Province
Florida
ZIP/Postal Code
33033
Country
United States
Facility Name
Investigator Site 11-004
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32224-1865
Country
United States
Facility Name
Investigator Site 11-179
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32277
Country
United States
Facility Name
Investigator Site 11-122
City
Medley
State/Province
Florida
ZIP/Postal Code
33166
Country
United States
Facility Name
Research Site 11-001
City
Miami Lakes
State/Province
Florida
ZIP/Postal Code
33014
Country
United States
Facility Name
Research Site 11-002
City
Miami Lakes
State/Province
Florida
ZIP/Postal Code
33014
Country
United States
Facility Name
Investigator Site 11-115
City
Miami
State/Province
Florida
ZIP/Postal Code
33125
Country
United States
Facility Name
Investigator Site 11-125
City
Miami
State/Province
Florida
ZIP/Postal Code
33144
Country
United States
Facility Name
Investigator Site 11-005
City
Miami
State/Province
Florida
ZIP/Postal Code
33155
Country
United States
Facility Name
Investigator Site 11-032
City
North Miami Beach
State/Province
Florida
ZIP/Postal Code
33169
Country
United States
Facility Name
Investigator Site 11-171
City
Orlando
State/Province
Florida
ZIP/Postal Code
32807
Country
United States
Facility Name
Investigator Site 11-025
City
Orlando
State/Province
Florida
ZIP/Postal Code
32810
Country
United States
Facility Name
Investigator Site 11-087
City
Orlando
State/Province
Florida
ZIP/Postal Code
32819
Country
United States
Facility Name
Investigator Site 11-177
City
Pembroke Pines
State/Province
Florida
ZIP/Postal Code
33026
Country
United States
Facility Name
Investigator Site 11-144
City
Pompano Beach
State/Province
Florida
ZIP/Postal Code
33064
Country
United States
Facility Name
Investigator Site 11-099
City
Tamarac
State/Province
Florida
ZIP/Postal Code
33321
Country
United States
Facility Name
Investigator Site 11-090
City
Tampa
State/Province
Florida
ZIP/Postal Code
33606
Country
United States
Facility Name
Investigator Site 11-163
City
Tampa
State/Province
Florida
ZIP/Postal Code
33614
Country
United States
Facility Name
Investigator Site 11-109
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30303
Country
United States
Facility Name
Investigator Site 11-015
City
Columbus
State/Province
Georgia
ZIP/Postal Code
31904
Country
United States
Facility Name
Investigator Site 11-141
City
Macon
State/Province
Georgia
ZIP/Postal Code
31201
Country
United States
Facility Name
Investigator Site 11-031
City
Arlington Heights
State/Province
Illinois
ZIP/Postal Code
60005
Country
United States
Facility Name
Investigator Site 11-051
City
Hazel Crest
State/Province
Illinois
ZIP/Postal Code
60429
Country
United States
Facility Name
Investigator Site 11-063
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61602
Country
United States
Facility Name
Investigator Site 11-137
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61614
Country
United States
Facility Name
Investigator Site 11-117
City
Merrillville
State/Province
Indiana
ZIP/Postal Code
46410
Country
United States
Facility Name
Investigator Site 11-129
City
Munster
State/Province
Indiana
ZIP/Postal Code
46321
Country
United States
Facility Name
Investigator Site 11-069
City
Richmond
State/Province
Indiana
ZIP/Postal Code
47347
Country
United States
Facility Name
Investigator Site 11-061
City
Owensboro
State/Province
Kentucky
ZIP/Postal Code
42303
Country
United States
Facility Name
Investigator Site 11-183
City
Opelousas
State/Province
Louisiana
ZIP/Postal Code
70570
Country
United States
Facility Name
Investigator Site 11-022
City
West Monroe
State/Province
Louisiana
ZIP/Postal Code
71291
Country
United States
Facility Name
Investigator Site 11-027
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21229
Country
United States
Facility Name
Investigator Site 11-023
City
Columbia
State/Province
Maryland
ZIP/Postal Code
21044
Country
United States
Facility Name
Investigator Site 11-132
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
Investigator Site 11-123
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48201
Country
United States
Facility Name
Investigator Site 11-121
City
Livonia
State/Province
Michigan
ZIP/Postal Code
48154
Country
United States
Facility Name
Investigator Site 11-076
City
Rochester
State/Province
Michigan
ZIP/Postal Code
48307
Country
United States
Facility Name
Investigator Site 11-189
City
Rochester
State/Province
Michigan
ZIP/Postal Code
48307
Country
United States
Facility Name
Investigator Site 11-068
City
Jackson
State/Province
Mississippi
ZIP/Postal Code
39216
Country
United States
Facility Name
Investigator Site 11-154
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64111
Country
United States
Facility Name
Investigator Site 11-094
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Investigator Site 11-071
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68256-9797
Country
United States
Facility Name
Investigator Site 11-049
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89102
Country
United States
Facility Name
Investigator Site 11-145
City
North Las Vegas
State/Province
Nevada
ZIP/Postal Code
89086
Country
United States
Facility Name
Investigator Site 11-088
City
Haddon Heights
State/Province
New Jersey
ZIP/Postal Code
08035
Country
United States
Facility Name
Investigator Site 11-054
City
Linden
State/Province
New Jersey
ZIP/Postal Code
07036
Country
United States
Facility Name
Investigator Site 11-148
City
New Brunswick
State/Province
New Jersey
ZIP/Postal Code
08901
Country
United States
Facility Name
Investigator Site 11-107
City
Newark
State/Province
New Jersey
ZIP/Postal Code
07102
Country
United States
Facility Name
Investigator Site 11-116
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87109
Country
United States
Facility Name
Investigator Site 11-127
City
Bronx
State/Province
New York
ZIP/Postal Code
10461
Country
United States
Facility Name
Investigator Site 11-151
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11203-2012
Country
United States
Facility Name
Investigator Site 11-126
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11234
Country
United States
Facility Name
Investigator Site 11-073
City
Buffalo
State/Province
New York
ZIP/Postal Code
14215-1145
Country
United States
Facility Name
Investigator Site 11-040
City
Manhasset
State/Province
New York
ZIP/Postal Code
11030
Country
United States
Facility Name
Investigator Site 11-053
City
Richmond Hill
State/Province
New York
ZIP/Postal Code
11419
Country
United States
Facility Name
Investigator Site 11-081
City
Staten Island
State/Province
New York
ZIP/Postal Code
10310
Country
United States
Facility Name
Investigator Site 11-021
City
Stony Brook
State/Province
New York
ZIP/Postal Code
11794
Country
United States
Facility Name
Investigator Site 11-120
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
Investigator Site 11-075
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28207
Country
United States
Facility Name
Investigator Site 11-018
City
Greenville
State/Province
North Carolina
ZIP/Postal Code
27834
Country
United States
Facility Name
Investigator Site 11-157
City
Lumberton
State/Province
North Carolina
ZIP/Postal Code
28358
Country
United States
Facility Name
Investigator Site 11-149
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43214
Country
United States
Facility Name
Investigator Site 11-064
City
Lorain
State/Province
Ohio
ZIP/Postal Code
44053
Country
United States
Facility Name
Investigator Site 11-042
City
Marion
State/Province
Ohio
ZIP/Postal Code
43302-6416
Country
United States
Facility Name
Investigator Site 11-187
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43623
Country
United States
Facility Name
Investigator Site 11-074
City
Bartlesville
State/Province
Oklahoma
ZIP/Postal Code
74006
Country
United States
Facility Name
Investigator Site 11-124
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Investigator Site 11-056
City
Hillsboro
State/Province
Oregon
ZIP/Postal Code
97123
Country
United States
Facility Name
Investigator Site 11-169
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Investigator Site 11-165
City
Erie
State/Province
Pennsylvania
ZIP/Postal Code
16507
Country
United States
Facility Name
Investigator Site 11-082
City
Hershey
State/Province
Pennsylvania
ZIP/Postal Code
17033
Country
United States
Facility Name
Investigator Site 11-110
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29607
Country
United States
Facility Name
Investigator Site 11-098
City
Greenwood
State/Province
South Carolina
ZIP/Postal Code
29646
Country
United States
Facility Name
Investigator Site 11-119
City
Lancaster
State/Province
South Carolina
ZIP/Postal Code
29720
Country
United States
Facility Name
Investigator Site 11-133
City
Rock Hill
State/Province
South Carolina
ZIP/Postal Code
29732
Country
United States
Facility Name
Investigator Site 11-152
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37403
Country
United States
Facility Name
Investigator Site 11-091
City
Jackson
State/Province
Tennessee
ZIP/Postal Code
38301
Country
United States
Facility Name
Investigator Site 11-142
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38117
Country
United States
Facility Name
Investigator Site 11-083
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38138
Country
United States
Facility Name
Investigator Site 11-134
City
Tullahoma
State/Province
Tennessee
ZIP/Postal Code
37388
Country
United States
Facility Name
Investigator Site 11-104
City
Allen
State/Province
Texas
ZIP/Postal Code
75013
Country
United States
Facility Name
Investigator Site 11-185
City
Allen
State/Province
Texas
ZIP/Postal Code
75013
Country
United States
Facility Name
Investigator Site 11-070
City
Amarillo
State/Province
Texas
ZIP/Postal Code
79106
Country
United States
Facility Name
Investigator Site 11-176
City
Dallas
State/Province
Texas
ZIP/Postal Code
75231
Country
United States
Facility Name
Investigator Site 11-092
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
Investigator Site 11-170
City
Denison
State/Province
Texas
ZIP/Postal Code
75020
Country
United States
Facility Name
Investigator Site 11-060
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Investigator Site 11-072
City
Gonzales
State/Province
Texas
ZIP/Postal Code
78629
Country
United States
Facility Name
Investigator Site 11-140
City
Houston
State/Province
Texas
ZIP/Postal Code
77002
Country
United States
Facility Name
Investigator Site 11-089
City
Houston
State/Province
Texas
ZIP/Postal Code
77070
Country
United States
Facility Name
Investigator Site 11-146
City
Houston
State/Province
Texas
ZIP/Postal Code
77077
Country
United States
Facility Name
Investigator Site 11-156
City
Houston
State/Province
Texas
ZIP/Postal Code
77094
Country
United States
Facility Name
Investigator Site 11-034
City
Katy
State/Province
Texas
ZIP/Postal Code
77450
Country
United States
Facility Name
Investigator Site 11-029
City
Lampasas
State/Province
Texas
ZIP/Postal Code
76550
Country
United States
Facility Name
Investigator Site 11-046
City
McKinney
State/Province
Texas
ZIP/Postal Code
75071
Country
United States
Facility Name
Investigator Site 11-147
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78215
Country
United States
Facility Name
Investigator Site 11-085
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Investigator Site 11-161
City
Sugar Land
State/Province
Texas
ZIP/Postal Code
77479
Country
United States
Facility Name
Investigator Site 11-160
City
Webster
State/Province
Texas
ZIP/Postal Code
77598
Country
United States
Facility Name
Investigator Site 11-178
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84132
Country
United States
Facility Name
Investigator Site 11-158
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23507
Country
United States
Facility Name
Investigator Site 11-188
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23510
Country
United States
Facility Name
Investigator Site 11-065
City
Morgantown
State/Province
West Virginia
ZIP/Postal Code
26506
Country
United States
Facility Name
Investigator Site 11-045
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States
Facility Name
Investigator Site 21-006
City
Ciudad Autonoma de Buenos Aire
State/Province
Buenos Aires
ZIP/Postal Code
C1093AAS
Country
Argentina
Facility Name
Investigator Site 21-007
City
Ciudadela
State/Province
Buenos Aires
ZIP/Postal Code
B1702BML
Country
Argentina
Facility Name
Investigator Site 21-020
City
Ramos Mejía
State/Province
Buenos Aires
ZIP/Postal Code
B1704ETD
Country
Argentina
Facility Name
Investigator Site 21-004
City
San Nicolás
State/Province
Buenos Aires
ZIP/Postal Code
B2900DPA
Country
Argentina
Facility Name
Investigator Site 21-011
City
Córdoba
State/Province
Cordoba
ZIP/Postal Code
5000
Country
Argentina
Facility Name
Investigator Site 21-021
City
Córdoba
State/Province
Cordoba
ZIP/Postal Code
X5000EVQ
Country
Argentina
Facility Name
Investigator Site 21-014
City
Córdoba
State/Province
Cordoba
ZIP/Postal Code
X5002AOQ
Country
Argentina
Facility Name
Investigator Site 21-015
City
Villa María
State/Province
Cordoba
ZIP/Postal Code
5900
Country
Argentina
Facility Name
Investigator Site 21-019
City
Mar Del Plata
State/Province
Provincia De Buenos Aires
ZIP/Postal Code
B7602CBM
Country
Argentina
Facility Name
Investigator Site 21-010
City
San Miguel De Tucumán
State/Province
Tucuman
ZIP/Postal Code
4000
Country
Argentina
Facility Name
Investigator Site 21-012
City
Ciudad Autonoma de Buenos Aires
ZIP/Postal Code
1425
Country
Argentina
Facility Name
Investigator Site 21-003
City
Ciudad Autonoma de Buenos Aires
ZIP/Postal Code
C1023AAB
Country
Argentina
Facility Name
Investigator Site 21-018
City
Ciudad Autonoma de Buenos Aires
ZIP/Postal Code
C1407GTN
Country
Argentina
Facility Name
Investigator Site 21-008
City
Ciudad Autonoma de Buenos Aires
ZIP/Postal Code
C1430CKE
Country
Argentina
Facility Name
Investigator Site 21-017
City
Salta
ZIP/Postal Code
A4406BPF
Country
Argentina
Facility Name
Investigator Site 21-005
City
San Luis
ZIP/Postal Code
5700
Country
Argentina
Facility Name
Investigator Site 21-009
City
Santa Fe
ZIP/Postal Code
3000
Country
Argentina
Facility Name
Investigator Site 44-002
City
Mechelen
State/Province
Antwerp
ZIP/Postal Code
2800
Country
Belgium
Facility Name
Investigator Site 44-001
City
Ghent
State/Province
Oost Vlaanderen
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Investigator Site 44-005
City
Aalst
ZIP/Postal Code
B-9300
Country
Belgium
Facility Name
Investigator Site 44-009
City
Brussels
ZIP/Postal Code
1200
Country
Belgium
Facility Name
Investigator Site 44-003
City
Genk
ZIP/Postal Code
3600
Country
Belgium
Facility Name
Investigator Site 44-008
City
Hasselt
ZIP/Postal Code
3500
Country
Belgium
Facility Name
Investigator Site 44-007
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
Investigator Site 44-006
City
Liège
ZIP/Postal Code
4000
Country
Belgium
Facility Name
Investigator Site 44-010
City
Roeselare
ZIP/Postal Code
8800
Country
Belgium
Facility Name
Investigator Site 44-004
City
Yvoir
ZIP/Postal Code
5530
Country
Belgium
Facility Name
Investigator Site 22-021
City
Salvador
State/Province
Bahia
ZIP/Postal Code
40170-130
Country
Brazil
Facility Name
Investigator Site 22-019
City
Fortaleza
State/Province
Ceará
ZIP/Postal Code
60430-370
Country
Brazil
Facility Name
Investigator Site 22-013
City
Fortaleza
State/Province
Ceará
ZIP/Postal Code
60840-285
Country
Brazil
Facility Name
Investigator Site 22-023
City
Brasília
State/Province
Distrito Federal
ZIP/Postal Code
70710-100
Country
Brazil
Facility Name
Investigator Site 22-012
City
Vitória
State/Province
Espirito Santo
ZIP/Postal Code
29043-260
Country
Brazil
Facility Name
Investigator Site 22-011
City
Belo Horizonte
State/Province
Minas Gerais
ZIP/Postal Code
30110-934
Country
Brazil
Facility Name
Investigator Site 22-005
City
Belo Horizonte
State/Province
Minas Gerais
ZIP/Postal Code
30150-240
Country
Brazil
Facility Name
Investigator Site 22-004
City
Uberlândia
State/Province
Minas Gerais
ZIP/Postal Code
38411-186
Country
Brazil
Facility Name
Investigator Site 22-010
City
Campina Grande Do Sul
State/Province
Paraná
ZIP/Postal Code
83430-000
Country
Brazil
Facility Name
Investigator Site 22-008
City
Canoas
State/Province
Rio Grande Do Sul
ZIP/Postal Code
92425-900
Country
Brazil
Facility Name
Investigator Site 22-009
City
Porto Alegre
State/Province
Rio Grande Do Sul
ZIP/Postal Code
90840-440
Country
Brazil
Facility Name
Investigator Site 22-003
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90020-090
Country
Brazil
Facility Name
Investigator Site 22-015
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90035-903
Country
Brazil
Facility Name
Investigator Site 22-002
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90620-001
Country
Brazil
Facility Name
Investigator Site 22-025
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
91350-200
Country
Brazil
Facility Name
Investigator Site 22-017
City
Blumenau
State/Province
SC
ZIP/Postal Code
89020-430
Country
Brazil
Facility Name
Investigator Site 22-007
City
Aracaju
State/Province
Sergipe
ZIP/Postal Code
49055-530
Country
Brazil
Facility Name
Investigator Site 22-016
City
Campinas
State/Province
São Paulo
ZIP/Postal Code
13083-970
Country
Brazil
Facility Name
Investigator Site 22-018
City
Ribeirão Preto
State/Province
São Paulo
ZIP/Postal Code
14051-140
Country
Brazil
Facility Name
Investigator Site 22-020
City
São José Do Rio Preto
State/Province
São Paulo
ZIP/Postal Code
15015-210
Country
Brazil
Facility Name
Investigator Site 22-024
City
Rio De Janeiro
ZIP/Postal Code
20241-180
Country
Brazil
Facility Name
Investigator Site 22-014
City
São Paulo
ZIP/Postal Code
05403-000
Country
Brazil
Facility Name
Investigator Site 22-022
City
São Paulo
ZIP/Postal Code
09080-110
Country
Brazil
Facility Name
Investigator Site 61-003
City
Burgas
ZIP/Postal Code
8000
Country
Bulgaria
Facility Name
Investigator Site 61-002
City
Pleven
ZIP/Postal Code
5800
Country
Bulgaria
Facility Name
Investigator Site 61-004
City
Plovdiv
ZIP/Postal Code
4002
Country
Bulgaria
Facility Name
Investigator Site 61-010
City
Ruse
ZIP/Postal Code
7002
Country
Bulgaria
Facility Name
Investigator Site 61-009
City
Sofia
ZIP/Postal Code
1233
Country
Bulgaria
Facility Name
Investigator Site 61-008
City
Sofia
ZIP/Postal Code
1379
Country
Bulgaria
Facility Name
Investigator Site 61-005
City
Sofia
ZIP/Postal Code
1431
Country
Bulgaria
Facility Name
Investigator Site 61-006
City
Sofia
ZIP/Postal Code
1527
Country
Bulgaria
Facility Name
Investigator Site 12-005
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R2H 2A6
Country
Canada
Facility Name
Investigator Site 12-013
City
Saint John's
State/Province
Newfoundland and Labrador
ZIP/Postal Code
A1B3V6
Country
Canada
Facility Name
Investigator Site 12-008
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R7R1
Country
Canada
Facility Name
Investigator Site 12-012
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5A5
Country
Canada
Facility Name
Investigator Site 12-010
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 2P6
Country
Canada
Facility Name
Investigator Site 12-002
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5B 1W8
Country
Canada
Facility Name
Investigator Site 12-009
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2G8
Country
Canada
Facility Name
Investigator Site 12-006
City
Sherbrooke
State/Province
Quebec
ZIP/Postal Code
J1G 2E8
Country
Canada
Facility Name
Investigator Site 12-004
City
Trois-Rivières
State/Province
Quebec
ZIP/Postal Code
G8Z 3R9
Country
Canada
Facility Name
Investigator Site 62-019
City
Brno
ZIP/Postal Code
65691
Country
Czechia
Facility Name
Investigator Site 62-004
City
Bílina
ZIP/Postal Code
41801
Country
Czechia
Facility Name
Investigator Site 62-005
City
Havlíčkův Brod
ZIP/Postal Code
58022
Country
Czechia
Facility Name
Investigator Site 62-017
City
Havířov
ZIP/Postal Code
73601
Country
Czechia
Facility Name
Investigator Site 62-013
City
Liberec
ZIP/Postal Code
46001
Country
Czechia
Facility Name
Investigator Site 62-015
City
Litovel
ZIP/Postal Code
78401
Country
Czechia
Facility Name
Investigator Site 62-010
City
Mariánské Lázně
ZIP/Postal Code
35301
Country
Czechia
Facility Name
Investigator Site 62-018
City
Náchod
ZIP/Postal Code
54701
Country
Czechia
Facility Name
Investigator Site 62-001
City
Praha
ZIP/Postal Code
12808
Country
Czechia
Facility Name
Investigator Site 62-012
City
Praha
ZIP/Postal Code
14059
Country
Czechia
Facility Name
Investigator Site 62-009
City
Praha
ZIP/Postal Code
16902
Country
Czechia
Facility Name
Investigator Site 62-011
City
Slaný
ZIP/Postal Code
27401
Country
Czechia
Facility Name
Investigator Site 62-016
City
Uherské Hradiště
ZIP/Postal Code
68601
Country
Czechia
Facility Name
Investigator Site 32-010
City
Bordeaux
ZIP/Postal Code
33075
Country
France
Facility Name
Investigator Site 32-002
City
La Tronche
ZIP/Postal Code
38700
Country
France
Facility Name
Investigator Site 32-014
City
Lille
ZIP/Postal Code
59000
Country
France
Facility Name
Investigator Site 32-020
City
Lyon
ZIP/Postal Code
76000
Country
France
Facility Name
Investigator Site 32-005
City
Montpellier
ZIP/Postal Code
34295
Country
France
Facility Name
Investigator Site 32-001
City
Nancy
ZIP/Postal Code
54500
Country
France
Facility Name
Investigator Site 32-004
City
Paris
ZIP/Postal Code
75010
Country
France
Facility Name
Investigator Site 32-008
City
Paris
ZIP/Postal Code
75013
Country
France
Facility Name
Investigator Site 32-017
City
Paris
ZIP/Postal Code
75013
Country
France
Facility Name
Investigator Site 32-007
City
Paris
ZIP/Postal Code
75018
Country
France
Facility Name
Investigator Site 32-003
City
Pau
ZIP/Postal Code
64000
Country
France
Facility Name
Investigator Site 32-015
City
Poitiers
ZIP/Postal Code
86021
Country
France
Facility Name
Investigator Site 32-013
City
Reims
ZIP/Postal Code
51092
Country
France
Facility Name
Investigator Site 32-019
City
Rouen
ZIP/Postal Code
76031
Country
France
Facility Name
Investigator Site 32-018
City
Saint-Brieuc
ZIP/Postal Code
22000
Country
France
Facility Name
Investigator Site 32-006
City
Toulon
ZIP/Postal Code
83100
Country
France
Facility Name
Investigator Site 32-012
City
Toulouse
ZIP/Postal Code
31400
Country
France
Facility Name
Investigator Site 32-009
City
Tourcoing
ZIP/Postal Code
59200
Country
France
Facility Name
Investigator Site 32-011
City
Valenciennes
ZIP/Postal Code
59300
Country
France
Facility Name
Investigator Site 32-016
City
Valenciennes
ZIP/Postal Code
59300
Country
France
Facility Name
Investigator Site 63-012
City
Batumi
ZIP/Postal Code
6004
Country
Georgia
Facility Name
Investigator Site 63-007
City
Tbilisi
ZIP/Postal Code
0102
Country
Georgia
Facility Name
Investigator Site 63-011
City
Tbilisi
ZIP/Postal Code
0112
Country
Georgia
Facility Name
Investigator Site 63-004
City
Tbilisi
ZIP/Postal Code
0131
Country
Georgia
Facility Name
Investigator Site 63-002
City
Tbilisi
ZIP/Postal Code
0159
Country
Georgia
Facility Name
Investigator Site 63-006
City
Tbilisi
ZIP/Postal Code
0159
Country
Georgia
Facility Name
Investigator Site 63-008
City
Tbilisi
ZIP/Postal Code
0159
Country
Georgia
Facility Name
Investigator Site 63-010
City
Tbilisi
ZIP/Postal Code
0159
Country
Georgia
Facility Name
Investigator Site 63-003
City
Tbilisi
ZIP/Postal Code
0167
Country
Georgia
Facility Name
Investigator Site 63-009
City
Tbilisi
ZIP/Postal Code
0172
Country
Georgia
Facility Name
Investigator Site 63-001
City
Tbilisi
ZIP/Postal Code
0180
Country
Georgia
Facility Name
Investigator Site 63-005
City
Tbilisi
ZIP/Postal Code
0186
Country
Georgia
Facility Name
Investigator Site 33-011
City
Coburg
State/Province
Bavarian
ZIP/Postal Code
96450
Country
Germany
Facility Name
Investigator Site 33-008
City
Greifswald
State/Province
Mecklenburg-Vorpommern
ZIP/Postal Code
17475
Country
Germany
Facility Name
Investigator Site 33-006
City
Homburg
State/Province
Saar
ZIP/Postal Code
D-66421
Country
Germany
Facility Name
Investigator Site 33-023
City
Bad Oeynhausen
ZIP/Postal Code
32545
Country
Germany
Facility Name
Investigator Site 33-020
City
Berlin
ZIP/Postal Code
10789
Country
Germany
Facility Name
Investigator Site 33-013
City
Berlin
ZIP/Postal Code
12559
Country
Germany
Facility Name
Investigator Site 33-015
City
Bielefeld
ZIP/Postal Code
33604
Country
Germany
Facility Name
Investigator Site 33-016
City
Bremen
ZIP/Postal Code
28277
Country
Germany
Facility Name
Investigator Site 33-004
City
Erfurt
ZIP/Postal Code
99097
Country
Germany
Facility Name
Investigator Site 33-001
City
Essen
ZIP/Postal Code
45138
Country
Germany
Facility Name
Investigator Site 33-019
City
Frankfurt
ZIP/Postal Code
60590
Country
Germany
Facility Name
Investigator Site 33-007
City
Frankfurt
ZIP/Postal Code
65929
Country
Germany
Facility Name
Investigator Site 33-018
City
Gießen
ZIP/Postal Code
35392
Country
Germany
Facility Name
Investigator Site 33-002
City
Halle
ZIP/Postal Code
06120
Country
Germany
Facility Name
Investigator Site 33-005
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
Facility Name
Investigator Site 33-022
City
Hanover
ZIP/Postal Code
30625
Country
Germany
Facility Name
Investigator Site 33-012
City
Heilbronn
ZIP/Postal Code
74177
Country
Germany
Facility Name
Investigator Site 33-017
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Facility Name
Investigator Site 33-021
City
Leipzig
ZIP/Postal Code
04103
Country
Germany
Facility Name
Investigator Site 33-010
City
Leverkusen
ZIP/Postal Code
51375
Country
Germany
Facility Name
Investigator Site 33-024
City
Minden
ZIP/Postal Code
32429
Country
Germany
Facility Name
Investigator Site 33-014
City
Nürnberg
ZIP/Postal Code
90402
Country
Germany
Facility Name
Investigator Site 33-003
City
Würzburg
ZIP/Postal Code
97078
Country
Germany
Facility Name
Investigator Site 64-010
City
Budapest
ZIP/Postal Code
1096
Country
Hungary
Facility Name
Investigator Site 64-002
City
Budapest
ZIP/Postal Code
1097
Country
Hungary
Facility Name
Investigator Site 64-006
City
Budapest
ZIP/Postal Code
1122
Country
Hungary
Facility Name
Investigator Site 64-009
City
Budapest
ZIP/Postal Code
1134
Country
Hungary
Facility Name
Investigator Site 64-001
City
Kecskemét
ZIP/Postal Code
6000
Country
Hungary
Facility Name
Investigator Site 64-007
City
Kistarcsa
ZIP/Postal Code
2143
Country
Hungary
Facility Name
Investigator Site 64-005
City
Nyiregyhaza
ZIP/Postal Code
4400
Country
Hungary
Facility Name
Investigator Site 35-008
City
Ashqelon
ZIP/Postal Code
78278
Country
Israel
Facility Name
Investigator Site 35-009
City
Be'er Ya'aqov
ZIP/Postal Code
6093000
Country
Israel
Facility Name
Investigator Site 35-003
City
Hadera
ZIP/Postal Code
3810101
Country
Israel
Facility Name
Investigator Site 35-006
City
Haifa
ZIP/Postal Code
3109601
Country
Israel
Facility Name
Investigator Site 35-007
City
Haifa
ZIP/Postal Code
3109601
Country
Israel
Facility Name
Investigator Site 35-002
City
H̱olon
ZIP/Postal Code
98100
Country
Israel
Facility Name
Investigator Site 35-005
City
Jerusalem
ZIP/Postal Code
9103102
Country
Israel
Facility Name
Investigator Site 35-014
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
Facility Name
Investigator Site 35-001
City
Jerusalem
ZIP/Postal Code
91240
Country
Israel
Facility Name
Investigator Site 35-010
City
Nahariya
ZIP/Postal Code
2210001
Country
Israel
Facility Name
Investigator Site 35-011
City
Petah tikva
ZIP/Postal Code
4941492
Country
Israel
Facility Name
Investigator Site 35-013
City
Ramat Gan
ZIP/Postal Code
5265601
Country
Israel
Facility Name
Investigator Site 35-012
City
Safed
ZIP/Postal Code
13100
Country
Israel
Facility Name
Investigator Site 35-016
City
Tiberias
ZIP/Postal Code
1520800
Country
Israel
Facility Name
Investigator Site 34-005
City
Ancona
Country
Italy
Facility Name
Investigator Site 34-002
City
Bergamo
ZIP/Postal Code
24127
Country
Italy
Facility Name
Investigator Site 34-007
City
Brescia
ZIP/Postal Code
25123
Country
Italy
Facility Name
Investigator Site 34-001
City
Caserta
ZIP/Postal Code
81100
Country
Italy
Facility Name
Investigator Site 34-009
City
Cona
ZIP/Postal Code
44120
Country
Italy
Facility Name
Investigator Site 34-014
City
Foggia
ZIP/Postal Code
71100
Country
Italy
Facility Name
Investigator Site 34-010
City
Genova
ZIP/Postal Code
16132
Country
Italy
Facility Name
Investigator Site 34-004
City
Milano
ZIP/Postal Code
20138
Country
Italy
Facility Name
Investigator Site 34-012
City
Piacenza
ZIP/Postal Code
29121
Country
Italy
Facility Name
Investigator Site 34-003
City
Roma
ZIP/Postal Code
00163
Country
Italy
Facility Name
Investigator Site 34-013
City
San Bonifacio
ZIP/Postal Code
37047
Country
Italy
Facility Name
Investigator Site 23-007
City
Cuauhtémoc
State/Province
Ciudad De Mexico
ZIP/Postal Code
06090
Country
Mexico
Facility Name
Investigator Site 23-005
City
Delegación Gustavo A. Madero
State/Province
Ciudad De Mexico
ZIP/Postal Code
07020
Country
Mexico
Facility Name
Investigator Site 23-012
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44100
Country
Mexico
Facility Name
Investigator Site 23-004
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44657
Country
Mexico
Facility Name
Investigator Site 23-010
City
San Pedro Garza Garcia
State/Province
Nuevo Léon
ZIP/Postal Code
66278
Country
Mexico
Facility Name
Investigator Site 23-011
City
Oaxaca de Juarez
State/Province
Oaxaca
ZIP/Postal Code
6800
Country
Mexico
Facility Name
Investigator Site 23-001
City
Santiago De Querétaro
State/Province
Querétaro
ZIP/Postal Code
76000
Country
Mexico
Facility Name
Investigator Site 23-002
City
Culiacán
State/Province
Sinaloa
ZIP/Postal Code
80230
Country
Mexico
Facility Name
Investigator Site 23-006
City
Xalapa
State/Province
Veracruz
ZIP/Postal Code
91193
Country
Mexico
Facility Name
Investigator Site 36-003
City
Rotterdam
State/Province
South Holland
ZIP/Postal Code
3000
Country
Netherlands
Facility Name
Investigator Site 36-002
City
's-Hertogenbosch
ZIP/Postal Code
5223GZ
Country
Netherlands
Facility Name
Investigator Site 36-012
City
Amstelveen
ZIP/Postal Code
1186AM
Country
Netherlands
Facility Name
Investigator Site 36-006
City
Blaricum
ZIP/Postal Code
1261 AN
Country
Netherlands
Facility Name
Investigator Site 36-009
City
Dirksland
ZIP/Postal Code
3247BW
Country
Netherlands
Facility Name
Investigator Site 36-015
City
Dordrecht
ZIP/Postal Code
3318 AT
Country
Netherlands
Facility Name
Investigator Site 36-007
City
Ede
ZIP/Postal Code
6716 RP
Country
Netherlands
Facility Name
Investigator Site 36-001
City
Groningen
ZIP/Postal Code
9713 GZ
Country
Netherlands
Facility Name
Investigator Site 36-013
City
Helmond
ZIP/Postal Code
5707HA
Country
Netherlands
Facility Name
Investigator Site 36-014
City
Hoorn
ZIP/Postal Code
1624 NP
Country
Netherlands
Facility Name
Investigator Site 36-010
City
Schiedam
ZIP/Postal Code
3118 JH
Country
Netherlands
Facility Name
Investigator Site 36-004
City
Tilburg
ZIP/Postal Code
5042 AD
Country
Netherlands
Facility Name
Investigator Site 36-011
City
Utrecht
ZIP/Postal Code
3582 KE
Country
Netherlands
Facility Name
Investigator Site 65-007
City
Białystok
ZIP/Postal Code
15-276
Country
Poland
Facility Name
Investigator Site 65-014
City
Katowice
ZIP/Postal Code
40-156
Country
Poland
Facility Name
Investigator Site 65-012
City
Kędzierzyn-Koźle
ZIP/Postal Code
47-200
Country
Poland
Facility Name
Investigator Site 65-019
City
Olsztyn
ZIP/Postal Code
10-010
Country
Poland
Facility Name
Investigator Site 65-015
City
Ostrowiec Świętokrzyski
ZIP/Postal Code
27-400
Country
Poland
Facility Name
Investigator Site 65-021
City
Pomorskie
ZIP/Postal Code
81-717
Country
Poland
Facility Name
Investigator Site 65-003
City
Poznań
ZIP/Postal Code
61-485
Country
Poland
Facility Name
Investigator Site 65-020
City
Poznań
ZIP/Postal Code
61-848
Country
Poland
Facility Name
Investigator Site 65-008
City
Rzeszów
ZIP/Postal Code
35-055
Country
Poland
Facility Name
Investigator Site 65-010
City
Wrocław
ZIP/Postal Code
50-556
Country
Poland
Facility Name
Investigator Site 65-005
City
Wrocław
ZIP/Postal Code
51-162
Country
Poland
Facility Name
Investigator Site 65-011
City
Zgierz
ZIP/Postal Code
95-100
Country
Poland
Facility Name
Investigator Site 65-001
City
Łódź
ZIP/Postal Code
90-549
Country
Poland
Facility Name
Investigator Site 65-018
City
Łódź
ZIP/Postal Code
93-513
Country
Poland
Facility Name
Investigator Site 66-014
City
Izhevsk
State/Province
Udmurt Republic
ZIP/Postal Code
426063
Country
Russian Federation
Facility Name
Investigator Site 66-008
City
Chelyabinsk
ZIP/Postal Code
454136
Country
Russian Federation
Facility Name
Investigator Site 66-001
City
Ekaterinburg
ZIP/Postal Code
620109
Country
Russian Federation
Facility Name
Investigator Site 66-016
City
Kazan
ZIP/Postal Code
420033
Country
Russian Federation
Facility Name
Investigator Site 66-010
City
Kemerovo
ZIP/Postal Code
650002
Country
Russian Federation
Facility Name
Investigator Site 66-015
City
Moscow
ZIP/Postal Code
111539
Country
Russian Federation
Facility Name
Investigator Site 66-004
City
Moscow
ZIP/Postal Code
119192
Country
Russian Federation
Facility Name
Investigator Site 66-011
City
Moscow
ZIP/Postal Code
119192
Country
Russian Federation
Facility Name
Investigator Site 66-017
City
Moscow
ZIP/Postal Code
124489
Country
Russian Federation
Facility Name
Investigator Site 66-002
City
Novosibirsk
ZIP/Postal Code
63008
Country
Russian Federation
Facility Name
Investigator Site 66-005
City
Penza
ZIP/Postal Code
440026
Country
Russian Federation
Facility Name
Investigator Site 66-007
City
Perm
ZIP/Postal Code
614097
Country
Russian Federation
Facility Name
Investigator Site 66-012
City
Petrozavodsk
ZIP/Postal Code
185019
Country
Russian Federation
Facility Name
Investigator Site 66-018
City
Ryazan'
ZIP/Postal Code
390039
Country
Russian Federation
Facility Name
Investigator Site 66-013
City
Saint Petersburg
ZIP/Postal Code
198205
Country
Russian Federation
Facility Name
Investigator Site 66-003
City
Saint Petersburg
ZIP/Postal Code
199106
Country
Russian Federation
Facility Name
Investigator Site 66-009
City
Tver
ZIP/Postal Code
170036
Country
Russian Federation
Facility Name
Investigator Site 67-010
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Investigator Site 67-002
City
Belgrade
ZIP/Postal Code
11040
Country
Serbia
Facility Name
Investigator Site 67-004
City
Belgrade
ZIP/Postal Code
11050
Country
Serbia
Facility Name
Investigator Site 67-008
City
Belgrade
ZIP/Postal Code
11080
Country
Serbia
Facility Name
Investigator Site 67-007
City
Niška Banja
ZIP/Postal Code
18205
Country
Serbia
Facility Name
Investigator Site 67-005
City
Niš
ZIP/Postal Code
18000
Country
Serbia
Facility Name
Investigator Site 67-001
City
Sremska Kamenica
ZIP/Postal Code
21204
Country
Serbia
Facility Name
Investigator Site 67-003
City
Šabac
ZIP/Postal Code
15000
Country
Serbia
Facility Name
Investigator Site 37-014
City
Palma De Mallorca
State/Province
Baleares
ZIP/Postal Code
07120
Country
Spain
Facility Name
Investigator Site 37-010
City
Castellón De La Plana
State/Province
Castellon
ZIP/Postal Code
12004
Country
Spain
Facility Name
Investigator Site 37-003
City
Barcelona
State/Province
Cataluña
ZIP/Postal Code
08003
Country
Spain
Facility Name
Investigator Site 37-005
City
Santiago De Compostela
State/Province
La Coruña
ZIP/Postal Code
015706
Country
Spain
Facility Name
Investigator Site 37-011
City
Majadahonda
State/Province
Madrid
ZIP/Postal Code
28222
Country
Spain
Facility Name
Investigator Site 37-024
City
Marbella
State/Province
Malaga
ZIP/Postal Code
029603
Country
Spain
Facility Name
Investigator Site 37-016
City
La Laguna
State/Province
Tenerife
ZIP/Postal Code
038320
Country
Spain
Facility Name
Investigator Site 37-001
City
Manises
State/Province
Valencia
ZIP/Postal Code
46940
Country
Spain
Facility Name
Investigator Site 37-012
City
Alicante
ZIP/Postal Code
03010
Country
Spain
Facility Name
Investigator Site 37-015
City
Badalona
ZIP/Postal Code
08916
Country
Spain
Facility Name
Investigator Site 37-007
City
Barcelona
ZIP/Postal Code
08041
Country
Spain
Facility Name
Investigator Site 37-002
City
Barcelona
ZIP/Postal Code
08907
Country
Spain
Facility Name
Investigator Site 37-018
City
Huelva
ZIP/Postal Code
021005
Country
Spain
Facility Name
Investigator Site 37-025
City
La Coruña
Country
Spain
Facility Name
Investigator Site 37-023
City
Lleida
ZIP/Postal Code
25198
Country
Spain
Facility Name
Investigator Site 37-004
City
Madrid
ZIP/Postal Code
028007
Country
Spain
Facility Name
Investigator Site 37-006
City
Madrid
ZIP/Postal Code
028041
Country
Spain
Facility Name
Investigator Site 37-021
City
Madrid
ZIP/Postal Code
28006
Country
Spain
Facility Name
Investigator Site 37-020
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
Investigator Site 37-026
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Investigator Site 37-022
City
Murcia
ZIP/Postal Code
300008
Country
Spain
Facility Name
Investigator Site 37-017
City
Málaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Investigator Site 37-013
City
Sevilla
ZIP/Postal Code
041007
Country
Spain
Facility Name
Investigator Site 37-009
City
Valencia
ZIP/Postal Code
046020
Country
Spain
Facility Name
Investigator Site 37-008
City
Valencia
ZIP/Postal Code
4610
Country
Spain
Facility Name
Investigator Site 68-008
City
Kharkiv
State/Province
Novobavarskiy
ZIP/Postal Code
61157
Country
Ukraine
Facility Name
Investigator Site 68-017
City
Dnipro
ZIP/Postal Code
49027
Country
Ukraine
Facility Name
Investigator Site 68-009
City
Ivano-Frankivs'k
ZIP/Postal Code
76008
Country
Ukraine
Facility Name
Investigator Site 68-005
City
Ivano-Frankivs'k
ZIP/Postal Code
76018
Country
Ukraine
Facility Name
Investigator Site 68-001
City
Kharkiv
ZIP/Postal Code
61039
Country
Ukraine
Facility Name
Investigator Site 68-011
City
Kharkiv
ZIP/Postal Code
61058
Country
Ukraine
Facility Name
Investigator Site 68-010
City
Kharkiv
ZIP/Postal Code
61103
Country
Ukraine
Facility Name
Investigator Site 68-002
City
Kharkiv
ZIP/Postal Code
61176
Country
Ukraine
Facility Name
Investigator Site 68-012
City
Kyiv
ZIP/Postal Code
01601
Country
Ukraine
Facility Name
Investigator Site 68-003
City
Kyiv
ZIP/Postal Code
0200
Country
Ukraine
Facility Name
Investigator Site 68-015
City
Kyiv
ZIP/Postal Code
02166
Country
Ukraine
Facility Name
Investigator Site 68-013
City
Kyiv
ZIP/Postal Code
03110
Country
Ukraine
Facility Name
Investigator Site 68-007
City
Kyiv
ZIP/Postal Code
04050
Country
Ukraine
Facility Name
Investigator Site 68-006
City
Lviv
ZIP/Postal Code
79013
Country
Ukraine
Facility Name
Investigator Site 68-014
City
Vinnytsia
ZIP/Postal Code
21000
Country
Ukraine
Facility Name
Investigator Site 68-016
City
Zaporizhzhya
ZIP/Postal Code
69106
Country
Ukraine
Facility Name
Investigator Site 68-004
City
Zhytomyr
ZIP/Postal Code
10002
Country
Ukraine
Facility Name
Investigator Site 39-012
City
Harlow
State/Province
Essex
ZIP/Postal Code
CM2 01QX
Country
United Kingdom
Facility Name
Investigator Site 39-003
City
Scunthorpe
State/Province
North Lincolshire
ZIP/Postal Code
DN15 7BH
Country
United Kingdom
Facility Name
Investigator Site 39-005
City
Dudley
State/Province
West Midlands
ZIP/Postal Code
DY1 2HQ
Country
United Kingdom
Facility Name
Investigator Site 39-009
City
Barnsley
ZIP/Postal Code
S75 2EP
Country
United Kingdom
Facility Name
Investigator Site 39-016
City
High Wycombe
ZIP/Postal Code
HP11 2TT
Country
United Kingdom
Facility Name
Investigator Site 39-008
City
Inverness
ZIP/Postal Code
IV2 3JH
Country
United Kingdom
Facility Name
Investigator Site 39-011
City
Leicester
ZIP/Postal Code
LE3 9QP
Country
United Kingdom
Facility Name
Investigator Site 39-013
City
Liverpool
ZIP/Postal Code
L9 7AL
Country
United Kingdom
Facility Name
Investigator Site 39-015
City
London
ZIP/Postal Code
SE5 9RS
Country
United Kingdom
Facility Name
Investigator Site 39-010
City
North Shields
ZIP/Postal Code
NE29 8NH
Country
United Kingdom
Facility Name
Investigator Site 39-007
City
Swansea
ZIP/Postal Code
SA6 6NL
Country
United Kingdom
Facility Name
Investigator Site 39-004
City
York
ZIP/Postal Code
YO31 8HE
Country
United Kingdom

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.
IPD Sharing Time Frame
Data can be requested 6 months after the primary publication and approval of the indication studied in the US and European Union (EU), whichever is later. Data will be indefinitely available for requesting
IPD Sharing Access Criteria
A research proposal must be approved by an independent review panel and the study sponsor and researchers must sign a data sharing agreement.
Citations:
PubMed Identifier
35900838
Citation
Butler J, Anker SD, Lund LH, Coats AJS, Filippatos G, Siddiqi TJ, Friede T, Fabien V, Kosiborod M, Metra M, Pina IL, Pinto F, Rossignol P, van der Meer P, Bahit C, Belohlavek J, Bohm M, Brugts JJ, Cleland JGF, Ezekowitz J, Bayes-Genis A, Gotsman I, Goudev A, Khintibidze I, Lindenfeld J, Mentz RJ, Merkely B, Montes EC, Mullens W, Nicolau JC, Parkhomenko A, Ponikowski P, Seferovic PM, Senni M, Shlyakhto E, Cohen-Solal A, Szecsody P, Jensen K, Dorigotti F, Weir MR, Pitt B. Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial. Eur Heart J. 2022 Nov 1;43(41):4362-4373. doi: 10.1093/eurheartj/ehac401.
Results Reference
derived
PubMed Identifier
33608263
Citation
Bolanos JA, Seliger SL. Recurrent Hyperkalemia in Renin-Angiotensin-Aldosterone System Inhibitor (RAASi) Treatment: Stuck between a Rock and a Hard Place. Clin J Am Soc Nephrol. 2021 Mar 8;16(3):345-347. doi: 10.2215/CJN.00950121. Epub 2021 Feb 19. No abstract available.
Results Reference
derived

Learn more about this trial

Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure (DIAMOND)

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