pCO2 Oscillations During Exercise: Relation to Cerebral Blood Flow and to Cognitive Dysfunction in COPD
Chronic Obstructive Pulmonary Disease
About this trial
This is an interventional basic science trial for Chronic Obstructive Pulmonary Disease focused on measuring COPD, Carbon dioxide partial pressure (pCO2), Cerebral blood flow (CBF), Cognitive dysfunction, Mild/Moderate Cognitive Impairment (MCI), Pulmonary Rehabilitation (PR), Standardized Mini Mental State Examination (SMMSE), Addenbrooke's Cognitive Examination (ACE-R), Montreal Cognitive Assessment (MoCA), Telephone Interview for Cognitive Status (TICS), Stroop test (Reaction Time)
Eligibility Criteria
Inclusion Criteria:
- Patients with Chronic Obstructive Pulmonary Disease (COPD) in Global Initiative on Obstructive Lung Disease (GOLD) stages II to IV
- COPD patients with mild to moderate cognitive impairment (MCI-group: n=100) and without cognitive impairment (Control-group: n=60)
- Normotensive (Blood Pressure range: 101-143/62-91 millimeters of mercury [mmHg])
Exclusion Criteria:
- Resting partial pressure of oxygen in arterial blood (paO2) <55 millimeters of mercury [mmHg]
- Resting partial pressure of carbon dioxide in arterial blood (paCO2) >45 millimeters of mercury [mmHg]
- last exacerbation ≤4weeks
- severe cognitive impairment/dementia
- other neuropsychiatric symptoms
Sites / Locations
- Klinikum Berchtesgadener Land der Schön-Kliniken
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Effect of PR in MCI-group
Effect of PR in control-group
Evaluation of the acute effect of a 3-week Pulmonary Rehabilitation (PR) program in cognitive function of MCI-Group using SMMSE, ACE-R, MoCA, TICS and Stroop test clinical instruments in reference to potential changes in pCO2 oscillation patterns (post-PR). Intervention: Pulmonary Rehabilitation program; 12 sessions of exercise training/breathing techniques.
Evaluation of the acute effect of a 3-week Pulmonary Rehabilitation (PR) program in cognitive function of control-group using SMMSE, ACE-R, MoCA, TICS and Stroop test clinical instruments in reference to potential changes in pCO2 oscillation patterns (post-PR). Intervention: Pulmonary Rehabilitation program; 12 sessions of exercise training/breathing techniques.