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Perception and Multisensory Integration in Neurological Patients Using fMRI

Primary Purpose

Acute Inflammatory Demyelinating Polyradiculoneuropathy, Myasthenia Gravis, Stroke

Status

Unknown status

Phase

Not Applicable

Locations

Israel

Study Type

Interventional

Intervention

Siemens magnetom avanto1.5 Tesla, Siemens magnetom trio A Tim system 3 Tesla

About this trial

This is an interventional basic science trial for Acute Inflammatory Demyelinating Polyradiculoneuropathy

Eligibility Criteria

18 Years - 80 Years (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

diagnosis of the investigated neuronal disease

Exclusion Criteria:

contraindication for MRI scan
pregnancy
refusal to participate in the study

Sites / Locations

Hadassah Medical Organization

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

study group

Arm Description

fMRI

Outcomes

Primary Outcome Measures

assessing hemodynamic responses by measurement of the Blood-oxygen-level dependence(BOLD)signal

Distinct maps of sensory and multisensory representations related to certain disorders will be assed by measurement of the Blood-oxygen-level dependence(BOLD)signal.

Secondary Outcome Measures

Full Information

NCT ID

NCT01469858

First Posted

November 1, 2011

Last Updated

November 8, 2011

Sponsor

Hadassah Medical Organization

1. Study Identification

Unique Protocol Identification Number

NCT01469858

Brief Title

Perception and Multisensory Integration in Neurological Patients Using fMRI

Official Title

Perception and Multisensory Integration in Neurological Patients Using fMRI

Study Type

Interventional

2. Study Status

Record Verification Date

September 2011

Overall Recruitment Status

Unknown status

Study Start Date

November 2011 (undefined)

Primary Completion Date

November 2013 (Anticipated)

Study Completion Date

November 2015 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Hadassah Medical Organization

4. Oversight

Data Monitoring Committee

5. Study Description

Brief Summary

The main objective of the study is to explore and map brain areas involved in sensory perception and multisensory integration in patients with central or peripheral neurological damage. The investigators hypothesize for example, that a change (compare to healthy subjects) in the perceptual maps and body representation could be detected and characterize in patients suffering from impairments of peripheral nerve conduction.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Acute Inflammatory Demyelinating Polyradiculoneuropathy, Myasthenia Gravis, Stroke, Anosognosia, Asomatognosia

7. Study Design

Primary Purpose

Basic Science

Study Phase

Not Applicable

Interventional Study Model

Single Group Assignment

Masking

None (Open Label)

Allocation

N/A

Enrollment

30 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

study group

Arm Type

Experimental

Arm Description

fMRI

Intervention Type

Device

Intervention Name(s)

Siemens magnetom avanto1.5 Tesla, Siemens magnetom trio A Tim system 3 Tesla

Intervention Description

functional magnetic resonance imaging

Primary Outcome Measure Information:

Title

assessing hemodynamic responses by measurement of the Blood-oxygen-level dependence(BOLD)signal

Description

Distinct maps of sensory and multisensory representations related to certain disorders will be assed by measurement of the Blood-oxygen-level dependence(BOLD)signal.

Time Frame

1 year

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Maximum Age & Unit of Time

80 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: diagnosis of the investigated neuronal disease Exclusion Criteria: contraindication for MRI scan pregnancy refusal to participate in the study

Central Contact Person:

First Name & Middle Initial & Last Name or Official Title & Degree

Shahar Arzi, MD PhD

Phone

97226777741

shahar.arzy@gmail.com

Facility Information:

Facility Name

Hadassah Medical Organization

City

Jerusalem

Country

Israel

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Arik Tzukert, DMD

Phone

00 972 2 6776095

arik@hadassah.org.il

First Name & Middle Initial & Last Name & Degree

Hadas Lemberg, PhD

Phone

00 972 2 6777572

lhadas@hadassah.org.il

First Name & Middle Initial & Last Name & Degree

Shahar Arzy, MD PhD

12. IPD Sharing Statement

Citations:

PubMed Identifier

16831974

Citation

Arzy S, Overney LS, Landis T, Blanke O. Neural mechanisms of embodiment: asomatognosia due to premotor cortex damage. Arch Neurol. 2006 Jul;63(7):1022-5. doi: 10.1001/archneur.63.7.1022.

Results Reference

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Perception and Multisensory Integration in Neurological Patients Using fMRI

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