Perception of Facial Emotions in Schizophrenia and 22q11 Deletion Syndrome (FaSchi22)
Primary Purpose
Schizophrenia
Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
schizophrenia
the 22q11 deletion syndrome
control group
Sponsored by
About this trial
This is an interventional diagnostic trial for Schizophrenia focused on measuring schizophrenia, Facial emotions
Eligibility Criteria
Inclusion Criteria:
- Aged 15-50 years old
- No psychiatric conditions or comorbidity
- Agreement from parents if participant is underage
- Patients with schizophrenia: diagnosis assessed with DSM5 criteria
- Patients with 22q11.2 DS: diagnosis assessed by genetic tests (CGH- array or FISH)
- No mental delay (IQ>70 according to the fNART)
- No modification of psychotropic treatment during the month before inclusion
Exclusion Criteria:
- Involvement in a current program of social cognition remediation
- Pregnancy
- Substance use disorder (criteria of DSM-5), except for caffeine and tobacco
- Neurologic disorders (vascular, infectious or neurodegenerative)
- Uncorrected visual deficit
- Guardianship
- Medical drugs with cerebral or psychological effect (e.g, corticosteroids)
- Resistance to antipsychotics
- Electroconvulsive therapy in the previous two months
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm Type
Other
Other
Arm Label
22Q11
SCHIZOPHRENIA
Arm Description
24 patients with 22Q11DS to determine whether the severity of the two disorders' symptoms is correlated with the cerebral response to facial expressions. To answer this question, a set of clinical and neuropsychological tests will be conducted for each patient.
24 patients with schizophrenia to determine whether the severity of the two disorders' symptoms is correlated with the cerebral response to facial expressions. To answer this question, a set of clinical and neuropsychological tests will be conducted for each patient.
Outcomes
Primary Outcome Measures
Steady-state visual evoked potentials (SSVEP) recorded during fast periodic visual stimulation (FPVS).
SSVEPs arise in response to the periodic presentation of emotional faces. They are analyzed in the frequency domain. Two types of responses are expected: the general visual response (6 Hz and its harmonics) and the expression-specific response (1.2 Hz and its harmonics). Both responses will be compared across the different groups.
Secondary Outcome Measures
Full Information
NCT ID
NCT02634671
First Posted
December 16, 2015
Last Updated
February 7, 2018
Sponsor
Hôpital le Vinatier
1. Study Identification
Unique Protocol Identification Number
NCT02634671
Brief Title
Perception of Facial Emotions in Schizophrenia and 22q11 Deletion Syndrome
Acronym
FaSchi22
Official Title
Facial Expression Perception by Intensity in Schizophrenia and 22q11.2 Deletion Syndrome: Neural Electrophysiological Evidence by Means of Fast Periodic Visual Stimulation
Study Type
Interventional
2. Study Status
Record Verification Date
February 2018
Overall Recruitment Status
Completed
Study Start Date
November 2015 (undefined)
Primary Completion Date
October 20, 2017 (Actual)
Study Completion Date
December 30, 2017 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Hôpital le Vinatier
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
Background:
The present study aims to identify the mechanisms underlying the deficit in facial emotion recognition reported both in schizophrenia and the 22q11.2 deletion syndrome, and thus, reveal a distinction between the two disorders. Indeed, despite the clinical overlap between the two syndromes, some of the symptoms appear to be specific to only one of them. In particular, the disturbance of visual functions is specifically observed in the 22q11.2DS. Hence, the difficulties in facial emotion recognition in schizophrenia and in the 22q11.DS are likely accounted by different cognitive impairments. Investigating which mechanisms are disturbed would allow a specialized support for patients.
Our main hypothesis is that the deficit in facial emotion recognition is more related to visual impairments in the 22q11.2DS than in schizophrenia. This hypothesis will be tested in two groups of patients (22q11.2DS and schizophrenic patients) and a control group (healthy subjects) using an experimental paradigm based on electroencephalography (EEG).
A second aim of this study is to determine whether the severity of the two disorders' symptoms is correlated with the cerebral response to facial expressions. To answer this question, a set of clinical and neuropsychological tests will be conducted for each patient.
Detailed Description
Methods:
This study will be conducted using visual steady-state visual evoked potentials (SSVEPs). Visual SSVEPs are periodic neural electrophysiological activities that arise in response to fast periodic visual stimulation (FPVS). They will be recorded in response to the periodic presentation of faces, according to an oddball paradigm. While pictures of faces will appear at a 6 Hz rate, only 1 out of 5 will display an emotion, corresponding to a 1.2 Hz oddball frequency. Different emotions will be tested (happiness, sadness, anger, fear and disgust), displayed with different intensities (20%, 60%, 100%). SSVEPs at 6 Hz will reflect general visual mechanisms (in response to a mixture of low-level (i.e., contrast coding) and high-level (i.e., face detection) processes). Importantly, SSVEPs at 1.2 Hz will index the visual mechanisms specifically involved in facial expression perception and their sensitivity to emotion intensity. Both measures will help determine the underlying brain topographies.
Alongside, clinical and neuropsychological tests will be conducted. While the clinical tests will evaluate the severity of the symptoms, the neuropsychological tests will assess different features such as attention, memory, verbal and visuo-spatial abilities. The patients' scores will be linked with their cerebral activity in response to facial expressions.
Outcomes:
To better understand the impairment of facial emotion recognition in schizophrenia and 22q11.2DS and to improve its care.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Schizophrenia
Keywords
schizophrenia, Facial emotions
7. Study Design
Primary Purpose
Diagnostic
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
70 (Actual)
8. Arms, Groups, and Interventions
Arm Title
22Q11
Arm Type
Other
Arm Description
24 patients with 22Q11DS to determine whether the severity of the two disorders' symptoms is correlated with the cerebral response to facial expressions. To answer this question, a set of clinical and neuropsychological tests will be conducted for each patient.
Arm Title
SCHIZOPHRENIA
Arm Type
Other
Arm Description
24 patients with schizophrenia to determine whether the severity of the two disorders' symptoms is correlated with the cerebral response to facial expressions. To answer this question, a set of clinical and neuropsychological tests will be conducted for each patient.
Intervention Type
Other
Intervention Name(s)
schizophrenia
Intervention Description
The present study aims to identify the mechanisms underlying the deficit in facial emotion recognition reported both in schizophrenia with a control group using an experimental paradigm based on electroencephalography (EEG)
Intervention Type
Other
Intervention Name(s)
the 22q11 deletion syndrome
Intervention Description
The present study aims to identify the mechanisms underlying the deficit in facial emotion recognition reported both in the 22q11.2 deletion syndrome with a control group using an experimental paradigm based on electroencephalography (EEG)
Intervention Type
Other
Intervention Name(s)
control group
Intervention Description
The present study aims to identify the mechanisms underlying the deficit in facial emotion recognition reported both in the schizophrenia and 22q11.2 deletion syndrome with a control group using an experimental paradigm based on electroencephalography (EEG)
Primary Outcome Measure Information:
Title
Steady-state visual evoked potentials (SSVEP) recorded during fast periodic visual stimulation (FPVS).
Description
SSVEPs arise in response to the periodic presentation of emotional faces. They are analyzed in the frequency domain. Two types of responses are expected: the general visual response (6 Hz and its harmonics) and the expression-specific response (1.2 Hz and its harmonics). Both responses will be compared across the different groups.
Time Frame
SSVEPs will be recorded during 20 sequences of emotional faces pictures. As each sequence lasts 80s, the EEG recording will be approximately 30-minutes-long.
10. Eligibility
Sex
All
Minimum Age & Unit of Time
15 Years
Maximum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Aged 15-50 years old
No psychiatric conditions or comorbidity
Agreement from parents if participant is underage
Patients with schizophrenia: diagnosis assessed with DSM5 criteria
Patients with 22q11.2 DS: diagnosis assessed by genetic tests (CGH- array or FISH)
No mental delay (IQ>70 according to the fNART)
No modification of psychotropic treatment during the month before inclusion
Exclusion Criteria:
Involvement in a current program of social cognition remediation
Pregnancy
Substance use disorder (criteria of DSM-5), except for caffeine and tobacco
Neurologic disorders (vascular, infectious or neurodegenerative)
Uncorrected visual deficit
Guardianship
Medical drugs with cerebral or psychological effect (e.g, corticosteroids)
Resistance to antipsychotics
Electroconvulsive therapy in the previous two months
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
DEMILY CAROLINE, PH
Organizational Affiliation
Centre régional de dépistage et de prises en charge des troubles psychiatriques d'origine génétique Pôle Ouest LE VINATIER HOSPITAL
Official's Role
Principal Investigator
12. IPD Sharing Statement
Learn more about this trial
Perception of Facial Emotions in Schizophrenia and 22q11 Deletion Syndrome
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