Peri-Articular-Multimodal Drug and Oral Celecoxib in Management of Postoperative Pain of Total Knee Arthroplasty
Postoperative Pain, Total Knee Arthroplasty
About this trial
This is an interventional treatment trial for Postoperative Pain focused on measuring Total knee arthroplasty, Pain, Multimodal analgesia, Range of motion
Eligibility Criteria
Inclusion Criteria:
- Clinical diagnosis of osteoarthritis
- Candidate for primary unilateral TKA
- Body mass index of 20-30 kg/m2
Exclusion Criteria:
- Unable to follow-up the assessments
- Having more than 20% defects in medical records
Sites / Locations
- Isfahan University of Medical Sciences
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Multimodal injection
epinephrine group (placebo group)
celecoxib group (control group)
The first group was treated using a preemptive periarticular injection of multimodal drugs. Therefore, a combination of drugs consisted of 50 mg bupivacaine hydrochloride 0.5% (AstraZeneca, Cenexi, France), 1 ml morphine sulfate 10 mg/ml (DarouPakhsh, Tehran, Iran), 300 mcg epinephrine (1:1000) (DarouPakhsh, Tehran, Iran) and 30 mg ketorolac (Caspian Tamin, Rasht, Iran) diluted by 0.9% sodium chloride solution to make a total 100 ml of injection drug was injected in periarticular area. The injections were done within 15 minutes before the incision in seven areas of the joint as followed: 15 ml in posterolateral soft tissue and lateral femoral periosteum, 15 ml posteromedial soft tissue and medial femoral periosteum, 20 ml inferomedial capsule, 20 ml superomedial capsule, 10 ml lateral capsule, 10 ml medial subcutaneous tissues and 10 ml lateral subcutaneous tissue.
The second group received 300 mcg epinephrine (1:1000) (DarouPakhsh, Tehran, Iran) peri-articulary, similar to the first group.
The third group administered celecoxib (200 mg) orally immediately before the surgery initiation.