Peripheral Perfusion and Oxygenation in Areas of Risk of Skin Integrity Impairment Exposed to Pressure Patterns. (POTER-DIC)
Pressure Ulcer
About this trial
This is an interventional diagnostic trial for Pressure Ulcer focused on measuring Pressure, Pressure Ulcer, Skin perfusion, Skin oxygenation
Eligibility Criteria
Phase 1:
Inclusion criteria:
- Healthy volunteers, between 20 to 65 years old, both female and male participants are being studied
- With no cardiovascular, neurological, digestive, endocrine, renal, gynecological, respiratory, hematologic, infectious, dermatological, autoimmune or diagnosed musculoskeletal disease or functional limitations,
- With tissue integrity and BMI between 18.5 to 25.9 kg/cm2 without scars in the sacred, back-lumbar, trochanteric, heels, elbows and shoulder blades areas.
Exclusion criteria:
- The usual consumption for any reason of alpha-beta-blocking agents, or alpha-beta agonists,
- Or directly or indirectly vasodilator-vasoconstrictor action drugs of any kind, •Anticoagulants,
- Topical or systemic steroids,
- Presence of pacemakers or implantable defibrillator,
- Smoking,
- High consumption of alcohol (>20g/week),
- Presence of tattoos in the areas of measurement,
- Lower limb amputation
Phase 2:
Inclusion criteria:
- Patients (both female and male), between 18 to 85 years old, admitted to acute hospitalization, with risk of skin integrity deterioration assessed by Braden scale (punctuation lower than 16)
- Without pressure ulcers,
- Who agree to participate in the study.
Exclusion criteria:
- Presence infusion of vasoactive drugs at the time of the study (dopamine, epinephrine, norepinephrine, dobutamine, nitroprusside, nitroglycerin, calcium channel blockers, ACE inhibitors).
- Regular oral treatment of alpha and beta-blockers
- And/or agonists or calcium channel blockers, Nitrates, ACE inhibitors, Angiotensin, Renin inhibitors, Diuretics, SSRIs, NSAIDs, will be accepted.
- Also patients with pacemakers and/or implanted defibrillator,
- Fever,
- Anemia with Hb <10g/dl,
- Hypotension with systolic blood pressure <80 mmHg,
- Presence of transfusions in the past 4 weeks,
- Consumption and derivatives of erythropoietin, iron supplements,
- Oral or parenteral anticoagulants will be excluded.
Sites / Locations
Arms of the Study
Arm 1
Experimental
Phase I
Interventions: Different positions will be applied to subjects to measure preipheral tissue oxygenation, pressure, and changes in microvascular flow. Subjects will be placed up to 4 hours in each of the standard positions for the experiment: supine decubitus (SD) right lateral decubitus (RLD), left lateral decubitus (LLD). SD measurements will be made at 0, 30 and 45 degrees of inclination to bed. RLD and LLD positions will be evaluated with a body inclination of 30 and 90ª. The subjects will lie down on a memory foam mattress for an articulated bed, as are commonly used at home, residential or hospital care. Between the subject and the mattress will be inserted the pressure measuring surface. Measurements in each position will be made during intervals of 0-4 hours in the same position (SD-RLD-LLD) in each of the inclinations of the bed (0º, 30°, 45 °) or body (30º, 90º), respectively.