Personalized B-fructan Diet in Inflammatory Bowel Disease Patients
Inflammatory Bowel Diseases, Ulcerative Colitis
About this trial
This is an interventional basic science trial for Inflammatory Bowel Diseases
Eligibility Criteria
Inclusion Criteria: Children (age 6-17) or young adults (age 18-39). Known or suspected UC or IBDU [there will be 2 control group: non-IBD (undergoing colonoscopy but found not to have IBD; and healthy (no GI symptoms, so not required to have colonoscopy; could be family members)] For UC: Remission-mild-moderate disease: Mayo score <10 Clinical indication for sedated colonoscopy Disease location: E2-E4 Stable treatment (not on steroids; biologics or immunomodulator not changed in last month) High likelihood that patients will be able to collect all samples and provide all data Exclusion Criteria: Use of antibiotics for a week or more over the last 3 months Use of probiotics or prebiotics at pharmacological doses (adding fibre sources to food or probiotics in yogurt, for example, are allowed) History of abdominal surgery, including appendectomy Documented enteric infection during the 3 months prior to endoscopy Presence of non-IBD bowel conditions (e.g., celiac), anatomical or mucosal abnormalities, motility disorder Presence of a systemic disease requiring treatment (cancer, ischemic heart disease, kidney failure, etc) Proctitis (E1) Systemic steroids (above 10 mg/day of Prednisone) Topical therapy within 1 week of endoscopy Recent change in IBD treatment (started biologics or IM over the last month) Pregnancy or planning to become pregnant during the study Inability to understand or sign the consent
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Placebo Comparator
Placebo Comparator
Experimental
Experimental
Randomized pectin diet
Randomized B-fructan diet
Personalized pectin diet
Personalized B-fructan diet