PET Imaging in Potentially Surgically Resectable Non-small Cell Lung Cancers (ELPET)
Non-small-cell Lung Carcinoma
About this trial
This is an interventional diagnostic trial for Non-small-cell Lung Carcinoma focused on measuring Positron-Emission Tomography, PET Scan, Lung Cancer, Thoracic Surgery, Diagnostic, Randomized Controlled Trial, Oncology
Eligibility Criteria
Inclusion Criteria: Histological or cytological proof of NSCLC Stage I, II, or IIIA NSCLC based upon clinical staging The primary lesion appears technically appropriate for surgical resection, based on information from the chest x-ray (CXR) and CT thorax. Age over 18 years Exclusion Criteria: Poor pulmonary function precluding radical surgery (inadequate pulmonary reserve for radical surgery) with predicted post-resection forced expiratory volume in 1 second (FEV1) < 0.8 liter or < 40% predicted, and diffusing capacity of the lung for carbon monoxide (DLCO) < 40% predicted Poor performance status (Eastern Cooperative Oncology Group [ECOG] 3-4) Significant concurrent medical problems (e.g. uncontrolled diabetes, active cardiac problems, significant chronic obstructive pulmonary disease) making the patient unfit for surgery Pregnant or lactating females Unable to lie supine for imaging with PET Patients with previously treated cancer other than non-melanotic skin cancer or carcinoma in situ of the cervix, unless disease-free for 5 years or greater Patients who, at the time of the initial evaluation, have already undergone a whole body PET/PET-CT, CT brain, MRI brain, total body bone scan or mediastinoscopy within 8 weeks prior to randomization will be excluded. However, patients who have had a CT scan of the thorax with abdomen are not excluded. Failure to provide informed consent
Sites / Locations
- St. Joseph's Healthcare Hamilton
- London Health Sciences Centre
- Credit Valley
- The Ottawa Hospital - General Campus
- Scarborough Hospital
- Sunnybrook/TEGH
- Toronto General Hospital
- St. Joseph's Health Care
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
1
2
Conventional Staging
PET Imaging