Back to resultsPETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years
Primary Purpose
Acute Lymphoblastic Leukemia
Status
Recruiting
Phase
Phase 4
Locations
Spain
Study Type
Interventional
Intervention
vINCRISTINE
Dexamethasone
Methotrexate
Cytosine arabinoside
Sponsored by
About this trial
This is an interventional treatment trial for Acute Lymphoblastic Leukemia focused on measuring Acute Lymphoblastic Leukemia
Eligibility Criteria
Inclusion Criteria:
Adults over 55 years diagnosed with acute lymphoblastic leukemia Ph 'negative and not previously treated with frailty (> 3 points in the Charlson comorbidity index)
Exclusion Criteria:
LAL
1. L3 type mature B phenotype (sIg +) or cytogenetic abnormalities characteristic of Burkitt LAL (t [8, 14], t [2, 8], t [8, 22]).
2 . biphenotypic acute leukemias and bilinear 3 . acute undifferentiated leukemia 4 . Patients with a Charlson comorbidity index less than or equal to 3 (and therefore that could potentially benefit from more intensive treatment PETHEMA LAL-07OLD).
5 . General condition affected (grades 3 and 4 WHO scale), not attributable to the LAL.
6 . LAL Ph 'positive (though still must register their LAL07OPH specific protocol).
7 . Lack of consent by the patient to use their clinical data
Sites / Locations
- H. Son LlatzerRecruiting
- Consorci Sanitari de TerrassaRecruiting
- Clínica Universitaria de NavarraRecruiting
- Complejo Hospitalario Universitario de AlbaceteRecruiting
- Fundación Hospital AlcorcónRecruiting
- Hospital de AlcorcónRecruiting
- Hoapital GeneralRecruiting
- Hospital General de AlicanteRecruiting
- Hospital General de AlicanteRecruiting
- Hospital Germans Trias i PujolRecruiting
- Hospital Clinic y Provincial de BarcelonaRecruiting
- Hospital de la Santa Creu i Sant Pau.Recruiting
- Hospital del MarRecruiting
- Hospital Valle HebrónRecruiting
- Institut Català d'oncologíaRecruiting
- Basurtuko OspitaleaRecruiting
- Hospital de CrucesRecruiting
- Complejo Hospitalario de CáceresRecruiting
- Complejo Hospitalario Reina SofíaRecruiting
- Area Hospitalaria Juan Ramón JimenezRecruiting
- Hospital Médico Quirúrgico Ciudad de JaénRecruiting
- H. de JerezRecruiting
- Hospital Juan CanalejoRecruiting
- Complejo Hospitalario LeónRecruiting
- Hospital Arnau de VilanovaRecruiting
- Complexo Hospitalario Xeral-CaldeRecruiting
- Clínica La ConcepciónRecruiting
- Clínica Puerta de HierroRecruiting
- Clínica RúberRecruiting
- Fundación Jiménez DíazRecruiting
- Hospital 12 de Octubre. MadridRecruiting
- Hospital Clinico San CarlosRecruiting
- Hospital Clínico San Carlos de MadridRecruiting
- Hospital de FuenlabradaRecruiting
- Hospital de la PrincesaRecruiting
- Hospital de Madrid, S.A.- Norte Hospital GeneralRecruiting
- Hospital La PazRecruiting
- Althaia, Xarxa Asistencial de ManresaRecruiting
- Fundación Hospital Sant Joan de Déu de MartorellRecruiting
- Hospital General Morales MeseguerRecruiting
- Hospital Morales Messeguer. MurciaRecruiting
- Hospital Sta. Maria del RosellRecruiting
- . Hospital Clínico Universitario Virgen de la VictoriaRecruiting
- Complejo Hospital Costa del SolRecruiting
- H. Carlos HayaRecruiting
- Hospital Carlos HayaRecruiting
- Hospital Central de AsturiasRecruiting
- Hospital del Río CarriónRecruiting
- Complejo Asistencial Son DuretaRecruiting
- Complejo Hospitalario de Pontevedra_Hospital MonteceloRecruiting
- Complejo Hospitalario de Pontevedra_Hospital ProvincialRecruiting
- Corporació Sanitaria Parc TaulíRecruiting
- Hospital Clinico UniversitarioRecruiting
- Hospital Clínico de SalamancaRecruiting
- Hospital Clínico Universitario de SalamancaRecruiting
- Hospital Clínico Universitario de SalamancaRecruiting
- Clínica Sant CamilRecruiting
- Hoaspital Marqués de ValdecillaRecruiting
- Complejo Hospitalario Universitario de SantiagoRecruiting
- Hospital General de SegoviaRecruiting
- Complejo Hospitalario Regional Virgen del RocíoRecruiting
- Hospital Joan XXIIIRecruiting
- Fundación Instituto Valenciano de OncologíaRecruiting
- Hoapital La FeRecruiting
- Hospital Clínico de Valencia.Recruiting
- Hospital Clínico de ValenciaRecruiting
- Hospital ClínicRecruiting
- Hospital Dr PessetRecruiting
- Hospital GeneralRecruiting
- Hospital La FeRecruiting
- Hospital Clínico de ValladolidRecruiting
- Complejo Hospitalario Universitario de VigoRecruiting
- Comarcal de VinarosRecruiting
- Hospital Clinico Lozano BlesaRecruiting
- Hospital Lozano Blesa. ZaragozaRecruiting
Outcomes
Primary Outcome Measures
Efficacy in terms of response rate
Secondary Outcome Measures
Efficacy in terms disease free survival
Efficacy in terms of global survival
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT01358201
Brief Title
PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years
Official Title
Treatment Protocol For All Fragile Patients Ph' Negative Over 55 Years
Study Type
Interventional
2. Study Status
Record Verification Date
January 2022
Overall Recruitment Status
Recruiting
Study Start Date
May 2010 (Actual)
Primary Completion Date
December 2022 (Anticipated)
Study Completion Date
December 2022 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
PETHEMA Foundation
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The biological characteristics of the adult LAL, karyotypic and phenotypic particular, are fundamentally different from those of Acute Lymphoblastic Leukemia (ALL) children and, consequently, the results of treatment are substantially lower. Additionally, elderly patients tolerate the drugs considered relatively low-key in the management of the LAL and suffer more toxicity. Although the LAL is much more common in patients over 60 years of age than in younger adults, older adults with ALL are clearly underrepresented in prospective controlled studies. A good portion of elderly patients are not able to tolerate the intensity of the standard treatment applied to children or young adults and a significant portion of them receive only palliative or supportive treatment. The data in the literature relating specifically to the elderly population are scarce and most of them have obtained a stratification by age of study designed for young people (CALGB, GMALL, PETHEMA). To date, the group's recommendation was to treat PETHEMA the LAL-96RI protocol for elderly patients because this protocol less aggressive than those used in high-risk ALL. However, the development of inhibitors of tyrosine kinases LAL effective in Bcr / abl positive, a relatively common type of LAL in the older patient, requires a differentiated treat these patients. Moreover, analysis of data from patients treated so far with the LAL-96RI protocol has shown mediocre results even for LAL Bcr / abl negative. This analysis also showed a significant benefit in survival related to the reduction of treatment (removal of the L-asparaginase during induction and cyclophosphamide at the end of induction) attributed to a reduction in toxicity
Detailed Description
Prephase (days -5 to -1) Dexamethasone 10 mg/m2 bolus day EV for 5 days (-5 to -1). Supplementary treatment: hydration minimum 2000 ml / day. allopurinol 300 mg / day. gastric protection (as center). daily monitoring of blood glucose daily monitoring of renal function.
Intrathecal treatment (diagnosis and prophylactic / therapeutic) day -5: 12 mg were administered intrathecal methotrexate. The morphological study of the CSF will be defining initial CNS involvement by LAL. Although it is recommended immunophenotypic study of CSF, the definition of CNS involvement by LAL (and its therapeutic consequences) based on morphological observation of blasts in CSF cytocentrifuge.
Remission induction :
Tolerance prephase period can be used to establish the final indication of treatment (standard protocol or frail patients). Day 0 is free of treatment and is considered as +1 the first day of induction.
Systemic treatment
Vincristine (VCR) 1 mg (absolute dose) EV 1, 8, 15 and 22.
Dexamethasone (DEX): 10 mg/m2 EV, IM or PO days 1-2, 8-9 days 15-16, 22-23.
Intrathecal chemotherapy
Triple therapy was administered with methotrexate (MTX), cytosine arabinoside (ARA-C) and hydrocortisone, days 1, 8, 15 and 22 (five doses total prophylactic between prephase and induction):
MTX 12 mg ARA-C 40 mg Dexamethasone 4 mg
If initial infiltration of the CNS is administered once every 72 hours until the disappearance of blast cell morphology CSF (cytocentrifugation) in at least two consecutive taps. Alternatively be administered liposomal cytarabine (DepoCyt) fortnightly if authorized by the center or in the context of a clinical trial
Maintenance treatment of first year :
Maintenance during the first year will start after full recovery after induction and after complete reassessment of the disease (including myelogram) and will last until one year from the time of documentation of complete remission.
The basic treatment to include mercaptopurine 50 mg/m2 PO day and methotrexate 20 mg/m2 IM weekly.
Once every 3 months will be added to maintenance treatment a "mini-reinduction" consisting
VCR: 1 mg (absolute dose), i.v., day 1.
Dexamethasone 40 mg / day, i.v. or p.o., days 1-2.
Not considered more doses of triple intrathecal therapy. Reinduction only be practiced during the first year after remission, so a total of 4 quarterly.
Maintenance of the second year:
After the first year of maintenance will perform a complete reassessment of the disease (including myelogram) and if the patient remains in complete remission maintenance will continue (without reinduction) until two years from the time of diagnosis.
The initial dose of mercaptopurine and methotrexate will be identical to the first year. Must comply (by increases or decreases of 20% of the dose) to maintain the numbers of neutrophil counts between 1.5 and 3x109/l and platelets above 100x109 / L
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acute Lymphoblastic Leukemia
Keywords
Acute Lymphoblastic Leukemia
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 4
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
100 (Anticipated)
8. Arms, Groups, and Interventions
Intervention Type
Drug
Intervention Name(s)
vINCRISTINE
Intervention Type
Drug
Intervention Name(s)
Dexamethasone
Intervention Type
Drug
Intervention Name(s)
Methotrexate
Intervention Type
Drug
Intervention Name(s)
Cytosine arabinoside
Primary Outcome Measure Information:
Title
Efficacy in terms of response rate
Time Frame
5 years
Secondary Outcome Measure Information:
Title
Efficacy in terms disease free survival
Time Frame
5 years
Title
Efficacy in terms of global survival
Time Frame
10 years
10. Eligibility
Sex
All
Minimum Age & Unit of Time
55 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Adults over 55 years diagnosed with acute lymphoblastic leukemia Ph 'negative and not previously treated with frailty (> 3 points in the Charlson comorbidity index)
Exclusion Criteria:
LAL
1. L3 type mature B phenotype (sIg +) or cytogenetic abnormalities characteristic of Burkitt LAL (t [8, 14], t [2, 8], t [8, 22]).
2 . biphenotypic acute leukemias and bilinear 3 . acute undifferentiated leukemia 4 . Patients with a Charlson comorbidity index less than or equal to 3 (and therefore that could potentially benefit from more intensive treatment PETHEMA LAL-07OLD).
5 . General condition affected (grades 3 and 4 WHO scale), not attributable to the LAL.
6 . LAL Ph 'positive (though still must register their LAL07OPH specific protocol).
7 . Lack of consent by the patient to use their clinical data
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Josep Mª Ribera, Dr
Email
jribera@iconcologia.net
Facility Information:
Facility Name
H. Son Llatzer
City
Palma de Mallorca
State/Province
Baleares
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bargay Lleoneart Joan, Dr
Facility Name
Consorci Sanitari de Terrassa
City
Terrassa
State/Province
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Name
Clínica Universitaria de Navarra
City
Pamplona
State/Province
Navarra
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Prosper Felipe, Dr
First Name & Middle Initial & Last Name & Degree
Prosper Felipe, Dr
Facility Name
Complejo Hospitalario Universitario de Albacete
City
Albacete
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Santiago José, Dr
Facility Name
Fundación Hospital Alcorcón
City
Alcorcón
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Peñalver Francisco Javier, Dr
Facility Name
Hospital de Alcorcón
City
Alcorcón
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Peñalver Francisco, Dr
First Name & Middle Initial & Last Name & Degree
Peñalver Francisco, Dr
Facility Name
Hoapital General
City
Alicante
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fernandez Abellan Pascual, Dr
Facility Name
Hospital General de Alicante
City
Alicante
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rivas Concepción, Dr
Facility Name
Hospital General de Alicante
City
Alicante
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fernández Abellán Pascual, Dr
First Name & Middle Initial & Last Name & Degree
Fernández Abellán Pascual, Dr
Facility Name
Hospital Germans Trias i Pujol
City
Badalona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ribera Josep Mª, Dr
First Name & Middle Initial & Last Name & Degree
Ribera Josep Mª, Dr
Facility Name
Hospital Clinic y Provincial de Barcelona
City
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Esteve Jordi, Dr
First Name & Middle Initial & Last Name & Degree
Esteve Jordi, Dr
Facility Name
Hospital de la Santa Creu i Sant Pau.
City
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sierra Jordi, Dr
Facility Name
Hospital del Mar
City
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Abella Eugenia, Dr
Facility Name
Hospital Valle Hebrón
City
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bueno Javier, Dr
Facility Name
Institut Català d'oncología
City
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Boqué Concha, Dr
First Name & Middle Initial & Last Name & Degree
Boqué Concha, Dr
Facility Name
Basurtuko Ospitalea
City
Basurto
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Beltran de Heredia José Mª, Dr
First Name & Middle Initial & Last Name & Degree
Beltran de Heredia Jose Mª, Dr
Facility Name
Hospital de Cruces
City
Bilbao
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Amutio Díez Elena, Dr
Facility Name
Complejo Hospitalario de Cáceres
City
Cáceres
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bergua Juan Miguel, Dr
First Name & Middle Initial & Last Name & Degree
Bergua Juan Miguel, Dr
Facility Name
Complejo Hospitalario Reina Sofía
City
Córdoba
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Torres Antonio, Dr
First Name & Middle Initial & Last Name & Degree
Torres Antonio, DR
Facility Name
Area Hospitalaria Juan Ramón Jimenez
City
Huelva
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fernández Antonio, Dr
First Name & Middle Initial & Last Name & Degree
Fernández Antonio, Dr
Facility Name
Hospital Médico Quirúrgico Ciudad de Jaén
City
Jaen
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alcala Antonio, Dr
First Name & Middle Initial & Last Name & Degree
Alcalá Antonio, Dr
Facility Name
H. de Jerez
City
Jerez de la Frontera
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
José Luis Guzmán Zamudio, Dr
First Name & Middle Initial & Last Name & Degree
Guzmán Zamudio José Luis, Dr
Facility Name
Hospital Juan Canalejo
City
La Coruña
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Deben Guillermo, Dr
First Name & Middle Initial & Last Name & Degree
Deben Guillermo, Dr
Facility Name
Complejo Hospitalario León
City
Leon
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fuertes Nuñez Marta, Dr
Facility Name
Hospital Arnau de Vilanova
City
Lleida
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sanchez Juan Manuel, Dr
First Name & Middle Initial & Last Name & Degree
Sanchez Juan Manuel, Dr
Facility Name
Complexo Hospitalario Xeral-Calde
City
Lugo
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Arias Jesús, Dr
Facility Name
Clínica La Concepción
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Román Alejandro, Dr
First Name & Middle Initial & Last Name & Degree
Román Alejandro, Dr
Facility Name
Clínica Puerta de Hierro
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Krisnk Isabel, Dr
Facility Name
Clínica Rúber
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martínez Carmen, Dr
Facility Name
Fundación Jiménez Díaz
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Prieto Elena, Dr
Facility Name
Hospital 12 de Octubre. Madrid
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lahuerta juan José, Dr
First Name & Middle Initial & Last Name & Degree
Lahuerta Juan José, Dr
Facility Name
Hospital Clinico San Carlos
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martínez Rafael, Dr
First Name & Middle Initial & Last Name & Degree
Martinez Rafael, Dr
Facility Name
Hospital Clínico San Carlos de Madrid
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Diaz Mediavilla Joaquin, Dr
First Name & Middle Initial & Last Name & Degree
Díaz Mediavilla Joaquín, Dr
Facility Name
Hospital de Fuenlabrada
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hernández Rivas José Angel, Dr
First Name & Middle Initial & Last Name & Degree
Hernández Rivas José Angel, Dr
Facility Name
Hospital de la Princesa
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Adrián Alegre, Dr
First Name & Middle Initial & Last Name & Degree
Alegre Adrián, Dr
Facility Name
Hospital de Madrid, S.A.- Norte Hospital General
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pérez de Oteyza Jaime, Dr
Facility Name
Hospital La Paz
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Canales Miguel Ángel, Dr
First Name & Middle Initial & Last Name & Degree
Canales Miguel Angel, Dr
Facility Name
Althaia, Xarxa Asistencial de Manresa
City
Manresa
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Subira Maricel, Dr
Facility Name
Fundación Hospital Sant Joan de Déu de Martorell
City
Martorell
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Las Heras German, Dr
Facility Name
Hospital General Morales Meseguer
City
Murcia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
De Arriba Felipe, Dr
Facility Name
Hospital Morales Messeguer. Murcia
City
Murcia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Amigo Mª Luz, Dr
First Name & Middle Initial & Last Name & Degree
Amigo Mª Luz, Dr
Facility Name
Hospital Sta. Maria del Rosell
City
Murcia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ibañez Jerónima, Dr
Facility Name
. Hospital Clínico Universitario Virgen de la Victoria
City
Málaga
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Moreno Mª José, Dr
Facility Name
Complejo Hospital Costa del Sol
City
Málaga
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
María Casanova Espinosa, Dr
First Name & Middle Initial & Last Name & Degree
Casanova Espinosa María, Dr
Facility Name
H. Carlos Haya
City
Málaga
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Negri Silvia, Dr
Facility Name
Hospital Carlos Haya
City
Málaga
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Barrios Manuel, Dr
First Name & Middle Initial & Last Name & Degree
Barrios Manuel, Dr
Facility Name
Hospital Central de Asturias
City
Oviedo
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rayón MC, Dr
Facility Name
Hospital del Río Carrión
City
Palencia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ortega Frenando, Dr
First Name & Middle Initial & Last Name & Degree
Ortega Fernando, Dr
Facility Name
Complejo Asistencial Son Dureta
City
Palma de Mallorca
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sampol Antonia
Facility Name
Complejo Hospitalario de Pontevedra_Hospital Montecelo
City
Pontevedra
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Allegue Mª José, Dr
Facility Name
Complejo Hospitalario de Pontevedra_Hospital Provincial
City
Pontevedra
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Constela Manuel, Dr
Facility Name
Corporació Sanitaria Parc Taulí
City
Sabadell
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rámila Elena, Dr
Facility Name
Hospital Clinico Universitario
City
Salamanca
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Del Cañizo Consuelo, Dr
Facility Name
Hospital Clínico de Salamanca
City
Salamanca
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
San Miguel Jesús, Dr
First Name & Middle Initial & Last Name & Degree
Mateos Maria Victoria, Dr
First Name & Middle Initial & Last Name & Degree
San Miguel Izquierdo Jesús, Dr
Facility Name
Hospital Clínico Universitario de Salamanca
City
Salamanca
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hernández Rivas Jesús Mª, Dr
First Name & Middle Initial & Last Name & Degree
Hernández Rivas Jesús Mª, Dr
Facility Name
Hospital Clínico Universitario de Salamanca
City
Salamanca
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mateos Mª Victoria, Dr
First Name & Middle Initial & Last Name & Degree
Mateos Mª Victoria, Dr
First Name & Middle Initial & Last Name & Degree
Mateo Gema, Dr
First Name & Middle Initial & Last Name & Degree
García Sanz Ramón, Dr
Facility Name
Clínica Sant Camil
City
Sant Pere de Ribes
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Asensio Antonio, Dr
Facility Name
Hoaspital Marqués de Valdecilla
City
Santander
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Conde Eulogio, Dr
Facility Name
Complejo Hospitalario Universitario de Santiago
City
Santiago de Compostela
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bello Jose Luis, Dr
Facility Name
Hospital General de Segovia
City
Segovia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hernández José Mariano
Facility Name
Complejo Hospitalario Regional Virgen del Rocío
City
Sevilla
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martín Sánchez Jesús, Dr
First Name & Middle Initial & Last Name & Degree
Martin Sanchez Jesús, Dr
Facility Name
Hospital Joan XXIII
City
Tarragona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Escoda Lourdes, Dr
First Name & Middle Initial & Last Name & Degree
Escoda Lourdes
Facility Name
Fundación Instituto Valenciano de Oncología
City
Valencia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Llorente Pablo, Dr
Facility Name
Hoapital La Fe
City
Valencia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sanz Miguel Angel, Dr
Phone
96 386 27 58
Email
msanz@uv.es
Facility Name
Hospital Clínico de Valencia.
City
Valencia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tormo Mar, Dra
First Name & Middle Initial & Last Name & Degree
Teruel Casasús Ana Isabel, Dr
Facility Name
Hospital Clínico de Valencia
City
Valencia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tormo Mar, Dr
Facility Name
Hospital Clínic
City
Valencia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Terol Maria José, Dr
First Name & Middle Initial & Last Name & Degree
Terol Mª José, Dr
Facility Name
Hospital Dr Pesset
City
Valencia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ferrer Secundino, Dr
First Name & Middle Initial & Last Name & Degree
Ferrer Secundino, Dr
Facility Name
Hospital General
City
Valencia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carbonell Félix, Dr
First Name & Middle Initial & Last Name & Degree
Carbonell Félix, Dr
Facility Name
Hospital La Fe
City
Valencia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
De la Rubia Javier, Dr
Email
delarubia_jav@gva.es
First Name & Middle Initial & Last Name & Degree
De la Rubia Javier, Dr
Facility Name
Hospital Clínico de Valladolid
City
Valladolid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fernandez Calvo Francisco, Dr
Facility Name
Complejo Hospitalario Universitario de Vigo
City
Vigo
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Poderós Concepción, Dr
Facility Name
Comarcal de Vinaros
City
Vinaros
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Montagud Mario, Dr
Facility Name
Hospital Clinico Lozano Blesa
City
Zaragoza
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Palomera Bernal Luis, Dr
Facility Name
Hospital Lozano Blesa. Zaragoza
City
Zaragoza
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Olave Mª Teresa, Dr
First Name & Middle Initial & Last Name & Degree
Olave Mª Teresa, Dr
12. IPD Sharing Statement
Links:
URL
https://www.fundacionpethema.es/
Description
Pethema Foundation
Learn more about this trial
PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years
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