Back to resultsPexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction (APEX-AMI)
Primary Purpose
Acute Myocardial Infarction
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Pexelizumab
Placebo infusion
Sponsored by
About this trial
This is an interventional treatment trial for Acute Myocardial Infarction
Eligibility Criteria
Inclusion Criteria: Cardiac symptoms for at least 20 minutes within past 6 hours; Will undergo primary PCI; Has ECG evidence of acute high risk ST elevation myocardial infarction; Willing and able to be followed for at least 12 months. Exclusion Criteria: Isolated low risk inferior wall myocardial infarction; Received fibrinolytic therapy; History of complement deficiency; Suspected neisserial infection; Participating in other investigational study; Pregnancy; Previous enrollment.
Sites / Locations
- Huntsville Hospital
- Mayo Clinic Hospital
- North Phoenix Heart Center
- Northwest Medical Center
- Sparks Regional Medical Center
- Arkansas State Hospital
- Brotman Medical Center
- Providence Saint Joseph Medical Center
- Palomar Medical Center
- Los Angeles Community Hospital
- Memorial Medical Center
- Sutter Memorial Hospital
- University of CA, San Diego Medical
- Sutter Medical Center of Santa Rosa
- Providence Holy Cross Medical Center
- University of Colorado Hospital
- St. Vincent Medical Center
- University of Connecticut Health Center
- Yale - New Haven
- George Washington University Hospital
- JFK Medical Center
- Morton Plant Hospital
- North Ridge Medical Center
- St. Luke's Hospital
- Health First Holmes Regional Medical Center
- Florida Heart Hospital
- Sarasota Memorial Hospital
- University Community Hospital
- St. Luke's Regional Medical Center
- Highland Park Hospital
- Ingalls Hospital
- Advocate Good Samaritan
- Elmhurst Hospital
- Trinity Medical Center
- Saint Francis Medical Center
- Trinity Medical Center
- Methodist Hospital
- VAMC
- Community Hospital South
- The Indiana Heart Hospital
- Munster Community Hospital
- Iowa Heart
- Via Christi Reginal Medical Center
- Central Baptist Hospital
- University of Kentucky
- The Jewish Hospital
- Baptist Hospital East
- Lousiana Heart Center
- Lousiana Heart Hospital
- MCLNO at New Orleans University Campus
- Tulane University Hospital and Clinic
- Eastern Maine Medical Center
- Maine Medical Center
- St. Joseph Medical Center
- Oakwood Hospital and Medical Center
- Henry Ford Hospital
- Sinai-Grace Hospital
- Spectrum Health
- Borgess Medical Center
- Mercy General Health Partners
- Northern Michigan Hospital
- St. Joseph Mercy-Oakland
- William Beaumont Hospital
- Covenant Medical Center
- Saint Mary Medical Center
- Providence Hospital
- William Beaumont Hospital
- Harper University Hospital
- Mercy Hospital
- St. Mary's Duluth Clinic Health System
- Fairview Southdale Hospital
- Abbott Northwestern Hospital
- North Memorial Medical Center
- Saint Mary Hospital
- Health East St. Joseph Hospital
- St. Cloud Hospital
- Methodist Hospital
- University of Missouri Health Sciences Center
- St. John's Hospital
- St. Louis University Hospital
- Barnes St. Peters Hospital
- Deaconess Billings Clinic
- St. Elizabeth Medical Center
- Sunrise Hospital
- Trinitas Hospital
- St. Joseph's Regional Medical Center
- New Mexico Heart Institute
- Albany Medical Center
- Monteflore Medical Center
- Maimonides Medical Center
- Wilson Memorial Medical Center
- Winthrop University Hospital
- St. Vincent's Catholic Medical Center
- Bellevue Hospital Center
- Vassar Brothers Medical Center
- Rochester General Hospital
- SUNY - Upstate Medical University
- Presbyterian Hospital
- Duke University Health Systems
- Moses Cone Hospital/LeBauer Healthcare
- Pitt County Memorial Hospital
- High Point Regional Health System
- Trinity Hospital
- Akron General Medical Center
- VAMC Cincinnati
- Bethesda North Hospital
- The University Hospital
- University Hospitals of Cleveland
- Cleveland Clinic Foundation
- MidWest Cardiology Research Foundation
- Med Central Mansfield
- Genesis Healthcare System
- Midwest Regional Medical Center
- University of Oklahoma Health Sciences Center
- VA Medical Center
- Integris Baptist Medical Center, Inc.
- Oklahoma Heart Hospital
- St. Charles Medical Center
- Providence Portland Medical Center
- Lehigh Valley Hospital
- Geisinger Medical Center
- Genesis Medical Center
- Hamot Medical Center
- Penn State Milton S. Hershey Medical Center
- Lancaster General Hospital
- Hospital of the University of Pennsylvania
- Temple University Hospital
- Jefferson Regional Medical Center
- Allegheny General Hospital
- Western Pennsylvania Hospital
- VA Pittsburgh Healthcare System
- The Chester County Hospital
- York Hospital
- Rhode Island Hospital
- Palmetto Richland Memorial Hospital
- Sisters of Charity Providence Hospitals
- Rapid City Regional Hospital
- Heart Hospital of South Dakota
- Jackson-Madison County General Hospital
- Wellmont Holston Valley Medical Center
- Fort Sanders Rgional Medical Center
- Baptist Hospital of East Tennessee
- Centennial Medical Center
- Methodist Medical Center
- Northwest Texas Healthcare System
- Seton Medical Center
- Presbyterian Hospital of Dallas
- Medical City Dallas
- Dallas Medical Center
- Parkland Health & Hospital System
- Brooke Army Medical Center
- Ben Taub General Hospital
- Memorial Hermann Hospital
- Michael E. DeBakey VA Medical Center
- Houston Northwest Medical Center
- Covenant Medical Center
- Northeast Baptist Hospital
- South Texas Veterans Health Care System Audie L. Murphy Division
- Scott & White Memorial Hospital
- East Texas Medical Center
- Trinity Mother Frances Hospital
- Citizens Medical Center
- Detar Hospital
- Cottonwood Hospital
- Inova Alexandria Hospital
- Universitiy of Virginia Health Science Center
- Rockingham Memorial Hospital
- Lynchburg General Hospital
- Herrico Doctors' Hospital - Forest
- Sentara Virginia Beach General Hospital
- Winchester Medical Center
- Overtake Hospital Medical Center
- Skagit Valley Hospital
- Harborview Medical Center
- MultiCare Medical Center (Tacoma General Hospital)
- St. Joseph Medical Center
- West Virginia University Hospital
- Franciscan Skemp Healthcare
- Froedtert Hospital
- Waukesha Memorial Hospital
- Canberra Hospital
- Concord Hospital
- Gosford Hospital
- St. George Hospital
- Liverpool Hospital
- Prince of Wales Hospital
- Royal North Shore Hospital
- Prince Charles Hospital
- Townsville Hospital
- Princess Alexandra Hospital
- Royal Adelaide Hospital
- Flinders Medical Centre
- The Queen Elizabeth Hospital
- Austin Hospital
- Box Hill Hospital
- Monash Medical Centre
- Royal Melbourne Hospital
- Victorian Heart Clinic
- Fremantle Hospital
- Sir Charles Gairdner Hospital
- Royal Perth Hospital
- Krankenhaus der Barmherzigen Schwestern
- Univ. Klinik f. Innere Medizin II
- Wilhelminenspital
- U.Z. Gasthuisberg
- ZOL Campus Sint-Jan
- Helig Hartziekenhuis
- AZ Middelheim
- CHR de la Citadelle
- Foothills Medical Centre
- University of Alberta Hospital
- Vancouver General Hospital
- St. Paul's Hospital
- Royal Jubilee Hospital
- Saint John Regional Hospital - New Brunswick Heart Centre
- General Hospital Health Sciences Centre
- Hamilton General Hospital
- Trillium Health Center
- Sunnybrook & Women's Health Sciences Centre
- Montreal Heart Institute/Research Centre
- Centre Hospitale de'Universite de Montreal (Pav Notre-Dame)_
- Hopital Sacre-Coeur de Montreal
- Quebec Heart Institute/Laval Hospital
- Centre Hospitalier Universitaire de Sherbrooke
- Regina General Hospital
- Kardiologicke odd. Nemocnice Ceske Budejovice as
- I. Interni klinika, Fakultni nemocnice Hradec
- Klinika kardiologie, IKEM
- Kardiologicke oddeleni, Masarykova nemocnice
- Interni kardiologicka klinika, Fakultni nemocnice Brno
- I. interni kardioangiologicka klinika, Fakultni nemocnice u Sv. Anny
- Kardiologicke odd., Krajska neocnice Liberec
- I. Interni klinika, FN Olomouc
- Interni klinika, FNsP Ostrava
- Kardio-Troll sro and Krajska nemocnice Pardubice
- Kardio-Troll sro and Krajska nemocnice Pardubice
- I. Interni klinika, Fakultni nemocnice Plzen
- Kardiocentrum, Fakultni nemocnice Kralovske Vinohrady
- II. Interni klinika, Vseobecna fakultni nemocnice
- Kardiologicke odd., Nemocnice Na Homoice
- Kardiologicka klinika FN v Motole
- Kardiocentrum, Nemocnice Podlesi sro
- Interni klinika, Batova nemocnice
- Aalborg Sygehus
- Skejby Sygehus
- Amtssygehuset i Gentofte
- Rigshospitalet
- Odense Universitets Hospital
- CHRU de Angers
- Clinique Saint Joseph
- Cardiologie Hopital Simone Veil
- Centre Hospitalier de Haguenau
- CHRU de Nantes
- Hopital a Pitie Salpetriere
- Hopital Lariboisiere
- Hopital Bichat
- Hopital du Haut Leveque
- Hopital Pontchaillou
- CHRU de Rouen
- Centre Cardiologique du Nord
- CHRU Hautepierre
- Hopital Rangueil
- Hopital d'adultes de Brabois (CHU de Nancy)
- Universitatsklinikum Mannheim
- Klinikum Augsburg, Stenglinstr. 2.
- Klinikum Coburg
- Stadt Krankenhaus Muenchen-Bogenhausen
- Kerckhoff-Klinik Bad Anuheim
- Stadt. Kliniken Kassel
- Allgemeines Krankenhaus Celle
- Herzzentrum Gottingen
- St. Johannes Krankenhaus
- Herzzentrum Duisburg
- Kliniken der Stadt Koln
- Helios Klinikum Wuppertal GmbH
- Klinikkum Lippe
- Klinikkum Ludwigshafen
- Herzzentrum
- Universitatsklinik Lubeck
- Klinik fur Innere Medizin 1
- Herz-Zentrum Bad Krozingen
- Universitatsklinik der Ruhr-Universitat Bochum
- Vivantes Klinikkum im Friedrichshain
- Vivantes Klinikum am Urban
- Allgemeines Krankenhaus St. Georg
- Universitatsklinikum Hamburg-Eppendorf
- Centro E Malan
- Presidio Ospedaliero di Cittadella
- U.O. Cardiologia
- A.O. SS. Antonio e Biagio e Cesare Arrigo
- Policlinico Sant'Orsola-Malpighi
- Ospedale Centrale di Bolzano
- A.O. Spedali di Civili
- A.O. della Regione Lombardia Presidio Ospedaliero Sant'Anna
- Ospedale Alessandro Manzoni
- Azienda Ospedaliera Carlo Poma
- Azienda Ospedaliera di Parma - Ospedale Maggiore
- Policlinico San Matteo - I.R.C.C.S.
- A. O. S. Salvatore
- Osepdale degli Intermi
- AO S. Camillo Forlanini
- Cardiologia Universitaria
- Ospedale S. Maria di Ca'Foncello
- Catharina Hospital
- Academic Hospital Maastricht
- Medeisch Centrum Alkmaar
- VUMC
- OLVG
- Isla Klinieken Location De Weezenlanden
- Sint Antonius Hospital
- University Medical Center Utrecht
- Erasmus Medical Centre
- Medisch Centrum Rijnmond-Zuid
- Christchurch Hospital
- Dunedin Hospital
- Waikato Hospital
- Auckland City Hospital
- Wellington Hospital
- I Klinika Kardiologii
- Klinika Chorob Serca i Naczyn
- II Katedra i Klinika Kardiologii
- I Klinika Choroby Wiencowej
- SPZOZ Dolnoslaski Szpital Specjalistyczny
- Hospital Garcia de Orta - Servico de Cardiologia
- Hospital Santa Cruz
- H. Fernando da Fonesca
- Hospitals da Universidade de Coimbra
- Hospital Curry Cabral
- H. Santa Maria
- Hospital Sao Joao - Servico de Cardiologia
- Centro Hospitalar de Vila Nova de Gala
- Ciutat Sanitaria i Universitaria de Bellvitge
- Hospital Virgen da la Arrixaca
- Hospital de Navarra
- Hospital General Universitario de Alicante
- Hospital Clinic i Provincial
- Hospital de Leon
- Hospital General Universitario Gregorio Maranon
- Hospital Puerta de Hierro
- Hospital Clinico San Carlos
- Hospital Clinico Universitario Virgen de la Victoria
- Hopspital Virgen del Rocio
- Universitetetssjukhuset Umea
- Uppsala University Hospital
- University Hospital of Geneva
- Herzklinik Bodensee am Weinberg AG
- Cardiocentro Ticino
- Kantonsspital Basel
- Kantonsspital St. Gallen
Arms of the Study
Arm 1
Arm 2
Arm Type
Placebo Comparator
Experimental
Arm Label
1
2
Arm Description
Placebo infusion
Pexelizumab infusion
Outcomes
Primary Outcome Measures
Reduction of all causes of mortality
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT00091637
Brief Title
Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction (APEX-AMI)
Official Title
APEX-AMI - Pexelizumab in Conjunction With Angioplasty
Study Type
Interventional
2. Study Status
Record Verification Date
August 2011
Overall Recruitment Status
Completed
Study Start Date
April 2004 (undefined)
Primary Completion Date
May 2007 (Actual)
Study Completion Date
May 2007 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
Procter and Gamble
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
In the setting of reperfusion therapy in an acute myocardial infarction using primary percutaneous intervention (PCI), the body's own inflammatory system involving the complement cascade may be harmful. This study will test the safety and efficacy of a novel complement inhibitor, pexelizumab to reduce mortality at 30 days.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acute Myocardial Infarction
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
5745 (Actual)
8. Arms, Groups, and Interventions
Arm Title
1
Arm Type
Placebo Comparator
Arm Description
Placebo infusion
Arm Title
2
Arm Type
Experimental
Arm Description
Pexelizumab infusion
Intervention Type
Drug
Intervention Name(s)
Pexelizumab
Intervention Description
Pexelizumab (2 mg/kg) intravenous , bolus for 10 minutes once
Intervention Type
Drug
Intervention Name(s)
Placebo infusion
Intervention Description
bolus infusion over a 10 minute period once
Primary Outcome Measure Information:
Title
Reduction of all causes of mortality
Time Frame
day 30
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Cardiac symptoms for at least 20 minutes within past 6 hours;
Will undergo primary PCI;
Has ECG evidence of acute high risk ST elevation myocardial infarction;
Willing and able to be followed for at least 12 months.
Exclusion Criteria:
Isolated low risk inferior wall myocardial infarction;
Received fibrinolytic therapy;
History of complement deficiency;
Suspected neisserial infection;
Participating in other investigational study;
Pregnancy;
Previous enrollment.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Thomas G Todaro, MD, JD, FACC
Organizational Affiliation
Procter and Gamble
Official's Role
Study Director
Facility Information:
Facility Name
Huntsville Hospital
City
Huntsville
State/Province
Alabama
ZIP/Postal Code
35801
Country
United States
Facility Name
Mayo Clinic Hospital
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85054
Country
United States
Facility Name
North Phoenix Heart Center
City
Phoenix
State/Province
Arizona
Country
United States
Facility Name
Northwest Medical Center
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85741
Country
United States
Facility Name
Sparks Regional Medical Center
City
Fort Smith
State/Province
Arkansas
ZIP/Postal Code
72901
Country
United States
Facility Name
Arkansas State Hospital
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72211
Country
United States
Facility Name
Brotman Medical Center
City
Beverly Hills
State/Province
California
ZIP/Postal Code
90230
Country
United States
Facility Name
Providence Saint Joseph Medical Center
City
Burbank
State/Province
California
ZIP/Postal Code
91505
Country
United States
Facility Name
Palomar Medical Center
City
Escondido
State/Province
California
ZIP/Postal Code
92025
Country
United States
Facility Name
Los Angeles Community Hospital
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Memorial Medical Center
City
Modesto
State/Province
California
ZIP/Postal Code
48201
Country
United States
Facility Name
Sutter Memorial Hospital
City
Sacramento
State/Province
California
ZIP/Postal Code
95825
Country
United States
Facility Name
University of CA, San Diego Medical
City
San Diego
State/Province
California
ZIP/Postal Code
92103-8784
Country
United States
Facility Name
Sutter Medical Center of Santa Rosa
City
Santa Rosa
State/Province
California
ZIP/Postal Code
95403
Country
United States
Facility Name
Providence Holy Cross Medical Center
City
Valencia
State/Province
California
ZIP/Postal Code
91355
Country
United States
Facility Name
University of Colorado Hospital
City
Denver
State/Province
Colorado
ZIP/Postal Code
80262
Country
United States
Facility Name
St. Vincent Medical Center
City
Bridgeport
State/Province
Connecticut
ZIP/Postal Code
06606
Country
United States
Facility Name
University of Connecticut Health Center
City
Farmington
State/Province
Connecticut
ZIP/Postal Code
06030-2202
Country
United States
Facility Name
Yale - New Haven
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06520
Country
United States
Facility Name
George Washington University Hospital
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20037
Country
United States
Facility Name
JFK Medical Center
City
Atlantis
State/Province
Florida
ZIP/Postal Code
33462
Country
United States
Facility Name
Morton Plant Hospital
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
North Ridge Medical Center
City
Ft. Lauderdale
State/Province
Florida
ZIP/Postal Code
33308
Country
United States
Facility Name
St. Luke's Hospital
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32224
Country
United States
Facility Name
Health First Holmes Regional Medical Center
City
Melbourne
State/Province
Florida
ZIP/Postal Code
32001
Country
United States
Facility Name
Florida Heart Hospital
City
Orlando
State/Province
Florida
ZIP/Postal Code
32803
Country
United States
Facility Name
Sarasota Memorial Hospital
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
University Community Hospital
City
Tampa
State/Province
Florida
ZIP/Postal Code
33613
Country
United States
Facility Name
St. Luke's Regional Medical Center
City
Boise
State/Province
Idaho
ZIP/Postal Code
63704
Country
United States
Facility Name
Highland Park Hospital
City
Bannockburn
State/Province
Illinois
ZIP/Postal Code
60015
Country
United States
Facility Name
Ingalls Hospital
City
Harvey
State/Province
Illinois
ZIP/Postal Code
80426
Country
United States
Facility Name
Advocate Good Samaritan
City
Lombard
State/Province
Illinois
ZIP/Postal Code
60148
Country
United States
Facility Name
Elmhurst Hospital
City
Lombard
State/Province
Illinois
ZIP/Postal Code
60148
Country
United States
Facility Name
Trinity Medical Center
City
Moline
State/Province
Illinois
ZIP/Postal Code
61265
Country
United States
Facility Name
Saint Francis Medical Center
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61603
Country
United States
Facility Name
Trinity Medical Center
City
Rock Island
State/Province
Illinois
ZIP/Postal Code
61201
Country
United States
Facility Name
Methodist Hospital
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
VAMC
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
Community Hospital South
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46227
Country
United States
Facility Name
The Indiana Heart Hospital
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
56250
Country
United States
Facility Name
Munster Community Hospital
City
Munster
State/Province
Indiana
ZIP/Postal Code
46321
Country
United States
Facility Name
Iowa Heart
City
Des Moines
State/Province
Iowa
ZIP/Postal Code
50314
Country
United States
Facility Name
Via Christi Reginal Medical Center
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67214
Country
United States
Facility Name
Central Baptist Hospital
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40503
Country
United States
Facility Name
University of Kentucky
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40536-0200
Country
United States
Facility Name
The Jewish Hospital
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Facility Name
Baptist Hospital East
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40207
Country
United States
Facility Name
Lousiana Heart Center
City
Chalmette
State/Province
Louisiana
ZIP/Postal Code
70043
Country
United States
Facility Name
Lousiana Heart Hospital
City
LaCombe
State/Province
Louisiana
ZIP/Postal Code
70445
Country
United States
Facility Name
MCLNO at New Orleans University Campus
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
Tulane University Hospital and Clinic
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
Eastern Maine Medical Center
City
Bangor
State/Province
Maine
ZIP/Postal Code
04401
Country
United States
Facility Name
Maine Medical Center
City
Portland
State/Province
Maine
ZIP/Postal Code
04102
Country
United States
Facility Name
St. Joseph Medical Center
City
Towson
State/Province
Maryland
ZIP/Postal Code
21204
Country
United States
Facility Name
Oakwood Hospital and Medical Center
City
Dearborn
State/Province
Michigan
ZIP/Postal Code
48123
Country
United States
Facility Name
Henry Ford Hospital
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
Sinai-Grace Hospital
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48235
Country
United States
Facility Name
Spectrum Health
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49503
Country
United States
Facility Name
Borgess Medical Center
City
Kalamazoo
State/Province
Michigan
ZIP/Postal Code
49048
Country
United States
Facility Name
Mercy General Health Partners
City
Muskegon
State/Province
Michigan
ZIP/Postal Code
49444
Country
United States
Facility Name
Northern Michigan Hospital
City
Petoskey
State/Province
Michigan
ZIP/Postal Code
49770
Country
United States
Facility Name
St. Joseph Mercy-Oakland
City
Pontiac
State/Province
Michigan
ZIP/Postal Code
48341-2982
Country
United States
Facility Name
William Beaumont Hospital
City
Royal Oak
State/Province
Michigan
ZIP/Postal Code
48073
Country
United States
Facility Name
Covenant Medical Center
City
Saginaw
State/Province
Michigan
ZIP/Postal Code
48601
Country
United States
Facility Name
Saint Mary Medical Center
City
Saginaw
State/Province
Michigan
ZIP/Postal Code
48601
Country
United States
Facility Name
Providence Hospital
City
Southfield
State/Province
Michigan
ZIP/Postal Code
48075
Country
United States
Facility Name
William Beaumont Hospital
City
Troy
State/Province
Michigan
ZIP/Postal Code
48085
Country
United States
Facility Name
Harper University Hospital
City
Warren
State/Province
Michigan
ZIP/Postal Code
48201
Country
United States
Facility Name
Mercy Hospital
City
Coon Rapids
State/Province
Minnesota
ZIP/Postal Code
55433
Country
United States
Facility Name
St. Mary's Duluth Clinic Health System
City
Duluth
State/Province
Minnesota
ZIP/Postal Code
55805
Country
United States
Facility Name
Fairview Southdale Hospital
City
Edina
State/Province
Minnesota
ZIP/Postal Code
55435
Country
United States
Facility Name
Abbott Northwestern Hospital
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55407
Country
United States
Facility Name
North Memorial Medical Center
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55422
Country
United States
Facility Name
Saint Mary Hospital
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55902
Country
United States
Facility Name
Health East St. Joseph Hospital
City
Saint Paul
State/Province
Minnesota
ZIP/Postal Code
55102
Country
United States
Facility Name
St. Cloud Hospital
City
St. Cloud
State/Province
Minnesota
ZIP/Postal Code
56303
Country
United States
Facility Name
Methodist Hospital
City
St. Louis Park
State/Province
Minnesota
ZIP/Postal Code
55426
Country
United States
Facility Name
University of Missouri Health Sciences Center
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65212
Country
United States
Facility Name
St. John's Hospital
City
Springfield
State/Province
Missouri
ZIP/Postal Code
65807
Country
United States
Facility Name
St. Louis University Hospital
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Barnes St. Peters Hospital
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63122
Country
United States
Facility Name
Deaconess Billings Clinic
City
Billings
State/Province
Montana
ZIP/Postal Code
59101
Country
United States
Facility Name
St. Elizabeth Medical Center
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68510
Country
United States
Facility Name
Sunrise Hospital
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89109
Country
United States
Facility Name
Trinitas Hospital
City
Elizabeth
State/Province
New Jersey
ZIP/Postal Code
07202
Country
United States
Facility Name
St. Joseph's Regional Medical Center
City
Fair Lawn
State/Province
New Jersey
ZIP/Postal Code
07410
Country
United States
Facility Name
New Mexico Heart Institute
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87102
Country
United States
Facility Name
Albany Medical Center
City
Albany
State/Province
New York
ZIP/Postal Code
12211
Country
United States
Facility Name
Monteflore Medical Center
City
Bronx
State/Province
New York
ZIP/Postal Code
10467
Country
United States
Facility Name
Maimonides Medical Center
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11219
Country
United States
Facility Name
Wilson Memorial Medical Center
City
Johnson City
State/Province
New York
ZIP/Postal Code
13790
Country
United States
Facility Name
Winthrop University Hospital
City
Mineola
State/Province
New York
ZIP/Postal Code
11504
Country
United States
Facility Name
St. Vincent's Catholic Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10011
Country
United States
Facility Name
Bellevue Hospital Center
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Facility Name
Vassar Brothers Medical Center
City
Poughkeepsie
State/Province
New York
ZIP/Postal Code
12601
Country
United States
Facility Name
Rochester General Hospital
City
Rochester
State/Province
New York
ZIP/Postal Code
14621
Country
United States
Facility Name
SUNY - Upstate Medical University
City
Syracuse
State/Province
New York
ZIP/Postal Code
13210
Country
United States
Facility Name
Presbyterian Hospital
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
Duke University Health Systems
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27705
Country
United States
Facility Name
Moses Cone Hospital/LeBauer Healthcare
City
Greensboro
State/Province
North Carolina
ZIP/Postal Code
27401
Country
United States
Facility Name
Pitt County Memorial Hospital
City
Greenville
State/Province
North Carolina
ZIP/Postal Code
27834
Country
United States
Facility Name
High Point Regional Health System
City
High Point
State/Province
North Carolina
ZIP/Postal Code
27262
Country
United States
Facility Name
Trinity Hospital
City
Minot
State/Province
North Dakota
ZIP/Postal Code
58701
Country
United States
Facility Name
Akron General Medical Center
City
Akron
State/Province
Ohio
ZIP/Postal Code
44307
Country
United States
Facility Name
VAMC Cincinnati
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45220
Country
United States
Facility Name
Bethesda North Hospital
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45242
Country
United States
Facility Name
The University Hospital
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267
Country
United States
Facility Name
University Hospitals of Cleveland
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44103
Country
United States
Facility Name
Cleveland Clinic Foundation
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
MidWest Cardiology Research Foundation
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43214
Country
United States
Facility Name
Med Central Mansfield
City
Mansfield
State/Province
Ohio
ZIP/Postal Code
44906
Country
United States
Facility Name
Genesis Healthcare System
City
Zanesville
State/Province
Ohio
ZIP/Postal Code
43701
Country
United States
Facility Name
Midwest Regional Medical Center
City
Midwest City
State/Province
Oklahoma
ZIP/Postal Code
73110
Country
United States
Facility Name
University of Oklahoma Health Sciences Center
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73104
Country
United States
Facility Name
VA Medical Center
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73104
Country
United States
Facility Name
Integris Baptist Medical Center, Inc.
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Oklahoma Heart Hospital
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73120
Country
United States
Facility Name
St. Charles Medical Center
City
Bend
State/Province
Oregon
ZIP/Postal Code
97701
Country
United States
Facility Name
Providence Portland Medical Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213
Country
United States
Facility Name
Lehigh Valley Hospital
City
Allentown
State/Province
Pennsylvania
ZIP/Postal Code
18105
Country
United States
Facility Name
Geisinger Medical Center
City
Danville
State/Province
Pennsylvania
ZIP/Postal Code
17822-2160
Country
United States
Facility Name
Genesis Medical Center
City
Davenport
State/Province
Pennsylvania
ZIP/Postal Code
58803
Country
United States
Facility Name
Hamot Medical Center
City
Erie
State/Province
Pennsylvania
ZIP/Postal Code
16550
Country
United States
Facility Name
Penn State Milton S. Hershey Medical Center
City
Hershey
State/Province
Pennsylvania
ZIP/Postal Code
17033
Country
United States
Facility Name
Lancaster General Hospital
City
Lancaster
State/Province
Pennsylvania
ZIP/Postal Code
17604
Country
United States
Facility Name
Hospital of the University of Pennsylvania
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Facility Name
Temple University Hospital
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19140
Country
United States
Facility Name
Jefferson Regional Medical Center
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15025
Country
United States
Facility Name
Allegheny General Hospital
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Facility Name
Western Pennsylvania Hospital
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15215
Country
United States
Facility Name
VA Pittsburgh Healthcare System
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15240
Country
United States
Facility Name
The Chester County Hospital
City
West Chester
State/Province
Pennsylvania
ZIP/Postal Code
19380
Country
United States
Facility Name
York Hospital
City
York
State/Province
Pennsylvania
ZIP/Postal Code
17405
Country
United States
Facility Name
Rhode Island Hospital
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02903
Country
United States
Facility Name
Palmetto Richland Memorial Hospital
City
Columbia
State/Province
South Carolina
ZIP/Postal Code
29203
Country
United States
Facility Name
Sisters of Charity Providence Hospitals
City
Columbia
State/Province
South Carolina
ZIP/Postal Code
29204
Country
United States
Facility Name
Rapid City Regional Hospital
City
Rapid City
State/Province
South Dakota
ZIP/Postal Code
57719
Country
United States
Facility Name
Heart Hospital of South Dakota
City
Sioux Falls
State/Province
South Dakota
ZIP/Postal Code
57108
Country
United States
Facility Name
Jackson-Madison County General Hospital
City
Jackson
State/Province
Tennessee
ZIP/Postal Code
38301
Country
United States
Facility Name
Wellmont Holston Valley Medical Center
City
Kingsport
State/Province
Tennessee
ZIP/Postal Code
37660
Country
United States
Facility Name
Fort Sanders Rgional Medical Center
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37916
Country
United States
Facility Name
Baptist Hospital of East Tennessee
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37920
Country
United States
Facility Name
Centennial Medical Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Facility Name
Methodist Medical Center
City
Oak Ridge
State/Province
Tennessee
ZIP/Postal Code
37830
Country
United States
Facility Name
Northwest Texas Healthcare System
City
Amarillo
State/Province
Texas
ZIP/Postal Code
79106
Country
United States
Facility Name
Seton Medical Center
City
Austin
State/Province
Texas
ZIP/Postal Code
78705
Country
United States
Facility Name
Presbyterian Hospital of Dallas
City
Dallas
State/Province
Texas
ZIP/Postal Code
57231
Country
United States
Facility Name
Medical City Dallas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75230
Country
United States
Facility Name
Dallas Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Facility Name
Parkland Health & Hospital System
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Facility Name
Brooke Army Medical Center
City
Fort Sam Houston
State/Province
Texas
ZIP/Postal Code
78234
Country
United States
Facility Name
Ben Taub General Hospital
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Memorial Hermann Hospital
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Michael E. DeBakey VA Medical Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Houston Northwest Medical Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77090
Country
United States
Facility Name
Covenant Medical Center
City
Lubbock
State/Province
Texas
ZIP/Postal Code
79410
Country
United States
Facility Name
Northeast Baptist Hospital
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78217
Country
United States
Facility Name
South Texas Veterans Health Care System Audie L. Murphy Division
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78258
Country
United States
Facility Name
Scott & White Memorial Hospital
City
Temple
State/Province
Texas
ZIP/Postal Code
76508
Country
United States
Facility Name
East Texas Medical Center
City
Tyler
State/Province
Texas
ZIP/Postal Code
75701
Country
United States
Facility Name
Trinity Mother Frances Hospital
City
Tyler
State/Province
Texas
ZIP/Postal Code
75701
Country
United States
Facility Name
Citizens Medical Center
City
Victoria
State/Province
Texas
ZIP/Postal Code
77901
Country
United States
Facility Name
Detar Hospital
City
Victoria
State/Province
Texas
ZIP/Postal Code
77901
Country
United States
Facility Name
Cottonwood Hospital
City
Murray
State/Province
Utah
ZIP/Postal Code
84107
Country
United States
Facility Name
Inova Alexandria Hospital
City
Alexandria
State/Province
Virginia
ZIP/Postal Code
22306
Country
United States
Facility Name
Universitiy of Virginia Health Science Center
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22908
Country
United States
Facility Name
Rockingham Memorial Hospital
City
Harrisonburg
State/Province
Virginia
ZIP/Postal Code
22801
Country
United States
Facility Name
Lynchburg General Hospital
City
Lynchburg
State/Province
Virginia
ZIP/Postal Code
24501
Country
United States
Facility Name
Herrico Doctors' Hospital - Forest
City
Richmond
State/Province
Virginia
Country
United States
Facility Name
Sentara Virginia Beach General Hospital
City
Virginia Beach
State/Province
Virginia
ZIP/Postal Code
23454
Country
United States
Facility Name
Winchester Medical Center
City
Winchester
State/Province
Virginia
ZIP/Postal Code
22601
Country
United States
Facility Name
Overtake Hospital Medical Center
City
Bellevue
State/Province
Washington
ZIP/Postal Code
98004
Country
United States
Facility Name
Skagit Valley Hospital
City
Mt. Vernon
State/Province
Washington
ZIP/Postal Code
98274
Country
United States
Facility Name
Harborview Medical Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98104
Country
United States
Facility Name
MultiCare Medical Center (Tacoma General Hospital)
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Facility Name
St. Joseph Medical Center
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Facility Name
West Virginia University Hospital
City
Morgantown
State/Province
West Virginia
ZIP/Postal Code
26506-9157
Country
United States
Facility Name
Franciscan Skemp Healthcare
City
La Crosse
State/Province
Wisconsin
ZIP/Postal Code
54601
Country
United States
Facility Name
Froedtert Hospital
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States
Facility Name
Waukesha Memorial Hospital
City
Waukesha
State/Province
Wisconsin
ZIP/Postal Code
53188
Country
United States
Facility Name
Canberra Hospital
City
Garran
State/Province
Australian Capital Territory
ZIP/Postal Code
2605
Country
Australia
Facility Name
Concord Hospital
City
Concord
State/Province
New South Wales
ZIP/Postal Code
2137
Country
Australia
Facility Name
Gosford Hospital
City
Gosford
State/Province
New South Wales
ZIP/Postal Code
2250
Country
Australia
Facility Name
St. George Hospital
City
Kogarah
State/Province
New South Wales
ZIP/Postal Code
2217
Country
Australia
Facility Name
Liverpool Hospital
City
Liverpool
State/Province
New South Wales
ZIP/Postal Code
2170
Country
Australia
Facility Name
Prince of Wales Hospital
City
Randwick
State/Province
New South Wales
ZIP/Postal Code
2031
Country
Australia
Facility Name
Royal North Shore Hospital
City
St. Leonards
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
Facility Name
Prince Charles Hospital
City
Chermside
State/Province
Queensland
ZIP/Postal Code
4032
Country
Australia
Facility Name
Townsville Hospital
City
Douglas
State/Province
Queensland
ZIP/Postal Code
4814
Country
Australia
Facility Name
Princess Alexandra Hospital
City
Wooloong Abba
State/Province
Queensland
ZIP/Postal Code
4102
Country
Australia
Facility Name
Royal Adelaide Hospital
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Flinders Medical Centre
City
Bedford Park
State/Province
South Australia
ZIP/Postal Code
5042
Country
Australia
Facility Name
The Queen Elizabeth Hospital
City
Woodville South
State/Province
South Australia
ZIP/Postal Code
5011
Country
Australia
Facility Name
Austin Hospital
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3084
Country
Australia
Facility Name
Box Hill Hospital
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3128
Country
Australia
Facility Name
Monash Medical Centre
City
Clayton
State/Province
Victoria
ZIP/Postal Code
3162
Country
Australia
Facility Name
Royal Melbourne Hospital
City
Parkville
State/Province
Victoria
ZIP/Postal Code
3050
Country
Australia
Facility Name
Victorian Heart Clinic
City
Richmond
State/Province
Victoria
ZIP/Postal Code
3121
Country
Australia
Facility Name
Fremantle Hospital
City
Fremantle
State/Province
Western Australia
ZIP/Postal Code
6160
Country
Australia
Facility Name
Sir Charles Gairdner Hospital
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
Facility Name
Royal Perth Hospital
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6000
Country
Australia
Facility Name
Krankenhaus der Barmherzigen Schwestern
City
Linz
ZIP/Postal Code
4010
Country
Austria
Facility Name
Univ. Klinik f. Innere Medizin II
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Wilhelminenspital
City
Wien
ZIP/Postal Code
1171
Country
Austria
Facility Name
U.Z. Gasthuisberg
City
Leuven
State/Province
Brabant
ZIP/Postal Code
3000
Country
Belgium
Facility Name
ZOL Campus Sint-Jan
City
Genk
State/Province
Limburg
ZIP/Postal Code
3600
Country
Belgium
Facility Name
Helig Hartziekenhuis
City
Roeselare
State/Province
Vlaanderen
ZIP/Postal Code
8800
Country
Belgium
Facility Name
AZ Middelheim
City
Antwerpen
ZIP/Postal Code
2020
Country
Belgium
Facility Name
CHR de la Citadelle
City
Liege
ZIP/Postal Code
4000
Country
Belgium
Facility Name
Foothills Medical Centre
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 2W8
Country
Canada
Facility Name
University of Alberta Hospital
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 2B7
Country
Canada
Facility Name
Vancouver General Hospital
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 1L8
Country
Canada
Facility Name
St. Paul's Hospital
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V6Z 1Y6
Country
Canada
Facility Name
Royal Jubilee Hospital
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8R 4R2
Country
Canada
Facility Name
Saint John Regional Hospital - New Brunswick Heart Centre
City
Saint John
State/Province
New Brunswick
ZIP/Postal Code
E2L 4L2
Country
Canada
Facility Name
General Hospital Health Sciences Centre
City
St. John's
State/Province
Newfoundland and Labrador
ZIP/Postal Code
A1B 3E4
Country
Canada
Facility Name
Hamilton General Hospital
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 2X2
Country
Canada
Facility Name
Trillium Health Center
City
Mississauga
State/Province
Ontario
ZIP/Postal Code
L58 2P7
Country
Canada
Facility Name
Sunnybrook & Women's Health Sciences Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
Facility Name
Montreal Heart Institute/Research Centre
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 1C8
Country
Canada
Facility Name
Centre Hospitale de'Universite de Montreal (Pav Notre-Dame)_
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2L 4M1
Country
Canada
Facility Name
Hopital Sacre-Coeur de Montreal
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H4J 1C5
Country
Canada
Facility Name
Quebec Heart Institute/Laval Hospital
City
Sainte-Foy
State/Province
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
Facility Name
Centre Hospitalier Universitaire de Sherbrooke
City
Sherbrooke
State/Province
Quebec
ZIP/Postal Code
J1H 5N4
Country
Canada
Facility Name
Regina General Hospital
City
Regina
State/Province
Saskatchewan
ZIP/Postal Code
S4P 0W5
Country
Canada
Facility Name
Kardiologicke odd. Nemocnice Ceske Budejovice as
City
Caske Budejovice
State/Province
Ceske Budejovice
ZIP/Postal Code
370 878
Country
Czech Republic
Facility Name
I. Interni klinika, Fakultni nemocnice Hradec
City
Kradec Kralove
State/Province
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czech Republic
Facility Name
Klinika kardiologie, IKEM
City
Prague 4
State/Province
Prague
ZIP/Postal Code
14021
Country
Czech Republic
Facility Name
Kardiologicke oddeleni, Masarykova nemocnice
City
Labem
State/Province
Usti nad Labem
ZIP/Postal Code
401 13
Country
Czech Republic
Facility Name
Interni kardiologicka klinika, Fakultni nemocnice Brno
City
Brno
ZIP/Postal Code
625 00
Country
Czech Republic
Facility Name
I. interni kardioangiologicka klinika, Fakultni nemocnice u Sv. Anny
City
Brno
ZIP/Postal Code
656 91
Country
Czech Republic
Facility Name
Kardiologicke odd., Krajska neocnice Liberec
City
Liberec
ZIP/Postal Code
460 63
Country
Czech Republic
Facility Name
I. Interni klinika, FN Olomouc
City
Olomouc
ZIP/Postal Code
775-20
Country
Czech Republic
Facility Name
Interni klinika, FNsP Ostrava
City
Ostrava
ZIP/Postal Code
708 52
Country
Czech Republic
Facility Name
Kardio-Troll sro and Krajska nemocnice Pardubice
City
Pardubice
ZIP/Postal Code
532 03
Country
Czech Republic
Facility Name
Kardio-Troll sro and Krajska nemocnice Pardubice
City
Pardubice
ZIP/Postal Code
53203
Country
Czech Republic
Facility Name
I. Interni klinika, Fakultni nemocnice Plzen
City
Plzen
ZIP/Postal Code
304 60
Country
Czech Republic
Facility Name
Kardiocentrum, Fakultni nemocnice Kralovske Vinohrady
City
Prague
ZIP/Postal Code
10034
Country
Czech Republic
Facility Name
II. Interni klinika, Vseobecna fakultni nemocnice
City
Prague
ZIP/Postal Code
128 08
Country
Czech Republic
Facility Name
Kardiologicke odd., Nemocnice Na Homoice
City
Prague
ZIP/Postal Code
150 30
Country
Czech Republic
Facility Name
Kardiologicka klinika FN v Motole
City
Prague
ZIP/Postal Code
15006
Country
Czech Republic
Facility Name
Kardiocentrum, Nemocnice Podlesi sro
City
Trinec
ZIP/Postal Code
739 61
Country
Czech Republic
Facility Name
Interni klinika, Batova nemocnice
City
Zlin
ZIP/Postal Code
462 75
Country
Czech Republic
Facility Name
Aalborg Sygehus
City
Aalborg
State/Province
Danmark
ZIP/Postal Code
9100
Country
Denmark
Facility Name
Skejby Sygehus
City
Aarhus
State/Province
Danmark
ZIP/Postal Code
8200
Country
Denmark
Facility Name
Amtssygehuset i Gentofte
City
Hellerup
State/Province
Danmark
ZIP/Postal Code
2900
Country
Denmark
Facility Name
Rigshospitalet
City
Kobenhavn
State/Province
Danmark
ZIP/Postal Code
DK-2100
Country
Denmark
Facility Name
Odense Universitets Hospital
City
Odense
ZIP/Postal Code
5000
Country
Denmark
Facility Name
CHRU de Angers
City
Angers
ZIP/Postal Code
49100
Country
France
Facility Name
Clinique Saint Joseph
City
Colmar Cedex
ZIP/Postal Code
66027
Country
France
Facility Name
Cardiologie Hopital Simone Veil
City
Eaubonne-Montmorency
ZIP/Postal Code
95601
Country
France
Facility Name
Centre Hospitalier de Haguenau
City
Haguenau
ZIP/Postal Code
67504
Country
France
Facility Name
CHRU de Nantes
City
Nantes
ZIP/Postal Code
44000
Country
France
Facility Name
Hopital a Pitie Salpetriere
City
Paris Cedex 13
ZIP/Postal Code
75743
Country
France
Facility Name
Hopital Lariboisiere
City
Paris
ZIP/Postal Code
75010
Country
France
Facility Name
Hopital Bichat
City
Paris
ZIP/Postal Code
75018
Country
France
Facility Name
Hopital du Haut Leveque
City
Pessac
ZIP/Postal Code
33604
Country
France
Facility Name
Hopital Pontchaillou
City
Rennes
ZIP/Postal Code
35000
Country
France
Facility Name
CHRU de Rouen
City
Rouen
ZIP/Postal Code
76000
Country
France
Facility Name
Centre Cardiologique du Nord
City
Saint Denis
ZIP/Postal Code
93200
Country
France
Facility Name
CHRU Hautepierre
City
Strasbourg
ZIP/Postal Code
67100
Country
France
Facility Name
Hopital Rangueil
City
Toulouse Cedex 9
ZIP/Postal Code
31059
Country
France
Facility Name
Hopital d'adultes de Brabois (CHU de Nancy)
City
Vandoeuvre les Nancy
ZIP/Postal Code
54511
Country
France
Facility Name
Universitatsklinikum Mannheim
City
Mannheim
State/Province
Baden-Wurttemberg
ZIP/Postal Code
66167
Country
Germany
Facility Name
Klinikum Augsburg, Stenglinstr. 2.
City
Augsburg
State/Province
Bavaria
ZIP/Postal Code
86156
Country
Germany
Facility Name
Klinikum Coburg
City
Coburg
State/Province
Bavaria
ZIP/Postal Code
96450
Country
Germany
Facility Name
Stadt Krankenhaus Muenchen-Bogenhausen
City
Munchen
State/Province
Bavaria
ZIP/Postal Code
81925
Country
Germany
Facility Name
Kerckhoff-Klinik Bad Anuheim
City
Bad Nauheim
State/Province
Hessen
ZIP/Postal Code
61231
Country
Germany
Facility Name
Stadt. Kliniken Kassel
City
Kassel
State/Province
Hessen
ZIP/Postal Code
34125
Country
Germany
Facility Name
Allgemeines Krankenhaus Celle
City
Celle
State/Province
Lower Saxony
ZIP/Postal Code
29223
Country
Germany
Facility Name
Herzzentrum Gottingen
City
Gottingen
State/Province
Lower Saxony
ZIP/Postal Code
37075
Country
Germany
Facility Name
St. Johannes Krankenhaus
City
Dortmund
State/Province
Nordhein Westfalen
ZIP/Postal Code
44137
Country
Germany
Facility Name
Herzzentrum Duisburg
City
Duisburg
State/Province
Nordhein Westfalen
ZIP/Postal Code
47137
Country
Germany
Facility Name
Kliniken der Stadt Koln
City
Koln
State/Province
Nordrhein Westfalen
ZIP/Postal Code
51109
Country
Germany
Facility Name
Helios Klinikum Wuppertal GmbH
City
Wuppertal
State/Province
Nordrhein Westfalen
ZIP/Postal Code
42117
Country
Germany
Facility Name
Klinikkum Lippe
City
Detmold
State/Province
North Rhine-Westphalia
ZIP/Postal Code
32756
Country
Germany
Facility Name
Klinikkum Ludwigshafen
City
Ludwigshafen
State/Province
Rhineland-Palatinate
ZIP/Postal Code
67063
Country
Germany
Facility Name
Herzzentrum
City
Bad Segeberg
State/Province
Schleswig Holstein
ZIP/Postal Code
23795
Country
Germany
Facility Name
Universitatsklinik Lubeck
City
Lubeck
State/Province
Schleswig-Holstein
ZIP/Postal Code
23538
Country
Germany
Facility Name
Klinik fur Innere Medizin 1
City
Jena
State/Province
Thuringia
ZIP/Postal Code
07740
Country
Germany
Facility Name
Herz-Zentrum Bad Krozingen
City
Krozingen
State/Province
Wurrtemberg
ZIP/Postal Code
79189
Country
Germany
Facility Name
Universitatsklinik der Ruhr-Universitat Bochum
City
Bad Oeynhausen
ZIP/Postal Code
32545
Country
Germany
Facility Name
Vivantes Klinikkum im Friedrichshain
City
Berlin
ZIP/Postal Code
10249
Country
Germany
Facility Name
Vivantes Klinikum am Urban
City
Berlin
ZIP/Postal Code
10967
Country
Germany
Facility Name
Allgemeines Krankenhaus St. Georg
City
Hamburg
ZIP/Postal Code
20099
Country
Germany
Facility Name
Universitatsklinikum Hamburg-Eppendorf
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
Facility Name
Centro E Malan
City
San Donato Milanese
State/Province
Milano
ZIP/Postal Code
20097
Country
Italy
Facility Name
Presidio Ospedaliero di Cittadella
City
Cittadella
State/Province
Padova
ZIP/Postal Code
35013
Country
Italy
Facility Name
U.O. Cardiologia
City
Reggio nell Emilia
State/Province
Reggio Emilla
ZIP/Postal Code
42100
Country
Italy
Facility Name
A.O. SS. Antonio e Biagio e Cesare Arrigo
City
Alessandria
ZIP/Postal Code
15100
Country
Italy
Facility Name
Policlinico Sant'Orsola-Malpighi
City
Bologna
ZIP/Postal Code
40128
Country
Italy
Facility Name
Ospedale Centrale di Bolzano
City
Bolzano
ZIP/Postal Code
39100
Country
Italy
Facility Name
A.O. Spedali di Civili
City
Brescia
ZIP/Postal Code
25123
Country
Italy
Facility Name
A.O. della Regione Lombardia Presidio Ospedaliero Sant'Anna
City
Como
ZIP/Postal Code
22100
Country
Italy
Facility Name
Ospedale Alessandro Manzoni
City
Lecco
ZIP/Postal Code
23900
Country
Italy
Facility Name
Azienda Ospedaliera Carlo Poma
City
Mantova
ZIP/Postal Code
46100
Country
Italy
Facility Name
Azienda Ospedaliera di Parma - Ospedale Maggiore
City
Parma
ZIP/Postal Code
43100
Country
Italy
Facility Name
Policlinico San Matteo - I.R.C.C.S.
City
Pavia
ZIP/Postal Code
27100
Country
Italy
Facility Name
A. O. S. Salvatore
City
Pesaro
ZIP/Postal Code
46100
Country
Italy
Facility Name
Osepdale degli Intermi
City
Rimni
ZIP/Postal Code
47900
Country
Italy
Facility Name
AO S. Camillo Forlanini
City
Roma
ZIP/Postal Code
00152
Country
Italy
Facility Name
Cardiologia Universitaria
City
Torino
ZIP/Postal Code
10126
Country
Italy
Facility Name
Ospedale S. Maria di Ca'Foncello
City
Treviso
ZIP/Postal Code
31100
Country
Italy
Facility Name
Catharina Hospital
City
Eindhovenb
State/Province
BR
ZIP/Postal Code
5623 EJ
Country
Netherlands
Facility Name
Academic Hospital Maastricht
City
Maastricht
State/Province
LI
ZIP/Postal Code
6229 HX
Country
Netherlands
Facility Name
Medeisch Centrum Alkmaar
City
Alkmaar
State/Province
NH
ZIP/Postal Code
1800 AM
Country
Netherlands
Facility Name
VUMC
City
Amsterdam
State/Province
NH
ZIP/Postal Code
1081 HV
Country
Netherlands
Facility Name
OLVG
City
Amsterdam
State/Province
NH
ZIP/Postal Code
1091 HD
Country
Netherlands
Facility Name
Isla Klinieken Location De Weezenlanden
City
Zwolle
State/Province
OV
ZIP/Postal Code
8011 JW
Country
Netherlands
Facility Name
Sint Antonius Hospital
City
Nieuwegein
State/Province
UT
ZIP/Postal Code
3435 CM
Country
Netherlands
Facility Name
University Medical Center Utrecht
City
Ultrecht
State/Province
UT
ZIP/Postal Code
3584 CX
Country
Netherlands
Facility Name
Erasmus Medical Centre
City
Rotterdam
State/Province
ZH
ZIP/Postal Code
3015 GD
Country
Netherlands
Facility Name
Medisch Centrum Rijnmond-Zuid
City
Rotterdam
State/Province
ZH
ZIP/Postal Code
3075 EA
Country
Netherlands
Facility Name
Christchurch Hospital
City
Christchurch
State/Province
Canterbury
ZIP/Postal Code
8001
Country
New Zealand
Facility Name
Dunedin Hospital
City
Dunedin
State/Province
Otago
ZIP/Postal Code
9001
Country
New Zealand
Facility Name
Waikato Hospital
City
Hamilton
State/Province
Waikoto
ZIP/Postal Code
2001
Country
New Zealand
Facility Name
Auckland City Hospital
City
Auckland
ZIP/Postal Code
1003
Country
New Zealand
Facility Name
Wellington Hospital
City
Wellington
ZIP/Postal Code
6002
Country
New Zealand
Facility Name
I Klinika Kardiologii
City
Katowice - Ochojec
ZIP/Postal Code
40-635
Country
Poland
Facility Name
Klinika Chorob Serca i Naczyn
City
Krakow
ZIP/Postal Code
31-202
Country
Poland
Facility Name
II Katedra i Klinika Kardiologii
City
Lodz
ZIP/Postal Code
91-347
Country
Poland
Facility Name
I Klinika Choroby Wiencowej
City
Warszawa
ZIP/Postal Code
04-628
Country
Poland
Facility Name
SPZOZ Dolnoslaski Szpital Specjalistyczny
City
Wroclaw
ZIP/Postal Code
50-420
Country
Poland
Facility Name
Hospital Garcia de Orta - Servico de Cardiologia
City
Almada
State/Province
Lisboa
ZIP/Postal Code
2801-951 Almada
Country
Portugal
Facility Name
Hospital Santa Cruz
City
Carnaxide
State/Province
Lisboa
ZIP/Postal Code
270-134
Country
Portugal
Facility Name
H. Fernando da Fonesca
City
Amadora
ZIP/Postal Code
3700-376 Amadora
Country
Portugal
Facility Name
Hospitals da Universidade de Coimbra
City
Coimbra
ZIP/Postal Code
3000-075 Coimbra
Country
Portugal
Facility Name
Hospital Curry Cabral
City
Lisboa
ZIP/Postal Code
1069-166 Lisboa
Country
Portugal
Facility Name
H. Santa Maria
City
Lisboa
ZIP/Postal Code
1600-190 LISBOA
Country
Portugal
Facility Name
Hospital Sao Joao - Servico de Cardiologia
City
Porto
ZIP/Postal Code
4200-319 Porto
Country
Portugal
Facility Name
Centro Hospitalar de Vila Nova de Gala
City
Vila Nova de Gala
ZIP/Postal Code
4434-502 Vila Nova de Gala
Country
Portugal
Facility Name
Ciutat Sanitaria i Universitaria de Bellvitge
City
L'Hospitalet de Llobregat
State/Province
Barcelona
ZIP/Postal Code
08907
Country
Spain
Facility Name
Hospital Virgen da la Arrixaca
City
El Palmar
State/Province
Murcia
ZIP/Postal Code
30120
Country
Spain
Facility Name
Hospital de Navarra
City
Pamplona
State/Province
Navarra
ZIP/Postal Code
31008
Country
Spain
Facility Name
Hospital General Universitario de Alicante
City
Alicante
ZIP/Postal Code
03010
Country
Spain
Facility Name
Hospital Clinic i Provincial
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Facility Name
Hospital de Leon
City
Leon
ZIP/Postal Code
24008
Country
Spain
Facility Name
Hospital General Universitario Gregorio Maranon
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Hospital Puerta de Hierro
City
Madrid
ZIP/Postal Code
28035
Country
Spain
Facility Name
Hospital Clinico San Carlos
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Hospital Clinico Universitario Virgen de la Victoria
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Hopspital Virgen del Rocio
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Facility Name
Universitetetssjukhuset Umea
City
Umea
ZIP/Postal Code
SE-901-85
Country
Sweden
Facility Name
Uppsala University Hospital
City
Uppsala
Country
Sweden
Facility Name
University Hospital of Geneva
City
Geneva 14
State/Province
Geneva
ZIP/Postal Code
CH-1211
Country
Switzerland
Facility Name
Herzklinik Bodensee am Weinberg AG
City
Kreuzlingen
State/Province
Thurgau
ZIP/Postal Code
8280
Country
Switzerland
Facility Name
Cardiocentro Ticino
City
Lugano
State/Province
Ticino
ZIP/Postal Code
6900
Country
Switzerland
Facility Name
Kantonsspital Basel
City
Bassel
ZIP/Postal Code
4031
Country
Switzerland
Facility Name
Kantonsspital St. Gallen
City
St. Gallen
ZIP/Postal Code
CH-9007
Country
Switzerland
12. IPD Sharing Statement
Citations:
PubMed Identifier
24176448
Citation
Bagai A, Armstrong PW, Stebbins A, Mahaffey KW, Hochman JS, Weaver WD, Patel MR, Granger CB, Lopes RD. Prognostic implications of left ventricular end-diastolic pressure during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: Findings from the Assessment of Pexelizumab in Acute Myocardial Infarction study. Am Heart J. 2013 Nov;166(5):913-9. doi: 10.1016/j.ahj.2013.08.006. Epub 2013 Sep 24.
Results Reference
derived
PubMed Identifier
23549644
Citation
Guptill JT, Mehta RH, Armstrong PW, Horton J, Laskowitz D, James S, Granger CB, Lopes RD. Stroke after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction: timing, characteristics, and clinical outcomes. Circ Cardiovasc Interv. 2013 Apr;6(2):176-83. doi: 10.1161/CIRCINTERVENTIONS.112.000159. Epub 2013 Apr 2.
Results Reference
derived
PubMed Identifier
23453104
Citation
Westerhout CM, Pieper KS, James SK, Mahaffey KW, de Werf FV, Califf RM, Granger CB, Armstrong PW. Dynamic modeling of 90-day mortality in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Am Heart J. 2013 Mar;165(3):354-62.e2. doi: 10.1016/j.ahj.2012.12.001. Epub 2013 Jan 15.
Results Reference
derived
PubMed Identifier
23351826
Citation
Patel MR, Westerhout CM, Granger CB, Brener SJ, Fu Y, Siha H, Kim RJ, Armstrong PW. Aborted myocardial infarction after primary percutaneous coronary intervention: magnetic resonance imaging insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart J. 2013 Feb;165(2):226-33. doi: 10.1016/j.ahj.2012.10.028. Epub 2012 Nov 24.
Results Reference
derived
PubMed Identifier
22814783
Citation
Truffa AA, Granger CB, White KR, Newby LK, Mehta RH, Hochman JS, Patel MR, Pieper KS, Al-Khalidi HR, Armstrong PW, Lopes RD. Serious infection after acute myocardial infarction: incidence, clinical features, and outcomes. JACC Cardiovasc Interv. 2012 Jul;5(7):769-76. doi: 10.1016/j.jcin.2012.03.018.
Results Reference
derived
PubMed Identifier
22795281
Citation
Martel C, Granger CB, Ghitescu M, Stebbins A, Fortier A, Armstrong PW, Bonnefoy A, Theroux P. Pexelizumab fails to inhibit assembly of the terminal complement complex in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Insight from a substudy of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart J. 2012 Jul;164(1):43-51. doi: 10.1016/j.ahj.2012.04.007. Epub 2012 Jun 15.
Results Reference
derived
PubMed Identifier
22589297
Citation
van Diepen S, Widimsky P, Lopes RD, White KR, Weaver WD, Van de Werf F, Ardissino D, van't Hof AW, Armstrong PW, Granger CB. Transfer times and outcomes in patients with ST-segment-elevation myocardial infarction undergoing interhospital transfer for primary percutaneous coronary intervention: APEX-AMI insights. Circ Cardiovasc Qual Outcomes. 2012 Jul 1;5(4):437-44. doi: 10.1161/CIRCOUTCOMES.112.965160. Epub 2012 May 15.
Results Reference
derived
PubMed Identifier
21304097
Citation
Hudson MP, Armstrong PW, O'Neil WW, Stebbins AL, Weaver WD, Widimsky P, Aylward PE, Ruzyllo W, Holmes D, Mahaffey KW, Granger CB. Mortality implications of primary percutaneous coronary intervention treatment delays: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction trial. Circ Cardiovasc Qual Outcomes. 2011 Mar;4(2):183-92. doi: 10.1161/CIRCOUTCOMES.110.945311. Epub 2011 Feb 8.
Results Reference
derived
PubMed Identifier
20501476
Citation
Huber K, Holmes DR Jr, van 't Hof AW, Montalescot G, Aylward PE, Betriu GA, Widimsky P, Westerhout CM, Granger CB, Armstrong PW. Use of glycoprotein IIb/IIIa inhibitors in primary percutaneous coronary intervention: insights from the APEX-AMI trial. Eur Heart J. 2010 Jul;31(14):1708-16. doi: 10.1093/eurheartj/ehq143. Epub 2010 May 25.
Results Reference
derived
PubMed Identifier
20435202
Citation
Alhadramy O, Westerhout CM, Brener SJ, Granger CB, Armstrong PW; APEX AMI Investigators. Is visual interpretation of coronary epicardial flow reliable in patients with ST-elevation myocardial infarction undergoing primary angioplasty? Insights from the angiographic substudy of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart J. 2010 May;159(5):899-904. doi: 10.1016/j.ahj.2010.02.028.
Results Reference
derived
PubMed Identifier
20129531
Citation
Patel MR, Worthley SG, Stebbins A, Dill T, Rademakers FE, Valeti US, Barsness GW, Van de Werf F, Hamm CW, Armstrong PW, Granger CB, Kim RJ. Pexelizumab and infarct size in patients with acute myocardial infarction undergoing primary percutaneous coronary Intervention: a delayed enhancement cardiac magnetic resonance substudy from the APEX-AMI trial. JACC Cardiovasc Imaging. 2010 Jan;3(1):52-60. doi: 10.1016/j.jcmg.2009.09.014. Epub 2010 Jan 12. Erratum In: JACC Cardiovasc Imaging. 2010 Jul;3(7):796. Velleti, Uma S [corrected to Valeti, Uma S].
Results Reference
derived
PubMed Identifier
20089518
Citation
Trendelenburg M, Theroux P, Stebbins A, Granger C, Armstrong P, Pfisterer M. Influence of functional deficiency of complement mannose-binding lectin on outcome of patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Eur Heart J. 2010 May;31(10):1181-7. doi: 10.1093/eurheartj/ehp597. Epub 2010 Jan 19.
Results Reference
derived
PubMed Identifier
19853693
Citation
Brener SJ, Westerhout CM, Fu Y, Todaro TG, Moliterno DJ, Wagner GS, Granger CB, Armstrong PW; APEX-AMI Investigators. Contribution of angiographic and electrocardiographic parameters of reperfusion to prediction of mortality and morbidity after acute ST-elevation myocardial infarction: Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction trial. Am Heart J. 2009 Nov;158(5):755-60. doi: 10.1016/j.ahj.2009.09.009. Epub 2009 Oct 3.
Results Reference
derived
PubMed Identifier
19389560
Citation
Armstrong PW, Fu Y, Westerhout CM, Hudson MP, Mahaffey KW, White HD, Todaro TG, Adams PX, Aylward PE, Granger CB. Baseline Q-wave surpasses time from symptom onset as a prognostic marker in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention. J Am Coll Cardiol. 2009 Apr 28;53(17):1503-9. doi: 10.1016/j.jacc.2009.01.046.
Results Reference
derived
PubMed Identifier
18779444
Citation
Buller CE, Fu Y, Mahaffey KW, Todaro TG, Adams P, Westerhout CM, White HD, van 't Hof AW, Van de Werf FJ, Wagner GS, Granger CB, Armstrong PW. ST-segment recovery and outcome after primary percutaneous coronary intervention for ST-elevation myocardial infarction: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Circulation. 2008 Sep 23;118(13):1335-46. doi: 10.1161/CIRCULATIONAHA.108.767772. Epub 2008 Sep 8.
Results Reference
derived
PubMed Identifier
17200474
Citation
APEX AMI Investigators; Armstrong PW, Granger CB, Adams PX, Hamm C, Holmes D Jr, O'Neill WW, Todaro TG, Vahanian A, Van de Werf F. Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: a randomized controlled trial. JAMA. 2007 Jan 3;297(1):43-51. doi: 10.1001/jama.297.1.43.
Results Reference
derived
Learn more about this trial
Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction (APEX-AMI)
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