Pharmacogenomics on Individualized Precise Treatment of Patients With Depression

Inclusion Criteria: Both biological parents are Chinese nationals; Conform to the diagnostic criteria of depression in the fifth edition of the American Diagnostic and Statistical Manual of Mental Disorders (DSM-5); The total score of 17 items of Hamilton Depression Scale (HAMD-17) is ≥ 17; Never used relevant antidepressant drugs; Have a certain visual and auditory discrimination, and have no understanding obstacle; Be able to independently complete the scale measurement; Education level above primary school; Obtain the written informed consent of the patient. If the patient is incapacitated during the onset of the disease, the written informed consent of the legal guardian is required. Exclusion Criteria: Patients with schizophrenia, schizoaffective disorder, bipolar affective disorder, mental retardation, generalized developmental disorder, delirium, dementia, cognitive dysfunction, alcohol dependence and other diagnoses; Suffering from serious organic diseases, such as diabetes, thyroid disease, hypertension, cardiovascular disease, brain injury, cerebral ischemia or hemorrhage; Patients with narrow angle glaucoma; History of epilepsy and febrile convulsion; Those who have taken drugs in the past; Syphilis specific antibody and AIDS antibody are positive; Those who received MECT or rTMS and other neuromodulation therapy one month before enrollment; The risk assessment indicates that there is a serious suicide attempt or excitement; Laboratory examination indicates that liver function and renal function are impaired; Pregnant or lactating women, or those who plan to have a pregnancy in the near future; Other contraindications of antidepressants.