Pharmacokinetics and Pharmacodynamics of Linezolid Continuous and Intermittent Administration
Side-effect of Antibiotic, Efficacy, Pharmacokinetics
About this trial
This is an interventional treatment trial for Side-effect of Antibiotic focused on measuring continuous infusion, intensive care unit, critically ill, linezolid, pharmacokinetics, pharmacodynamics
Eligibility Criteria
Inclusion Criteria: patients hospitalized in the intensive care unit, female or male sex, age over 18 years, linezolid is prescribed by the attending physician, in empirical treatment or based on the antibiogram. Exclusion Criteria: documented severe liver failure (Child-Pugh C). no informed consent signed
Sites / Locations
- University Clinical Municipal HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Linezolid continuous infusion
Linezolid Intermittent administration
In the intervention arm, Linezolid is administered 600 mg as loading dose as an infusion lasting one hour (flow rate 300 ml/h), followed by continuous infusion of 1200 mg linezolid over 24 hours (flow rate 25 ml/h) which is immediately initiated. The continuous infusion is administered until the end of the treatment.
In the comparator arm, 600 mg dose of Linezolid is administered as one-hour infusion (flow rate 300 ml/h). Two doses at 12-h intervals are infused until the end of the treatment.