Back to resultsPhase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-12)
Primary Purpose
Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer
Status
Recruiting
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
MRTX849
Docetaxel
Sponsored by
About this trial
This is an interventional treatment trial for Metastatic Non Small Cell Lung Cancer focused on measuring KRAS G12C, Non-small cell lung cancer, NSCLC, Metastatic Cancer, Docetaxel, Phase 3 Clinical Trial, Adagrasib, KRAS, KRAZATI
Eligibility Criteria
Inclusion Criteria:
- Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation.
- Candidacy to receive treatment with docetaxel.
Crossover Inclusion Criteria:
- Evidence of RECIST 1.1 defined disease progression on docetaxel per BICR
- ECOG performance status 0-2
Exclusion Criteria:
- Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510, Sotorasib).
- Active brain metastases.
Crossover Exclusion Criteria:
- Receipt of any other systemic anti-cancer therapy after last administration of docetaxel on the study.
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Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
MRTX849
Docetaxel
Arm Description
Outcomes
Primary Outcome Measures
Progression-free Survival (PFS)
Defined as time from randomization until disease progression or death from any cause, whichever occurs first.
Secondary Outcome Measures
Overall Survival (OS)
Defined as time from date of randomization to date of death due to any cause.
Objective Response Rate (ORR)
Defined as the percent of patients documented to have a confirmed CR or PR.
Duration of Response (DOR)
Defined as the time from date of the first documentation of objective tumor response (CR or PR) to the first documentation of either Progression of Disease (PD) or death due to any cause, whichever occurs first.
1-year Survival Rate
Safety
characterized by type, incidence, severity, timing, seriousness and relationship to study treatment of AEs, laboratory abnormalities, and number of patients discontinuing study treatment due to an adverse event.
Population PK parameters of MRTX849
Data for this Outcome Measure will not be reported here but will be used in a Population PK Analysis which will include participants who were not enrolled in this study, and issued in a separate report. ClinicalTrials.gov is designed for reporting results from only those participants who were enrolled in the study and described in the Participant Flow and Baseline Characteristics modules
Patient Reported Outcomes (PROs)
To be assessed by Lung Cancer Symptom Scale (LCSS).
Quality of LIfe Assessment
To be assessed by European Quality of Life Five Dimensions Questionnaire (EQ-5D-5L).
Full Information
NCT ID
NCT04685135
First Posted
December 21, 2020
Last Updated
October 6, 2023
Sponsor
Mirati Therapeutics Inc.
1. Study Identification
Unique Protocol Identification Number
NCT04685135
Brief Title
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
Acronym
KRYSTAL-12
Official Title
A Randomized Phase 3 Study of MRTX849 Versus Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation
Study Type
Interventional
2. Study Status
Record Verification Date
October 2023
Overall Recruitment Status
Recruiting
Study Start Date
April 1, 2021 (Actual)
Primary Completion Date
March 2024 (Anticipated)
Study Completion Date
December 2024 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Mirati Therapeutics Inc.
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 (adagrasib) versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer
Keywords
KRAS G12C, Non-small cell lung cancer, NSCLC, Metastatic Cancer, Docetaxel, Phase 3 Clinical Trial, Adagrasib, KRAS, KRAZATI
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
450 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
MRTX849
Arm Type
Experimental
Arm Title
Docetaxel
Arm Type
Active Comparator
Intervention Type
Drug
Intervention Name(s)
MRTX849
Other Intervention Name(s)
adagrasib, KRAZATI
Intervention Description
21 day cycles
Intervention Type
Drug
Intervention Name(s)
Docetaxel
Other Intervention Name(s)
Taxotere
Intervention Description
21 day cycles
Primary Outcome Measure Information:
Title
Progression-free Survival (PFS)
Description
Defined as time from randomization until disease progression or death from any cause, whichever occurs first.
Time Frame
32 Months
Secondary Outcome Measure Information:
Title
Overall Survival (OS)
Description
Defined as time from date of randomization to date of death due to any cause.
Time Frame
49 Months
Title
Objective Response Rate (ORR)
Description
Defined as the percent of patients documented to have a confirmed CR or PR.
Time Frame
32 Months
Title
Duration of Response (DOR)
Description
Defined as the time from date of the first documentation of objective tumor response (CR or PR) to the first documentation of either Progression of Disease (PD) or death due to any cause, whichever occurs first.
Time Frame
49 Months
Title
1-year Survival Rate
Time Frame
49 Months
Title
Safety
Description
characterized by type, incidence, severity, timing, seriousness and relationship to study treatment of AEs, laboratory abnormalities, and number of patients discontinuing study treatment due to an adverse event.
Time Frame
49 Months
Title
Population PK parameters of MRTX849
Description
Data for this Outcome Measure will not be reported here but will be used in a Population PK Analysis which will include participants who were not enrolled in this study, and issued in a separate report. ClinicalTrials.gov is designed for reporting results from only those participants who were enrolled in the study and described in the Participant Flow and Baseline Characteristics modules
Time Frame
49 Months
Title
Patient Reported Outcomes (PROs)
Description
To be assessed by Lung Cancer Symptom Scale (LCSS).
Time Frame
49 Months
Title
Quality of LIfe Assessment
Description
To be assessed by European Quality of Life Five Dimensions Questionnaire (EQ-5D-5L).
Time Frame
49 Months
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation.
Candidacy to receive treatment with docetaxel.
Crossover Inclusion Criteria:
Evidence of RECIST 1.1 defined disease progression on docetaxel per BICR
ECOG performance status 0-2
Exclusion Criteria:
Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510, Sotorasib).
Active brain metastases.
Crossover Exclusion Criteria:
Receipt of any other systemic anti-cancer therapy after last administration of docetaxel on the study.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Mirati Therapeutics Study Locator Services
Phone
1-844-893-5530
Email
miratistudylocator@careboxhealth.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Julie Meade, MD
Organizational Affiliation
Mirati Therapeutics Inc.
Official's Role
Study Director
Facility Information:
Facility Name
Research Site
City
Duarte
State/Province
California
ZIP/Postal Code
91010
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Long Beach
State/Province
California
ZIP/Postal Code
90813
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Santa Rosa
State/Province
California
ZIP/Postal Code
95403
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Whittier
State/Province
California
ZIP/Postal Code
90603
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Grand Junction
State/Province
Colorado
ZIP/Postal Code
81502
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Lafayette
State/Province
Colorado
ZIP/Postal Code
80026
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Lone Tree
State/Province
Colorado
ZIP/Postal Code
80124
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33308
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32204
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32256
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Miami Beach
State/Province
Florida
ZIP/Postal Code
33140
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Plantation
State/Province
Florida
ZIP/Postal Code
33322
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Athens
State/Province
Georgia
ZIP/Postal Code
30607
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Marietta
State/Province
Georgia
ZIP/Postal Code
30060
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Goshen
State/Province
Indiana
ZIP/Postal Code
46526
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46237
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Munster
State/Province
Indiana
ZIP/Postal Code
46321
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Westwood
State/Province
Kansas
ZIP/Postal Code
66205
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67214
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Scarborough
State/Province
Maine
ZIP/Postal Code
04074
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Frederick
State/Province
Maryland
ZIP/Postal Code
21702
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Billings
State/Province
Montana
ZIP/Postal Code
59102
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
East Brunswick
State/Province
New Jersey
ZIP/Postal Code
08816
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Teaneck
State/Province
New Jersey
ZIP/Postal Code
07666
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Syracuse
State/Province
New York
ZIP/Postal Code
13210
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kettering
State/Province
Ohio
ZIP/Postal Code
45429
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Salem
State/Province
Oregon
ZIP/Postal Code
97301
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02903
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Irving
State/Province
Texas
ZIP/Postal Code
75063
Country
United States
Individual Site Status
Recruiting
Facility Name
Research Site
City
Bedford Park
Country
Australia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Douglas
Country
Australia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Heidelberg
Country
Australia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Mackay
Country
Australia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Saint Leonards
Country
Australia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Tweed Heads
Country
Australia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Wollongong
Country
Australia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Woolloongabba
Country
Australia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Klagenfurt
Country
Austria
Individual Site Status
Recruiting
Facility Name
Research Site
City
Salzburg
Country
Austria
Individual Site Status
Recruiting
Facility Name
Research Site
City
Vienna
Country
Austria
Individual Site Status
Recruiting
Facility Name
Research Site
City
Brussels
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Research Site
City
Charleroi
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Research Site
City
Edegem
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Research Site
City
Gent
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Research Site
City
Hasselt
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Research Site
City
Roeselare
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Research Site
City
Ronse
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Research Site
City
Yvoir
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Research Site
City
Beijing
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Changchun
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Changsha
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Chengdu
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Chongqing
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Fuzhou
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Guangxi
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Guangzhou
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Hangzhou
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Harbin
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Jinan
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Linyi
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Nanchang
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Nanjing
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Qingdao
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Shanghai
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Shenyang
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Wuhan
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Xiamen
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Xinxiang
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Xuzhou
Country
China
Individual Site Status
Recruiting
Facility Name
Research Site
City
Zhengzhou
Country
China
Individual Site Status
Recruiting
Facility Name
Research SIte
City
Hořovice
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Olomouc
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Prague
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Praha 2
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Research Site
City
Brest
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Bron
Country
France
Individual Site Status
Recruiting
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Research Site
City
Caen
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Créteil
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Dijon Cedex
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Gleizé
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
La Tronche
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Limoges cedex
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Marseille
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Montpellier
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Mulhouse
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Nice
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Quimper
Country
France
Individual Site Status
Recruiting
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Research Site
City
Saint Herblain
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Saint-Priest-en-Jarez
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Strasbourg
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Tours Cedex 9
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
Villejuif
Country
France
Individual Site Status
Recruiting
Facility Name
Research Site
City
München
State/Province
Bayern
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Bad Berka
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Bonn
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Essen
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research site
City
Gauting
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Gießen
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Großhansdorf
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Halle (Saale)
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Jena
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kassel
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Köln
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Löwenstein
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Lübeck
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Offenbach
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Oldenburg
Country
Germany
Individual Site Status
Recruiting
Facility Name
Research Site
City
Athens
Country
Greece
Individual Site Status
Recruiting
Facility Name
Research Site
City
Heraklion
Country
Greece
Individual Site Status
Recruiting
Facility Name
Research Site
City
Larissa
Country
Greece
Individual Site Status
Recruiting
Facility Name
Research Site
City
Néa Kifisiá
Country
Greece
Individual Site Status
Recruiting
Facility Name
Research Site
City
Néo Fáliro
Country
Greece
Individual Site Status
Recruiting
Facility Name
Research Site
City
Thessaloníki
Country
Greece
Individual Site Status
Recruiting
Facility Name
Research Site
City
Volos
Country
Greece
Individual Site Status
Recruiting
Facility Name
Research Site
City
Hong Kong
Country
Hong Kong
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kowloon
Country
Hong Kong
Individual Site Status
Recruiting
Facility Name
Research Site
City
Shatin
Country
Hong Kong
Individual Site Status
Recruiting
Facility Name
Research Site
City
Budapest
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Research Site
City
Gyula
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Research Site
City
Gyöngyös
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Research Site
City
Székesfehérvár
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Research Site
City
Törökbálint
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Research Site
City
Dublin
Country
Ireland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Galway
Country
Ireland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Limerick
Country
Ireland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Alessandria
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Avellino
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Aviano
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Bari
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Brescia
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Candiolo
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Catania
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Firenze
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Genova
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Lecce
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Meldola
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Milano
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Milan
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Napoli
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Novara
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Parma
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Perugia
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Pesaro
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Ravenna
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Roma
Country
Italy
Individual Site Status
Recruiting
Facility Name
Research Site
City
Busan
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Research Site
City
Cheongju-si
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Research Site
City
Daegu
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Research Site
City
Hwasun
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Research Site
City
Incheon
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Research Site
City
Seongnam-si
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Research Site
City
Seoul
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Research Site
City
Suwon-si
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Research Site
City
Amsterdam
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Research Site
City
Breda
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Research Site
City
Den Haag
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Research Site
City
Maastricht
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Research Site
City
Nieuwegein
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Research Site
City
Nijmegen
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Research Site
City
Utrecht
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Research Site
City
Lublin
State/Province
Lubelskie
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Lublin
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Otwock
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Rzeszów
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Skorzewo
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Toruń
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Warszawa
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Łódź
Country
Poland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Almada
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Research Site
City
Braga
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Research Site
City
Coimbra
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Research Site
City
Guimarães
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Research Site
City
Lisboa
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Research Site
City
Lisbon
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Research Site
City
Loures
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Research Site
City
Porto
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Research Site
City
Santa Maria Da Feira
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Research Site
City
Setúbal
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Research Site
City
Vila Nova De Gaia
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Research Site
City
Baia Mare
Country
Romania
Individual Site Status
Recruiting
Facility Name
Research Site
City
Braşov
Country
Romania
Individual Site Status
Recruiting
Facility Name
Research Site
City
Bucharest
Country
Romania
Individual Site Status
Recruiting
Facility Name
Research Site
City
Bucuresti
Country
Romania
Individual Site Status
Recruiting
Facility Name
Research Site
City
Cluj-Napoca
Country
Romania
Individual Site Status
Recruiting
Facility Name
Research Site
City
Constanţa
Country
Romania
Individual Site Status
Recruiting
Facility Name
Research Site
City
Craiova
Country
Romania
Individual Site Status
Recruiting
Facility Name
Research Site
City
Iaşi
Country
Romania
Individual Site Status
Recruiting
Facility Name
Research Site
City
Timişoara
Country
Romania
Individual Site Status
Recruiting
Facility Name
Research Site
City
Chelyabinsk
Country
Russian Federation
Individual Site Status
Recruiting
Facility Name
Research Site
City
Izhevsk
Country
Russian Federation
Individual Site Status
Recruiting
Facility Name
Research Site
City
Kursk
Country
Russian Federation
Individual Site Status
Recruiting
Facility Name
Research Site
City
Moscow
Country
Russian Federation
Individual Site Status
Recruiting
Facility Name
Research Site
City
Nizhniy Novgorod
Country
Russian Federation
Individual Site Status
Recruiting
Facility Name
Research Site
City
Novosibirsk
Country
Russian Federation
Individual Site Status
Recruiting
Facility Name
Research Site
City
Omsk
Country
Russian Federation
Individual Site Status
Recruiting
Facility Name
Research Site
City
Saint Petersburg
Country
Russian Federation
Individual Site Status
Recruiting
Facility Name
Research Site
City
Saint-Petersburg
Country
Russian Federation
Individual Site Status
Recruiting
Facility Name
Research Site
City
Singapore
Country
Singapore
Individual Site Status
Recruiting
Facility Name
Research Site
City
A Coruña
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Alicante
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Badalona
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Barakaldo
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Cordoba
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Girona
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Granada
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
León
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Lugo
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Malaga
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Palma De Mallorca
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Santander
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Sevilla
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Valencia
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Zaragoza
Country
Spain
Individual Site Status
Recruiting
Facility Name
Research Site
City
Basel
Country
Switzerland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Thun
Country
Switzerland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Winterthur
Country
Switzerland
Individual Site Status
Recruiting
Facility Name
Research Site
City
Birmingham
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Edinburgh
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Glasgow
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Leicester
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Research Site
City
Manchester
Country
United Kingdom
Individual Site Status
Recruiting
12. IPD Sharing Statement
Plan to Share IPD
No
Learn more about this trial
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
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