Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options.

Inclusion Criteria: Patient with vascular malformation causing risk of one or more of the following based on unanimous assessment of designated physicians in the multidisciplinary Vascular Anomalies Team. airway/respiratory/visual/auditory/neurologic compromise; high output cardiac failure; life-threatening or disabling hemorrhage(cutaneous/GI/intracranial/ parenchymal/cavitary); skeletal distortion/destruction/erosion; life-threatening or disabling soft tissue distortion or destruction Patient must be felt to have failed, be unable to significantly benefit from, or be at risk for other available therapies, including surgeries, embolization, and sclerotherapy based on unanimous assessment of designated physicians in the multidisciplinary Vascular Anomalies Team. Patient must be felt to have one or more physical, imaging, photographic, physiologic or other measurable features that can be measured on a regular basis for preliminary evaluation of efficacy. The feature(s) must be agreed on by the designated physicians in the multidisciplinary Vascular Anomalies Team). Signed Patient informed consent. Exclusion Criteria: Pregnancy Patient nursing child. Female patient of childbearing potential unwilling to receive contraceptive counseling and use reliable contraceptive method. Patient enrolled in any other clinical trial involving an investigational agent (unless approved by the designated physicians on the multidisciplinary team) Parent or guardian or child unwilling to provide consent or assent.