Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS-Related Primary Central Nervous System Lymphoma
Lymphoma, Non-Hodgkin, HIV Infections
About this trial
This is an interventional treatment trial for Lymphoma, Non-Hodgkin focused on measuring Vincristine, Cyclophosphamide, Cytarabine, Dexamethasone, Doxorubicin, Granulocyte Colony-Stimulating Factor, Combined Modality Therapy, Acquired Immunodeficiency Syndrome, Antineoplastic Agents, Combined, Brain Neoplasms, Lymphoma, High-Grade, Lymphoma, Intermediate-Grade
Eligibility Criteria
Inclusion Criteria Concurrent Medication: Required: PCP prophylaxis with Bactrim, dapsone, or aerosolized pentamidine. Oral candidiasis prophylaxis with fluconazole, ketoconazole, or clotrimazole oral troches. Antiretroviral agent available by therapy IND. MAI prophylaxis with rifabutin (in patients with CD4 counts < 100 cells/mm3). Patients must have: HIV infection. Primary CNS lymphoma with NO systemic involvement. Prior Medication: Allowed: Prior corticosteroids. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: Concomitant malignancy other than Kaposi's sarcoma, curatively treated carcinoma in situ of the cervix, or squamous or basal cell carcinoma of the skin. Active uncontrolled infection. Renal failure, active nonmalignant duodenal ulcer, uncontrolled diabetes mellitus, or other serious medical conditions that would preclude aggressive cytotoxic chemotherapy administration. Active heart disease (congestive heart failure or heart block greater than first degree on EKG). Concurrent Medication: Excluded: Any investigational agent other than antiretroviral agents available by therapy IND. Patients with the following prior conditions are excluded: No prior malignancy other than Kaposi's sarcoma, curatively treated carcinoma in situ of the cervix, or squamous cell or basal cell carcinoma of the skin. No new infectious complications within the past 2 weeks that require a change in antibiotics. History of myocardial infarction within the past 3 months. Prior Medication: Excluded: Prior chemotherapy other than for Kaposi's sarcoma.
Sites / Locations
- San Francisco AIDS Clinic / San Francisco Gen Hosp
- San Francisco Gen Hosp
- Univ of Colorado Health Sciences Ctr
- Beth Israel Deaconess - West Campus
- ECOG Data Management Office
- Mount Sinai Med Ctr
- Julio Arroyo