Phase I/II Clinical Trial of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) in Canada
COVID-19
About this trial
This is an interventional prevention trial for COVID-19 focused on measuring COVID-19, vaccine, Ad5, Safety, Immunogenicity, Dose-escalation, SARS-CoV-2
Eligibility Criteria
Inclusion criteria for the phase I portion of the study:
- Healthy adults from 18 to <55 and 65-<85 years of age at the time of enrollment;
- Able to provide consent to participate in and having signed an Informed Consent Form (ICF);
- Able and willing to complete all the scheduled study procedures during the whole study follow-up period (about 6-8 months, depending on group);
- Negative result of HIV, hepatitis B and C screening;
- Oral temperature < 38.0℃;
- Negative IgG and IgM antibodies against COVID-19;
- Negative result of real-time quantitative PCR screening of nasopharyngeal swabs/sputum for SARS-CoV-2;
- A body mass index (BMI) between 18-35;
- Hematological examination is within normal range, or no greater than a grade 1 abnormality and no clinical significance as assessed by the study investigator (including white blood cell count, lymphocyte count, neutrophil count, eosinophil count, platelet, hemoglobin, alanine aminotransferase ALT, aspartate aminotransferase AST, total bilirubin, blood glucose and creatinine);
- Transient mild laboratory abnormalities may be rescreened once and the participant will be deemed eligible if the laboratory repeat test is normal as per local laboratory normal values and investigator assessment.
- Good general health status, as determined by history and physical examination no greater than 14 days prior to administration of the test article.
- If female of child-bearing potential and heterosexually active, has practiced adequate contraception for 30 days prior to injection, has a negative pregnancy test on the day of injection, and has agreed to continue adequate contraception until 180 days after injection. (Please refer to the glossary for the definition of child-bearing potential and adequate contraception).
Inclusion criteria for the phase II portion of the study will be detailed in an amended synopsis/study protocol.
Exclusion criteria for the phase I portion of the study:
- Personal history of seizure disorder, encephalopathy or psychosis;
- Allergic history to any vaccine, or allergic to any ingredient of the Ad5-nCoV;
- Woman is pregnant or lactating, positive urine pregnancy test or plan to become pregnant during the next 6 months;
- Any acute febrile disease (oral temperature ≥38.0℃ or active infectious disease on the day of vaccination;
- Medical history of SARS (SARS-CoV-1);
- Serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension not controlled with medication;
- Serious chronic disease such as asthma, diabetes and thyroid disease, etc.;
- Congenital or acquired angioedema;
- Immunodeficiency, asplenia or functional asplenia;
- Platelet disorder or other bleeding disorder that may cause intramuscular injection contraindication;
- Immunosuppressive medication, anti-allergic, cytotoxic therapy, inhaled corticosteroids (excluding corticosteroid spray for allergic rhinitis, surface corticosteroid therapy for acute non-complicated dermatitis) in the last 6 months;
- Prior administration of blood products in last 4 months;
- Other vaccination(s) or investigational drugs within 1 month before study onset, or planned use during the study period;
- Prior administration of live attenuated vaccine within 1 month before study onset;
- Prior administration of subunit or inactivated vaccine within 14 days before study onset;
- Current anti-tuberculosis therapy;
- Any condition that in the opinion of the investigators may interfere with the participants' compliance or evaluation of study objectives or informed consent (i.e. medical, psychological, social or other conditions, etc.) Exclusion criteria for the phase II portion of the study will be detailed in an amended synopsis/study protocol.
Sites / Locations
- Canadian Center for Vaccinology
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Arm 9
Arm 10
Arm 11
Arm 12
Arm 13
Arm 14
Arm 15
Arm 16
Arm 17
Arm 18
Arm 19
Arm 20
Arm 21
Arm 22
Arm 23
Arm 24
Arm 25
Arm 26
Arm 27
Arm 28
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Experimental
Placebo Comparator
phase ⅠLow single dose (18-<55)
phase ⅠPlacebo low single dose (18-<55)
phase ⅠLow 2 dose (18-<55)
phase ⅠPlacebo low 2 dose (18-<55)
phase ⅠLow single dose (65-<85)
phase ⅠPlacebo low single dose (65-<85)
phase ⅠLow 2 dose (65-<85)
phase ⅠPlacebo low 2 dose (65-<85)
phase ⅠMedium single dose (65-<85)
phase ⅠPlacebo medium single dose (65-<85)
phase ⅠMedium 2 dose (65-<85)
phase ⅠPlacebo medium 2 dose (65-<85)
Phase II Low single dose (18-<55)
Phase II placebo low single dose (18-<55)
Phase II Low 2 dose (18-<55)
Phase II placebo low 2 dose (18-<55)
Phase II Low single dose (55-<85)
Phase II placebo low single dose (55-<85)
Phase II Low 2 dose (55-<85)
Phase II placebo low 2 dose (55-<85)
Phase II medium single dose (55-<85)
Phase II placebo medium single dose (55-<85)
Phase II medium 2 dose (55-<85)
Phase II placebo medium 2 dose (55-<85)
Phase II Low 1 or 2 dose (18-<55)
Phase II placebo 1 or 2 dose (18-<55)
Phase II Low or medium dosage 1 or 2 dose (55-<85)
Phase II placebo Low or medium,1 or 2 dose (55-<85)
12 subjects, Ad5-nCoV containing 5E10 vp, single dose, Intramuscular administration
6 subjects, Placebo containing 0 vp, single dose, Intramuscular administration
12 subjects, Ad5-nCoV containing 5E10 vp, 2 dose 56 days apart, Intramuscular administration
6 subjects, Placebo containing 0 vp, 2 dose 56 days apart, Intramuscular administration
12 subjects, Ad5-nCoV containing 5E10 vp, single dose, Intramuscular administration
3 subjects, Placebo containing 0 vp, single dose, Intramuscular administration
12 subjects, Ad5-nCoV containing 5E10 vp, 2 dose 56 days apart, Intramuscular administration
3 subjects, Placebo containing 0 vp, 2 dose 56 days apart, Intramuscular administration
12 subjects, Ad5-nCoV containing 10E10 vp, single dose, Intramuscular administration
3 subjects, Placebo containing 0 vp, single dose, Intramuscular administration
12 subjects, Ad5-nCoV containing 10E10 vp, 2 dose 56 days apart, Intramuscular administration
3 subjects, Placebo containing 0 vp, 2 dose 56 days apart, Intramuscular administration
50 subjects, Ad5-nCoV containing 5E10 vp, single dose, Intramuscular administration
10 subjects,Placebo containing 0 vp, single dose, Intramuscular administration
50 subjects, Ad5-nCoV containing 5E10 vp, 2 dose 56 days apart, Intramuscular administration
10 subjects,Placebo containing 0 vp, 2 dose 56 days apart, Intramuscular administration
50 subjects, Ad5-nCoV containing 5E10 vp, single dose, Intramuscular administration
10 subjects,Placebo containing 0 vp, single dose, Intramuscular administration
50 subjects, Ad5-nCoV containing 5E10 vp, 2 dose 56 days apart, Intramuscular administration
10 subjects,Placebo containing 0 vp, 2 dose 56 days apart, Intramuscular administration
50 subjects, Ad5-nCoV containing 10E10 vp, single dose, Intramuscular administration
10 subjects,Placebo containing 0 vp, single dose, Intramuscular administration
50 subjects,Ad5-nCoV containing 10E10 vp, 2 dose 56 days apart, Intramuscular administration
10 subjects,Placebo containing 0 vp, 2 dose 56 days apart, Intramuscular administration
100 subjects,Ad5-nCoV containing 5E10 vp, 1or2 dose, Intramuscular administration ,according to the Previous trial results
20 subjects,placebo containing 0 vp, 1or2 dose, Intramuscular administration
100 subjects,Ad5-nCoV containing 5E10 vp or 10E10vp, 1or2 dose, Intramuscular administration,according to the Previous trial results
20 subjects,placebo containing 0 vp, 1or2 dose, Intramuscular administration