search
Back to results

Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma (ACT IV)

Primary Purpose

Glioblastoma, Small Cell Glioblastoma, Giant Cell Glioblastoma

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Rindopepimut (CDX-110) with GM-CSF
Temozolomide
KLH
Sponsored by
Celldex Therapeutics
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Glioblastoma focused on measuring EGFRvIII, Glioblastoma, Small cell, Giant cell, Gliosarcoma, oligodendroglial, Brain Cancer, Brain Tumor, radiotherapy, chemoradiation, Tumor, temozolomide, EGFR variant III

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria-

Among other criteria, patients must meet the following conditions to be eligible for the study:

  1. Adult patients, ≥ 18 years old
  2. Newly diagnosed glioblastoma
  3. Attempted surgical resection followed by conventional chemoradiation
  4. Documented EGFRvIII positive tumor status by a Sponsor designated laboratory
  5. No evidence of progressive disease from the post-operative period to the post-chemoradiation period
  6. Candidate for, and agrees to receive, adjuvant (maintenance) temozolomide therapy
  7. Systemic corticosteroid therapy at ≤2 mg of dexamethasone or equivalent per day for at least 3 days prior to randomization
  8. WHO-ECOG Performance Status ≤ 2
  9. Patients of childbearing/reproductive potential will be instructed to use birth control as defined by your doctor.

Exclusion Criteria-

Among other criteria, patients who meet the following conditions are NOT eligible for the study:

  1. Stereotactic biopsy only (without further surgical resection)
  2. Presence of diffuse leptomeningeal disease, gliomatosis cerebri, or infratentorial disease.
  3. History, presence, or suspicion of metastatic disease
  4. Patients who have received any additional treatment for glioblastoma, aside from surgical resection and chemoradiation with temozolomide
  5. Active systemic infection requiring treatment
  6. History of any malignancy (other than glioblastoma) during the last three years except non-melanoma skin cancer, in situ cervical cancer, treated superficial bladder cancer, cured, early-stage prostate cancer in a patient with PSA level less than ULN,or other carcinoma in situ that has been adequately treated and cured.
  7. Planned major surgery
  8. Evidence of current drug or alcohol abuse
  9. Known allergy or hypersensitivity to keyhole limpet hemocyanin (KLH), GM-CSF (sargramostim; LEUKINE®), polysorbate 80 or yeast derived products, or a history of anaphylactic reactions to shellfish proteins
  10. Severe acute or chronic medical or psychiatric condition or laboratory abnormality that could increase the risk associated with participating in a clinical trial
  11. Women who are pregnant or lactating

Sites / Locations

  • University of Alabama at Birmingham
  • University of South Alabama Mitchell Cancer Institute
  • Barrow Neurological Institute at St. Joseph's Hospital and Medical Center
  • University of Arizona Health Network
  • University of Arkansas for Medical Sciences
  • City of Hope Cancer Center
  • UC San Diego Moores Cancer Center
  • USC Norris Comprehensive Cancer Center
  • Chao Family Comprehensive Cancer Center
  • Kaiser Permanente, Redwood City Medical Center
  • University of California, Davis
  • University of California, San Francisco
  • Stanford Cancer Institute, Stanford University
  • Hartford Hospital
  • Yale University Medical Center
  • Christiana Care Health Services
  • University of Florida
  • Mount Sinai Medical Center, Comprehensive Cancer Center
  • MD Anderson Cancer Center Orlando
  • Tampa General Hospital
  • Atlanta Cancer Care
  • Winship Cancer Institute, Emory University School of Medicine
  • Georgia Regents University
  • Kaiser Permanente Hawaii Moanalua Medical Center
  • Northwestern University Robert H. Lurie Comprehensive Cancer Center
  • Rush University Medical Center
  • University of Chicago
  • North Shore University Health System
  • Loyola University Medical Center
  • Covenant Clinic / Iowa Spine and Brain Institute
  • University of Kentucky
  • Norton Cancer Institute
  • Mary Bird Perkins Cancer Center
  • LSU Health Sciences Center, Feist-Weiller Cancer Center
  • Anne Arundel Medical Center
  • Johns Hopkins University School of Medicine
  • Center for Cancer and Blood Disorders, PC
  • Dana-Farber Cancer Institute and Mass General Hospital
  • Dana-Farber Cancer Institute
  • University of Massachusetts Memorial Medical Center
  • University of Michigan Health System
  • Edward W. Sparrow Hospital Association - Sparrow Regional Cancer Center
  • St. Mary's of Michigan Medical Center/Field Neurosciences Institute
  • Allina Health, Abbott Northwestern Hospital, John Nasseff Neuroscience Institute
  • Ellis Fischel Cancer Center
  • Washington University in St. Louis
  • Southeast Nebraska Cancer Center
  • Dartmouth Hitchcock Medical Center
  • New Jersey Neuroscience Institute, JFK Medical Center
  • John Theurer Cancer Center at Hackensack University Medical Center
  • Monmouth Medical Center
  • Dent Neurosciences Research Institute
  • Montefiore Medical Center
  • New York Methodist Hospital
  • The Long Island Brain Tumor Center at Neurology Surgery, P.C.
  • North Shore University Hospital
  • Columbia University Medical Center - The Neurologic Institute of New York
  • Weill Cornell Medical College
  • University of Rochester Medical Center
  • SUNY Upstate Medical University
  • Brain and Spine Surgeons of New York
  • The Preston Robert Tisch Brain Tumor Center at Duke University Medical Center
  • Wake Forest Baptist Health
  • University of Cincinnati Cancer Institute
  • University Hospitals, Case Medical Center (Cleveland)
  • Cleveland Clinic Foundation
  • Ohio State University
  • Providence Portland Medical Center, Oncology & Hematology Care
  • Pacific Neurosurgical
  • Lehigh Valley Physician Group-Hematology-Oncology Associates
  • University of Pennsylvania
  • Temple University Hospital
  • West Penn. Allegheny Health System
  • University of Pittsburgh Cancer Institute
  • Medical University of South Carolina - Department of Neuroscience
  • University of Tennessee Medical Center - Knoxville
  • Sarah Cannon Research Institute
  • Vanderbilt-Ingram Cancer Center
  • Texas Oncology Midtwon
  • Baylor Research Institute
  • The Methodist Neurological Institute
  • University of Utah Department of Neurosurgery
  • Fletcher Allen Health Care
  • University of Virginia Healthcare System
  • Swedish Neuroscience Institute
  • University of Washington Medical Center
  • University of Wisconsin Paul P Carbone Comprehensive Cancer Center
  • Medical College of Wisconsin
  • Prince of Wales Hospital
  • Royal North Shore Hospital
  • The Crown Princess Mary Cancer Centre, Westmead Hospital
  • Royal Brisbane and Women's Hospital
  • Mater Adult Hospital, Mater Misericordiae Health Services Brisbane Limited
  • Royal Adelaide Hospital
  • Calvary North Adelaide Hospital
  • Royal Hobart Hospital
  • Launceston General Hospital
  • Monash Medical Centre
  • Austin Health
  • Epworth Healthcare
  • Sir Charles Gairdner Hospital
  • Liverpool Hospital
  • Medical University Innsbruck, Dept of Neurology, Anichstrabe 35
  • Medizinische Universität Wien, Innere Medizin I, Onkologie
  • Universitair Ziekenhuis Antwerpen
  • ZNA Middelheim
  • Ghent University Hospital
  • Hospital Mae de Deus-Centro de Pesquisa em Oncologia Clinica
  • Centro de Pesquisas Clinicas da Fundação Dr Amaral Carvalho
  • Fundação Faculdade Regional de Medicina de de São José do Rio Preto - Hospital de Base
  • Instituto Nacional do Cancer (INCA)
  • Hospital Albert Einstein
  • Instituto do Câncer do Estado de São Paulo - ICESP
  • Real e Benemerita Associação Portuguesa de Beneficiência/ Hospital São José
  • Hospital A C Camargo
  • Foothills Hospital Medical Centre
  • British Columbia Cancer Agency, Vancouver Clinic
  • BC Cancer Agency - Vancouver Island Centre
  • University of Manitoba-Cancer Care Manitoba
  • QEII Health Sciences Centre
  • Juravinski Cancer Centre
  • London Regional Cancer Program, London Health Sciences Centre
  • Ottawa Hospital, Regional Cancer Centre
  • Sunnybrook Health Sciences Centre
  • Centre Hospitalier de l'Universite de Montreal (CHUM) - Hopital Notre-Dame
  • Montreal Neurological Institute and Hospital
  • CHUS Hôpital Fleurimont
  • CHUQ L'Hotel Dieu de Qujebec
  • Fundacion Santa Fe
  • Hospital Ceske Budejovice
  • Umiversity Hospital (Fakultni Nemocnice)
  • Hospital Na Homolce
  • Multiscan s.r.o.
  • Masaryk´s Hospital Usti nad Labem
  • Institut de Cancerologie de I'Quest-Paul Papin
  • Institute Bergonie
  • Centre Leon Berard de Lyon
  • ICM Val d'Aurel Montpellier
  • Institut de Cancerologie de L'Quest-Center Rane Gauducheau
  • Service de Neurologie-GH
  • Centre Eugene Marquis
  • Institut de Cancerologie de l'ouest-Center Rene Gauducheau
  • Institut Gustave Roussy
  • Klinik und Poliklinik fur Neurologie der Universitat Regensburg
  • Strahlenklinik Universitatsklinikum Erlangen
  • Dr. Senchkenbergisches Institut fur Neuroonkologie
  • University Hospital Hamburg Kopf und Neurozentrum
  • Universitaetsklinikum Heidelberg, Neurologische Klinik, IM Neuenheimer Feld 672
  • University Medical Centre
  • Universitaetsklinikum Muenster
  • LMU Munich
  • NNA
  • "HYGEIA" Hospital
  • Országos Onkológiai Intézet Sugárterápiás Osztály
  • Debreceni Egyetem Orvos- és Egészségtudományi Centrum Onkológiai Intézet
  • Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház, Sugárterápiás Osztály
  • Pécsi Tudományegyetem Általános Orvostudományi Kar
  • Szegedi Tudományegyetem Onkoterápiás Klinika
  • Vas Megyei Markusovszky Lajos Általános Rehabilitációs és Gyógyfürdő Kórház, Egyetemi Oktatókórház Nonprofit Zrt
  • City Cancer Centre, Vijayawada
  • HCG - Bangalore Institute of Oncology, Bangalore
  • Amrita Institute of Medical Sciences and Research Centre, Kochi
  • Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram
  • Marathwada Regional Cancer Centre and Research Institute - Government
  • Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute
  • Tata Memorial Hospital , Mumbai
  • Indraprastha Apollo Hospital, New Delhi
  • Sahyadri Hospitals Limited
  • Dr. Rai Memorial Medical Centre, Chennai
  • HCG Shanti Mukand Hospital - Curie Cancer Centre, Delhi
  • Soroka University M.C.
  • Rambam Health Care Campus
  • Hadassah Medical Center
  • SHEBA Medical Center
  • Tel-Aviv Sourasky Medical Center
  • UO Oncologie Medica Dipartimento Oncologico
  • Fondazione IRCCS Instituto Neurologico Carlo Besta
  • Sacred Heart Catholic University
  • Universita e AO Citta delia Scienza, Universita Di Torino
  • Grupo Médico Camino S.C.
  • Hospital Civil de Guadalajara "Fray Antonio Alcalde"
  • Ensayos Clínicos y Medicina de Alta Especialidad, S.C.
  • Servicios Medicos de Investigacion Clinica Sc
  • Hospital Central "Ignacio Morones Prieto"
  • Medisch Centrum Haaglanden
  • VUMC
  • Radboud University Nijmegen Medical Center
  • Christchurch Hospital
  • Palmerston North Hospital
  • Waikato Hospital, Regional Cancer Centre
  • Waikato Hospital, Regional Cancer Center
  • Hospital Almanzor Aguinaga Asenjo
  • Instituto Oncologico Miraflores
  • Clinica Anglo Americana
  • Clinica Ricardo Palma
  • Oncosalud
  • Institut Catala d Oncologia
  • Dra. Sonia Del Barco Berron, ICO Girona Avda,
  • Hospital Clinic
  • ICO Badalona-Hospital Germans Trias i Pujol
  • Hospital 12 de Octubre
  • Kantonsspital Aarau Medizinische Onkologie Tellstrasse
  • CHUV, Centre Hospitalier Universitaire Vaudois
  • Oncology Institute of Southern Switzerland (IOSI)
  • Inselspital, Universitatsspital Bern, Universitatsklinik fur Medizinische Onkologie, Freiburgstrasse
  • Hopitaux Universitaires de Geneve-HUG-Centre d'Oncologie
  • Brain Tumor Center, University Hospital Zurich
  • National Cheng Kung University Hospital
  • Kaohsiung Chang Gung Memorial Hospital
  • Chang Gung Memorial Hospital Linkou Branch
  • Taichung Veterans General Hospital
  • Chi Mei Medical Center
  • Tri-Service General Hospital
  • Siriraj Hospital
  • King Chulalongkorn Memorial Hospital
  • Maharaj Nakorn Chiang Mai Hospital
  • Songkhlanagarind Hospital
  • Royal Marsden NHS Foundation Trust
  • The Bristol Haematology and Oncology Centre
  • Edinburgh Cancer Centre Western General Hospital
  • Beatson West of Scotland Cancer Centrel
  • Guy's and St Thomas' NHS, Westminister Bridge Road
  • Nottingham City Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Rindopepimut/GM-CSF plus Temozolomide

KLH plus Temozolomide

Arm Description

Outcomes

Primary Outcome Measures

Overall Survival
The primary efficacy endpoint of Overall Survival is defined as the number of months from randomization to the date of death (whatever the cause), and will be censored for patients who remain alive at completion of the study for patients with a gross total resection (~n=374). The overall survival of patients will be monitored and compared between the two study arms until the end of the study.

Secondary Outcome Measures

Progression-free survival
Compare progression-free survival between the two treatment arms
Safety and Tolerability
Safety and tolerability will be measured by comparing the two arms in regards to vital sign measurement, physical and neurological examination, adverse events reporting, ECOG performance status, and EORTC core Quality of Life Questionnaire

Full Information

First Posted
November 21, 2011
Last Updated
January 11, 2018
Sponsor
Celldex Therapeutics
search

1. Study Identification

Unique Protocol Identification Number
NCT01480479
Brief Title
Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma
Acronym
ACT IV
Official Title
An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF With Adjuvant Temozolomide in Patients With Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma
Study Type
Interventional

2. Study Status

Record Verification Date
April 2017
Overall Recruitment Status
Completed
Study Start Date
November 2011 (undefined)
Primary Completion Date
November 2016 (Actual)
Study Completion Date
November 2016 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Celldex Therapeutics

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
This 2-arm, randomized, phase III study will investigate the efficacy and safety of the addition of rindopepimut (an experimental cancer vaccine that may act to promote anti-cancer effects in patients who have tumors that express the EGFRvIII protein) to the current standard of care (temozolomide) in patients with recently diagnosed glioblastoma, a type of brain cancer. All patients will be administered temozolomide, the standard treatment for glioblastoma. Half the patients will be randomly assigned to receive rindopepimut and half the patients will be randomly assigned to receive a control called keyhole limpet hemocyanin. Patients will be treated in a blinded fashion (neither the patient or the doctor will know which arm of the study the patient is on). Patients will be treated until disease progression or intolerance to therapy and all patients will be followed for survival.
Detailed Description
The purpose of this research study is to find out whether adding an experimental vaccine called rindopepimut (also known as CDX-110) to the commonly used chemotherapy drug temozolomide can help improve the life expectancy of patients with newly diagnosed, resected EGFRvIII positive glioblastoma. The duration of participation in this study may be up to 5 years. After you are screened and enrolled in the study, you will be administered temozolomide and either rindopepimut/GM-CSF or KLH until either disease progression or intolerance to the medications. If your tumor progresses while on this study, your doctor may treat you with other therapies that are not part of the study.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Glioblastoma, Small Cell Glioblastoma, Giant Cell Glioblastoma, Gliosarcoma, Glioblastoma With Oligodendroglial Component
Keywords
EGFRvIII, Glioblastoma, Small cell, Giant cell, Gliosarcoma, oligodendroglial, Brain Cancer, Brain Tumor, radiotherapy, chemoradiation, Tumor, temozolomide, EGFR variant III

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigator
Allocation
Randomized
Enrollment
745 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Rindopepimut/GM-CSF plus Temozolomide
Arm Type
Experimental
Arm Title
KLH plus Temozolomide
Arm Type
Active Comparator
Intervention Type
Drug
Intervention Name(s)
Rindopepimut (CDX-110) with GM-CSF
Other Intervention Name(s)
CDX-110 with sargramostim (GM-CSF) (Leukine®)
Intervention Description
Two intradermal injections two weeks apart, followed by monthly injections until tumor progression or intolerance. Each dose will be 0.8 mL containing approximately 500 mcg CDX-110 and 150 mcg GM CSF.
Intervention Type
Drug
Intervention Name(s)
Temozolomide
Other Intervention Name(s)
Temodar, Temodal
Intervention Description
150 to 200 mg/m2 for 5 days during each 28-day cycle for a minimum of six cycles or a maximum of 12 cycles, or until intolerance or progression.
Intervention Type
Drug
Intervention Name(s)
KLH
Intervention Description
Two intradermal injections two weeks apart, followed by monthly injections until tumor progression or intolerance. Each dose will be 0.8mL containing approximately 100mcg of KLH.
Primary Outcome Measure Information:
Title
Overall Survival
Description
The primary efficacy endpoint of Overall Survival is defined as the number of months from randomization to the date of death (whatever the cause), and will be censored for patients who remain alive at completion of the study for patients with a gross total resection (~n=374). The overall survival of patients will be monitored and compared between the two study arms until the end of the study.
Time Frame
During treatment and every three months from end of treatment through end of study or approximately up to 5 years.
Secondary Outcome Measure Information:
Title
Progression-free survival
Description
Compare progression-free survival between the two treatment arms
Time Frame
Every 12 weeks from Day 1 through progression or initiation of other anti-cancer therapy
Title
Safety and Tolerability
Description
Safety and tolerability will be measured by comparing the two arms in regards to vital sign measurement, physical and neurological examination, adverse events reporting, ECOG performance status, and EORTC core Quality of Life Questionnaire
Time Frame
Until day 28 of follow up

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria- Among other criteria, patients must meet the following conditions to be eligible for the study: Adult patients, ≥ 18 years old Newly diagnosed glioblastoma Attempted surgical resection followed by conventional chemoradiation Documented EGFRvIII positive tumor status by a Sponsor designated laboratory No evidence of progressive disease from the post-operative period to the post-chemoradiation period Candidate for, and agrees to receive, adjuvant (maintenance) temozolomide therapy Systemic corticosteroid therapy at ≤2 mg of dexamethasone or equivalent per day for at least 3 days prior to randomization WHO-ECOG Performance Status ≤ 2 Patients of childbearing/reproductive potential will be instructed to use birth control as defined by your doctor. Exclusion Criteria- Among other criteria, patients who meet the following conditions are NOT eligible for the study: Stereotactic biopsy only (without further surgical resection) Presence of diffuse leptomeningeal disease, gliomatosis cerebri, or infratentorial disease. History, presence, or suspicion of metastatic disease Patients who have received any additional treatment for glioblastoma, aside from surgical resection and chemoradiation with temozolomide Active systemic infection requiring treatment History of any malignancy (other than glioblastoma) during the last three years except non-melanoma skin cancer, in situ cervical cancer, treated superficial bladder cancer, cured, early-stage prostate cancer in a patient with PSA level less than ULN,or other carcinoma in situ that has been adequately treated and cured. Planned major surgery Evidence of current drug or alcohol abuse Known allergy or hypersensitivity to keyhole limpet hemocyanin (KLH), GM-CSF (sargramostim; LEUKINE®), polysorbate 80 or yeast derived products, or a history of anaphylactic reactions to shellfish proteins Severe acute or chronic medical or psychiatric condition or laboratory abnormality that could increase the risk associated with participating in a clinical trial Women who are pregnant or lactating
Facility Information:
Facility Name
University of Alabama at Birmingham
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
Facility Name
University of South Alabama Mitchell Cancer Institute
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36604
Country
United States
Facility Name
Barrow Neurological Institute at St. Joseph's Hospital and Medical Center
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85013
Country
United States
Facility Name
University of Arizona Health Network
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85724
Country
United States
Facility Name
University of Arkansas for Medical Sciences
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
City of Hope Cancer Center
City
Duarte
State/Province
California
ZIP/Postal Code
91010
Country
United States
Facility Name
UC San Diego Moores Cancer Center
City
La Jolla
State/Province
California
ZIP/Postal Code
92093
Country
United States
Facility Name
USC Norris Comprehensive Cancer Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Chao Family Comprehensive Cancer Center
City
Orange
State/Province
California
ZIP/Postal Code
92868
Country
United States
Facility Name
Kaiser Permanente, Redwood City Medical Center
City
Redwood City
State/Province
California
ZIP/Postal Code
94063
Country
United States
Facility Name
University of California, Davis
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
Facility Name
University of California, San Francisco
City
San Francisco
State/Province
California
ZIP/Postal Code
94143
Country
United States
Facility Name
Stanford Cancer Institute, Stanford University
City
Stanford
State/Province
California
ZIP/Postal Code
94305
Country
United States
Facility Name
Hartford Hospital
City
Hartford
State/Province
Connecticut
ZIP/Postal Code
06102
Country
United States
Facility Name
Yale University Medical Center
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06520
Country
United States
Facility Name
Christiana Care Health Services
City
Newark
State/Province
Delaware
ZIP/Postal Code
19713
Country
United States
Facility Name
University of Florida
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32611
Country
United States
Facility Name
Mount Sinai Medical Center, Comprehensive Cancer Center
City
Miami Beach
State/Province
Florida
ZIP/Postal Code
33140
Country
United States
Facility Name
MD Anderson Cancer Center Orlando
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Facility Name
Tampa General Hospital
City
Tampa
State/Province
Florida
ZIP/Postal Code
33606
Country
United States
Facility Name
Atlanta Cancer Care
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30005
Country
United States
Facility Name
Winship Cancer Institute, Emory University School of Medicine
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30322
Country
United States
Facility Name
Georgia Regents University
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
Facility Name
Kaiser Permanente Hawaii Moanalua Medical Center
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96819
Country
United States
Facility Name
Northwestern University Robert H. Lurie Comprehensive Cancer Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611
Country
United States
Facility Name
Rush University Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
University of Chicago
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Facility Name
North Shore University Health System
City
Evanston
State/Province
Illinois
ZIP/Postal Code
60201
Country
United States
Facility Name
Loyola University Medical Center
City
Maywood
State/Province
Illinois
ZIP/Postal Code
60153
Country
United States
Facility Name
Covenant Clinic / Iowa Spine and Brain Institute
City
Waterloo
State/Province
Iowa
ZIP/Postal Code
50702
Country
United States
Facility Name
University of Kentucky
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40536-0093
Country
United States
Facility Name
Norton Cancer Institute
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Facility Name
Mary Bird Perkins Cancer Center
City
Baton Rouge
State/Province
Louisiana
ZIP/Postal Code
70809
Country
United States
Facility Name
LSU Health Sciences Center, Feist-Weiller Cancer Center
City
Shreveport
State/Province
Louisiana
ZIP/Postal Code
71103
Country
United States
Facility Name
Anne Arundel Medical Center
City
Annapolis
State/Province
Maryland
ZIP/Postal Code
21401
Country
United States
Facility Name
Johns Hopkins University School of Medicine
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21231
Country
United States
Facility Name
Center for Cancer and Blood Disorders, PC
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20817
Country
United States
Facility Name
Dana-Farber Cancer Institute and Mass General Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02115
Country
United States
Facility Name
Dana-Farber Cancer Institute
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
University of Massachusetts Memorial Medical Center
City
Worcester
State/Province
Massachusetts
ZIP/Postal Code
01655
Country
United States
Facility Name
University of Michigan Health System
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Facility Name
Edward W. Sparrow Hospital Association - Sparrow Regional Cancer Center
City
Lansing
State/Province
Michigan
ZIP/Postal Code
48912
Country
United States
Facility Name
St. Mary's of Michigan Medical Center/Field Neurosciences Institute
City
Saginaw
State/Province
Michigan
ZIP/Postal Code
48604
Country
United States
Facility Name
Allina Health, Abbott Northwestern Hospital, John Nasseff Neuroscience Institute
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55407
Country
United States
Facility Name
Ellis Fischel Cancer Center
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65203
Country
United States
Facility Name
Washington University in St. Louis
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Southeast Nebraska Cancer Center
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68510
Country
United States
Facility Name
Dartmouth Hitchcock Medical Center
City
Lebanon
State/Province
New Hampshire
ZIP/Postal Code
03756
Country
United States
Facility Name
New Jersey Neuroscience Institute, JFK Medical Center
City
Edison
State/Province
New Jersey
ZIP/Postal Code
08818
Country
United States
Facility Name
John Theurer Cancer Center at Hackensack University Medical Center
City
Hackensack
State/Province
New Jersey
ZIP/Postal Code
07601
Country
United States
Facility Name
Monmouth Medical Center
City
Long Branch
State/Province
New Jersey
ZIP/Postal Code
07740
Country
United States
Facility Name
Dent Neurosciences Research Institute
City
Amherst
State/Province
New York
ZIP/Postal Code
14226
Country
United States
Facility Name
Montefiore Medical Center
City
Bronx
State/Province
New York
ZIP/Postal Code
10467
Country
United States
Facility Name
New York Methodist Hospital
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11215
Country
United States
Facility Name
The Long Island Brain Tumor Center at Neurology Surgery, P.C.
City
Great Neck
State/Province
New York
ZIP/Postal Code
11021
Country
United States
Facility Name
North Shore University Hospital
City
Manhasset
State/Province
New York
ZIP/Postal Code
11030-3186
Country
United States
Facility Name
Columbia University Medical Center - The Neurologic Institute of New York
City
New York
State/Province
New York
ZIP/Postal Code
10032
Country
United States
Facility Name
Weill Cornell Medical College
City
New York
State/Province
New York
ZIP/Postal Code
10065
Country
United States
Facility Name
University of Rochester Medical Center
City
Rochester
State/Province
New York
ZIP/Postal Code
14642
Country
United States
Facility Name
SUNY Upstate Medical University
City
Syracuse
State/Province
New York
ZIP/Postal Code
13210
Country
United States
Facility Name
Brain and Spine Surgeons of New York
City
White Plains
State/Province
New York
ZIP/Postal Code
10604
Country
United States
Facility Name
The Preston Robert Tisch Brain Tumor Center at Duke University Medical Center
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27710
Country
United States
Facility Name
Wake Forest Baptist Health
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157
Country
United States
Facility Name
University of Cincinnati Cancer Institute
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267
Country
United States
Facility Name
University Hospitals, Case Medical Center (Cleveland)
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
Cleveland Clinic Foundation
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
Ohio State University
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Providence Portland Medical Center, Oncology & Hematology Care
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213
Country
United States
Facility Name
Pacific Neurosurgical
City
Portland
State/Province
Oregon
ZIP/Postal Code
97227
Country
United States
Facility Name
Lehigh Valley Physician Group-Hematology-Oncology Associates
City
Allentown
State/Province
Pennsylvania
ZIP/Postal Code
18103
Country
United States
Facility Name
University of Pennsylvania
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Facility Name
Temple University Hospital
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19140
Country
United States
Facility Name
West Penn. Allegheny Health System
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Facility Name
University of Pittsburgh Cancer Institute
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15232
Country
United States
Facility Name
Medical University of South Carolina - Department of Neuroscience
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Facility Name
University of Tennessee Medical Center - Knoxville
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37920
Country
United States
Facility Name
Sarah Cannon Research Institute
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Facility Name
Vanderbilt-Ingram Cancer Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232
Country
United States
Facility Name
Texas Oncology Midtwon
City
Austin
State/Province
Texas
ZIP/Postal Code
78705
Country
United States
Facility Name
Baylor Research Institute
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
The Methodist Neurological Institute
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
University of Utah Department of Neurosurgery
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84112
Country
United States
Facility Name
Fletcher Allen Health Care
City
Burlington
State/Province
Vermont
ZIP/Postal Code
05405
Country
United States
Facility Name
University of Virginia Healthcare System
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22908
Country
United States
Facility Name
Swedish Neuroscience Institute
City
Seattle
State/Province
Washington
ZIP/Postal Code
98122
Country
United States
Facility Name
University of Washington Medical Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98195
Country
United States
Facility Name
University of Wisconsin Paul P Carbone Comprehensive Cancer Center
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53792
Country
United States
Facility Name
Medical College of Wisconsin
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States
Facility Name
Prince of Wales Hospital
City
Randwick
State/Province
New South Wales
ZIP/Postal Code
2031
Country
Australia
Facility Name
Royal North Shore Hospital
City
St Leonards
State/Province
New South Wales
ZIP/Postal Code
2605
Country
Australia
Facility Name
The Crown Princess Mary Cancer Centre, Westmead Hospital
City
Westmead
State/Province
New South Wales
ZIP/Postal Code
2145
Country
Australia
Facility Name
Royal Brisbane and Women's Hospital
City
Herston
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
Facility Name
Mater Adult Hospital, Mater Misericordiae Health Services Brisbane Limited
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Facility Name
Royal Adelaide Hospital
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Calvary North Adelaide Hospital
City
North Adelaide
State/Province
South Australia
ZIP/Postal Code
5006
Country
Australia
Facility Name
Royal Hobart Hospital
City
Hobart
State/Province
Tasmania
ZIP/Postal Code
7000
Country
Australia
Facility Name
Launceston General Hospital
City
Launceston
State/Province
Tasmania
ZIP/Postal Code
7250
Country
Australia
Facility Name
Monash Medical Centre
City
Clayton
State/Province
Victoria
ZIP/Postal Code
3199
Country
Australia
Facility Name
Austin Health
City
Heidelberg
State/Province
Victoria
ZIP/Postal Code
3084
Country
Australia
Facility Name
Epworth Healthcare
City
Richmond
State/Province
Victoria
ZIP/Postal Code
3121
Country
Australia
Facility Name
Sir Charles Gairdner Hospital
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
06008
Country
Australia
Facility Name
Liverpool Hospital
City
Liverpool
ZIP/Postal Code
2107
Country
Australia
Facility Name
Medical University Innsbruck, Dept of Neurology, Anichstrabe 35
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
Facility Name
Medizinische Universität Wien, Innere Medizin I, Onkologie
City
Vienna
ZIP/Postal Code
1090
Country
Austria
Facility Name
Universitair Ziekenhuis Antwerpen
City
Edegem
State/Province
Antwerp
ZIP/Postal Code
2650
Country
Belgium
Facility Name
ZNA Middelheim
City
Antwerpen
ZIP/Postal Code
B-2020
Country
Belgium
Facility Name
Ghent University Hospital
City
Ghent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Hospital Mae de Deus-Centro de Pesquisa em Oncologia Clinica
City
Porto Alegre
State/Province
Rio Grande Do Sul
ZIP/Postal Code
90840-440
Country
Brazil
Facility Name
Centro de Pesquisas Clinicas da Fundação Dr Amaral Carvalho
City
Jaú
State/Province
São Paulo
ZIP/Postal Code
17210-120
Country
Brazil
Facility Name
Fundação Faculdade Regional de Medicina de de São José do Rio Preto - Hospital de Base
City
São José do Rio Preto
State/Province
São Paulo
ZIP/Postal Code
15090-000
Country
Brazil
Facility Name
Instituto Nacional do Cancer (INCA)
City
Rio de Janeiro
ZIP/Postal Code
20231-050
Country
Brazil
Facility Name
Hospital Albert Einstein
City
Sao Paulo
ZIP/Postal Code
05652-900
Country
Brazil
Facility Name
Instituto do Câncer do Estado de São Paulo - ICESP
City
São Paulo
ZIP/Postal Code
01246-000
Country
Brazil
Facility Name
Real e Benemerita Associação Portuguesa de Beneficiência/ Hospital São José
City
São Paulo
ZIP/Postal Code
01321-001
Country
Brazil
Facility Name
Hospital A C Camargo
City
São Paulo
ZIP/Postal Code
01509-900
Country
Brazil
Facility Name
Foothills Hospital Medical Centre
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T3J 5N6
Country
Canada
Facility Name
British Columbia Cancer Agency, Vancouver Clinic
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 4E6
Country
Canada
Facility Name
BC Cancer Agency - Vancouver Island Centre
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8X 4V6
Country
Canada
Facility Name
University of Manitoba-Cancer Care Manitoba
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R3E0V9
Country
Canada
Facility Name
QEII Health Sciences Centre
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 1V7
Country
Canada
Facility Name
Juravinski Cancer Centre
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8V 5C2
Country
Canada
Facility Name
London Regional Cancer Program, London Health Sciences Centre
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 4L6
Country
Canada
Facility Name
Ottawa Hospital, Regional Cancer Centre
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
Facility Name
Sunnybrook Health Sciences Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N3M5
Country
Canada
Facility Name
Centre Hospitalier de l'Universite de Montreal (CHUM) - Hopital Notre-Dame
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2L 4M1
Country
Canada
Facility Name
Montreal Neurological Institute and Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3A 2B4
Country
Canada
Facility Name
CHUS Hôpital Fleurimont
City
Shenbrooke
State/Province
Quebec
ZIP/Postal Code
J1H5N4
Country
Canada
Facility Name
CHUQ L'Hotel Dieu de Qujebec
City
Quebec
ZIP/Postal Code
G1R 2J6
Country
Canada
Facility Name
Fundacion Santa Fe
City
Bogota
State/Province
Bogota D.C
ZIP/Postal Code
000
Country
Colombia
Facility Name
Hospital Ceske Budejovice
City
Ceske Budejovice
ZIP/Postal Code
370 01
Country
Czechia
Facility Name
Umiversity Hospital (Fakultni Nemocnice)
City
Prague
ZIP/Postal Code
150 06
Country
Czechia
Facility Name
Hospital Na Homolce
City
Prague
ZIP/Postal Code
150 30
Country
Czechia
Facility Name
Multiscan s.r.o.
City
Praha 5
ZIP/Postal Code
155-00
Country
Czechia
Facility Name
Masaryk´s Hospital Usti nad Labem
City
Usti nad Labem
ZIP/Postal Code
401-13
Country
Czechia
Facility Name
Institut de Cancerologie de I'Quest-Paul Papin
City
Angers
ZIP/Postal Code
49933
Country
France
Facility Name
Institute Bergonie
City
Bordeaux
ZIP/Postal Code
33076
Country
France
Facility Name
Centre Leon Berard de Lyon
City
Lyon
ZIP/Postal Code
69373
Country
France
Facility Name
ICM Val d'Aurel Montpellier
City
Montpellier
ZIP/Postal Code
342298
Country
France
Facility Name
Institut de Cancerologie de L'Quest-Center Rane Gauducheau
City
Nantes
ZIP/Postal Code
44805
Country
France
Facility Name
Service de Neurologie-GH
City
Paris
ZIP/Postal Code
75013
Country
France
Facility Name
Centre Eugene Marquis
City
Rennes
ZIP/Postal Code
35042
Country
France
Facility Name
Institut de Cancerologie de l'ouest-Center Rene Gauducheau
City
St Herblain
ZIP/Postal Code
44805
Country
France
Facility Name
Institut Gustave Roussy
City
Villejuif
ZIP/Postal Code
94805
Country
France
Facility Name
Klinik und Poliklinik fur Neurologie der Universitat Regensburg
City
Regensburg
State/Province
Bavaria
ZIP/Postal Code
93053
Country
Germany
Facility Name
Strahlenklinik Universitatsklinikum Erlangen
City
Erlangen
ZIP/Postal Code
D-91054
Country
Germany
Facility Name
Dr. Senchkenbergisches Institut fur Neuroonkologie
City
Frankfurt
ZIP/Postal Code
D-60528
Country
Germany
Facility Name
University Hospital Hamburg Kopf und Neurozentrum
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
Facility Name
Universitaetsklinikum Heidelberg, Neurologische Klinik, IM Neuenheimer Feld 672
City
Heidelberg
ZIP/Postal Code
69120
Country
Germany
Facility Name
University Medical Centre
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Facility Name
Universitaetsklinikum Muenster
City
Muenster
ZIP/Postal Code
48149
Country
Germany
Facility Name
LMU Munich
City
Munich
ZIP/Postal Code
D-81377
Country
Germany
Facility Name
NNA
City
Athens
State/Province
Attiki
ZIP/Postal Code
11521
Country
Greece
Facility Name
"HYGEIA" Hospital
City
Marousi
State/Province
District Of Attica
ZIP/Postal Code
151 23
Country
Greece
Facility Name
Országos Onkológiai Intézet Sugárterápiás Osztály
City
Budapest
ZIP/Postal Code
1122
Country
Hungary
Facility Name
Debreceni Egyetem Orvos- és Egészségtudományi Centrum Onkológiai Intézet
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Facility Name
Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház, Sugárterápiás Osztály
City
Miskolc
ZIP/Postal Code
3526
Country
Hungary
Facility Name
Pécsi Tudományegyetem Általános Orvostudományi Kar
City
Pécs
ZIP/Postal Code
7624
Country
Hungary
Facility Name
Szegedi Tudományegyetem Onkoterápiás Klinika
City
Szeged
ZIP/Postal Code
6720
Country
Hungary
Facility Name
Vas Megyei Markusovszky Lajos Általános Rehabilitációs és Gyógyfürdő Kórház, Egyetemi Oktatókórház Nonprofit Zrt
City
Szombathely
ZIP/Postal Code
9700
Country
Hungary
Facility Name
City Cancer Centre, Vijayawada
City
Vijayawada
State/Province
Andhra Pradesh
ZIP/Postal Code
520002
Country
India
Facility Name
HCG - Bangalore Institute of Oncology, Bangalore
City
Bengaluru
State/Province
Karnataka
ZIP/Postal Code
560027
Country
India
Facility Name
Amrita Institute of Medical Sciences and Research Centre, Kochi
City
Kochi
State/Province
Kerala
ZIP/Postal Code
682 026
Country
India
Facility Name
Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram
City
Thiruvananthapuram
State/Province
Kerala
ZIP/Postal Code
695 011
Country
India
Facility Name
Marathwada Regional Cancer Centre and Research Institute - Government
City
Aurangabad
State/Province
Maharashtra
ZIP/Postal Code
431001
Country
India
Facility Name
Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute
City
Andheri-West
State/Province
Mumbai
ZIP/Postal Code
400 053
Country
India
Facility Name
Tata Memorial Hospital , Mumbai
City
Parel
State/Province
Mumbai
ZIP/Postal Code
400012
Country
India
Facility Name
Indraprastha Apollo Hospital, New Delhi
City
Jasola Viha
State/Province
New Delhi
ZIP/Postal Code
110076
Country
India
Facility Name
Sahyadri Hospitals Limited
City
Erandauame
State/Province
Pune
ZIP/Postal Code
411004
Country
India
Facility Name
Dr. Rai Memorial Medical Centre, Chennai
City
Chennai
State/Province
Tamil Nadu
ZIP/Postal Code
600018
Country
India
Facility Name
HCG Shanti Mukand Hospital - Curie Cancer Centre, Delhi
City
Delhi
ZIP/Postal Code
110092
Country
India
Facility Name
Soroka University M.C.
City
Beer-Sheva
ZIP/Postal Code
84101
Country
Israel
Facility Name
Rambam Health Care Campus
City
Haifa
ZIP/Postal Code
3109601
Country
Israel
Facility Name
Hadassah Medical Center
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
Facility Name
SHEBA Medical Center
City
Tel Hashomer
ZIP/Postal Code
52126
Country
Israel
Facility Name
Tel-Aviv Sourasky Medical Center
City
Tel-Aviv
ZIP/Postal Code
64239
Country
Israel
Facility Name
UO Oncologie Medica Dipartimento Oncologico
City
Bologna
ZIP/Postal Code
40139
Country
Italy
Facility Name
Fondazione IRCCS Instituto Neurologico Carlo Besta
City
Milano
ZIP/Postal Code
20133
Country
Italy
Facility Name
Sacred Heart Catholic University
City
Rome
ZIP/Postal Code
00168
Country
Italy
Facility Name
Universita e AO Citta delia Scienza, Universita Di Torino
City
Torino
ZIP/Postal Code
10126
Country
Italy
Facility Name
Grupo Médico Camino S.C.
City
Mexico
State/Province
D.F
ZIP/Postal Code
03310
Country
Mexico
Facility Name
Hospital Civil de Guadalajara "Fray Antonio Alcalde"
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
34000
Country
Mexico
Facility Name
Ensayos Clínicos y Medicina de Alta Especialidad, S.C.
City
Culiacán
State/Province
Sinaloa
ZIP/Postal Code
80020
Country
Mexico
Facility Name
Servicios Medicos de Investigacion Clinica Sc
City
Durango
ZIP/Postal Code
34000
Country
Mexico
Facility Name
Hospital Central "Ignacio Morones Prieto"
City
San Luis Potosí
ZIP/Postal Code
78240
Country
Mexico
Facility Name
Medisch Centrum Haaglanden
City
The Hague
State/Province
Zuid Holland
ZIP/Postal Code
2512 VA
Country
Netherlands
Facility Name
VUMC
City
Amsterdam
ZIP/Postal Code
1081HV
Country
Netherlands
Facility Name
Radboud University Nijmegen Medical Center
City
Nijmegen
ZIP/Postal Code
6525 GA
Country
Netherlands
Facility Name
Christchurch Hospital
City
Christchurch Central
State/Province
Christchurch
ZIP/Postal Code
8011
Country
New Zealand
Facility Name
Palmerston North Hospital
City
Roslyn
State/Province
Palmerston North
ZIP/Postal Code
4414
Country
New Zealand
Facility Name
Waikato Hospital, Regional Cancer Centre
City
Hamilton
State/Province
Waikato District
ZIP/Postal Code
3240
Country
New Zealand
Facility Name
Waikato Hospital, Regional Cancer Center
City
Hamilton
State/Province
Waikato Distric
ZIP/Postal Code
3240
Country
New Zealand
Facility Name
Hospital Almanzor Aguinaga Asenjo
City
Chiclayo
Country
Peru
Facility Name
Instituto Oncologico Miraflores
City
Lima
ZIP/Postal Code
Lima 18
Country
Peru
Facility Name
Clinica Anglo Americana
City
Lima
ZIP/Postal Code
Lima 27
Country
Peru
Facility Name
Clinica Ricardo Palma
City
Lima
ZIP/Postal Code
Lima 27
Country
Peru
Facility Name
Oncosalud
City
Lima
ZIP/Postal Code
Lima 41
Country
Peru
Facility Name
Institut Catala d Oncologia
City
LaHospitalet De Lubregat
State/Province
Catalonia
ZIP/Postal Code
08908
Country
Spain
Facility Name
Dra. Sonia Del Barco Berron, ICO Girona Avda,
City
Franca
State/Province
Girona
ZIP/Postal Code
17007
Country
Spain
Facility Name
Hospital Clinic
City
Barcelona
ZIP/Postal Code
8036
Country
Spain
Facility Name
ICO Badalona-Hospital Germans Trias i Pujol
City
Barcelonia
ZIP/Postal Code
08916
Country
Spain
Facility Name
Hospital 12 de Octubre
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Facility Name
Kantonsspital Aarau Medizinische Onkologie Tellstrasse
City
Aarau
State/Province
AG
ZIP/Postal Code
5001
Country
Switzerland
Facility Name
CHUV, Centre Hospitalier Universitaire Vaudois
City
Lausanne
State/Province
VD
ZIP/Postal Code
1011
Country
Switzerland
Facility Name
Oncology Institute of Southern Switzerland (IOSI)
City
Bellinzona
ZIP/Postal Code
6500
Country
Switzerland
Facility Name
Inselspital, Universitatsspital Bern, Universitatsklinik fur Medizinische Onkologie, Freiburgstrasse
City
Bern
ZIP/Postal Code
3010
Country
Switzerland
Facility Name
Hopitaux Universitaires de Geneve-HUG-Centre d'Oncologie
City
Geneva
ZIP/Postal Code
1211
Country
Switzerland
Facility Name
Brain Tumor Center, University Hospital Zurich
City
Zurich
ZIP/Postal Code
8091
Country
Switzerland
Facility Name
National Cheng Kung University Hospital
City
Tainan City
State/Province
Bei District
ZIP/Postal Code
704
Country
Taiwan
Facility Name
Kaohsiung Chang Gung Memorial Hospital
City
Kaohsiung
ZIP/Postal Code
83301
Country
Taiwan
Facility Name
Chang Gung Memorial Hospital Linkou Branch
City
Taichung
ZIP/Postal Code
40705
Country
Taiwan
Facility Name
Taichung Veterans General Hospital
City
Taichung
ZIP/Postal Code
40705
Country
Taiwan
Facility Name
Chi Mei Medical Center
City
Tainan City - Yongkang District
ZIP/Postal Code
710
Country
Taiwan
Facility Name
Tri-Service General Hospital
City
Taipei city - Neihu District
ZIP/Postal Code
00114
Country
Taiwan
Facility Name
Siriraj Hospital
City
Bangkoknoi
State/Province
Bangkok
ZIP/Postal Code
10700
Country
Thailand
Facility Name
King Chulalongkorn Memorial Hospital
City
Patumwan
State/Province
Bankok
ZIP/Postal Code
10330
Country
Thailand
Facility Name
Maharaj Nakorn Chiang Mai Hospital
City
Amphoe Muang
State/Province
Chiang Mai
ZIP/Postal Code
50200
Country
Thailand
Facility Name
Songkhlanagarind Hospital
City
Hat Yai
State/Province
Songkla
ZIP/Postal Code
90110
Country
Thailand
Facility Name
Royal Marsden NHS Foundation Trust
City
Sutton
State/Province
Surrey
ZIP/Postal Code
SM2 5PT
Country
United Kingdom
Facility Name
The Bristol Haematology and Oncology Centre
City
Bristol
ZIP/Postal Code
BS2 8ED
Country
United Kingdom
Facility Name
Edinburgh Cancer Centre Western General Hospital
City
Edinburgh
ZIP/Postal Code
EH4 2XU
Country
United Kingdom
Facility Name
Beatson West of Scotland Cancer Centrel
City
Glasgow
ZIP/Postal Code
G12 0NY
Country
United Kingdom
Facility Name
Guy's and St Thomas' NHS, Westminister Bridge Road
City
London
ZIP/Postal Code
SE17EH
Country
United Kingdom
Facility Name
Nottingham City Hospital
City
Nottingham
ZIP/Postal Code
NG5 1PB
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
28844499
Citation
Weller M, Butowski N, Tran DD, Recht LD, Lim M, Hirte H, Ashby L, Mechtler L, Goldlust SA, Iwamoto F, Drappatz J, O'Rourke DM, Wong M, Hamilton MG, Finocchiaro G, Perry J, Wick W, Green J, He Y, Turner CD, Yellin MJ, Keler T, Davis TA, Stupp R, Sampson JH; ACT IV trial investigators. Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial. Lancet Oncol. 2017 Oct;18(10):1373-1385. doi: 10.1016/S1470-2045(17)30517-X. Epub 2017 Aug 23.
Results Reference
result

Learn more about this trial

Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma

We'll reach out to this number within 24 hrs