Photobiomodulation Therapy Combined With Static Magnetic Field in Patients With COVID-19
COVID-19, Respiratory Failure
About this trial
This is an interventional treatment trial for COVID-19 focused on measuring Photobiomodulation Therapy, Static Magnetic Fields, Low-Level Laser Therapy, COVID-19, Invasive Mechanical Ventilation, Respiratory Muscles, Intensive Care United
Eligibility Criteria
Inclusion Criteria:
- Patients admitted to the adult Intensive Care Unit with Covid-19 infection;
- Need for orotracheal intubation;
- Invasive mechanical ventilation due to respiratory failure.
Exclusion Criteria:
- Suspected patients who had a negative result of the diagnostic examination for COVID-19 infection;
- Patients positioned in pronation for more than 24 hours;
- Cancer patients;
- Pregnancy.
Sites / Locations
- Hospital Tacchini
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
PBMT/sMF
Placebo PBMT/sMF
Active PBMT/sMF will be applied once a day, during the ICU stay, until discharge or death. The patients will receive standard physical therapy care associated with PBMT/sMF. PBMT/sMF will be applied using MR5™ ACTIV PRO LaserShower, manufactured by Multi Radiance Medical (Solon, OH, USA). This device has 4 diodes of 905 nm (1.25 mW each diode, 0.32 cm2 each), 8 diodes of 633 nm (25 mW each diode, 0.85 cm2 - each), and 8 diodes of 850 nm (40 mW each diode, 0.56 cm2 - each). The static magnetic field is 110 mT.
Placebo PBMT/sMF will be applied once a day, during the ICU stay, until discharge or death. The patients will receive standard physical therapy care associated with placebo PBMT/sMF. The placebo PBMT will be applied using MR5™ ACTIV PRO LaserShower Laser Therapy System, manufactured by Multi Radiance Medical (Solon, OH, USA). The ACTIV PRO emits 905nm, and 850nm via an electric diode energy source with outputs to 0%. The static magnetic field will be also turned off. The 660nm light via an electric diode energy source with outputs to >1% to appear like the active comparator.