Physical Exercise as an Additional Treatment for Alzheimer Disease
Alzheimer Disease
About this trial
This is an interventional treatment trial for Alzheimer Disease focused on measuring Alzheimer's disease, Aerobic exercise, Physical training, Cognitive function, Functional capacity.
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of Alzheimer Disease according to the National Institute of Neurological and Communicative Disorders and Stroke- Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) and National Institute of Neurological Disorders and Stroke- Association Internationale pour la Recherche et l' Enseignement en Neurosciences (NINDS-AIREN),respectively
- Mini-Mental State Examination (MMSE) score ≥ 15
- Clinical Dementia Rating (CDR) score 1
- Regular use of anticholinesterase drugs for at least six months
- Cardiologist's authorization
- At least six months without practicing physical exercises.
Exclusion Criteria:
- Clinical depression or Cornell Scale ≥ 7
- Other types of dementia
- Physical limitation due to other pathologies or associated neurological disease
- Severe or uncontrolled arterial hypertension
- Marked visual and/or auditory deficit
- Incapacity to perform physical exercise due to neurological or neuromuscular impairments
- Illiteracy
- Less than six months of treatment at the outpatient unit.
Sites / Locations
- Universidade Federal do Rio de Janeiro
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Aerobic exercise
Control group
The training exercise intensity is established at 60% of VO2máx. Each aerobic session began with a 10-minute warm-up period (40%VO2máx), followed by 20 minutes of continuous treadmill walking at an intensity established by 60% of VO2máx. The exercise session will be concluded with a 5 minutes of cool down. Heart hate (Polar® Sport Tester, Finland) and perceived exertion (Borg Scale) will be monitored and recorded at each five minutes during each exercise session by physical education instructors.
All participants were asked not to commence any new exercise regimen.