Physiologic Growth Hormone Effects in HIV Lipodystrophy

Inclusion Criteria: Men and women age 18-60 Previously diagnosed HIV infection Stable antiviral regimen for at least 12 weeks prior to enrollment Waist-to-hip ratio >0.90 for men and >0.85 for women Evidence of at least one of the following recent changes: *increased abdominal girth, *relative loss of fat in the extremities, *relative loss of fat in the face Simulated peak GH response to arginine/GHRH of less than 7.5 mcg/dL Exclusion Criteria: Use of Megace, anti-diabetic agents, GH, or other anabolic agents, pharmacologic glucocorticoid (prednisone >5 mg/day or its equivalent) for 3 months prior to enrollment. Patients on a standard dose of testosterone for documented hypogonadism will be allowed to enter the protocol. Women taking standard estrogen replacement therapy for >3 months will be allowed in the study. Diabetes mellitus Other severe chronic illness HgB <9.0 g/dL, creatinine >1.4 mg/dL, or PSA >4 ng/mL Positive BHCG or failure to use appropriate birth control during study. Acceptable methods include oral contraceptives, depo provera or combined progesterone-estrogen injections, transdermal contraceptive patches, IUD's, barrier devices (condoms, diaphragms), and abstinence. Carpal tunnel syndrome Active malignancy or history of pituitary malignancy, history of colon cancer or prostate malignancy