Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease (COMPLETE-2)

Inclusion Criteria: Patients presenting with STEMI or type 1 NSTEMI and within 72 hours of successful culprit-lesion PCI Residual coronary artery disease defined as at least 1 additional non-infarct-related coronary artery stenosis that meets all of the following criteria: Amenable to successful treatment with PCI At least 50% diameter stenosis by visual estimation At least 2.5 mm in diameter Planned complete revascularization strategy for qualifying MI Exclusion Criteria: Planned or prior coronary artery bypass graft (CABG) surgery Inability to clearly identify a culprit lesion for STEMI or NSTEMI based on angiographic appearance and/or ECG changes and/or regional wall motion abnormalities Prior PCI of a non-culprit lesion in a different vessel from the culprit lesion within 45 days of randomization Planned medical treatment of all qualifying non-culprit lesions (i.e., no PCI) Presence of severe non-culprit-lesion stenosis with reduced epicardial flow (TIMI flow ≤ 2) or >90% visual diameter stenosis Presence of a chronic total occlusion (CTO) if it is the only qualifying non-culprit lesion (patients with a CTO plus additional qualifying non-culprit lesions are eligible) The only qualifying non-culprit lesion is in the same vessel territory as the culprit lesion Baseline STEMI or NSTEMI was due to a suspected non-atherothrombotic mechanism such as type 2 MI (supply-demand mismatch), including spontaneous coronary artery dissection or coronary artery embolism Non-cardiovascular co-morbidity with expected life expectancy <2 years Any other medical, geographic, or social factor making study participation impractical or precluding 5 year follow-up