Back to resultsPivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM (EF-32)
Primary Purpose
Glioblastoma Multiforme
Status
Recruiting
Phase
Not Applicable
Locations
International
Study Type
Interventional
Intervention
Optune®
Sponsored by
About this trial
This is an interventional treatment trial for Glioblastoma Multiforme focused on measuring GBM
Eligibility Criteria
Inclusion Criteria:
- Histologically confirmed diagnosis of GBM according to WHO classification criteria.
- Age ≥ 22 years in US and Age ≥ 18 years in Ex-US
- Recovered from maximal debulking surgery, if applicable (gross total resection, partial resection, and biopsy-only patients are all acceptable)
- Planned treatment with RT/TMZ followed by TTFields and maintenance TMZ (150-200 mg/m2 daily x 5 d, q28 days)
- Karnofsky performance status ≥ 70
- Life expectancy ≥ least 3 months
- Participants of childbearing age must use highly effective contraception. An effective method of birth control is defined as one that results in a failure rate of less than 1% per year when used consistently and correctly. The Investigator must approve the selected method, and may consult with a gynecologist as needed.
- All patients must understand and voluntarily sign an informed consent document prior to any study related assessments/procedures being conducted.
- Stable or decreasing dose of corticosteroids for the last 7 days prior to randomization, if applicable.
- Concomitant RT with TMZ treatment planned to start no later than 8 weeks from surgery
- Women of childbearing potential must have a negative β-HCG pregnancy test documented within 14 days prior to registration
- Is able to have MRI with contrast of the brain
Exclusion Criteria:
- Progressive disease (per investigator's assessment)
- Infratentorial or leptomeningeal disease
- Participation in another clinical treatment study during the pre-treatment and/or the treatment phase of the study
- Pregnancy or breast-feeding.
Significant co-morbidities at baseline which would preclude maintenance RT or TMZ treatment, as determined by the investigator:
- Thrombocytopenia (platelet count < 100 x 103/μL)
- Neutropenia (absolute neutrophil count < 1.5 x 103/μL)
- CTC grade 4 non-hematological Toxicity (except for alopecia, nausea, vomiting)
- Significant liver function impairment - AST or ALT > 3 times the upper limit of normal
- Total bilirubin > 1.5 x upper limit of normal
- Significant renal impairment (serum creatinine > 1.7 mg/dL, or > 150 µmol/l)
- History of any psychiatric condition that might impair patient's ability to understand or comply with the requirements of the study or to provide consent
- Implanted pacemaker, defibrillator, deep brain stimulator, other implanted electronic devices in the brain, or documented clinically significant arrhythmias.
- Evidence of increased intracranial pressure (midline shift > 5mm, clinically significant papilledema, vomiting and nausea or reduced level of consciousness)
- History of hypersensitivity reaction to TMZ or a history of hypersensitivity to DTIC.
- Any other cytotoxic or biologic anti-tumor therapy received prior to enrollment will be considered exclusion.
- Admitted to an institution by administrative or court order.
- Known allergies to medical adhesives or hydrogel
- A skull defect (such as, missing bone with no replacement)
- Prior radiation treatment to the brain for the treatment of GBM
- Any serious surgical/post-operative condition that may risk the patient according to the investigator
Standard TTFields exclusion criteria include
- Active implanted medical devices
- Bullet fragments
- Skull defects
Sites / Locations
- Grandview Cancer CenterRecruiting
- Banner MD Anderson Cancer CenterRecruiting
- Mayo Clinic- Arizona
- University of Arizona Cancer CenterRecruiting
- Highlands Oncology GroupRecruiting
- City of Hope National Medical CenterRecruiting
- TRIO - St. Jude Heritage Healthcare/St. Jude Medical CenterRecruiting
- University of California at San Diego - Moores Cancer CenterRecruiting
- Norris Comprehensive Cancer Center at USCRecruiting
- Cedars - Sinai Medical CenterRecruiting
- Providence St. Joseph Medical Center and The Roy and Patricia Disney Family Cancer CenterRecruiting
- Hoag Memorial Hospital - Hoag Cancer CenterRecruiting
- St. Joseph Hospital of OrangeRecruiting
- University of California - Irvine/UCI Medical CenterRecruiting
- Stanford University Cancer InstituteRecruiting
- Sharp Memorial Hospital - X-Ray Medical Group Radiation OncologyRecruiting
- University of California San Francisco Medical Center
- John Wayne Cancer Institute at St. John's Health CenterRecruiting
- University of Colorado Cancer Center AnschutzRecruiting
- HCA Research Institute - Blue Sky Neurology - Denver
- Hartford Healthcare Medical Group - Hartford Hospital The Gray Cancer CenterRecruiting
- Lynn Cancer Institute, Marcus Neuroscience Institute
- Baptist Health - JacksonvilleRecruiting
- Mayo ClinicRecruiting
- AdventHealthRecruiting
- Orlando Health UF Health Cancer CenterRecruiting
- H. Lee Moffitt Cancer Center and Research Institute, IncRecruiting
- Piedmont Healthcare Brain Tumor Center
- The Emory Clinic - Emory Healthcare - Winship Cancer InstituteRecruiting
- Northside Hospital, Inc.Recruiting
- Rush University Medical Center
- University of ChicagoRecruiting
- Parkview Cancer Institute - Fort Wayne Radiation Oncology AssociatesRecruiting
- The University of Kansas Cancer CenterRecruiting
- University of Louisville - James Graham Brown Cancer CenterRecruiting
- Norton Cancer InstituteRecruiting
- LSU Health Sciences Center, New Orleans
- Ochsner Health SystemRecruiting
- Maine Medical Partners Neurology - Neurosurgery & Spine AssociatesRecruiting
- John Hopkins School of MedicineRecruiting
- Tufts Medical CenterRecruiting
- University of Massachusetts Chan Medical SchoolRecruiting
- University of Michigan Comprehensive Cancer Center
- Abbott Northwestern Hospital - Givens Brain Tumor CenterRecruiting
- University of Minnesota Health Clinics and Surgery Center
- University of Mississippi Medical CenterRecruiting
- University of Missouri - Ellis Fischel Cancer CenterRecruiting
- Health Midwest Ventures Group, Inc - Sarah Cannon HCA Midwest Brain and Spine
- Washington University School of Medicine
- Dartmouth-Hitchcock Medical CenterRecruiting
- JFK Neuroscience Institute, HMH JFK University Medical CenterRecruiting
- Hackensack University Medical Center - John Theurer Cancer Center
- Northwell Health System Brain Tumor CenterRecruiting
- NYU Langone - Laura & Issac Perimutter Cancer CenterRecruiting
- Mount Sinai - Icahn School of MedicineRecruiting
- New York Presbyterian - Columbia UniversityRecruiting
- University of Rochester Medical CenterRecruiting
- SUNY Upstate Medical UniversityRecruiting
- University of North Carolina Brain Tumor Program - UNC Lineberger Comprehensive Cancer CenterRecruiting
- Novant Health Cancer Institute Radiation OncologyRecruiting
- Vidant Medical CenterRecruiting
- Forsyth Medical Center-Novant HealthRecruiting
- Wake Forest Baptist Comprehensive Cancer CenterRecruiting
- University of Cincinnati Cancer InstituteRecruiting
- The James Cancer Hospital and Solove Research Institute - Arthur G James Cancer HospitalRecruiting
- Oregon Health & Science University (OHSU)Recruiting
- Geisinger Health System
- Neuroscience Center, Philadelphia University of PennsylvaniaRecruiting
- University of Pennsylvania
- Thomas Jefferson University HospitalRecruiting
- Allegheny Health Network Cancer InstituteRecruiting
- UPMC Hillman Cancer CenterRecruiting
- Rhode Island HospitalRecruiting
- MUSC Radiation Oncology Brain & Spine Tumor ProgramRecruiting
- SCRI - Tennessee OncologyRecruiting
- West Cancer Center - GermantownRecruiting
- SCRI - Tennessee OncologyRecruiting
- Texas Oncology Midtown - Austin Brain Tumor CenterRecruiting
- Baylor Charles A. Sammons Cancer Center - Baylor University Medical CenterRecruiting
- John Peter Smith Health Network - JPS Cancer CenterRecruiting
- Houston Methodist HospitalRecruiting
- UT Health Mischer Neuroscience - Memorial Herman - UT NeurosciencesRecruiting
- San Antonio Cancer Institute
- Baylor Scott & White Medical CenterRecruiting
- The University of Vermont Medical Center - University of Vermont Cancer CenterRecruiting
- Massey Cancer Center - VCU Medical Center
- Swedish Health ServicesRecruiting
- UW Medical Center - Alvord Brain Tumor CenterRecruiting
- West Virginia University Cancer InstituteRecruiting
- Innsbruck University Hospital
- Kepler University Hospital
- University Hospital Salzburg
- Hospital Erasme
- University Hospital Liege - Sart TilmanRecruiting
- The Ottawa Hospital Cancer CentreRecruiting
- Princess Margaret Cancer CentreRecruiting
- Sunnybrook Research Institute - Odette Cancer CentreRecruiting
- CHUM Centre de RechercheRecruiting
- Universite de Sherbrooke - Sherbrooke Centre Hospitalier UniversitaRecruiting
- Masaryk Memorial Cancer Institute
- University Hospital Plzeň
- Na Homolce Hospital
- Institut de cancérologie de l'Ouest
- Pierre Wertheimer Hospital
- Hôpital la Timone
- University Hospital Nice
- Pitié-Salpêtrière University Hospital
- Institut de cancérologie de l'Ouest
- University Institute Cancer Toulouse Oncopole
- Gustave Roussy Institute
- Charité Campus Virchow Clinic
- University Hospital EssenRecruiting
- University Medical Center FreiburgRecruiting
- University Hospital LeipzigRecruiting
- Rechts der Isar HospitalRecruiting
- University Hospital TübingenRecruiting
- Rambam Medical CenterRecruiting
- Hadassah Medical Center - Ein KeremRecruiting
- Rabin Medical CenterRecruiting
- Sheba Medical CenterRecruiting
- Tel Aviv Sourasky Medical CenterRecruiting
- Hokkaido University HospitalRecruiting
- Kanazawa University HospitalRecruiting
- Saitama Medical University International Medical CenterRecruiting
- Kyorin University HospitalRecruiting
- Tokyo Women's Medical University HospitalRecruiting
- Lausanne University HospitalRecruiting
- University Hospital ZurichRecruiting
- Clatterbridge Cancer CentreRecruiting
- Guy's HospitalRecruiting
- Charing Cross HospitalRecruiting
- Nottingham University Hospitals NHS TrustRecruiting
- Royal Preston HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
Optune® + RT + TMZ for 6 weeks
RT +TMZ for 6 weeks
Arm Description
Optune® + RT + TMZ for 6 weeks, followed by Optune® + TMZ until the tumor progresses. Optune treatment is maintained until second disease progression or 24 months.
RT +TMZ for 6 weeks followed by Optune® + TMZ until the tumor progresses. Optune treatment is maintained until second disease progression or 24 months.
Outcomes
Primary Outcome Measures
Overall Survival (OS)
Survival will be measured from the time of randomization until date patient is alive.
Secondary Outcome Measures
Progression Free Survival (PFS)
PFS will be measured from the date of randomization to the date of progression.
1- and 2-year survival rates
The analyses will be performed based on estimated proportions of patients who are on study at 12 and 24 months in both arms of the study.
Overall Radiological response (ORR)
The analyses will be performed based on the RANO criteria, and comparison between the rates of response.
Next progression-free survival (PFS2)
PFS2 will be measured from the time of randomization to second tumor progression.
Progression-free survival at 6 (PFS6) and 12 months (PFS12)
The analyses will be estimated proportions of patients who are progression-free at 6 and 12 months in both arms of the study.
Severity and frequency of adverse events
The analyses will be performed based on the incidence, severity, frequency of adverse events, and their association with study treatments.
Pathological changes in resected GBM tumors following study treatments
Pathological changes in the tumors and also underwent another surgical resection while on the study.
Quality of Life EORTC Questionnaire
The analyses will be assessed using the EORTC QLQ C-30 questionnaire with BN-20 (brain symptom) supplement.
Dependence of overall survival on TTFields dose at the tumor
Examining the dependence of overall survival on TTFields dose delivered to the tumor bed will be performed in both the treatment and control arms.
The NANO scale
The Neurological assessment in Neuro-Oncology will be assessed using the NANO scale questionnaire and per RANO criteria.
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT04471844
Brief Title
Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM
Acronym
EF-32
Official Title
EF-32: Pivotal, Randomized, Open-Label Study of Optune® (Tumor Treating Fields, 200kHz) Concomitant With Radiation Therapy and Temozolomide for the Treatment of Newly Diagnosed Glioblastoma
Study Type
Interventional
2. Study Status
Record Verification Date
September 2023
Overall Recruitment Status
Recruiting
Study Start Date
December 8, 2020 (Actual)
Primary Completion Date
August 2024 (Anticipated)
Study Completion Date
August 2026 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
NovoCure GmbH
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
Yes
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM patients, compared to radiation therapy and temozolomide alone. In both arms, Optune® and maintenance temozolomide are continued following radiation therapy.
Detailed Description
Optune® is a medical device that has been approved for the treatment of recurrent and newly diagnosed glioblastoma (GBM) by the Food and Drug Administration (FDA) in the United States. Optune® has obtained a CE mark in Europe for recurrent and newly diagnosed GBM.
The current standard of care for GBM includes the addition of Optune® to maintenance temozolomide (TMZ), following the completion of radiation therapy (RT).
The purpose of the current study is to test if the earlier introduction of Optune®, at the time of radiation therapy (which is given together with temozolomide), improves clinical outcomes compared to the standard of care.
The study will randomize 950 subjects equally to one of two treatment arms:
Treatment arm I: Patients receive TTFields at 200 kHz to the brain using the Optune® System together with RT and TMZ, followed by maintenance TMZ concomitant with the Optune® treatment.
Treatment arm II: Patients receive RT and TMZ alone, followed by maintenance TMZ concomitant with TTFields at 200 kHz to the brain using the Optune®.
All patients are to receive standard RT and TMZ treatment followed by maintenance TMZ chemotherapy and Optune® according to the current standard of care regimen.
Optune® will continue until second disease progression per RANO Criteria or 24 months (the earlier of the two) unless any of the treatment discontinuation conditions described under criteria for patient withdrawal or termination are met.
After surgery or biopsy, subjects that would like to participate will be required to submit samples of their tumor to a lab for testing. The results of this test will be used for randomization into the trial.
If the subject is assigned to the treatment group that will start Optune® therapy during radiation therapy, Optune® therapy will begin within 7 days of enrolling in the study and no later than the first day of RT and TMZ treatment.
After the initial visit, subjects will continue treatment at home, while pursuing normal daily routines. Subjects are required to use the device for at least 18 hours a day. Short breaks in treatment for personal hygiene and other personal needs is allowed. Total usage time will be recorded and provided to the sponsor.
Subjects will be required to return to the clinic every 4 weeks until study participation ends. Once every 8 weeks until the tumor potentially returns twice, subjects will have a contrast MRI of the head and neurological exam performed for the first 6 months of the study and then at least every three months until a total time period of 24 months.Once every 12 weeks until second disease progression, subjects will also fill out a quality of life questionnaire.
After the second time the tumor returns, subjects will return to the clinic for one final visit approximately 30 days after the last treatment with Optune®.
After discontinuing Optune® subjects will be contacted once per month by telephone to answer basic questions about their health status.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Glioblastoma Multiforme
Keywords
GBM
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
Randomly assigned equally to one of two groups:
a. Treatment arm I: Patients receive TTFields at 200 kHz to the brain using the Optune® System together with RT and TMZ, followed by maintenance TMZ concomitant with the Optune® treatment.
Treatment arm II: Patients receive RT and TMZ alone, followed by maintenance TMZ concomitant with TTFields at 200 kHz to the brain using the Optune®.
Masking
None (Open Label)
Allocation
Randomized
Enrollment
950 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Optune® + RT + TMZ for 6 weeks
Arm Type
Experimental
Arm Description
Optune® + RT + TMZ for 6 weeks, followed by Optune® + TMZ until the tumor progresses. Optune treatment is maintained until second disease progression or 24 months.
Arm Title
RT +TMZ for 6 weeks
Arm Type
Active Comparator
Arm Description
RT +TMZ for 6 weeks followed by Optune® + TMZ until the tumor progresses. Optune treatment is maintained until second disease progression or 24 months.
Intervention Type
Device
Intervention Name(s)
Optune®
Intervention Description
Optune® is a commercial, portable, battery-operated device intended for continuous home use, which delivers TTFields at a frequency of 200kHz to the brain by means of insulated transducer arrays. The Optune® device produces electric forces intended to disrupt cancer cell division.
In treatment arm I, the patient starts Optune® concurrently with RT/TMZ for 6 weeks, followed by Optune® + TMZ until second disease progression.
In treatment arm II, the patient starts RT/TMZ for 6 weeks, followed by Optune® + TMZ until second disease progression.
The study treatment plan will continue for 24 months, if no tumor progression.
Primary Outcome Measure Information:
Title
Overall Survival (OS)
Description
Survival will be measured from the time of randomization until date patient is alive.
Time Frame
5 years
Secondary Outcome Measure Information:
Title
Progression Free Survival (PFS)
Description
PFS will be measured from the date of randomization to the date of progression.
Time Frame
5 years
Title
1- and 2-year survival rates
Description
The analyses will be performed based on estimated proportions of patients who are on study at 12 and 24 months in both arms of the study.
Time Frame
5 years
Title
Overall Radiological response (ORR)
Description
The analyses will be performed based on the RANO criteria, and comparison between the rates of response.
Time Frame
5 years
Title
Next progression-free survival (PFS2)
Description
PFS2 will be measured from the time of randomization to second tumor progression.
Time Frame
5 years
Title
Progression-free survival at 6 (PFS6) and 12 months (PFS12)
Description
The analyses will be estimated proportions of patients who are progression-free at 6 and 12 months in both arms of the study.
Time Frame
5 years
Title
Severity and frequency of adverse events
Description
The analyses will be performed based on the incidence, severity, frequency of adverse events, and their association with study treatments.
Time Frame
5 years
Title
Pathological changes in resected GBM tumors following study treatments
Description
Pathological changes in the tumors and also underwent another surgical resection while on the study.
Time Frame
5 years
Title
Quality of Life EORTC Questionnaire
Description
The analyses will be assessed using the EORTC QLQ C-30 questionnaire with BN-20 (brain symptom) supplement.
Time Frame
5 years
Title
Dependence of overall survival on TTFields dose at the tumor
Description
Examining the dependence of overall survival on TTFields dose delivered to the tumor bed will be performed in both the treatment and control arms.
Time Frame
5 years
Title
The NANO scale
Description
The Neurological assessment in Neuro-Oncology will be assessed using the NANO scale questionnaire and per RANO criteria.
Time Frame
5 years
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Histologically confirmed diagnosis of GBM according to WHO classification criteria.
Age ≥ 22 years in US and Age ≥ 18 years in Ex-US
Recovered from maximal debulking surgery, if applicable (gross total resection, partial resection, and biopsy-only patients are all acceptable)
Planned treatment with RT/TMZ followed by TTFields and maintenance TMZ (150-200 mg/m2 daily x 5 d, q28 days)
Karnofsky performance status ≥ 70
Life expectancy ≥ least 3 months
Participants of childbearing age must use highly effective contraception. An effective method of birth control is defined as one that results in a failure rate of less than 1% per year when used consistently and correctly. The Investigator must approve the selected method, and may consult with a gynecologist as needed.
All patients must understand and voluntarily sign an informed consent document prior to any study related assessments/procedures being conducted.
Stable or decreasing dose of corticosteroids for the last 7 days prior to randomization, if applicable.
Concomitant RT with TMZ treatment planned to start no later than 8 weeks from surgery
Women of childbearing potential must have a negative β-HCG pregnancy test documented within 14 days prior to registration
Is able to have MRI with contrast of the brain
Exclusion Criteria:
Progressive disease (per investigator's assessment)
Infratentorial or leptomeningeal disease
Participation in another clinical treatment study during the pre-treatment and/or the treatment phase of the study
Pregnancy or breast-feeding.
Significant co-morbidities at baseline which would preclude maintenance RT or TMZ treatment, as determined by the investigator:
Thrombocytopenia (platelet count < 100 x 103/μL)
Neutropenia (absolute neutrophil count < 1.5 x 103/μL)
CTC grade 4 non-hematological Toxicity (except for alopecia, nausea, vomiting)
Significant liver function impairment - AST or ALT > 3 times the upper limit of normal
Total bilirubin > 1.5 x upper limit of normal
Significant renal impairment (serum creatinine > 1.7 mg/dL, or > 150 µmol/l)
History of any psychiatric condition that might impair patient's ability to understand or comply with the requirements of the study or to provide consent
Implanted pacemaker, defibrillator, deep brain stimulator, other implanted electronic devices in the brain, or documented clinically significant arrhythmias.
Evidence of increased intracranial pressure (midline shift > 5mm, clinically significant papilledema, vomiting and nausea or reduced level of consciousness)
History of hypersensitivity reaction to TMZ or a history of hypersensitivity to DTIC.
Any other cytotoxic or biologic anti-tumor therapy received prior to enrollment will be considered exclusion.
Admitted to an institution by administrative or court order.
Known allergies to medical adhesives or hydrogel
A skull defect (such as, missing bone with no replacement)
Prior radiation treatment to the brain for the treatment of GBM
Any serious surgical/post-operative condition that may risk the patient according to the investigator
Standard TTFields exclusion criteria include
Active implanted medical devices
Bullet fragments
Skull defects
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Doron Manzur, MD
Phone
+1 603 206 2337
Email
clinicaltrials@novocure.com
First Name & Middle Initial & Last Name or Official Title & Degree
Doria Kaluza
Phone
+1 603 206 2337
Email
clinicaltrials@novocure.com
Facility Information:
Facility Name
Grandview Cancer Center
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35243
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jennifer De Los Santos, MD
Phone
205-971-1800
Email
jennifer.delossantos@grandviewhealth.com
Facility Name
Banner MD Anderson Cancer Center
City
Gilbert
State/Province
Arizona
ZIP/Postal Code
85234
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Traci Purifoy-Glaspie
Email
Traci.Purifoy-Glaspie@bannerhealth.com
Email
Terence.Roberts@bannerhealth.com
First Name & Middle Initial & Last Name & Degree
Terence Roberts
Facility Name
Mayo Clinic- Arizona
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85054
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
University of Arizona Cancer Center
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85719
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Baldasarre Stea, MD
Phone
520-626-2218
Email
bstea@email.arizona.edu
Facility Name
Highlands Oncology Group
City
Fayetteville
State/Province
Arkansas
ZIP/Postal Code
72762
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Thaddeus J Beck, MD
Phone
479-587-1700
Email
tbeck@hogonc.com
Facility Name
City of Hope National Medical Center
City
Duarte
State/Province
California
ZIP/Postal Code
91010
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jana Portnow, MD
Phone
626-218-3793
Email
jportnow@coh.org
Facility Name
TRIO - St. Jude Heritage Healthcare/St. Jude Medical Center
City
Fullerton
State/Province
California
ZIP/Postal Code
92835
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Park, MD
Phone
714-446-5900
Email
david.park@stjoe.org
Facility Name
University of California at San Diego - Moores Cancer Center
City
La Jolla
State/Province
California
ZIP/Postal Code
92093
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Piccioni, MD
Phone
858-534-0254
Email
dpiccioni@ucsd.edu
Facility Name
Norris Comprehensive Cancer Center at USC
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jason Ye, MD
Phone
323-865-3052
Email
jason.ye@med.usc.edu
Facility Name
Cedars - Sinai Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90266
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jethro Hu, MD
Phone
310-248-7141
Email
jethro.hu@cshs.org
Facility Name
Providence St. Joseph Medical Center and The Roy and Patricia Disney Family Cancer Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
91505
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Naveed Wagle, MD
Phone
323-865-0721
Email
naveed.wagle@jwci.org
Facility Name
Hoag Memorial Hospital - Hoag Cancer Center
City
Newport Beach
State/Province
California
ZIP/Postal Code
92663
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jose Carrillo, MD
Phone
949-764-4430
Email
jose.carrillo@hoag.org
Facility Name
St. Joseph Hospital of Orange
City
Orange
State/Province
California
ZIP/Postal Code
92868
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joscelyn Green
Phone
714-734-6220
Email
joscelyn.green@stjoe.org
First Name & Middle Initial & Last Name & Degree
Rachelle Alquitela
Phone
(714) 734-6200
Email
rachelle.alquitela@stjoe.org
First Name & Middle Initial & Last Name & Degree
Lars Anker
Facility Name
University of California - Irvine/UCI Medical Center
City
Orange
State/Province
California
ZIP/Postal Code
92868
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiao Tang Kong, MD
Phone
714-456-7214
Email
xkong@hs.uci.edu
Facility Name
Stanford University Cancer Institute
City
Palo Alto
State/Province
California
ZIP/Postal Code
94303
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Seema Nagpal, MD
Phone
650-725-8630
Email
snagpal@stanford.edu
First Name & Middle Initial & Last Name & Degree
Seema Nagpal
Facility Name
Sharp Memorial Hospital - X-Ray Medical Group Radiation Oncology
City
San Diego
State/Province
California
ZIP/Postal Code
92123
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Siavash Jabbari, MD
Phone
619-644-4500
Email
siavashjabbari@gmail.com
Facility Name
University of California San Francisco Medical Center
City
San Francisco
State/Province
California
ZIP/Postal Code
94143
Country
United States
Individual Site Status
Completed
Facility Name
John Wayne Cancer Institute at St. John's Health Center
City
Santa Monica
State/Province
California
ZIP/Postal Code
90404
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Akanksha Sharma, MD
Phone
409-256-6874
Email
akanksha.sharma@providence.org
Facility Name
University of Colorado Cancer Center Anschutz
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Denise Damek, MD
Phone
303-724-2184
Email
denise.damek@cuanschutz.edu
Facility Name
HCA Research Institute - Blue Sky Neurology - Denver
City
Englewood
State/Province
Colorado
ZIP/Postal Code
80113
Country
United States
Individual Site Status
Completed
Facility Name
Hartford Healthcare Medical Group - Hartford Hospital The Gray Cancer Center
City
New London
State/Province
Connecticut
ZIP/Postal Code
06320
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alexis Demopolous, MD
Phone
860-696-5169
Email
alexis.demopolous@hhchealth.org
Facility Name
Lynn Cancer Institute, Marcus Neuroscience Institute
City
Boca Raton
State/Province
Florida
ZIP/Postal Code
33486
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Baptist Health - Jacksonville
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32207
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Robert Cavaliere, MD
Phone
904-202-7300
Email
robert.cavaliere@bmcjax.com
Facility Name
Mayo Clinic
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32224
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jennifer Peterson, MD
Phone
904-717-0207
Email
peterson.jennifer2@mayo.edu
Facility Name
AdventHealth
City
Orlando
State/Province
Florida
ZIP/Postal Code
32804
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sherif Makar, MD
Phone
321-906-8712
Email
sherif.makar.md@adventhealth.com
Facility Name
Orlando Health UF Health Cancer Center
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicholas Avgeropoulos, MD
Phone
321-841-7218
Email
Nicholas.Avgeropoulos@OrlandoHealth.com
Facility Name
H. Lee Moffitt Cancer Center and Research Institute, Inc
City
Tampa
State/Province
Florida
ZIP/Postal Code
33612
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Yu, MD
Phone
813-745-8741
Email
michael.yu@moffitt.org
Facility Name
Piedmont Healthcare Brain Tumor Center
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30309
Country
United States
Individual Site Status
Completed
Facility Name
The Emory Clinic - Emory Healthcare - Winship Cancer Institute
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30322
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hui-Kuo Shu, MD
Phone
404-778-3473
Email
hgshu@emory.edu
Facility Name
Northside Hospital, Inc.
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30342
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gina Volas-Redd, MD
Phone
770-590-8311
Email
gena.volas@gacancer.com
Facility Name
Rush University Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
University of Chicago
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60617
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Veronika Seseri
Email
vseseri@bsd.uchicago.edu
First Name & Middle Initial & Last Name & Degree
Amanda Spratt
Email
aspratt@bsd.uchicago.edu
First Name & Middle Initial & Last Name & Degree
Steven Chmura
Facility Name
Parkview Cancer Institute - Fort Wayne Radiation Oncology Associates
City
Fort Wayne
State/Province
Indiana
ZIP/Postal Code
46845
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Brian Chang, MD
Phone
260-266-9100
Email
bchang02@gmail.com
Facility Name
The University of Kansas Cancer Center
City
Overland Park
State/Province
Kansas
ZIP/Postal Code
66210
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shalina Gupta-Burt, MD
Phone
785-295-8008
Email
sguptaburt@kumc.edu
Facility Name
University of Louisville - James Graham Brown Cancer Center
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shiao Woo, MD
Phone
502-561-2700
Email
shiao.woo@louisville.edu
Facility Name
Norton Cancer Institute
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40241
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kaylyn Sinicrope, MD
Phone
541-968-7896
Email
kaylyn.sinicrope@nortonhealthcare.org
Facility Name
LSU Health Sciences Center, New Orleans
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70072
Country
United States
Individual Site Status
Completed
Facility Name
Ochsner Health System
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121-2429
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marcus Ware, MD
Phone
504-842-4000
Email
mware@ochsner.org
Facility Name
Maine Medical Partners Neurology - Neurosurgery & Spine Associates
City
South Portland
State/Province
Maine
ZIP/Postal Code
04106
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christine Lu-Emerson, MD
Phone
207-883-1414
Email
cluemerson@mmc.org
Facility Name
John Hopkins School of Medicine
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21287
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lawrence Kleinberg, MD
Phone
410-614-2597
Email
kleinla@jhmi.edu
Facility Name
Tufts Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02111
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Suriya Jeyapalan, MD
Phone
617-636-2694
Email
sjeyapalan@tuftsmedicalcenter.org
Facility Name
University of Massachusetts Chan Medical School
City
Worcester
State/Province
Massachusetts
ZIP/Postal Code
01655
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alex Agrillo
Phone
774-455-4456
Email
alexandra.agrillo@umassmed.edu
First Name & Middle Initial & Last Name & Degree
David Cachia
Facility Name
University of Michigan Comprehensive Cancer Center
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Individual Site Status
Completed
Facility Name
Abbott Northwestern Hospital - Givens Brain Tumor Center
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55407
Country
United States
Individual Site Status
Recruiting
Facility Contact:
Phone
612-863-3452
Email
neurooncologyresearch@allina.com
First Name & Middle Initial & Last Name & Degree
Andrea Wasilewski, MD
Facility Name
University of Minnesota Health Clinics and Surgery Center
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55455
Country
United States
Individual Site Status
Withdrawn
Facility Name
University of Mississippi Medical Center
City
Jackson
State/Province
Mississippi
ZIP/Postal Code
39213
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lynette Harper
Email
lharper@umc.edu
First Name & Middle Initial & Last Name & Degree
Jennifer Barnes
Email
jbarnes@umc.edu
First Name & Middle Initial & Last Name & Degree
Mark Anderson
Facility Name
University of Missouri - Ellis Fischel Cancer Center
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65212
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gregg Biedermann, MD
Phone
573-884-8264
Email
biedermanng@health.missouri.edu
Facility Name
Health Midwest Ventures Group, Inc - Sarah Cannon HCA Midwest Brain and Spine
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64132
Country
United States
Individual Site Status
Withdrawn
Facility Name
Washington University School of Medicine
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Individual Site Status
Completed
Facility Name
Dartmouth-Hitchcock Medical Center
City
Lebanon
State/Province
New Hampshire
ZIP/Postal Code
03756
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Amy Chan, MD
Phone
603-650-5104
Email
amy.m.chan@hitchcock.org
Facility Name
JFK Neuroscience Institute, HMH JFK University Medical Center
City
Edison
State/Province
New Jersey
ZIP/Postal Code
08820
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joseph Landolfi, MD
Phone
732-321-7010
Email
Joseph.Landolfi@hackensackmeridian.org
Facility Name
Hackensack University Medical Center - John Theurer Cancer Center
City
Hackensack
State/Province
New Jersey
ZIP/Postal Code
07601
Country
United States
Individual Site Status
Completed
Facility Name
Northwell Health System Brain Tumor Center
City
Lake Success
State/Province
New York
ZIP/Postal Code
11042
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anuj Goenka, MD
Phone
516-321-3000
Email
agoenka@northwell.edu
Facility Name
NYU Langone - Laura & Issac Perimutter Cancer Center
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Erik Sulman, MD
Phone
646-501-6153
Email
erik.sulman@nyulangone.org
Facility Name
Mount Sinai - Icahn School of Medicine
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Disha Jain
Email
Disha.jain@mssm.edu
Phone
212-824-8579
Email
Lyndon.kim@mssm.edu
First Name & Middle Initial & Last Name & Degree
Lyndon Kim
Facility Name
New York Presbyterian - Columbia University
City
New York
State/Province
New York
ZIP/Postal Code
10032
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fabio Iwamoto, MD
Phone
212-342-0571
Email
fi2146@cumc.columbia.edu
Facility Name
University of Rochester Medical Center
City
Rochester
State/Province
New York
ZIP/Postal Code
14642
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nimish Mohile, MD
Phone
585-275-5823
Email
nimish_mohile@urmc.rochester.edu
Facility Name
SUNY Upstate Medical University
City
Syracuse
State/Province
New York
ZIP/Postal Code
13210
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ruham Alshiekh Nasany
Phone
315-464-3510
Email
nasanyr@upstate.edu
Facility Name
University of North Carolina Brain Tumor Program - UNC Lineberger Comprehensive Cancer Center
City
Chapel Hill
State/Province
North Carolina
ZIP/Postal Code
27599
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Colette Shen, MD
Phone
984-974-0400
Email
colette_shen@med.unc.edu
Facility Name
Novant Health Cancer Institute Radiation Oncology
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Scott L McGinnis, MD
Phone
704-316-6630
Email
lsmcginnis@novanthealth.org
Facility Name
Vidant Medical Center
City
Greenville
State/Province
North Carolina
ZIP/Postal Code
27834
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jasmin Jo, MD
Phone
252-816-2273
Email
Jasmin.Jo@vidanthealth.com
Facility Name
Forsyth Medical Center-Novant Health
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Volker Stieber, MD
Phone
336-718-5810
Email
vwstieber@novanthealth.org
Facility Name
Wake Forest Baptist Comprehensive Cancer Center
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Glenn Lesser, MD
Phone
336-716-9527
Email
glesser@wakehealth.edu
Facility Name
University of Cincinnati Cancer Institute
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kyle Wang, MD
Phone
603-244-9889
Email
wang2kl@ucmail.uc.edu
Facility Name
The James Cancer Hospital and Solove Research Institute - Arthur G James Cancer Hospital
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Piere Giglio, MD
Phone
614-293-4448
Email
pierre.giglio@osumc.edu
Facility Name
Oregon Health & Science University (OHSU)
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
John Minger
Phone
503-494-8756
Email
mingerj@ohsu.edu
Email
murphbl@ohsu.edu
First Name & Middle Initial & Last Name & Degree
Blair Murphy, MD
Facility Name
Geisinger Health System
City
Danville
State/Province
Pennsylvania
ZIP/Postal Code
17822
Country
United States
Individual Site Status
Withdrawn
Facility Name
Neuroscience Center, Philadelphia University of Pennsylvania
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Emily C McCoy
Email
Emily.Mccoy@Pennmedicine.upenn.edu
First Name & Middle Initial & Last Name & Degree
Penn Brain Tumor Center Research
Email
NCRD-BTC@uphs.upenn.edu
First Name & Middle Initial & Last Name & Degree
Steven Brem
Facility Name
University of Pennsylvania
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Steven Brem, MD
Phone
215-662-3487
Email
steven.brem@uphs.upenn.edu
Facility Name
Thomas Jefferson University Hospital
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wenyin Shi, MD
Phone
215-955-6702
Email
wenyin.shi@jefferson.edu
Facility Name
Allegheny Health Network Cancer Institute
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Helen Andreko
Phone
412-359-3400
Email
helen.andreko@ahn.org
First Name & Middle Initial & Last Name & Degree
Paul Woods
Email
Paul.Woods@AHN.ORG
First Name & Middle Initial & Last Name & Degree
Zachary Horne, MD
Facility Name
UPMC Hillman Cancer Center
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15232
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Frank Lieberman, MD
Phone
412-648-6507
Email
liebermanf@upmc.edu
Facility Name
Rhode Island Hospital
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02903
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Steven Toms, MD
Phone
401-793-9175
Email
steven.toms@lifespan.org
Facility Name
MUSC Radiation Oncology Brain & Spine Tumor Program
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Scott Lindhorst, MD
Phone
843-792-9016
Email
lindhors@musc.edu
Facility Name
SCRI - Tennessee Oncology
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37404
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Robert Graham, MD
Phone
434-409-7128
Email
rmgraham@tnonc.com
Facility Name
West Cancer Center - Germantown
City
Germantown
State/Province
Tennessee
ZIP/Postal Code
38138
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Matthew Ballo, MD
Phone
901-683-0055
Email
mballo@westclinic.com
Facility Name
SCRI - Tennessee Oncology
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Spigel, MD
Phone
615-524-4016
Email
colleen.shaw@sarahcannon.com
Facility Name
Texas Oncology Midtown - Austin Brain Tumor Center
City
Austin
State/Province
Texas
ZIP/Postal Code
78705
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andrew Brenner, MD
Phone
512-421-4100
Email
andrew.brenner@usoncology.com
Facility Name
Baylor Charles A. Sammons Cancer Center - Baylor University Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Karen Fink, MD
Phone
214-820-8690
Email
karen.fink@bswhealth.org
Facility Name
John Peter Smith Health Network - JPS Cancer Center
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Emmanuel Mantilla, MD
Phone
817-702-8300
Email
emantill@jpshealth.org
Facility Name
Houston Methodist Hospital
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ivo Tremont, MD
Phone
713-441-3831
Email
itremont@houstonmethodist.org
Facility Name
UT Health Mischer Neuroscience - Memorial Herman - UT Neurosciences
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jay-Jinguang Zhu, MD
Phone
832-799-7362
Email
jay.jiguang.zhu@uth.tmc.edu
Facility Name
San Antonio Cancer Institute
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Individual Site Status
Withdrawn
Facility Name
Baylor Scott & White Medical Center
City
Temple
State/Province
Texas
ZIP/Postal Code
76508
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anne Tann, MD
Phone
254-724-2417
Email
anne.tann@bswhealth.org
Facility Name
The University of Vermont Medical Center - University of Vermont Cancer Center
City
Burlington
State/Province
Vermont
ZIP/Postal Code
05401
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alissa Thomas, MD
Phone
802-656-8982
Email
alissa.thomas@uvmhealth.org
Facility Name
Massey Cancer Center - VCU Medical Center
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23298
Country
United States
Individual Site Status
Withdrawn
Facility Name
Swedish Health Services
City
Seattle
State/Province
Washington
ZIP/Postal Code
98109
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kester Phillips, MD
Phone
206-320-2300
Email
Kester.phillips@swedish.org
Facility Name
UW Medical Center - Alvord Brain Tumor Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98109
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tresa McGranahan, MD
Phone
206-520-5000
Email
tmcgranahan@uwmedicine.org
Facility Name
West Virginia University Cancer Institute
City
Morgantown
State/Province
West Virginia
ZIP/Postal Code
26506
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sonikpreet Aulakh, MD
Phone
248-463-8181
Email
sonikpreet.aulakh@hsc.wvu.edu
Facility Name
Innsbruck University Hospital
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
Individual Site Status
Active, not recruiting
Facility Name
Kepler University Hospital
City
Linz
ZIP/Postal Code
4020
Country
Austria
Individual Site Status
Active, not recruiting
Facility Name
University Hospital Salzburg
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Individual Site Status
Active, not recruiting
Facility Name
Hospital Erasme
City
Brussels
ZIP/Postal Code
1070
Country
Belgium
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Olivier De Witte, Prof
Phone
0032 2 555 3357
Email
olivier.de.witte@erasme.ulb.ac.be
Facility Name
University Hospital Liege - Sart Tilman
City
Liège
ZIP/Postal Code
B35, 4000
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pierre Freres, Dr.
Phone
0032 4 242 52 00
Email
pfreres@chuliege.be
Facility Name
The Ottawa Hospital Cancer Centre
City
Ottawa
State/Province
Ontario
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Garth Nicholas, Prof
Phone
(613) 737-7700
Email
gnicholas@toh.ca
Facility Name
Princess Margaret Cancer Centre
City
Toronto
State/Province
Ontario
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Warren Mason, Prof
Phone
416-946-2249
Email
warren.mason@uhn.on.ca
Facility Name
Sunnybrook Research Institute - Odette Cancer Centre
City
Toronto
State/Province
Ontario
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jay Detsky, Dr.
Phone
416.480.4806
Email
jay.detsky@sunnybrook.ca
Facility Name
CHUM Centre de Recherche
City
Montréal
State/Province
Quebec
ZIP/Postal Code
H2X1R9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mom Phat, Prof
Phone
(514) 890-8000
Email
mom.phat.chum@ssss.gouv.qc.ca
Email
sarah.lapointe.med@ssss.gouv.qc.ca
First Name & Middle Initial & Last Name & Degree
Sarah Lapointe
Facility Name
Universite de Sherbrooke - Sherbrooke Centre Hospitalier Universita
City
Sherbrooke
State/Province
Quebec
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Mathieu, Prof
Phone
(819) 564-5251
Email
david.mathieu@usherbrooke.ca
Facility Name
Masaryk Memorial Cancer Institute
City
Brno
ZIP/Postal Code
656 53
Country
Czechia
Individual Site Status
Active, not recruiting
Facility Name
University Hospital Plzeň
City
Pilsen
ZIP/Postal Code
305 99
Country
Czechia
Individual Site Status
Active, not recruiting
Facility Name
Na Homolce Hospital
City
Prague
ZIP/Postal Code
150 30
Country
Czechia
Individual Site Status
Active, not recruiting
Facility Name
Institut de cancérologie de l'Ouest
City
Angers
ZIP/Postal Code
49055
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Pierre Wertheimer Hospital
City
Bron
ZIP/Postal Code
69677
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Hôpital la Timone
City
Marseille
ZIP/Postal Code
13305
Country
France
Individual Site Status
Active, not recruiting
Facility Name
University Hospital Nice
City
Nice
ZIP/Postal Code
06000
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Pitié-Salpêtrière University Hospital
City
Paris
ZIP/Postal Code
75013
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Institut de cancérologie de l'Ouest
City
Saint Herblain
ZIP/Postal Code
44800
Country
France
Individual Site Status
Active, not recruiting
Facility Name
University Institute Cancer Toulouse Oncopole
City
Toulouse
ZIP/Postal Code
31059
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Gustave Roussy Institute
City
Villejuif
ZIP/Postal Code
94805
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Charité Campus Virchow Clinic
City
Berlin
ZIP/Postal Code
13353
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Kaul, Dr.
Phone
0049 30 450 527 112
Email
david.kaul@charite.de
Facility Name
University Hospital Essen
City
Essen
ZIP/Postal Code
45147
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Glas, Prof
Phone
0049 201 723 2461
Email
martin.glas@uk-essen.de
Facility Name
University Medical Center Freiburg
City
Freiburg
ZIP/Postal Code
79106
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carmen Meffle
Phone
+49 761 270 95880
Email
carmen.meffle@uniklinik-freiburg.de
First Name & Middle Initial & Last Name & Degree
Anca-Ligia Grosu, Prof
Facility Name
University Hospital Leipzig
City
Leipzig
ZIP/Postal Code
04103
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Claudia Göpel, Dr.
Phone
+49 (0) 341 / 97 18214
Email
claudia.goepel@medizin.uni-leipzig.de
First Name & Middle Initial & Last Name & Degree
Clemens Seidel, Dr
Facility Name
Rechts der Isar Hospital
City
Munich
ZIP/Postal Code
81675
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jan Stefan Kirschke, Prof
Phone
+49 89 4140 4501
Email
jan.kirschke@tum.de
Facility Name
University Hospital Tübingen
City
Tübingen
ZIP/Postal Code
72076
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Susanne Luginsland
Phone
0049 7071 29-83269
Email
tabatabai.office@med.uni-tuebingen.de
First Name & Middle Initial & Last Name & Degree
Tabatabai Ghazaleh, Prof.
Facility Name
Rambam Medical Center
City
Haifa
ZIP/Postal Code
3109601
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Liat Rapaport
Phone
+972 04 7776731
Email
O_trials@rmc.gov.il
First Name & Middle Initial & Last Name & Degree
Tzahala Tzuk-Shina, Dr
Facility Name
Hadassah Medical Center - Ein Kerem
City
Jerusalem
ZIP/Postal Code
9112001
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Prof
First Name & Middle Initial & Last Name & Degree
Anat Mordechai
Phone
972-2-6778719
Email
matan29@hadassah.org.il
First Name & Middle Initial & Last Name & Degree
Alexander Lossos, Prof
Facility Name
Rabin Medical Center
City
Petah Tikva
ZIP/Postal Code
49100
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shlomit Yust-Katz, Dr.
Phone
00(972) 3937-8077
Email
shlomit2@clalit.org.il
Facility Name
Sheba Medical Center
City
Ramat Gan
ZIP/Postal Code
52621
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alisa Taliansky, Dr.
Phone
+972 52 46 47 494
Email
alisa.talianski@sheba.health.gov.il
Facility Name
Tel Aviv Sourasky Medical Center
City
Tel Aviv
ZIP/Postal Code
64239
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carmit Ben Harosh
Phone
972-3-6974397
Email
Carmitbh@tlvmc.gov.il
First Name & Middle Initial & Last Name & Degree
Jonathan Roth, Prof.
Facility Name
Hokkaido University Hospital
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
060-8648
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hidefumi Aoyama
Phone
+81 11-706-5977
Email
h-aoyama2019@med.hokudai.ac.jp
Facility Name
Kanazawa University Hospital
City
Kanazawa-shi
State/Province
Ishikawa-Ken
ZIP/Postal Code
920-8641
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mitsutoshi Nakada
Phone
+81 76-265-2383
Email
mnakada@med.kanazawa-u.ac.jp
Facility Name
Saitama Medical University International Medical Center
City
Hidaka-shi
State/Province
Saitama-Ken
ZIP/Postal Code
350-1298
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kazuhiko Mishima
Phone
+81 42-984-4177
Email
kmishima@saitama-med.ac.jp
Facility Name
Kyorin University Hospital
City
Mitaka-shi
State/Province
Tokyo-To
ZIP/Postal Code
181-8611
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Motoo Nagane
Phone
+81 422-47-5511
Email
mnagane@ks.kyorin-u.ac.jp
Facility Name
Tokyo Women's Medical University Hospital
City
Shinjuku-ku
State/Province
Tokyo-To
ZIP/Postal Code
162-8666
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shunsuke Tsuzuki
Phone
+81 11-706-5977
Email
tsuzuki.shunsuke@twmu.ac.jp
Facility Name
Lausanne University Hospital
City
Lausanne
ZIP/Postal Code
CH-1011
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andreas Hottinger, Dr.
Phone
0041 21 314 46 90
Email
Andreas.Hottinger@chuv.ch
Facility Name
University Hospital Zurich
City
Zürich
ZIP/Postal Code
8091
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Patrick Roth, Prof.
Phone
00(41) 4425-55511
Email
patrick.roth@usz.ch
Facility Name
Clatterbridge Cancer Centre
City
Liverpool
ZIP/Postal Code
L7 8YA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shaveta Mehta
Phone
+44 0151 556 5054
Email
shaveta.mehta1@nhs.net
Facility Name
Guy's Hospital
City
London
ZIP/Postal Code
SE1 9RT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christopher Bayliss
Email
brainresearchteam@gstt.nhs.uk
First Name & Middle Initial & Last Name & Degree
Lucy Brazil, Dr.
Facility Name
Charing Cross Hospital
City
London
ZIP/Postal Code
W6 8RF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Matthew Williams
Phone
+44 203313 0303
Email
matthew.williams@imperial.ac.uk
Facility Name
Nottingham University Hospitals NHS Trust
City
Nottingham
ZIP/Postal Code
NG5 1PB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Elvira Amaro
Phone
0115 9691169
Ext
74690
Email
Elvira.Amaro@nuh.nhs.uk
First Name & Middle Initial & Last Name & Degree
Karen Foweraker
Facility Name
Royal Preston Hospital
City
Preston
ZIP/Postal Code
PR29HT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Issac Phang, Dr.
Phone
(+44) 01772 522575
Email
isaac.phang@lthtr.nhs.uk
12. IPD Sharing Statement
Citations:
PubMed Identifier
36336899
Citation
Miller R, Niazi M, Russial O, Poiset S, Shi W. Tumor treating fields with radiation for glioblastoma: a narrative review. Chin Clin Oncol. 2022 Oct;11(5):40. doi: 10.21037/cco-22-90.
Results Reference
derived
PubMed Identifier
35574391
Citation
Miller R, Song A, Ali A, Niazi M, Bar-Ad V, Martinez N, Glass J, Alnahhas I, Andrews D, Judy K, Evans J, Farrell C, Werner-Wasik M, Chervoneva I, Ly M, Palmer J, Liu H, Shi W. Scalp-Sparing Radiation With Concurrent Temozolomide and Tumor Treating Fields (SPARE) for Patients With Newly Diagnosed Glioblastoma. Front Oncol. 2022 Apr 29;12:896246. doi: 10.3389/fonc.2022.896246. eCollection 2022.
Results Reference
derived
Learn more about this trial
Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM
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