search
Back to results

Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial (POINT)

Primary Purpose

Ischemic Attack, Transient

Status
Terminated
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Clopidogrel
placebo
Sponsored by
University of California, San Francisco
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Ischemic Attack, Transient focused on measuring Transient Ischemic Attack, TIA, minor stroke

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Neurological deficit (based on history or exam) attributed to focal brain ischemia and EITHER:

    • High risk TIA: Complete resolution of the deficit at the time of randomization AND ABCD2 score of (greater than or equal to) 4 OR
    • Minor ischemic stroke: residual deficit with NIHSS of (less than or equal to) 3 at the time of randomization
  • Ability to randomize within 12 hours of time last known free of new ischemic symptoms.
  • Head CT or MRI ruling out hemorrhage or other pathology, such as vascular malformation, tumor, or abscess, that could explain symptoms or contraindicate therapy.
  • Ability to tolerate aspirin at a does of 50-325 mg/day.

Exclusion Criteria

  • Age <18 years
  • TIA symptoms limited to isolated numbness, isolated visual changes, or isolated dizziness/vertigo.
  • In the judgment of the treating physician, a candidate for thrombolysis, endarterectomy or endovascular intervention, unless the subject declines both endarterectomy and endovascular intervention at the time of evaluation for eligibility.
  • Receipt of any intravenous or intra-arterial thrombolysis within 1 week prior to index event.
  • Gastrointestinal bleed or major surgery within 3 months prior to index event.
  • History of nontraumatic intracranial hemorrhage.
  • Clear indication for anticoagulation (e.g., warfarin, heparin) anticipated during the study period (atrial fibrillation, mechanical heart valve, deep venous thrombosis, pulmonary embolism, antiphospholipid antibody syndrome, hypercoagulable state).
  • Qualifying ischemic event induced by angiography or surgery.
  • Severe non-cardiovascular comorbidity with life expectancy <3 months.

  • Contraindication to clopidogrel or aspirin.

    • Known allergy
    • Severe renal (serum creatinine >2 mg/dL or 176.8umol/L) or hepatic insufficiency (prior or concurrent diagnosis, with International Normalized Ratio (INR)>1.5 or any resultant complication, such as variceal bleeding, encephalopathy, or icterus)
    • Hemostatic disorder or systemic bleeding in the past 3 months
    • Current thrombocytopenia (platelet count <100 x10^9/l) or neutropenia (<1 x10^9/l)
    • History of drug-induced hematologic or hepatic abnormalities
  • Anticipated requirement for long-term (>7 day) non-study antiplatelet drugs (eg, dipyridamole, clopidogrel, ticlopidine), or Non-steroidal Anti-inflammatory Drugs (NSAIDs) affecting platelet function (such as prior vascular stent or arthritis).
  • Inability to swallow medications.
  • At risk for pregnancy: premenopausal or post menopausal woman within 12 months of last menses without a negative pregnancy test or not committing to adequate birth control (e.g., oral contraceptive, two methods of barrier birth control, or abstinence).
  • Unavailability for follow-up.
  • Signed and dated informed consent not obtained from patient.
  • Other neurological conditions that would complicate assessment of outcomes during follow-up.
  • Ongoing treatment in another study of an investigational therapy that may potentially interact with study drug, or treatment in such a study within the last 7 days.
  • Previously enrolled in the POINT study.

Sites / Locations

  • Chandler Regional Medical Center
  • Banner University Medical Center - Tucson Campus
  • Mercy San Juan Medical Center
  • UCSD Health La Jolla
  • Loma Linda University Medical Center
  • Long Beach Memorial Medical Center
  • Kaiser Permanente Los Angeles Medical Center
  • Cedars-Sinai Medical Center
  • Ronald Reagan UCLA Medical Center
  • Desert Regional Medical Center
  • Huntington Memorial Hospital
  • UC Davis Medical Center
  • Mercy General Hospital
  • Scripps Mercy Hospital San Diego
  • UCSD Medical Center - Hillcrest Hospital
  • San Francisco General Hospital
  • UCSF Medical Center
  • Stanford University Medical Center
  • Los Robles Hospital and Medical Center
  • University of Colorado Hospital
  • Swedish Medical Center
  • St. Anthony Hospital
  • Yale-New Haven Hospital
  • Christiana Hospital
  • George Washington University Hospital
  • UF Health Shands Hospital
  • University of Florida
  • Sarasota Memorial Hospital
  • Grady Memorial Hospital
  • Emory University Hospital Midtown
  • Emory University Hospital
  • Augusta University Medical Center
  • the Queen's Medical Center
  • Northwestern Memorial Hospital
  • Rush University Medical Center
  • University of Illinois Hospital
  • Alexian Brothers Medical Center
  • Evanston Hospital
  • NorthShore Glenbrook Hospital
  • Presence Saint Joseph Medical Center
  • Loyola University Medical Center
  • Southern Illinois University Memorial Medical Center
  • University of Iowa Hospitals and Clinics
  • University of Kansas Hospital
  • St. Elizabeth Medical Center South
  • St. Elizabeth Hospital
  • St. Elizabeth Hospital Fort Thomas
  • University of Kentucky Hospital
  • University of Louisville Hospital
  • University of Maryland Medical Center
  • Frederick Memorial Hospital
  • Massachusetts General Hospital
  • Brigham and Women's Hospital
  • Boston Medical Center
  • Beth Israel Deaconess Medical Center
  • UMASS Memorial Medical Center
  • Detroit Receiving Hospital
  • Harper University Hospital
  • Henry Ford Hospital
  • Sinai-Grace Hospital
  • St. John Hospital and Medical Center
  • Mercy Health Saint Mary's
  • William Beaumont Hospital
  • William Beaumont Hospital - Troy
  • Henry Ford West Bloomfield Hospital
  • Fairview Southdale Hospital
  • Abbott Northwestern Hospital
  • Hennepin County Medical Center
  • University of Minnesota Medical Center Hospital
  • Mayo Clinic Saint Mary's Campus
  • United Hospital
  • Barnes Jewish Hospital
  • Mercy Hospital
  • Mercy Hospital
  • Benefis Hospitals Inc
  • Great Falls Clinic Hospital, Great Falls
  • Dartmouth-Hitchcock Medical Center
  • Cooper University Hospital
  • JFK Medical Center
  • Hackensack University Medical Center
  • Jersey Shore University Medical Center
  • Robert Wood Johnson University Hospital
  • Lincoln Medical and Mental Health Center
  • Kings County Hospital Center
  • SUNY Downstate Medical Center
  • Maimonides Medical Center
  • Buffalo General Medical Center
  • New York Presbyterian / Columbia University Medical Center
  • NYP Weill Cornell Medical Center
  • Rochester General Hospital
  • Strong Memorial Hospital
  • Stony Brook University Hospital
  • SUNY Upstate Medical University
  • Guilford Neurologic Associates
  • Wake Forest Baptist Medical Center
  • Summa Akron City Hospital
  • Mercy Health West Hospital
  • Christ Hospital
  • University of Cincinnati Medical Center
  • Good Samaritan Hospital
  • Jewish Hospital
  • Bethesda North Hospital
  • MetroHealth Medical Center
  • Cleveland Clinic
  • OSU Wexner Medical Center
  • Mount Carmel East Hospital
  • Miami Valley Hospital
  • University of Toledo Medical Center
  • Providence Portland Medical Center
  • Providence St. Vincent Medical Center
  • Oregon Health and Science University Hospital
  • Portland VA Medical Center
  • Abington Memorial Hospital
  • Lehigh Valley Hospital
  • Pennsylvania State Hershey Medical Center
  • Hahnemann University Hospital
  • Hospital of the University of Pennsylvania
  • Penn Presbyterian Medical Center
  • Pennsylvania Hospital
  • Thomas Jefferson University Hospital
  • Temple University Hospital
  • UPMC Presbyterian Hospital
  • UPMC Shadyside Hospital
  • WellSpan York Hospital
  • Rhode Island Hospital
  • Medical University of South Carolina University Hospital
  • Palmetto Health Richland
  • Vanderbilt University Hospital
  • University Medical Center Brackenridge
  • Seton Medical Center
  • Texas Health Presbyterian Hospital - Dallas
  • Valley Baptist Medical Center - Harlingen
  • Ben Taub General Hospital
  • Houston Methodist Hospital
  • Memorial Hermann Texas Medical Center
  • University of Texas Health Science Center San Antonio
  • UVA Medical Center
  • Bon Secours St. Francis Medical Center
  • Bon Secours St. Mary's Hospital
  • Henrico Doctors' Hospital - Forest Campus
  • Henrico Doctors' Hospital - Parham Campus
  • Harborview Medical Center
  • University of Washington Medical Center
  • WVU Healthcare Ruby Memorial Hospital
  • Columbia St. Mary's Hospital
  • Aurora St. Luke's Medical Center
  • Froedtert Memorial Lutheran Hospital
  • Gosford Hospital
  • John Hunter Hospital
  • Royal Adelaide Hospital
  • Box Hill Hospital
  • Monash Medical Centre
  • The Northern Hospital
  • Footscray Hospital
  • Austin Hospital
  • Royal Melbourne Hospital
  • University of Calgary - Foothills Campus
  • Grey Nuns Hospital
  • University of Alberta Hospital
  • Vancouver General Hospital
  • London Health Sciences Center
  • Charles LeMoyne Hospital
  • Montreal General Hospital
  • Notre-Dame Hospital
  • Enfant-Jesus Hospital
  • Helsinki University Central Hospital
  • Turku University Hospital
  • Fleyriat Hospital
  • Pierre Wetheimer Hospital
  • Adolphe de Rothschild Ophthalmologic Foundation
  • Bichat-Claude Bernard Hospital
  • Pitie-Salpetriere Hospital
  • Foch Hospital
  • University Hospital of Ulm
  • Neurological Clinic Bad Neustadt
  • Vivantes Hospital Neukolln
  • Central Bremen Hospital
  • University Hospital Essen
  • University Hospital Frankfurt
  • University Medical Center Hamburg
  • Hannover Medical School
  • University Hospital Heidelberg
  • University Hospital Schleswig-Holstein Kiel Campus
  • University Medical Center Leipzig
  • University Hospital Munster
  • Mexican Association for Clinical Research
  • Central Hospital Dr. Ignacio Morones Prieto
  • Culiacan General Hospital
  • Neurosciences Clinical Trials
  • ABC Medical Center Santa Fe
  • Auckland City Hospital
  • Hospital del Mar
  • Santa Creu and Sant Pau Hospital
  • Vall d'Hebron Hospital
  • Basurto Hospital
  • Burgos University Hospital
  • Hospital Donostia
  • Girona University HOspital
  • La Fe University Hospital
  • Miguel Servet Hospital
  • Addenbrooke's Hospital
  • Queen Elizabeth University Hospital
  • Northwick Park Hospital
  • The Royal London Hospital
  • University College Hospital
  • Luton and Dunstable University Hospital
  • John Radcliffe Hospital
  • Royal United Hospital - Bath
  • Southampton General Hospital
  • Royal Stoke University Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Placebo Comparator

Arm Label

clopidogrel

placebo

Arm Description

Patients assigned to clopidogrel in addition to aspirin

Patients assigned to placebo in addition to aspirin

Outcomes

Primary Outcome Measures

Composite of Ischemic Stroke, Myocardial Infarction, or Death From Ischemic Vascular Causes
Primary efficacy outcome: Number of Participants with Ischemic Stroke, Myocardial Infarction, or Death From Ischemic Vascular Causes
Major Hemorrhage
Primary safety outcome: Number of Participants with major hemorrhage

Secondary Outcome Measures

Ischemic Stroke
Secondary efficacy outcome:Number of participants with Ischemic stroke
Myocardial Infarction
Secondary efficacy outcome: Number of participants with Myocardial infarction
Death From Ischemic Vascular Causes
Secondary efficacy outcome: Number of participants with Death from ischemic vascular causes
Ischemic or Hemorrhagic Stroke
Secondary efficacy outcome: Number of participants with Ischemic or hemorrhagic stroke
Composite of Ischemic Stroke, Myocardial Infarction, Death From Ischemic Vascular Causes, or Major Hemorrhage
Secondary efficacy outcome: Number of participants with ischemic stroke, myocardial infarction, death from ischemic vascular causes, or major hemorrhage

Full Information

First Posted
October 6, 2009
Last Updated
November 14, 2018
Sponsor
University of California, San Francisco
Collaborators
Neurological Emergencies Treatment Trials Network (NETT), Medical University of South Carolina, The Emmes Company, LLC
search

1. Study Identification

Unique Protocol Identification Number
NCT00991029
Brief Title
Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial
Acronym
POINT
Official Title
Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial
Study Type
Interventional

2. Study Status

Record Verification Date
November 2018
Overall Recruitment Status
Terminated
Why Stopped
The trial was halted by the DSMB.
Study Start Date
May 28, 2010 (Actual)
Primary Completion Date
April 9, 2018 (Actual)
Study Completion Date
April 9, 2018 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University of California, San Francisco
Collaborators
Neurological Emergencies Treatment Trials Network (NETT), Medical University of South Carolina, The Emmes Company, LLC

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
A transient ischemic attack (TIA) is a transient episode of neurological dysfunction caused by focal brain, spinal cord, or retinal ischemia, without acute infarction. An ischemic stroke is a cerebral infarction. In POINT, eligibility is limited to brain TIAs and to minor ischemic strokes (with an NIH Stroke Scale [NIHSS] score less than or equal to 3). TIAs are common [25], and are often harbingers of disabling strokes. Approximately 250,000-350,000 TIAs are diagnosed each year in the US. Given median survival of more than 8 years [32], there are approximately 2.4 million TIA survivors. In a national survey, one in fifteen of those over 65 years old reported a history of TIA [33], which is equivalent to a prevalence of 2.3 million in older Americans. Based on the prevalence of undiagnosed transient neurological events, the true incidence of TIA may be twice as high as the rates of diagnosis [33]. Based on our review of the National Inpatient Sample for 1997-2003, there were an average of 200,000 hospital admissions for TIA each year, with annual charges climbing quickly in the period to $2.6 billion in 2003. Composite endpoint of new ischemic vascular events: ischemic stroke, myocardial infarction or ischemic vascular death at 90 days.
Detailed Description
Platelet-Oriented Inhibition in New TIA and minor ischemic stroke (POINT) Trial, is a prospective, randomized, double-blind, multicenter trial with the primary null hypothesis that, in patients with TIA or minor ischemic stroke treated with aspirin 50-325 mg/day, there is no difference in the event-free survival at 90 days in those treated with clopidogrel (600 mg loading dose then 75 mg/day) compared to placebo when subjects are randomized within 12 hours of time last known free of new ischemic symptoms. Its primary objective is to determine whether clopidogrel 75 mg/day by mouth after a loading dose of 600 mg of clopidogrel is effective in preventing major ischemic vascular events (ischemic stroke, myocardial infarction, and ischemic vascular death) at 90 days when initiated within 12 hours of TIA or minor ischemic stroke onset in patients receiving aspirin 50-325 mg/day (with a dose of 150-200 mg daily for 5 days followed by 75-100 mg daily strongly recommended). Patients over 18 years of age with high-risk TIA (defined as an ABCD2 score greater than or equal to 4) or minor ischemic stroke (with NIHSS less than or equal to 3) who can be treated within 12 hours of time last known free of new ischemic symptoms will be enrolled. Subjects will be randomized 1:1 (clopidogrel: placebo), controlling for clinical center. A study participant's eligibility will be determined by site personnel prior to accessing the Randomization Module in the WebDCU™, a web-enabled clinical trials management system that was developed by the NETT Statistics and Data Management Center (SDMC) at Medical University of South Carolina (MUSC).Qualified users will access the Randomization Interface and complete a protocol-specific eligibility checklist. If the Randomization Interface finds the patient to be eligible based on the information provided, a randomization number and a confirmatory e-mail are generated. Each subject is followed for 90 days from randomization; the trial will be completed in 7 years. A total of 5,840 patients will be recruited. Recruitment will occur over 90 months, with a goal rate of 0.40 subjects/site/month for US sites, and a goal rate of 0.47 subjects/site/month for OUS sites. Current participating sites can be found at: http://www.pointtrial.org/node/18.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Ischemic Attack, Transient
Keywords
Transient Ischemic Attack, TIA, minor stroke

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
4881 (Actual)

8. Arms, Groups, and Interventions

Arm Title
clopidogrel
Arm Type
Active Comparator
Arm Description
Patients assigned to clopidogrel in addition to aspirin
Arm Title
placebo
Arm Type
Placebo Comparator
Arm Description
Patients assigned to placebo in addition to aspirin
Intervention Type
Drug
Intervention Name(s)
Clopidogrel
Other Intervention Name(s)
Plavix
Intervention Description
Loading dose of 600mg followed by 75 milligrams, oral, one tablet daily for 89 days
Intervention Type
Drug
Intervention Name(s)
placebo
Intervention Description
Loading dose of 8 tablets followed by one tablet daily for 89 days
Primary Outcome Measure Information:
Title
Composite of Ischemic Stroke, Myocardial Infarction, or Death From Ischemic Vascular Causes
Description
Primary efficacy outcome: Number of Participants with Ischemic Stroke, Myocardial Infarction, or Death From Ischemic Vascular Causes
Time Frame
Up to 90 days
Title
Major Hemorrhage
Description
Primary safety outcome: Number of Participants with major hemorrhage
Time Frame
Up to 90 days
Secondary Outcome Measure Information:
Title
Ischemic Stroke
Description
Secondary efficacy outcome:Number of participants with Ischemic stroke
Time Frame
Up to 90 days
Title
Myocardial Infarction
Description
Secondary efficacy outcome: Number of participants with Myocardial infarction
Time Frame
Up to 90 days
Title
Death From Ischemic Vascular Causes
Description
Secondary efficacy outcome: Number of participants with Death from ischemic vascular causes
Time Frame
Up to 90 days
Title
Ischemic or Hemorrhagic Stroke
Description
Secondary efficacy outcome: Number of participants with Ischemic or hemorrhagic stroke
Time Frame
Up to 90 days
Title
Composite of Ischemic Stroke, Myocardial Infarction, Death From Ischemic Vascular Causes, or Major Hemorrhage
Description
Secondary efficacy outcome: Number of participants with ischemic stroke, myocardial infarction, death from ischemic vascular causes, or major hemorrhage
Time Frame
Up to 90 days
Other Pre-specified Outcome Measures:
Title
Hemorrhagic Stroke
Description
Other safety outcome: Number of participants with Hemorrhagic stroke
Time Frame
up to 90 days
Title
Symptomatic Intracerebral Hemorrhage
Description
Other safety outcome: Number of participants with Symptomatic intracerebral hemorrhage
Time Frame
up to 90 days
Title
Other Symptomatic Intracranial Hemorrhage
Description
Other safety outcome: Number of participants with other symptomatic intracranial hemorrhage
Time Frame
up to 90 days
Title
Major Hemorrhage Other Than Intracranial Hemorrhage
Description
Other safety outcome: Number of Participants with Major hemorrhage other than intracranial hemorrhage
Time Frame
up to 90 days
Title
Minor Hemorrhage
Description
Other safety outcome:Number of Participants with Minor hemorrhage
Time Frame
up to 90 days
Title
Death From Any Cause
Description
Other safety outcome: Number of Participants with Death from any cause
Time Frame
up to 90 days

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Neurological deficit (based on history or exam) attributed to focal brain ischemia and EITHER: High risk TIA: Complete resolution of the deficit at the time of randomization AND ABCD2 score of (greater than or equal to) 4 OR Minor ischemic stroke: residual deficit with NIHSS of (less than or equal to) 3 at the time of randomization Ability to randomize within 12 hours of time last known free of new ischemic symptoms. Head CT or MRI ruling out hemorrhage or other pathology, such as vascular malformation, tumor, or abscess, that could explain symptoms or contraindicate therapy. Ability to tolerate aspirin at a does of 50-325 mg/day. Exclusion Criteria Age <18 years TIA symptoms limited to isolated numbness, isolated visual changes, or isolated dizziness/vertigo. In the judgment of the treating physician, a candidate for thrombolysis, endarterectomy or endovascular intervention, unless the subject declines both endarterectomy and endovascular intervention at the time of evaluation for eligibility. Receipt of any intravenous or intra-arterial thrombolysis within 1 week prior to index event. Gastrointestinal bleed or major surgery within 3 months prior to index event. History of nontraumatic intracranial hemorrhage. Clear indication for anticoagulation (e.g., warfarin, heparin) anticipated during the study period (atrial fibrillation, mechanical heart valve, deep venous thrombosis, pulmonary embolism, antiphospholipid antibody syndrome, hypercoagulable state). Qualifying ischemic event induced by angiography or surgery. Severe non-cardiovascular comorbidity with life expectancy <3 months. Contraindication to clopidogrel or aspirin. Known allergy Severe renal (serum creatinine >2 mg/dL or 176.8umol/L) or hepatic insufficiency (prior or concurrent diagnosis, with International Normalized Ratio (INR)>1.5 or any resultant complication, such as variceal bleeding, encephalopathy, or icterus) Hemostatic disorder or systemic bleeding in the past 3 months Current thrombocytopenia (platelet count <100 x10^9/l) or neutropenia (<1 x10^9/l) History of drug-induced hematologic or hepatic abnormalities Anticipated requirement for long-term (>7 day) non-study antiplatelet drugs (eg, dipyridamole, clopidogrel, ticlopidine), or Non-steroidal Anti-inflammatory Drugs (NSAIDs) affecting platelet function (such as prior vascular stent or arthritis). Inability to swallow medications. At risk for pregnancy: premenopausal or post menopausal woman within 12 months of last menses without a negative pregnancy test or not committing to adequate birth control (e.g., oral contraceptive, two methods of barrier birth control, or abstinence). Unavailability for follow-up. Signed and dated informed consent not obtained from patient. Other neurological conditions that would complicate assessment of outcomes during follow-up. Ongoing treatment in another study of an investigational therapy that may potentially interact with study drug, or treatment in such a study within the last 7 days. Previously enrolled in the POINT study.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
S. Claiborne Johnston, MD, PhD
Organizational Affiliation
University of Texas - Austin
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
J. Donald Easton, MD
Organizational Affiliation
University of California, San Francisco
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Anthony S. Kim, MD, MAS
Organizational Affiliation
University of California, San Francisco
Official's Role
Principal Investigator
Facility Information:
Facility Name
Chandler Regional Medical Center
City
Chandler
State/Province
Arizona
ZIP/Postal Code
85224
Country
United States
Facility Name
Banner University Medical Center - Tucson Campus
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85724
Country
United States
Facility Name
Mercy San Juan Medical Center
City
Carmichael
State/Province
California
ZIP/Postal Code
95608
Country
United States
Facility Name
UCSD Health La Jolla
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Loma Linda University Medical Center
City
Loma Linda
State/Province
California
ZIP/Postal Code
92354
Country
United States
Facility Name
Long Beach Memorial Medical Center
City
Long Beach
State/Province
California
ZIP/Postal Code
90806
Country
United States
Facility Name
Kaiser Permanente Los Angeles Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90027
Country
United States
Facility Name
Cedars-Sinai Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
Ronald Reagan UCLA Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90095
Country
United States
Facility Name
Desert Regional Medical Center
City
Palm Springs
State/Province
California
ZIP/Postal Code
92262
Country
United States
Facility Name
Huntington Memorial Hospital
City
Pasadena
State/Province
California
ZIP/Postal Code
91105
Country
United States
Facility Name
UC Davis Medical Center
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
Facility Name
Mercy General Hospital
City
Sacramento
State/Province
California
ZIP/Postal Code
95819
Country
United States
Facility Name
Scripps Mercy Hospital San Diego
City
San Diego
State/Province
California
ZIP/Postal Code
92103
Country
United States
Facility Name
UCSD Medical Center - Hillcrest Hospital
City
San Diego
State/Province
California
ZIP/Postal Code
92103
Country
United States
Facility Name
San Francisco General Hospital
City
San Francisco
State/Province
California
ZIP/Postal Code
94110
Country
United States
Facility Name
UCSF Medical Center
City
San Francisco
State/Province
California
ZIP/Postal Code
94143
Country
United States
Facility Name
Stanford University Medical Center
City
Stanford
State/Province
California
ZIP/Postal Code
94305
Country
United States
Facility Name
Los Robles Hospital and Medical Center
City
Thousand Oaks
State/Province
California
ZIP/Postal Code
91360
Country
United States
Facility Name
University of Colorado Hospital
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
Swedish Medical Center
City
Englewood
State/Province
Colorado
ZIP/Postal Code
80113
Country
United States
Facility Name
St. Anthony Hospital
City
Lakewood
State/Province
Colorado
ZIP/Postal Code
80228
Country
United States
Facility Name
Yale-New Haven Hospital
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06510
Country
United States
Facility Name
Christiana Hospital
City
Newark
State/Province
Delaware
ZIP/Postal Code
19713
Country
United States
Facility Name
George Washington University Hospital
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20037
Country
United States
Facility Name
UF Health Shands Hospital
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32608
Country
United States
Facility Name
University of Florida
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32209
Country
United States
Facility Name
Sarasota Memorial Hospital
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
Grady Memorial Hospital
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30303
Country
United States
Facility Name
Emory University Hospital Midtown
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30308
Country
United States
Facility Name
Emory University Hospital
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30322
Country
United States
Facility Name
Augusta University Medical Center
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
Facility Name
the Queen's Medical Center
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96813
Country
United States
Facility Name
Northwestern Memorial Hospital
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611
Country
United States
Facility Name
Rush University Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
University of Illinois Hospital
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Alexian Brothers Medical Center
City
Elk Grove Village
State/Province
Illinois
ZIP/Postal Code
60007
Country
United States
Facility Name
Evanston Hospital
City
Evanston
State/Province
Illinois
ZIP/Postal Code
60201
Country
United States
Facility Name
NorthShore Glenbrook Hospital
City
Glenview
State/Province
Illinois
ZIP/Postal Code
60026
Country
United States
Facility Name
Presence Saint Joseph Medical Center
City
Joliet
State/Province
Illinois
ZIP/Postal Code
60435
Country
United States
Facility Name
Loyola University Medical Center
City
Maywood
State/Province
Illinois
ZIP/Postal Code
60153
Country
United States
Facility Name
Southern Illinois University Memorial Medical Center
City
Springfield
State/Province
Illinois
ZIP/Postal Code
62781
Country
United States
Facility Name
University of Iowa Hospitals and Clinics
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
University of Kansas Hospital
City
Kansas City
State/Province
Kansas
ZIP/Postal Code
66160
Country
United States
Facility Name
St. Elizabeth Medical Center South
City
Edgewood
State/Province
Kentucky
ZIP/Postal Code
41017
Country
United States
Facility Name
St. Elizabeth Hospital
City
Florence
State/Province
Kentucky
ZIP/Postal Code
41042
Country
United States
Facility Name
St. Elizabeth Hospital Fort Thomas
City
Fort Thomas
State/Province
Kentucky
ZIP/Postal Code
41075
Country
United States
Facility Name
University of Kentucky Hospital
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40536
Country
United States
Facility Name
University of Louisville Hospital
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Facility Name
University of Maryland Medical Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21201
Country
United States
Facility Name
Frederick Memorial Hospital
City
Frederick
State/Province
Maryland
ZIP/Postal Code
21701
Country
United States
Facility Name
Massachusetts General Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
Brigham and Women's Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02115
Country
United States
Facility Name
Boston Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02118
Country
United States
Facility Name
Beth Israel Deaconess Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
UMASS Memorial Medical Center
City
Worcester
State/Province
Massachusetts
ZIP/Postal Code
01655
Country
United States
Facility Name
Detroit Receiving Hospital
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48201
Country
United States
Facility Name
Harper University Hospital
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48201
Country
United States
Facility Name
Henry Ford Hospital
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
Sinai-Grace Hospital
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48235
Country
United States
Facility Name
St. John Hospital and Medical Center
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48236
Country
United States
Facility Name
Mercy Health Saint Mary's
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49503
Country
United States
Facility Name
William Beaumont Hospital
City
Royal Oak
State/Province
Michigan
ZIP/Postal Code
48073
Country
United States
Facility Name
William Beaumont Hospital - Troy
City
Troy
State/Province
Michigan
ZIP/Postal Code
48085
Country
United States
Facility Name
Henry Ford West Bloomfield Hospital
City
West Bloomfield
State/Province
Michigan
ZIP/Postal Code
48322
Country
United States
Facility Name
Fairview Southdale Hospital
City
Edina
State/Province
Minnesota
ZIP/Postal Code
55435
Country
United States
Facility Name
Abbott Northwestern Hospital
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55407
Country
United States
Facility Name
Hennepin County Medical Center
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55415
Country
United States
Facility Name
University of Minnesota Medical Center Hospital
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55454
Country
United States
Facility Name
Mayo Clinic Saint Mary's Campus
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55902
Country
United States
Facility Name
United Hospital
City
Saint Paul
State/Province
Minnesota
ZIP/Postal Code
55102
Country
United States
Facility Name
Barnes Jewish Hospital
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Mercy Hospital
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63141
Country
United States
Facility Name
Mercy Hospital
City
Springfield
State/Province
Missouri
ZIP/Postal Code
65804
Country
United States
Facility Name
Benefis Hospitals Inc
City
Great Falls
State/Province
Montana
ZIP/Postal Code
59405
Country
United States
Facility Name
Great Falls Clinic Hospital, Great Falls
City
Great Falls
State/Province
Montana
ZIP/Postal Code
59405
Country
United States
Facility Name
Dartmouth-Hitchcock Medical Center
City
Lebanon
State/Province
New Hampshire
ZIP/Postal Code
03766
Country
United States
Facility Name
Cooper University Hospital
City
Camden
State/Province
New Jersey
ZIP/Postal Code
08103
Country
United States
Facility Name
JFK Medical Center
City
Edison
State/Province
New Jersey
ZIP/Postal Code
08820
Country
United States
Facility Name
Hackensack University Medical Center
City
Hackensack
State/Province
New Jersey
ZIP/Postal Code
07601
Country
United States
Facility Name
Jersey Shore University Medical Center
City
Neptune
State/Province
New Jersey
ZIP/Postal Code
07753
Country
United States
Facility Name
Robert Wood Johnson University Hospital
City
New Brunswick
State/Province
New Jersey
ZIP/Postal Code
08901
Country
United States
Facility Name
Lincoln Medical and Mental Health Center
City
Bronx
State/Province
New York
ZIP/Postal Code
10451
Country
United States
Facility Name
Kings County Hospital Center
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11203
Country
United States
Facility Name
SUNY Downstate Medical Center
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11203
Country
United States
Facility Name
Maimonides Medical Center
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11219
Country
United States
Facility Name
Buffalo General Medical Center
City
Buffalo
State/Province
New York
ZIP/Postal Code
14203
Country
United States
Facility Name
New York Presbyterian / Columbia University Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10032
Country
United States
Facility Name
NYP Weill Cornell Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10065
Country
United States
Facility Name
Rochester General Hospital
City
Rochester
State/Province
New York
ZIP/Postal Code
14621
Country
United States
Facility Name
Strong Memorial Hospital
City
Rochester
State/Province
New York
ZIP/Postal Code
14642
Country
United States
Facility Name
Stony Brook University Hospital
City
Stony Brook
State/Province
New York
ZIP/Postal Code
11794
Country
United States
Facility Name
SUNY Upstate Medical University
City
Syracuse
State/Province
New York
ZIP/Postal Code
13210
Country
United States
Facility Name
Guilford Neurologic Associates
City
Greensboro
State/Province
North Carolina
ZIP/Postal Code
27405
Country
United States
Facility Name
Wake Forest Baptist Medical Center
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157
Country
United States
Facility Name
Summa Akron City Hospital
City
Akron
State/Province
Ohio
ZIP/Postal Code
44304
Country
United States
Facility Name
Mercy Health West Hospital
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45211
Country
United States
Facility Name
Christ Hospital
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Facility Name
University of Cincinnati Medical Center
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Facility Name
Good Samaritan Hospital
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45220
Country
United States
Facility Name
Jewish Hospital
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45236
Country
United States
Facility Name
Bethesda North Hospital
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45242
Country
United States
Facility Name
MetroHealth Medical Center
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44109
Country
United States
Facility Name
Cleveland Clinic
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
OSU Wexner Medical Center
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Mount Carmel East Hospital
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43213
Country
United States
Facility Name
Miami Valley Hospital
City
Dayton
State/Province
Ohio
ZIP/Postal Code
45409
Country
United States
Facility Name
University of Toledo Medical Center
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43614
Country
United States
Facility Name
Providence Portland Medical Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213
Country
United States
Facility Name
Providence St. Vincent Medical Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Facility Name
Oregon Health and Science University Hospital
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Portland VA Medical Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Abington Memorial Hospital
City
Abington
State/Province
Pennsylvania
ZIP/Postal Code
19001
Country
United States
Facility Name
Lehigh Valley Hospital
City
Allentown
State/Province
Pennsylvania
ZIP/Postal Code
18103
Country
United States
Facility Name
Pennsylvania State Hershey Medical Center
City
Hershey
State/Province
Pennsylvania
ZIP/Postal Code
17033
Country
United States
Facility Name
Hahnemann University Hospital
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19102
Country
United States
Facility Name
Hospital of the University of Pennsylvania
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Facility Name
Penn Presbyterian Medical Center
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Facility Name
Pennsylvania Hospital
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Facility Name
Thomas Jefferson University Hospital
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Facility Name
Temple University Hospital
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19140
Country
United States
Facility Name
UPMC Presbyterian Hospital
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Facility Name
UPMC Shadyside Hospital
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15232
Country
United States
Facility Name
WellSpan York Hospital
City
York
State/Province
Pennsylvania
ZIP/Postal Code
17403
Country
United States
Facility Name
Rhode Island Hospital
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02903
Country
United States
Facility Name
Medical University of South Carolina University Hospital
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Facility Name
Palmetto Health Richland
City
Columbia
State/Province
South Carolina
ZIP/Postal Code
29203
Country
United States
Facility Name
Vanderbilt University Hospital
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37323
Country
United States
Facility Name
University Medical Center Brackenridge
City
Austin
State/Province
Texas
ZIP/Postal Code
78701
Country
United States
Facility Name
Seton Medical Center
City
Austin
State/Province
Texas
ZIP/Postal Code
78705
Country
United States
Facility Name
Texas Health Presbyterian Hospital - Dallas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75231
Country
United States
Facility Name
Valley Baptist Medical Center - Harlingen
City
Harlingen
State/Province
Texas
ZIP/Postal Code
78550
Country
United States
Facility Name
Ben Taub General Hospital
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Houston Methodist Hospital
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Memorial Hermann Texas Medical Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
University of Texas Health Science Center San Antonio
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
UVA Medical Center
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22908
Country
United States
Facility Name
Bon Secours St. Francis Medical Center
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23114
Country
United States
Facility Name
Bon Secours St. Mary's Hospital
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23226
Country
United States
Facility Name
Henrico Doctors' Hospital - Forest Campus
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23229
Country
United States
Facility Name
Henrico Doctors' Hospital - Parham Campus
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23294
Country
United States
Facility Name
Harborview Medical Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98104
Country
United States
Facility Name
University of Washington Medical Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98195
Country
United States
Facility Name
WVU Healthcare Ruby Memorial Hospital
City
Morgantown
State/Province
West Virginia
ZIP/Postal Code
26505
Country
United States
Facility Name
Columbia St. Mary's Hospital
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53211
Country
United States
Facility Name
Aurora St. Luke's Medical Center
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53215
Country
United States
Facility Name
Froedtert Memorial Lutheran Hospital
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States
Facility Name
Gosford Hospital
City
Gosford
State/Province
New South Wales
Country
Australia
Facility Name
John Hunter Hospital
City
New Lambton
State/Province
New South Wales
Country
Australia
Facility Name
Royal Adelaide Hospital
City
Adelaide
State/Province
South Australia
Country
Australia
Facility Name
Box Hill Hospital
City
Box Hill
State/Province
Victoria
Country
Australia
Facility Name
Monash Medical Centre
City
Clayton
State/Province
Victoria
Country
Australia
Facility Name
The Northern Hospital
City
Epping
State/Province
Victoria
Country
Australia
Facility Name
Footscray Hospital
City
Footscray
State/Province
Victoria
Country
Australia
Facility Name
Austin Hospital
City
Heidelberg
State/Province
Victoria
Country
Australia
Facility Name
Royal Melbourne Hospital
City
Parkville
State/Province
Victoria
Country
Australia
Facility Name
University of Calgary - Foothills Campus
City
Calgary
State/Province
Alberta
Country
Canada
Facility Name
Grey Nuns Hospital
City
Edmonton
State/Province
Alberta
Country
Canada
Facility Name
University of Alberta Hospital
City
Edmonton
State/Province
Alberta
Country
Canada
Facility Name
Vancouver General Hospital
City
Vancouver
State/Province
British Columbia
Country
Canada
Facility Name
London Health Sciences Center
City
London
State/Province
Ontario
Country
Canada
Facility Name
Charles LeMoyne Hospital
City
Greenfield Park
State/Province
Quebec
Country
Canada
Facility Name
Montreal General Hospital
City
Montreal
State/Province
Quebec
Country
Canada
Facility Name
Notre-Dame Hospital
City
Montreal
State/Province
Quebec
Country
Canada
Facility Name
Enfant-Jesus Hospital
City
Quebec
Country
Canada
Facility Name
Helsinki University Central Hospital
City
Helsinki
Country
Finland
Facility Name
Turku University Hospital
City
Turku
Country
Finland
Facility Name
Fleyriat Hospital
City
Bourg-en-Bresse
Country
France
Facility Name
Pierre Wetheimer Hospital
City
Bron
Country
France
Facility Name
Adolphe de Rothschild Ophthalmologic Foundation
City
Paris
Country
France
Facility Name
Bichat-Claude Bernard Hospital
City
Paris
Country
France
Facility Name
Pitie-Salpetriere Hospital
City
Paris
Country
France
Facility Name
Foch Hospital
City
Suresnes
Country
France
Facility Name
University Hospital of Ulm
City
Ulm
State/Province
Baden-Württemberg
ZIP/Postal Code
89081
Country
Germany
Facility Name
Neurological Clinic Bad Neustadt
City
Bad Neustadt an der Saale
Country
Germany
Facility Name
Vivantes Hospital Neukolln
City
Berlin
Country
Germany
Facility Name
Central Bremen Hospital
City
Bremen
Country
Germany
Facility Name
University Hospital Essen
City
Essen
Country
Germany
Facility Name
University Hospital Frankfurt
City
Frankfurt
Country
Germany
Facility Name
University Medical Center Hamburg
City
Hamburg
Country
Germany
Facility Name
Hannover Medical School
City
Hannover
Country
Germany
Facility Name
University Hospital Heidelberg
City
Heidelberg
Country
Germany
Facility Name
University Hospital Schleswig-Holstein Kiel Campus
City
Kiel
Country
Germany
Facility Name
University Medical Center Leipzig
City
Leipzig
Country
Germany
Facility Name
University Hospital Munster
City
Munster
Country
Germany
Facility Name
Mexican Association for Clinical Research
City
Pachuca
State/Province
Hidalgo
Country
Mexico
Facility Name
Central Hospital Dr. Ignacio Morones Prieto
City
San Luis Potosí
State/Province
San Luis Potosi
ZIP/Postal Code
78240
Country
Mexico
Facility Name
Culiacan General Hospital
City
Culiacan
State/Province
Sinaloa
Country
Mexico
Facility Name
Neurosciences Clinical Trials
City
Culiacan
State/Province
Sinaloa
Country
Mexico
Facility Name
ABC Medical Center Santa Fe
City
Mexico City
Country
Mexico
Facility Name
Auckland City Hospital
City
Auckland
Country
New Zealand
Facility Name
Hospital del Mar
City
Barcelona
Country
Spain
Facility Name
Santa Creu and Sant Pau Hospital
City
Barcelona
Country
Spain
Facility Name
Vall d'Hebron Hospital
City
Barcelona
Country
Spain
Facility Name
Basurto Hospital
City
Bilbao
Country
Spain
Facility Name
Burgos University Hospital
City
Burgos
Country
Spain
Facility Name
Hospital Donostia
City
Donostia
Country
Spain
Facility Name
Girona University HOspital
City
Girona
Country
Spain
Facility Name
La Fe University Hospital
City
Valencia
Country
Spain
Facility Name
Miguel Servet Hospital
City
Zaragoza
Country
Spain
Facility Name
Addenbrooke's Hospital
City
Cambridge
Country
United Kingdom
Facility Name
Queen Elizabeth University Hospital
City
Glasgow
Country
United Kingdom
Facility Name
Northwick Park Hospital
City
Harrow
Country
United Kingdom
Facility Name
The Royal London Hospital
City
London
Country
United Kingdom
Facility Name
University College Hospital
City
London
Country
United Kingdom
Facility Name
Luton and Dunstable University Hospital
City
Luton
Country
United Kingdom
Facility Name
John Radcliffe Hospital
City
Oxford
Country
United Kingdom
Facility Name
Royal United Hospital - Bath
City
Somerset
Country
United Kingdom
Facility Name
Southampton General Hospital
City
Southampton
Country
United Kingdom
Facility Name
Royal Stoke University Hospital
City
Stoke-on-Trent
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
18207691
Citation
Ovbiagele B. Antiplatelet therapy in management of transient ischemic attack: overview and evidence-based rationale. J Emerg Med. 2008 May;34(4):389-96. doi: 10.1016/j.jemermed.2007.08.056. Epub 2008 Jan 18.
Results Reference
background
PubMed Identifier
17993293
Citation
Giles MF, Rothwell PM. Risk of stroke early after transient ischaemic attack: a systematic review and meta-analysis. Lancet Neurol. 2007 Dec;6(12):1063-72. doi: 10.1016/S1474-4422(07)70274-0. Epub 2007 Nov 13.
Results Reference
background
PubMed Identifier
17928271
Citation
Kernan WN, Schindler JL. Rapid intervention for TIA: a new standard emerges. Lancet Neurol. 2007 Nov;6(11):940-1. doi: 10.1016/S1474-4422(07)70249-1. No abstract available.
Results Reference
background
PubMed Identifier
17639101
Citation
Rothwell PM. Transient ischaemic attacks: time to wake up. Heart. 2007 Aug;93(8):893-4. doi: 10.1136/hrt.2007.121111.
Results Reference
background
PubMed Identifier
18369165
Citation
Streifler JY. Early stroke risk after a transient ischemic attack: can it be minimized? Stroke. 2008 Jun;39(6):1655-6. doi: 10.1161/STROKEAHA.107.510248. Epub 2008 Mar 27. No abstract available.
Results Reference
background
PubMed Identifier
17928045
Citation
Dean N, Shuaib A. Transient ischaemic attacks: unstable, treatable, neglected. Lancet. 2007 Oct 20;370(9596):1398-400. doi: 10.1016/S0140-6736(07)61449-4. No abstract available.
Results Reference
background
PubMed Identifier
17931979
Citation
Kennedy J, Hill MD, Ryckborst KJ, Eliasziw M, Demchuk AM, Buchan AM; FASTER Investigators. Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. Lancet Neurol. 2007 Nov;6(11):961-9. doi: 10.1016/S1474-4422(07)70250-8. Epub 2007 Oct 10.
Results Reference
background
PubMed Identifier
18503057
Citation
Geisler T, Zurn C, Paterok M, Gohring-Frischholz K, Bigalke B, Stellos K, Seizer P, Kraemer BF, Dippon J, May AE, Herdeg C, Gawaz M. Statins do not adversely affect post-interventional residual platelet aggregation and outcomes in patients undergoing coronary stenting treated by dual antiplatelet therapy. Eur Heart J. 2008 Jul;29(13):1635-43. doi: 10.1093/eurheartj/ehn212. Epub 2008 May 24.
Results Reference
background
PubMed Identifier
18440347
Citation
Lotfi A, Schweiger MJ, Giugliano GR, Murphy SA, Cannon CP; TIMI 22 Investigators. High-dose atorvastatin does not negatively influence clinical outcomes among clopidogrel treated acute coronary syndrome patients--a Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) analysis. Am Heart J. 2008 May;155(5):954-8. doi: 10.1016/j.ahj.2007.12.009. Epub 2008 Feb 19.
Results Reference
background
PubMed Identifier
15023882
Citation
Mitsios JV, Papathanasiou AI, Rodis FI, Elisaf M, Goudevenos JA, Tselepis AD. Atorvastatin does not affect the antiplatelet potency of clopidogrel when it is administered concomitantly for 5 weeks in patients with acute coronary syndromes. Circulation. 2004 Mar 23;109(11):1335-8. doi: 10.1161/01.CIR.0000124581.18191.15. Epub 2004 Mar 15.
Results Reference
background
PubMed Identifier
18636229
Citation
Riondino S, Petrini N, Donato L, Torromeo C, Tanzilli G, Pulcinelli FM, Barilla F. Effects of rosuvastatin on platelet inhibition by clopidogrel in cardiovascular patients. J Thromb Thrombolysis. 2009 Aug;28(2):151-5. doi: 10.1007/s11239-008-0254-6. Epub 2008 Jul 18.
Results Reference
background
PubMed Identifier
17659194
Citation
Saw J, Brennan DM, Steinhubl SR, Bhatt DL, Mak KH, Fox K, Topol EJ; CHARISMA Investigators. Lack of evidence of a clopidogrel-statin interaction in the CHARISMA trial. J Am Coll Cardiol. 2007 Jul 24;50(4):291-5. doi: 10.1016/j.jacc.2007.01.097. Epub 2007 Jul 10.
Results Reference
background
PubMed Identifier
12925453
Citation
Saw J, Steinhubl SR, Berger PB, Kereiakes DJ, Serebruany VL, Brennan D, Topol EJ; Clopidogrel for the Reduction of Events During Observation Investigators. Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial. Circulation. 2003 Aug 26;108(8):921-4. doi: 10.1161/01.CIR.0000088780.57432.43. Epub 2003 Aug 18.
Results Reference
background
PubMed Identifier
18217151
Citation
Trenk D, Hochholzer W, Frundi D, Stratz C, Valina CM, Bestehorn HP, Buttner HJ, Neumann FJ. Impact of cytochrome P450 3A4-metabolized statins on the antiplatelet effect of a 600-mg loading dose clopidogrel and on clinical outcome in patients undergoing elective coronary stent placement. Thromb Haemost. 2008 Jan;99(1):174-81. doi: 10.1160/TH07-08-0503.
Results Reference
background
PubMed Identifier
11147987
Citation
Johnston SC, Gress DR, Browner WS, Sidney S. Short-term prognosis after emergency department diagnosis of TIA. JAMA. 2000 Dec 13;284(22):2901-6. doi: 10.1001/jama.284.22.2901.
Results Reference
background
PubMed Identifier
18705908
Citation
Coutts SB, Eliasziw M, Hill MD, Scott JN, Subramaniam S, Buchan AM, Demchuk AM; VISION study group. An improved scoring system for identifying patients at high early risk of stroke and functional impairment after an acute transient ischemic attack or minor stroke. Int J Stroke. 2008 Feb;3(1):3-10. doi: 10.1111/j.1747-4949.2008.00182.x.
Results Reference
background
PubMed Identifier
15929051
Citation
Coutts SB, Simon JE, Eliasziw M, Sohn CH, Hill MD, Barber PA, Palumbo V, Kennedy J, Roy J, Gagnon A, Scott JN, Buchan AM, Demchuk AM. Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imaging. Ann Neurol. 2005 Jun;57(6):848-54. doi: 10.1002/ana.20497.
Results Reference
background
PubMed Identifier
18275919
Citation
Algra A, van Gijn J, Halkes PH, Kappelle LJ, Koudstaal PJ; ESPRIT Study Group. Interpretation of ESPRIT in the FASTER trial. Lancet Neurol. 2008 Mar;7(3):198-9; author reply 199. doi: 10.1016/S1474-4422(08)70030-9. No abstract available.
Results Reference
background
PubMed Identifier
17928270
Citation
Lavallee PC, Meseguer E, Abboud H, Cabrejo L, Olivot JM, Simon O, Mazighi M, Nifle C, Niclot P, Lapergue B, Klein IF, Brochet E, Steg PG, Leseche G, Labreuche J, Touboul PJ, Amarenco P. A transient ischaemic attack clinic with round-the-clock access (SOS-TIA): feasibility and effects. Lancet Neurol. 2007 Nov;6(11):953-60. doi: 10.1016/S1474-4422(07)70248-X.
Results Reference
background
PubMed Identifier
19200786
Citation
Luengo-Fernandez R, Gray AM, Rothwell PM. Effect of urgent treatment for transient ischaemic attack and minor stroke on disability and hospital costs (EXPRESS study): a prospective population-based sequential comparison. Lancet Neurol. 2009 Mar;8(3):235-43. doi: 10.1016/S1474-4422(09)70019-5. Epub 2009 Feb 4.
Results Reference
background
PubMed Identifier
18753639
Citation
Yusuf S, Diener HC, Sacco RL, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlof B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, VanderMaelen C, Voigt T, Weber M, Yoon BW; PRoFESS Study Group. Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med. 2008 Sep 18;359(12):1225-37. doi: 10.1056/NEJMoa0804593. Epub 2008 Aug 27.
Results Reference
background
PubMed Identifier
18753638
Citation
Sacco RL, Diener HC, Yusuf S, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlof B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, Vandermaelen C, Voigt T, Weber M, Yoon BW; PRoFESS Study Group. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med. 2008 Sep 18;359(12):1238-51. doi: 10.1056/NEJMoa0805002. Epub 2008 Aug 27.
Results Reference
background
PubMed Identifier
9756590
Citation
Brown RD Jr, Petty GW, O'Fallon WM, Wiebers DO, Whisnant JP. Incidence of transient ischemic attack in Rochester, Minnesota, 1985-1989. Stroke. 1998 Oct;29(10):2109-13. doi: 10.1161/01.str.29.10.2109.
Results Reference
background
PubMed Identifier
11387488
Citation
Kissela B, Broderick J, Woo D, Kothari R, Miller R, Khoury J, Brott T, Pancioli A, Jauch E, Gebel J, Shukla R, Alwell K, Tomsick T. Greater Cincinnati/Northern Kentucky Stroke Study: volume of first-ever ischemic stroke among blacks in a population-based study. Stroke. 2001 Jun;32(6):1285-90. doi: 10.1161/01.str.32.6.1285.
Results Reference
background
PubMed Identifier
10582972
Citation
Williams GR, Jiang JG, Matchar DB, Samsa GP. Incidence and occurrence of total (first-ever and recurrent) stroke. Stroke. 1999 Dec;30(12):2523-8. doi: 10.1161/01.str.30.12.2523.
Results Reference
background
PubMed Identifier
15731465
Citation
Kleindorfer D, Panagos P, Pancioli A, Khoury J, Kissela B, Woo D, Schneider A, Alwell K, Jauch E, Miller R, Moomaw C, Shukla R, Broderick JP. Incidence and short-term prognosis of transient ischemic attack in a population-based study. Stroke. 2005 Apr;36(4):720-3. doi: 10.1161/01.STR.0000158917.59233.b7. Epub 2005 Feb 24.
Results Reference
background
PubMed Identifier
16609106
Citation
Edlow JA, Kim S, Pelletier AJ, Camargo CA Jr. National study on emergency department visits for transient ischemic attack, 1992-2001. Acad Emerg Med. 2006 Jun;13(6):666-72. doi: 10.1197/j.aem.2006.01.014. Epub 2006 Apr 11.
Results Reference
background
PubMed Identifier
3590245
Citation
Howard G, Toole JF, Frye-Pierson J, Hinshelwood LC. Factors influencing the survival of 451 transient ischemic attack patients. Stroke. 1987 May-Jun;18(3):552-7. doi: 10.1161/01.str.18.3.552.
Results Reference
background
PubMed Identifier
18282526
Citation
Shah KH, Kleckner K, Edlow JA. Short-term prognosis of stroke among patients diagnosed in the emergency department with a transient ischemic attack. Ann Emerg Med. 2008 Mar;51(3):316-23. doi: 10.1016/j.annemergmed.2007.08.016. Epub 2007 Oct 25. Erratum In: Ann Emerg Med. 2008 Jun;51(6):774.
Results Reference
background
PubMed Identifier
18071162
Citation
Wu CM, McLaughlin K, Lorenzetti DL, Hill MD, Manns BJ, Ghali WA. Early risk of stroke after transient ischemic attack: a systematic review and meta-analysis. Arch Intern Med. 2007 Dec 10;167(22):2417-22. doi: 10.1001/archinte.167.22.2417.
Results Reference
background
PubMed Identifier
15051693
Citation
Gladstone DJ, Kapral MK, Fang J, Laupacis A, Tu JV. Management and outcomes of transient ischemic attacks in Ontario. CMAJ. 2004 Mar 30;170(7):1099-104. doi: 10.1503/cmaj.1031349.
Results Reference
background
PubMed Identifier
15192239
Citation
Lisabeth LD, Ireland JK, Risser JM, Brown DL, Smith MA, Garcia NM, Morgenstern LB. Stroke risk after transient ischemic attack in a population-based setting. Stroke. 2004 Aug;35(8):1842-6. doi: 10.1161/01.STR.0000134416.89389.9d. Epub 2004 Jun 10.
Results Reference
background
PubMed Identifier
15051694
Citation
Eliasziw M, Kennedy J, Hill MD, Buchan AM, Barnett HJ; North American Symptomatic Carotid Endarterectomy Trial Group. Early risk of stroke after a transient ischemic attack in patients with internal carotid artery disease. CMAJ. 2004 Mar 30;170(7):1105-9. doi: 10.1503/cmaj.1030460.
Results Reference
background
PubMed Identifier
15184607
Citation
Hill MD, Yiannakoulias N, Jeerakathil T, Tu JV, Svenson LW, Schopflocher DP. The high risk of stroke immediately after transient ischemic attack: a population-based study. Neurology. 2004 Jun 8;62(11):2015-20. doi: 10.1212/01.wnl.0000129482.70315.2f.
Results Reference
background
PubMed Identifier
15993230
Citation
Rothwell PM, Giles MF, Flossmann E, Lovelock CE, Redgrave JN, Warlow CP, Mehta Z. A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. Lancet. 2005 Jul 2-8;366(9479):29-36. doi: 10.1016/S0140-6736(05)66702-5.
Results Reference
background
PubMed Identifier
12855835
Citation
Lovett JK, Dennis MS, Sandercock PA, Bamford J, Warlow CP, Rothwell PM. Very early risk of stroke after a first transient ischemic attack. Stroke. 2003 Aug;34(8):e138-40. doi: 10.1161/01.STR.0000080935.01264.91. Epub 2003 Jul 10.
Results Reference
background
PubMed Identifier
12686331
Citation
Rao SV, Ohman EM, Granger CB, Armstrong PW, Gibler WB, Christenson RH, Hasselblad V, Stebbins A, McNulty S, Newby LK. Prognostic value of isolated troponin elevation across the spectrum of chest pain syndromes. Am J Cardiol. 2003 Apr 15;91(8):936-40. doi: 10.1016/s0002-9149(03)00107-3.
Results Reference
background
PubMed Identifier
4690325
Citation
Whisnant JP, Matsumoto N, Elveback LR. Transient cerebral ischemic attacks in a community. Rochester, Minnesota, 1955 through 1969. Mayo Clin Proc. 1973 Mar;48(3):194-8. No abstract available.
Results Reference
background
PubMed Identifier
7303066
Citation
Humphrey PR, Marshall J. Transient ischemic attacks and strokes with recovery prognosis and investigation. Stroke. 1981 Nov-Dec;12(6):765-9. doi: 10.1161/01.str.12.6.765.
Results Reference
background
PubMed Identifier
4038103
Citation
Putman SF, Adams HP Jr. Usefulness of heparin in initial management of patients with recent transient ischemic attacks. Arch Neurol. 1985 Oct;42(10):960-2. doi: 10.1001/archneur.1985.04060090042011.
Results Reference
background
PubMed Identifier
2648650
Citation
Biller J, Bruno A, Adams HP Jr, Godersky JC, Loftus CM, Mitchell VL, Banwart KJ, Jones MP. A randomized trial of aspirin or heparin in hospitalized patients with recent transient ischemic attacks. A pilot study. Stroke. 1989 Apr;20(4):441-7. doi: 10.1161/01.str.20.4.441.
Results Reference
background
PubMed Identifier
2349586
Citation
Dennis M, Bamford J, Sandercock P, Warlow C. Prognosis of transient ischemic attacks in the Oxfordshire Community Stroke Project. Stroke. 1990 Jun;21(6):848-53. doi: 10.1161/01.str.21.6.848.
Results Reference
background
PubMed Identifier
14744823
Citation
Coull AJ, Lovett JK, Rothwell PM; Oxford Vascular Study. Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services. BMJ. 2004 Feb 7;328(7435):326. doi: 10.1136/bmj.37991.635266.44. Epub 2004 Jan 26.
Results Reference
background
PubMed Identifier
15486333
Citation
Daffertshofer M, Mielke O, Pullwitt A, Felsenstein M, Hennerici M. Transient ischemic attacks are more than "ministrokes". Stroke. 2004 Nov;35(11):2453-8. doi: 10.1161/01.STR.0000144050.90132.8e. Epub 2004 Oct 14.
Results Reference
background
PubMed Identifier
15618448
Citation
Whitehead MA, McManus J, McAlpine C, Langhorne P. Early recurrence of cerebrovascular events after transient ischaemic attack. Stroke. 2005 Jan;36(1):1; author reply 1. doi: 10.1161/01.str.0000149929.92356.f1. No abstract available.
Results Reference
background
PubMed Identifier
16322498
Citation
Correia M, Silva MR, Magalhaes R, Guimaraes L, Silva MC. Transient ischemic attacks in rural and urban northern Portugal: incidence and short-term prognosis. Stroke. 2006 Jan;37(1):50-5. doi: 10.1161/01.STR.0000195209.26543.8f. Epub 2005 Dec 1.
Results Reference
background
PubMed Identifier
17234986
Citation
Purroy F, Molina CA, Montaner J, Alvarez-Sabin J. Absence of usefulness of ABCD score in the early risk of stroke of transient ischemic attack patients. Stroke. 2007 Mar;38(3):855-6; author reply 857. doi: 10.1161/01.STR.0000257306.00512.d3. Epub 2007 Jan 18. No abstract available.
Results Reference
background
PubMed Identifier
20826243
Citation
Wang Y, Johnston SC; CHANCE Investigators. Rationale and design of a randomized, double-blind trial comparing the effects of a 3-month clopidogrel-aspirin regimen versus aspirin alone for the treatment of high-risk patients with acute nondisabling cerebrovascular event. Am Heart J. 2010 Sep;160(3):380-386.e1. doi: 10.1016/j.ahj.2010.05.017.
Results Reference
background
PubMed Identifier
23803136
Citation
Wang Y, Wang Y, Zhao X, Liu L, Wang D, Wang C, Wang C, Li H, Meng X, Cui L, Jia J, Dong Q, Xu A, Zeng J, Li Y, Wang Z, Xia H, Johnston SC; CHANCE Investigators. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013 Jul 4;369(1):11-9. doi: 10.1056/NEJMoa1215340. Epub 2013 Jun 26.
Results Reference
background
PubMed Identifier
35538232
Citation
Diener HC, Easton JD, Hart RG, Kasner S, Kamel H, Ntaios G. Review and update of the concept of embolic stroke of undetermined source. Nat Rev Neurol. 2022 Aug;18(8):455-465. doi: 10.1038/s41582-022-00663-4. Epub 2022 May 10.
Results Reference
derived
PubMed Identifier
35043692
Citation
Mac Grory B, Piccini JP, Yaghi S, Poli S, De Havenon A, Rostanski SK, Weiss M, Xian Y, Johnston SC, Feng W. Hyperglycemia, Risk of Subsequent Stroke, and Efficacy of Dual Antiplatelet Therapy: A Post Hoc Analysis of the POINT Trial. J Am Heart Assoc. 2022 Feb;11(3):e023223. doi: 10.1161/JAHA.121.023223. Epub 2022 Jan 19.
Results Reference
derived
PubMed Identifier
32568642
Citation
Meschia JF, Walton RL, Farrugia LP, Ross OA, Elm JJ, Farrant M, Meurer WJ, Lindblad AS, Barsan W, Ching M, Gentile N, Ross M, Nahab F, Easton JD, Kim AS, Zurita KG, Cucchiara B, Johnston SC. Efficacy of Clopidogrel for Prevention of Stroke Based on CYP2C19 Allele Status in the POINT Trial. Stroke. 2020 Jul;51(7):2058-2065. doi: 10.1161/STROKEAHA.119.028713. Epub 2020 Jun 17.
Results Reference
derived
PubMed Identifier
32091536
Citation
Kamel H, Zhang C, Kleindorfer DO, Levitan EB, Howard VJ, Howard G, Soliman EZ, Johnston SC. Association of Black Race With Early Recurrence After Minor Ischemic Stroke or Transient Ischemic Attack: Secondary Analysis of the POINT Randomized Clinical Trial. JAMA Neurol. 2020 May 1;77(5):601-605. doi: 10.1001/jamaneurol.2020.0010.
Results Reference
derived
PubMed Identifier
32078486
Citation
Cucchiara B, Elm J, Easton JD, Coutts SB, Willey JZ, Biros MH, Ross MA, Johnston SC. Disability After Minor Stroke and Transient Ischemic Attack in the POINT Trial. Stroke. 2020 Mar;51(3):792-799. doi: 10.1161/STROKEAHA.119.027465. Epub 2020 Feb 12.
Results Reference
derived
PubMed Identifier
31490536
Citation
Farrant M, Easton JD, Adelman EE, Cucchiara BL, Barsan WG, Tillman HJ, Elm JJ, Kim AS, Lindblad AS, Palesch YY, Zhao W, Pauls K, Walsh KB, Marti-Fabregas J, Bernstein RA, Johnston SC. Assessment of the End Point Adjudication Process on the Results of the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial: A Secondary Analysis. JAMA Netw Open. 2019 Sep 4;2(9):e1910769. doi: 10.1001/jamanetworkopen.2019.10769.
Results Reference
derived
PubMed Identifier
31238700
Citation
Johnston SC, Elm JJ, Easton JD, Farrant M, Barsan WG, Kim AS, Lindblad AS, Palesch YY, Zurita KG, Albers GW, Cucchiara BL, Kleindorfer DO, Lutsep HL, Pearson C, Sethi P, Vora N; POINT and Neurological Emergencies Treatment Trials Network Investigators. Time Course for Benefit and Risk of Clopidogrel and Aspirin After Acute Transient Ischemic Attack and Minor Ischemic Stroke. Circulation. 2019 Aug 20;140(8):658-664. doi: 10.1161/CIRCULATIONAHA.119.040713. Epub 2019 Jun 26.
Results Reference
derived
PubMed Identifier
31034032
Citation
Tillman H, Johnston SC, Farrant M, Barsan W, Elm JJ, Kim AS, Lindblad AS, Palesch YY, Easton JD. Risk for Major Hemorrhages in Patients Receiving Clopidogrel and Aspirin Compared With Aspirin Alone After Transient Ischemic Attack or Minor Ischemic Stroke: A Secondary Analysis of the POINT Randomized Clinical Trial. JAMA Neurol. 2019 Jul 1;76(7):774-782. doi: 10.1001/jamaneurol.2019.0932.
Results Reference
derived
PubMed Identifier
29766750
Citation
Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, Kim AS, Lindblad AS, Palesch YY; Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators. Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA. N Engl J Med. 2018 Jul 19;379(3):215-225. doi: 10.1056/NEJMoa1800410. Epub 2018 May 16.
Results Reference
derived
PubMed Identifier
26464429
Citation
Zhao W, Pauls K. Architecture design of a generic centralized adjudication module integrated in a web-based clinical trial management system. Clin Trials. 2016 Apr;13(2):223-33. doi: 10.1177/1740774515611889. Epub 2015 Oct 13.
Results Reference
derived
PubMed Identifier
23879752
Citation
Johnston SC, Easton JD, Farrant M, Barsan W, Battenhouse H, Conwit R, Dillon C, Elm J, Lindblad A, Morgenstern L, Poisson SN, Palesch Y. Platelet-oriented inhibition in new TIA and minor ischemic stroke (POINT) trial: rationale and design. Int J Stroke. 2013 Aug;8(6):479-83. doi: 10.1111/ijs.12129.
Results Reference
derived

Learn more about this trial

Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial

We'll reach out to this number within 24 hrs