"Platelet Rich Plasma for the Management of Post-Viral Olfactory Dysfunction.
Olfactory Disorder, Olfaction Disorders
About this trial
This is an interventional treatment trial for Olfactory Disorder focused on measuring Olfaction, Smell
Eligibility Criteria
Inclusion Criteria: Adult patients suffering from either post-viral or post-COVID smell loss of any duration, without a history of nasal surgery, nasal polyposis, chronic rhinosinusitis, or intranasal tumors Patients who are post-COVID must report at least a positive home test on history Patients with post-viral etiology must have recall of a viral illness that immediately preceded smell loss Exclusion Criteria: History of olfactory dysfunction predating COVID-19 infection History of trauma, previous surgery, or obstructive cause of OD (nasal polyps, chronic rhinosinusitis) Pregnancy Patients who are unable to provide consent Patients with known bleeding disorders Patients with known malignancies
Sites / Locations
- Thomas Jefferson University Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Placebo Comparator
Experimental
Placebo Comparator
Less than 12 months PRP- Test
Less than 12 months placebo- control
More than 12 months PRP- Test
More than 12 months Placebo- Control
Patients randomized into the less than 12 months PRP arm will receive 3 doses of topical PRP each month apart and their sense of smell will be assessed during each visit followed by a monthly remote assessment of smell from home.
Patients randomized into the less than 12 months placebo arm will receive saline topically every month apart and their sense of smell will be assessed during each visit followed by a monthly remote assessment of smell from home.
Patients randomized into more than 12 months PRP arm will receive 3 doses of topical PRP each month apart and their sense of smell will be assessed during each visit followed by a monthly remote assessment of smell from home.
Patients randomized into the less than 12 months placebo arm will receive saline topically every month apart and their sense of smell will be assessed during each visit followed by a monthly remote assessment of smell from home.