Positron Emission Tomography in Prostate Cancer
Prostate Cancer
About this trial
This is an interventional diagnostic trial for Prostate Cancer focused on measuring stage I prostate cancer, stage IIB prostate cancer, stage IIA prostate cancer, stage III prostate cancer
Eligibility Criteria
Inclusion Criteria Newly diagnosed prostate cancer Has completed conventional staging examinations, including biopsy with Gleason score, CT scan of the abdomen and pelvis, and whole-body bone scintigraphy AND conventional staging examinations negative Candidate for curative radical prostatectomy OR curative radiotherapy OR staging lymphadenectomy prior to surgery Deemed to be at medium or high risk for recurrence after initial curative treatment, as defined by 1 of the following criteria: Gleason score 7 AND prostate-specific antigen (PSA) 10-20 ng/mL Gleason score ≥ 8 AND PSA < 10 ng/mL Gleason score ≥ 8 AND PSA > 10 ng/mL Any Gleason score AND PSA > 20 ng/mL Exclusion Therapy: Not a candidate for treatment by surgery or radiation therapy with curative intent Inability to give informed consent Patients with other invasive malignancies, with the exception of non-melanoma skin cancer, who had (or have) any evidence of other cancer present within the last 5 years
Sites / Locations
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
Active Comparator
Surgery - Negative PET scan
Surgery - Positive PET scan
Radiation therapy Negative or Positive PET scan
If patient is candidate for surgery with curative intent or staging lymphadenectomy, he will be enrolled in the study. If patient's PET scan is negative, the patient will receive the curative therapy and be followed for recurrence.
If patient is candidate for surgery with curative intent or staging lymphadenectomy, he will be enrolled in the study. If patient's PET scan is positive, the patient will receive the curative therapy and be followed for recurrence or receive alternative therapy.
If patient is candidate for radiation therapy with curative intent, he will be enrolled. If PET scan is negative he will receive curative therapy and be followed for PSA recurrence. If PET scan is positive he may receive confirmatory studies and then if negative, not indicated, or refused he will receive curative therapy be followed for PSA recurrence. If PET scan is positive and received positive confirmatory studies he will receive curative therapy and followed for recurrence.