Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar (PEOPLE)
Leprosy
About this trial
This is an interventional prevention trial for Leprosy
Eligibility Criteria
Inclusion Criteria:
- Living in one of the study villages
- Aged 2 years and above
- Able and willing to provide informed consent
Exclusion Criteria:
- Signs of active leprosy (*)
- Signs of active pulmonary tuberculosis (cough ≥2 weeks duration) (*)
- Having received Rifampicin within the last 24 months (*)
(*) These people may still be included for yearly leprosy screening, but will be excluded to receive PEP
Sites / Locations
- Damien Foundation
- Damien Foundation
- Fondation Raoul Follereau
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
No Intervention
Other
Experimental
Other
No PEP
Household PEP
PEP 100m
PEP 100m + positive for anti-PGL-I IgM Ab
No PEP will be distributed
PEP will be given to all household contacts of an incident leprosy patient
PEP will be given to all household contacts of leprosy patients and to all other people living within a 100m radius of an incident leprosy patient.
PEP will be given to all household contacts of leprosy patients and to all other people living within a 100m radius of an incident leprosy patient who test positive in the UCP-LFA detecting anti-M. leprae PGL-I IgM Ab in fingerstick blood (anti-PGL-I)