Post-Treatment Effects of Naltrexone

Inclusion Criteria: Meets current diagnosis of alcohol dependence and have been abstinent for a minimum of 3 and maximum of 21 days prior to treatment Must be able to participate in an 18-month outpatient study, and live within a one hour or less commute to treatment facility. Must be fluent in English. Women of childbearing potential must have a negative pregnancy test. Exclusion Criteria: Severe hepatic disease or a liver function test greater than 4 times normal. Opiate use in the last 14 days or a history of opioid dependence in the past year. Pregnant or lactating females who are not using a reliable method of birth control. Inability to follow medication instructions and safety precautions. Comorbid substance dependence diagnosis in the past 6-months, excluding nicotine or marijuana dependence. Use of medications intended to decrease drinking. Meets criteria for bipolar disorder, schizophrenia, bulimia/anorexia, dementia, major depression.