Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III Rectal Cancer
Adenocarcinoma of the Rectum, Stage II Rectal Cancer, Stage III Rectal Cancer
About this trial
This is an interventional treatment trial for Adenocarcinoma of the Rectum focused on measuring Rectal cancer, Bevacizumab
Eligibility Criteria
Inclusion Criteria: Histologically confirmed adenocarcinoma of the rectum meeting 1 of the following clinical (e.g., before neoadjuvant therapy) or pathologic staging criteria: T3, N+, M0 T3, N0, M0 T4, N0, M0 Any T, N1-2, M0 T4, N0-2, M0 disease must meet 1 of the following criteria: Clinically fixed tumor on rectal examination with tumor adherent to the pelvic sidewall or sacrum Hydronephrosis on Computed Tomography (CT) scan or Intravenous Pyelogram (IVP) Ureteric or bladder invasion as documented by cystoscopy and cytology or biopsy Invasion into prostate Vaginal or uterine involvement Must have undergone complete tumor resection >= 28 days ago and able to begin treatment by day 56 Must have undergone concurrent neoadjuvant chemoradiotherapy* NOTE: *Neoadjuvant chemoradiotherapy received on protocol NSABP-R-04 allowed provided it met these criteria Must have undergone prior radiotherapy at 40-55.8 Gy** AND received 1 of the following chemotherapy regimens: Continuous infusion of fluorouracil with or without oxaliplatin; fluorouracil and leucovorin calcium Capecitabine with or without oxaliplatin; capecitabine with or without oxaliplatin OR a continuous infusion of fluorouracil with or without oxaliplatin received on protocol NSABP-R-04 NOTE: **Intensity-modulated radiotherapy allowed ECOG performance status 0-1 Platelet count >= 100,000/mm^3 Absolute granulocyte count >= 1,500/mm^3 Bilirubin normal (unless chronic grade 1 bilirubin elevation due to Gilbert's disease or similar syndrome due to slow conjugation of bilirubin) Alkaline phosphatase (AP) < 2.5 times upper limit of normal (ULN) and aspartate aminotransferase (AST) < 1.5 times ULN Hepatitis B and C negative (for patients with AP > normal) unless previously vaccinated Serum creatinine =< 1.5 times ULN Urine protein:creatinine (UPC) ratio < 1.0 OR urine protein < 1 g on 24-hour urine collection International Normalized Ratio (INR) =< 1.5 INR > 1.5 allowed provided patient is on full-dose anticoagulants AND meets all of the following criteria: In-range INR (i.e., between 2 and 3) on a stable dose of warfarin or low molecular weight heparin No active bleeding or pathological condition that is associated with a high risk of bleeding Negative pregnancy test Fertile patients must use effective contraception during and for at least 3 months after study treatment No other previous or concurrent malignancy except nonmelanoma skin cancer, breast cancer in situ, carcinoma in situ of the cervix, or previously treated nonpelvic cancer that has been disease-free for > 5 years Patients with a history of breast cancer (without evidence of disease) who remain on hormonal therapy for > 5 years are eligible Patients with a history of hypertension must have blood pressure < 150/90 mm Hg AND be on a stable regimen of antihypertensive therapy No other prior chemotherapy or pelvic radiotherapy except as neoadjuvant treatment for current diagnosis of rectal cancer Concurrent participation on protocol NSABP-R-04 allowed Exclusion Criteria: Pregnant or nursing Evidence of metastatic disease on the surgical/intraoperative examination Evidence of metastatic disease confirmed by CT scan, Magnetic resonance imaging (MRI), or ultrasound of the liver or chest CT scan or chest x-ray within the past 6 months Evidence of tumor outside of the pelvis, including liver metastases, peritoneal seeding, or metastatic inguinal lymphadenopathy Concurrent major surgery Active bleeding not related to the primary rectal tumor within the past 6 months Active inflammatory bowel disease or other serious medical illness which might limit the ability of the patient to receive protocol therapy Active gastroduodenal ulcer determined by endoscopy Serious or nonhealing wound, skin ulcer, or bone fracture Clinically significant peripheral sensory or motor neuropathy >= grade 2 Nonmalignant systemic disease (e.g., cardiovascular, renal, or hepatic) that would preclude study treatment including, but not limited to, any of the following: New York Heart Association class III or IV congestive heart failure Concurrent symptomatic arrhythmia Transient ischemic attack or cerebrovascular accident Arterial thromboembolic event, unstable angina, or myocardial infarction within the past 12 months Significant peripheral vascular disease Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude study requirements Significant traumatic injury within the past 28 days Known allergy to platinum compounds Prior invasive procedure, including either of the following: Major surgical procedure or open biopsy within the past 28 days Core biopsy or other minor procedure, except placement of a vascular access device, within the past 7 days
Sites / Locations
- Providence Hospital
- Providence Alaska Medical Center
- Mayo Clinic in Arizona
- Saint Bernards Regional Medical Center
- Alta Bates Summit Medical Center-Herrick Campus
- Mills - Peninsula Hospitals
- East Bay Radiation Oncology Center
- Eden Hospital Medical Center
- Valley Medical Oncology Consultants-Castro Valley
- Kaiser Permanente, Fremont
- Valley Medical Oncology Consultants-Fremont
- Cancer Care Associates of Fresno Medical Group Inc
- Saint Jude Medical Center
- Glendale Memorial Hospital and Health Center
- Marin General Hospital
- Kaiser Permanente, Hayward
- Saint Rose Hospital
- University of Southern California/Norris Cancer Center
- Contra Costa Regional Medical Center
- Fremont - Rideout Cancer Center
- Community Hospital of Monterey Peninsula
- El Camino Hospital
- Palo Alto Medical Foundation-Camino Division
- Sutter Cancer Research Consortium
- Highland General Hospital
- Alta Bates Summit Medical Center - Summit Campus
- Bay Area Breast Surgeons Inc
- Bay Area Tumor Institute CCOP
- Larry G Strieff MD Medical Corporation
- Tom K Lee Inc
- Kaiser Permanente-Oakland
- Desert Regional Medical Center
- Palo Alto Medical Foundation Heath Care
- Valley Care Health System - Pleasanton
- Valley Medical Oncology Consultants
- Kaiser Permanente-Redwood City
- Kaiser Permanente-Richmond
- Kaiser Permanente-Roseville
- University of California at Davis Cancer Center
- Kaiser Permanente-South Sacramento
- Kaiser Permanente - Sacramento
- Salinas Valley Memorial
- University of California At San Diego
- Kaiser Permanente
- Kaiser Permanente-San Francisco
- California Pacific Medical Center
- Kaiser Permanente-Santa Teresa-San Jose
- Doctors Medical Center- JC Robinson Regional Cancer Center
- Kaiser Permanente-San Rafael
- Kaiser Permanente Medical Center - Santa Clara
- Kaiser Permanente-Santa Rosa
- Kaiser Permanente-South San Francisco
- Kaiser Permanente-Stockton
- Tahoe Forest Cancer Center
- Kaiser Permanente-Vallejo
- Sutter Solano Medical Center
- Kaiser Permanente-Walnut Creek
- The Medical Center of Aurora
- Boulder Community Hospital
- Penrose-Saint Francis Healthcare
- Memorial Hospital Colorado Springs
- Porter Adventist Hospital
- Exempla Saint Joseph Hospital
- Presbyterian - Saint Lukes Medical Center - Health One
- Rose Medical Center
- Colorado Cancer Research Program CCOP
- Swedish Medical Center
- Front Range Cancer Specialists
- Saint Mary's Hospital and Regional Medical Center
- North Colorado Medical Center
- Saint Anthony Hospital
- Sky Ridge Medical Center
- Longmont United Hospital
- McKee Medical Center
- Saint Mary Corwin Medical Center
- North Suburban Medical Center
- Exempla Lutheran Medical Center
- Eastern Connecticut Hematology and Oncology Associates
- Beebe Medical Center
- Christiana Care Health System-Christiana Hospital
- Washington Hospital Center
- Lombardi Comprehensive Cancer Center at Georgetown University
- Holy Cross Hospital
- Mayo Clinic in Florida
- Jupiter Medical Center
- The Watson Clinic
- Mount Sinai Medical Center CCOP
- University of Miami Miller School of Medicine-Sylvester Cancer Center
- Cancer Specialists of North Florida-Orange Park
- University Cancer and Blood Center LLC
- Piedmont Hospital
- Atlanta Regional CCOP
- Northside Hospital
- Saint Joseph's Hospital of Atlanta
- Georgia Regents University
- Well Star Cobb Hospital
- Atlanta VA Medical Center
- Dekalb Medical Center
- Gwinnett Medical Center
- Medical Center of Central Georgia
- Wellstar Kennestone Hospital
- Southern Regional Medical Center
- Harbin Clinic Medical Oncology and Clinical Research
- Memorial Health University Medical Center
- Pali Momi Medical Center
- Oncare Hawaii Inc-POB II
- Queen's Medical Center
- Straub Clinic and Hospital
- University of Hawaii
- Oncare Hawaii Inc-Kuakini
- The Cancer Center of Hawaii-Liliha
- Kapiolani Medical Center for Women and Children
- Tripler Army Medical Center
- Maui Memorial Medical Center
- Pacific Cancer Institute of Maui
- Saint Alphonsus Regional Medical Center
- Saint Luke's Mountain States Tumor Institute
- Hematology Oncology Associates of Eastern Idaho
- Portneuf Medical Center
- Saint Anthony's Health
- Rush - Copley Medical Center
- Saint Joseph Medical Center
- Graham Hospital Association
- Memorial Hospital
- Mount Sinai Hospital Medical Center
- Hematology and Oncology Associates
- Northwestern University
- John H Stroger Jr Hospital of Cook County
- Jesse Brown Veterans Affairs Medical Center
- Rush University Medical Center
- Mercy Hospital and Medical Center
- Swedish Covenant Hospital
- Resurrection Healthcare
- University of Chicago
- Decatur Memorial Hospital
- Good Samaritan Hospital
- Elmhurst Memorial Hospital
- Eureka Hospital
- NorthShore University HealthSystem-Evanston Hospital
- Saint Francis Hospital
- Galesburg Cottage Hospital
- Illinois CancerCare Galesburg
- Western Illinois Cancer Treatment Center
- Mason District Hospital
- Hinsdale Hematology Oncology Associates Incorporated
- Hopedale Medical Complex - Hospital
- Midwest Center for Hematology Oncology
- Joliet Oncology-Hematology Associates Limited
- Kewanee Hospital
- North Shore Hematology Oncology
- Mcdonough District Hospital
- Loyola University Medical Center
- Garneau, Stewart C MD (UIA Investigator)
- Porubcin, Michael MD (UIA Investigator)
- Sharis, Christine M MD (UIA Investigator)
- Stoffel, Thomas J MD (UIA Investigator)
- Vigliotti, Antonio, P.G. M.D. (UIA Investigator)
- Good Samaritan Regional Health Center
- Edward Hospital/Cancer Center
- Illinois Cancer Specialists-Niles
- Bromenn Regional Medical Center
- Community Cancer Center Foundation
- Illinois CancerCare-Ottawa Clinic
- Ottawa Regional Hospital and Healthcare Center
- Pekin Cancer Treatment Center
- Pekin Hospital
- Methodist Medical Center of Illinois
- Proctor Hospital
- OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
- Illinois CancerCare-Peoria
- Illinois Oncology Research Association CCOP
- OSF Saint Francis Medical Center
- Illinois Valley Hospital
- Valley Radiation Oncology
- Perry Memorial Hospital
- Swedish American Hospital
- Edward H Kaplan MD and Associates
- Hematology Oncology Associates of Illinois - Skokie
- Midwest Cancer Research Group Incorporated
- Saint Margaret's Hospital
- Memorial Medical Center
- Carle Cancer Center
- Carle Clinic-Urbana Main
- Saint Francis Hospital and Health Centers
- Elkhart General Hospital
- Fort Wayne Medical Oncology and Hematology Inc-Parkview
- Saint Vincent Hospital and Health Services
- Community Howard Regional Health
- IU Health La Porte Hospital
- Franciscan Saint Anthony Health-Michigan City
- Saint Joseph Regional Medical Center-Mishawaka
- IU Health Ball Memorial Hospital
- Oncology Hematology Associates of Southwest Indiana
- Reid Hospital and Health Care Services
- Memorial Hospital of South Bend
- Northern Indiana Cancer Research Consortium
- McFarland Clinic PC-William R Bliss Cancer Center
- Constantinou, Costas L MD (UIA Investigator)
- Cedar Rapids Oncology Association
- Oncology Associates at Mercy Medical Center
- Medical Oncology and Hematology Associates-West Des Moines
- Genesis Medical Center - East Campus
- Genesis Medical Center - West Campus
- Mercy Capitol
- Iowa Methodist Medical Center
- Iowa Oncology Research Association CCOP
- Medical Oncology and Hematology Associates-Des Moines
- Medical Oncology and Hematology Associates-Laurel
- Mercy Medical Center - Des Moines
- Iowa Lutheran Hospital
- University of Iowa Hospitals and Clinics
- Mercy Medical Center - North Iowa
- Siouxland Regional Cancer Center
- Siouxland Hematology Oncology Associates
- Mercy Medical Center-Sioux City
- Saint Luke's Regional Medical Center
- Cedar Valley Medical Specialists
- Covenant Medical Center
- Hospital District Sixth of Harper County
- Cancer Center of Kansas - Chanute
- Cancer Center of Kansas - Dodge City
- Cancer Center of Kansas - El Dorado
- Cancer Center of Kansas - Fort Scott
- Cancer Center of Kansas-Independence
- University of Kansas Medical Center
- Cancer Center of Kansas-Kingman
- Lawrence Memorial Hospital
- Cancer Center of Kansas - Newton
- Olathe Cancer Center
- Cancer Center of Kansas - Parsons
- Cancer Center of Kansas - Pratt
- Cancer Center of Kansas - Salina
- Stormont-Vail Regional Health Center
- Cancer Center of Kansas - Wellington
- Associates In Womens Health
- Cancer Center of Kansas-Wichita Medical Arts Tower
- Cancer Center of Kansas - Main Office
- Via Christi Regional Medical Center
- Wichita CCOP
- Cancer Center of Kansas - Winfield
- The James Graham Brown Cancer Center at University of Louisville
- Eastern Maine Medical Center
- Saint Mary's Regional Medical Center
- Maine Medical Center- Scarborough Campus
- Franklin Square Hospital Center
- Memorial Hospital at Easton - Shore Regional Cancer Center
- Union Hospital of Cecil County
- Eastern Cooperative Oncology Group
- Caritas Saint Elizabeth's Medical Center
- Lahey Hospital and Medical Center
- Simonds-Sinon Regional Cancer Center
- Berkshire Hematology Oncology PC
- University of Massachusetts Medical School
- Bixby Medical Center
- Hickman Cancer Center
- Saint Joseph Mercy Hospital
- Michigan Cancer Research Consortium Community Clinical Oncology Program
- Bronson Battle Creek
- Spectrum Health Big Rapids Hospital
- Oakwood Hospital
- Wayne State University/Karmanos Cancer Institute
- Saint John Hospital and Medical Center
- Green Bay Oncology - Escanaba
- Hurley Medical Center
- Genesys Regional Medical Center-West Flint Campus
- Grand Rapids Clinical Oncology Program
- Mercy Health Saint Mary's
- Spectrum Health at Butterworth Campus
- Holland Community Hospital
- Green Bay Oncology - Iron Mountain
- Allegiance Health
- Sparrow Hospital
- Saint Mary Mercy Hospital
- Marquette General Hospital
- Community Cancer Center of Monroe
- Mercy Memorial Hospital
- Mercy Health Partners-Hackley Campus
- Mercy Health Mercy Campus
- Saint Joseph Mercy Oakland
- Saint Joseph Mercy Port Huron
- William Beaumont Hospital-Royal Oak
- Saint Mary's of Michigan
- Lakeland Hospital
- Munson Medical Center
- Saint John Macomb-Oakland Hospital
- Metro Health Hospital
- Sanford Clinic North-Bemidgi
- Fairview Ridges Hospital
- Mercy Hospital
- Essentia Health Duluth Clinic CCOP
- Essentia Health Saint Mary's Medical Center
- Miller-Dwan Hospital
- Fairview-Southdale Hospital
- Unity Hospital
- Hutchinson Area Health Care
- Meeker County Memorial Hospital
- Mayo Clinic Health Systems-Mankato
- Minnesota Oncology Hematology PA-Maplewood
- Saint John's Hospital - Healtheast
- Abbott-Northwestern Hospital
- Virginia Piper Cancer Institute
- Hennepin County Medical Center
- Minneapolis Veterans Medical Center
- North Memorial Medical Health Center
- Mayo Clinic
- Metro-Minnesota CCOP
- Park Nicollet Clinic - Saint Louis Park
- Regions Hospital
- Saint Joseph's Hospital - Healtheast
- United Hospital
- Saint Francis Regional Medical Center
- Ridgeview Medical Center
- Rice Memorial Hospital
- Minnesota Oncology and Hematology PA-Woodbury
- Woodwinds Health Campus
- Southeast Missouri Hospital
- Saint Francis Medical Center
- Freeman Health System
- Mercy Hospital-Joplin
- Saint Louis Cancer and Breast Institute-South City
- Saint Louis University Hospital
- Washington University School of Medicine
- Missouri Baptist Medical Center
- Center for Cancer Care and Research
- Saint John's Mercy Medical Center
- Saint Louis-Cape Girardeau CCOP
- Mercy Hospital Springfield
- CoxHealth South Hospital
- Montana Cancer Consortium CCOP
- Northern Rockies Radiation Oncology Center
- Saint Vincent Healthcare
- Hematology-Oncology Centers of the Northern Rockies PC
- Billings Clinic
- Deaconess Medical Center
- Bozeman Deaconess Cancer Center
- Bozeman Deaconess Hospital
- Saint James Community Hospital and Cancer Treatment Center
- Benefis Healthcare- Sletten Cancer Institute
- Berdeaux, Donald MD (UIA Investigator)
- Great Falls Clinic
- Northern Montana Hospital
- Saint Peter's Community Hospital
- Glacier Oncology PLLC
- Kalispell Medical Oncology
- Kalispell Regional Medical Center
- Community Medical Hospital
- Montana Cancer Specialists
- Saint Patrick Hospital - Community Hospital
- Guardian Oncology and Center for Wellness
- Nebraska Cancer Research Center
- Missouri Valley Cancer Consortium CCOP
- Nebraska Methodist Hospital
- Alegent Health Immanuel Medical Center
- Alegent Health Bergan Mercy Medical Center
- Creighton University Medical Center
- University of Nebraska Medical Center
- University Medical Center of Southern Nevada
- Nevada Cancer Research Foundation CCOP
- Exeter Hospital
- Cheshire Medical Center-Dartmouth-Hitchcock Keene
- Elliot Hospital
- Ocean Medical Center
- Cooper Hospital University Medical Center
- Cancer Institute of New Jersey At Hamilton
- Monmouth Medical Center
- Mountainside Hospital
- Morristown Memorial Hospital
- Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County
- Rutgers Cancer Institute of New Jersey
- Newark Beth Israel Medical Center
- Valley Hospital
- Sparta Cancer Treatment Center
- Overlook Hospital
- Virtua West Jersey Hospital Voorhees
- Hematology Oncology Associates
- University of New Mexico Cancer Center
- Presbyterian Kaseman Hospital
- New Mexico Cancer Care Associates
- Albert Einstein College of Medicine
- Montefiore Medical Center
- Kings County Hospital
- State University of New York Downstate Medical Center
- University Hospital of Brooklyn
- Veterans Affairs Western New York Health Care System-Buffalo
- Roswell Park Cancer Institute
- Hematology Oncology Associates of Central New York PC-East Syracuse
- Glens Falls Hospital
- Orange Regional Medical Center
- New York University Langone Medical Center
- Columbia University Medical Center
- Weill Medical College of Cornell University
- Highland Hospital
- Interlakes Foundation Inc-Rochester
- University of Rochester
- State University of New York Upstate Medical University
- Community General Hospital
- Mission Hospital-Memorial Campus
- Cone Health Alamance Regional Medical Center
- Carolinas Medical Center
- Carolinas Medical Center - Northeast
- Wayne Memorial Hospital
- Wayne Radiation Oncology
- Rutherford Hospital
- Wilson Medical Center
- Bismarck Cancer Center
- Mid Dakota Clinic
- Saint Alexius Medical Center
- Sanford Bismarck Medical Center
- Sanford Clinic North-Fargo
- Sanford Medical Center-Fargo
- Altru Cancer Center
- Mary Rutan Hospital
- Toledo Clinic Cancer Centers-Bowling Green
- Mercy Medical Center
- Aultman Health Foundation
- Adena Regional Medical Center
- The Christ Hospital
- University of Cincinnati
- Case Western Reserve University
- MetroHealth Medical Center
- Cleveland Clinic Foundation
- North Coast Cancer Care-Clyde
- Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
- Riverside Methodist Hospital
- Columbus CCOP
- Grant Medical Center
- Mount Carmel Health Center West
- Doctors Hospital
- Grandview Hospital
- Good Samaritan Hospital - Dayton
- Miami Valley Hospital
- Samaritan North Health Center
- Dayton CCOP
- Veteran Affairs Medical Center
- Grady Memorial Hospital
- Hematology Oncology Center Incorporated
- Blanchard Valley Hospital
- Atrium Medical Center-Middletown Regional Hospital
- Fremont Memorial Hospital
- Wayne Hospital
- Cleveland Clinic Cancer Center Independence
- Cole, Sharon, K. M.D. (UIA Investigator)
- Kettering Medical Center
- Fairfield Medical Center
- Lima Memorial Hospital
- Marietta Memorial Hospital
- Saint Luke's Hospital
- Toledo Clinic Cancer Centers-Maumee
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
- Licking Memorial Hospital
- Saint Charles Hospital
- Toledo Clinic Cancer Centers-Oregon
- Firelands Regional Medical Center
- North Coast Cancer Care
- Springfield Regional Medical Center
- Flower Hospital
- Mercy Hospital of Tiffin
- The Toledo Hospital/Toledo Children's Hospital
- Saint Vincent Mercy Medical Center
- University of Toledo
- Toledo Community Hospital Oncology Program CCOP
- Mercy Saint Anne Hospital
- Stark, Michael, Edward. M.D. (UIA Investigator)
- Toledo Clinic Cancer Centers-Toledo
- Upper Valley Medical Center
- Fulton County Health Center
- Saint Ann's Hospital
- Clinton Memorial Hospital
- Cleveland Clinic Wooster Specialty Center
- Greene Memorial Hospital
- Genesis HealthCare System
- University of Oklahoma Health Sciences Center
- Cancer Care Associates
- Natalie Warren Bryant Cancer Center at Saint Francis
- Saint Charles Medical Center-Bend
- Providence Milwaukie Hospital
- Providence Portland Medical Center
- Western Oncology Research Consortium
- Adventist Medical Center
- Providence Saint Vincent Medical Center
- Kaiser Permanente
- Abington Memorial Hospital
- Lehigh Valley Hospital
- Saint Luke's University Hospital-Bethlehem Campus
- Bryn Mawr Hospital
- Geisinger Medical Center
- Armstrong Center for Medicine and Health
- Riddle Hospital
- Paoli Memorial Hospital
- University of Pennsylvania/Abramson Cancer Center
- Pennsylvania Hospital
- Thomas Jefferson University Hospital
- Fox Chase Cancer Center
- Albert Einstein Medical Center
- Allegheny Cancer Center at Allegheny General Hospital
- University of Pittsburgh
- Pottstown Memorial Medical Center
- Mercy Hospital
- Hematology and Oncology Associates of North East Pennsylvania
- Scranton Hematology Oncology
- Geisinger Medical Group
- Reading Hospital
- Geisinger Wyoming Valley
- Lankenau Hospital
- Mainline Health CCOP
- WellSpan Health-York Hospital
- Hematology and Oncology Associates of Rhode Island Inc
- Kent County Hospital
- AnMed Health Hospital
- Roper Hospital
- McLeod Regional Medical Center
- Greenville Health System Cancer Institute/Greenville CCOP
- Spartanburg Regional Medical Center
- Upstate Carolina CCOP
- Sanford Cancer Center-Oncology Clinic
- Medical X-Ray Center
- Sanford USD Medical Center - Sioux Falls
- Wellmont Holston Valley Hospital and Medical Center
- Thompson Cancer Survival Center
- University of Tennessee - Memphis
- Nashville Oncology Associates PC
- Tennessee Oncology PLLC- Centennial Medical Center
- Meharry Medical College
- Vanderbilt-Ingram Cancer Center
- Parkland Memorial Hospital
- Zale Lipshy University Hospital
- Saint Paul Hospital
- University of Texas Southwestern Medical Center
- Texas Tech University Health Sciences Center
- Scott and White Memorial Hospital
- American Fork Hospital
- Sandra L Maxwell Cancer Center
- Logan Regional Hospital
- Cottonwood Hospital Medical Center
- Intermountain Medical Center
- McKay-Dee Hospital Center
- Utah Valley Regional Medical Center
- Dixie Medical Center Regional Cancer Center
- Intermountain Health Care
- Utah Cancer Specialists-Salt Lake City
- Huntsman Cancer Institute/University of Utah
- LDS Hospital
- University of Vermont
- Martha Jefferson Hospital
- University of Virginia
- Fredericksburg Oncology Inc
- Virginia Oncology Associates-Hampton
- Rockingham Memorial Hospital Hahn Cancer Center
- Lynchburg Hematology-Oncology Clinic
- Southwest VA Regional Cancer Center
- Auburn Regional Medical Center
- PeaceHealth Saint Joseph Medical Center
- Harrison HealthPartners Hematology and Oncology-Bremerton
- Providence Centralia Hospital
- Saint Francis Hospital
- Columbia Basin Hematology and Oncology PLLC
- Providence - Saint Peter Hospital
- Good Samaritan Community Hospital
- Minor and James Medical PLLC
- Group Health Cooperative-Seattle
- Swedish Medical Center-First Hill
- The Polyclinic
- University of Washington Medical Center
- Cancer Care Northwest - Spokane South
- Rockwood Clinic
- Allenmore Hospital
- Northwest CCOP
- Saint Joseph Medical Center
- Multicare Health System
- Madigan Army Medical Center
- Saint Clare Hospital
- PeaceHealth Southwest Medical Center
- Compass Oncology Vancouver
- Camden-Clark Memorial Hospital
- Marshfield Clinic Cancer Center at Sacred Heart
- Sacred Heart Hospital
- Aurora Cancer Care-Southern Lakes
- Agnesian Cancer Center
- Aurora Cancer Care-Glendale
- Green Bay Oncology at Saint Vincent Hospital
- Saint Vincent Hospital
- Green Bay Oncology Limited at Saint Mary's Hospital
- Saint Mary's Hospital
- Mercy Health System
- Mayo Clinic Health System-Franciscan Healthcare
- Bay Area Medical Center
- Marshfield Clinic
- Saint Joseph's Hospital
- Medical Consultants Limited
- Marshfield Clinic-Minocqua Center
- Green Bay Oncology - Oconto Falls
- Marshfield Clinic at James Beck Cancer Center
- Marshfield Clinic-Rice Lake Center
- Vince Lombardi Cancer Clinic-Sheboygan
- Saint Michael's Hospital
- Green Bay Oncology - Sturgeon Bay
- Marshfield Clinic-Wausau Center
- Marshfield Clinic - Weston Center
- Marshfield Clinic - Wisconsin Rapids Center
- Welch Cancer Center
- Cross Cancer Institute
- Atlantic Health Sciences Corporation-Saint John Regional Hospital
- Grand River Regional Cancer Centre at Grand River Hospital
- London Regional Cancer Program
- Credit Valley Hospital
- Lakeridge Health Oshawa
- Ottawa Health Research Institute-General Division
- Thunder Bay Regional Health Science Centre
- Saint Michael's Hospital
- University Health Network-Princess Margaret Hospital
- CSSS Champlain-Charles Le Moyne
- CHUQ - Pavilion Hotel-Dieu de Quebec
- Allan Blair Cancer Centre
- Saskatoon Cancer Centre
- Instituto Nacional de Enfermedades Neoplasicas
- I Gonzales Martinez-Oncologic Hospital
- San Juan City Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Arm I
Arm II
Patients receive oxaliplatin IV over 2 hours, leucovorin calcium IV over 2 hours, and fluorouracil IV on day 1 followed by fluorouracil IV continuously over 46 hours on days 1 and 2. Treatment repeats every 2 weeks for up to 12 courses.
Patients receive bevacizumab IV over 30-90 minutes on day 1. Patients also receive oxaliplatin, leucovorin calcium, and fluorouracil as in arm I.