Practice Structure on Motor Learning in Post-Stroke Patients
Primary Purpose
Stroke
Status
Completed
Phase
Not Applicable
Locations
Brazil
Study Type
Interventional
Intervention
Structure practice
Sponsored by
About this trial
This is an interventional treatment trial for Stroke focused on measuring motor learning, hemiplegia, stroke, practice, physiotherapy
Eligibility Criteria
Inclusion Criteria:
- First cerebrovascular accident
- Lesion covering the middle and the anterior cerebral artery territories
- Presence of hemiplegia or hemiparesis
- Mini-Mental State Examination (MMSE) score above 24 (19)
- Sufficient attention and comprehension to perform the task
- Absence of other associated neurological diseases.
Exclusion Criteria:
- Acute medical problems
- Uncorrected vision loss
- Previous history of psychiatric admission
- History of multiple strokes, transient ischemic attacks
- Pathology of the less affected, ipsilateral to stroke upper extremity that would affect ability to perform the task
- Score of 23 or less on the MMSE
- Difficulty in comprehension of verbal command and simple instructions
- Aphasia of comprehension.
Sites / Locations
- Camila Torriani
Arms of the Study
Arm 1
Arm Type
Other
Arm Label
1, 2
Arm Description
Outcomes
Primary Outcome Measures
change in performance during the acquisition; performance exhibited during the transfer phase was maintained during retention phases 1 and 2; and differences between the groups during the transfer phase and retention phases
Secondary Outcome Measures
Full Information
NCT ID
NCT00604747
First Posted
January 17, 2008
Last Updated
January 29, 2008
Sponsor
University of Sao Paulo
1. Study Identification
Unique Protocol Identification Number
NCT00604747
Brief Title
Practice Structure on Motor Learning in Post-Stroke Patients
Official Title
The Effects of Practice Structure on Motor Learning in Post-Stroke Patients
Study Type
Interventional
2. Study Status
Record Verification Date
January 2008
Overall Recruitment Status
Completed
Study Start Date
August 2006 (undefined)
Primary Completion Date
July 2007 (Actual)
Study Completion Date
July 2007 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
University of Sao Paulo
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
Background: The literature indicates that, in relation to motor learning, healthy subjects benefit more from random practice than from constant practice. However, this effect is not well known in post-stroke patients. Objective: The goal of this study was to investigate the effects of practice structure on motor learning in post-stroke patients. Methods: Participants included an experimental group (EG) of post-stroke patients: 17 males and females; and a control group (CG) of healthy individuals: 17 males and females. At the acquisition phase, all participants performed 30 trials of a coincident timing task. Nine individuals from each group practiced constantly (C) at a stimulus propagation speed of 3 mph, and eight from each group practiced randomly (R) at speeds of 2, 3, and 5 mph. Subsequent phases included: 1) transfer, 2) retention after 15 minutes, and 3) retention after 3 days. Each of these phases included 20 trials: 10 at a speed of 1 mph, and 10 at a speed of 4 mph. Intra- and inter-group comparisons were made employing an alpha level of 0.05 (5%).
Detailed Description
Utilized was Bassin's anticipation timer (Lafayette Instruments #50575), which is comprised of a control screen, one 1.52 m gutter with 32 diodes placed on it linearly, and a response button. The screen has a digital display, with commands that permit the operator to control the stimulus propagation speed and the preparatory interval speed. Once activated, the screen exhibits an alert signal, and, after the preparatory interval, it initiates the propagation of a luminous stimulus, lighting the 32 diodes successively. The task required participants to press the response button simultaneously with the illumination of the last diode. The digital display showed the error measure (em): that is, the difference between the illumination of the last diode and the response.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Stroke
Keywords
motor learning, hemiplegia, stroke, practice, physiotherapy
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
34 (Actual)
8. Arms, Groups, and Interventions
Arm Title
1, 2
Arm Type
Other
Intervention Type
Other
Intervention Name(s)
Structure practice
Other Intervention Name(s)
experimental group (EG), control group (CG)
Intervention Description
there were 2 groups which received random practice and constant practice during acquisition phase
Primary Outcome Measure Information:
Title
change in performance during the acquisition; performance exhibited during the transfer phase was maintained during retention phases 1 and 2; and differences between the groups during the transfer phase and retention phases
Time Frame
time in miliseconds
10. Eligibility
Sex
All
Minimum Age & Unit of Time
40 Years
Maximum Age & Unit of Time
62 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
First cerebrovascular accident
Lesion covering the middle and the anterior cerebral artery territories
Presence of hemiplegia or hemiparesis
Mini-Mental State Examination (MMSE) score above 24 (19)
Sufficient attention and comprehension to perform the task
Absence of other associated neurological diseases.
Exclusion Criteria:
Acute medical problems
Uncorrected vision loss
Previous history of psychiatric admission
History of multiple strokes, transient ischemic attacks
Pathology of the less affected, ipsilateral to stroke upper extremity that would affect ability to perform the task
Score of 23 or less on the MMSE
Difficulty in comprehension of verbal command and simple instructions
Aphasia of comprehension.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Camila Torriani
Organizational Affiliation
University of São Paulo
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Camila Torriani
Organizational Affiliation
University of São Paulo
Official's Role
Study Chair
Facility Information:
Facility Name
Camila Torriani
City
São Paulo
State/Province
SP
ZIP/Postal Code
02415000
Country
Brazil
12. IPD Sharing Statement
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Practice Structure on Motor Learning in Post-Stroke Patients
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