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Pre-dinner vs. Post-dinner Exercise on Glycemic Control

Primary Purpose

Type 2 Diabetes

Status

Completed

Phase

Not Applicable

Locations

Study Type

Interventional

Intervention

No exercise

Meal then exercise

exercise then meal

About this trial

This is an interventional other trial for Type 2 Diabetes focused on measuring GIP, GLP-1, exercise timing, resistance exercise, glucose concentrations

Eligibility Criteria

25 Years - 55 Years (Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Obese ( body mass index 30-45 kg/m2)
Physician diagnosed with type 2 diabetes receiving standard medical care
Non-smokers
Pregnancy
Lactating mothers

Exclusion Criteria:

Insulin
Surgical weight loss
Orthopedic limitations to exercise
Weight loss in the previous 3 months

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Arm Label

No exercise

Meal then exercise

exercise then meal

Arm Description

participants will remain sedentary during testing

45 min of resistance training will be performed after a standard meal

45 min of resistance training will be performed prior to a standard meal

Outcomes

Primary Outcome Measures

glucose concentrations

Secondary Outcome Measures

triglyceride concentrations

Full Information

NCT ID

NCT02180620

First Posted

June 30, 2014

Last Updated

June 6, 2017

Sponsor

University of Missouri-Columbia

1. Study Identification

Unique Protocol Identification Number

NCT02180620

Brief Title

Pre-dinner vs. Post-dinner Exercise on Glycemic Control

Official Title

Exercise Timing and Postprandial Glycemia in Type 2 Diabetes

Study Type

Interventional

2. Study Status

Record Verification Date

June 2017

Overall Recruitment Status

Completed

Study Start Date

September 2013 (undefined)

Primary Completion Date

April 2014 (Actual)

Study Completion Date

April 2014 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Principal Investigator

Name of the Sponsor

University of Missouri-Columbia

4. Oversight

Data Monitoring Committee

5. Study Description

Brief Summary

With many medications we prescribe them relative to time of day or a meal. This study established if pre dinner vs post dinner exercise was more effective at altering post dinner glucose and triglyceride levels vs no exercise at all.

Detailed Description

All participants completed three trials in a random order in which they consumed a standardized dinner meal with 1) no RE (NoRE), 2) pre-dinner RE (RE→M), and 3) post-dinner RE beginning 45 min after dinner (M→RE). Diet was standardized during the day of testing. Participants reported to the lab for testing sometime between 3 - 5:30 p.m. and upon arrival a venous catheter was inserted into a forearm vein. Frequent blood sampling, indirect calorimetry measurements, and subjective well-being measurements ensued for ~5.75 h while the participants were in the lab.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Type 2 Diabetes

Keywords

GIP, GLP-1, exercise timing, resistance exercise, glucose concentrations

7. Study Design

Primary Purpose

Other

Study Phase

Not Applicable

Interventional Study Model

Crossover Assignment

Masking

None (Open Label)

Allocation

Non-Randomized

Enrollment

13 (Actual)

8. Arms, Groups, and Interventions

Arm Title

No exercise

Arm Type

Experimental

Arm Description

participants will remain sedentary during testing

Arm Title

Meal then exercise

Arm Type

Experimental

Arm Description

45 min of resistance training will be performed after a standard meal

Arm Title

exercise then meal

Arm Type

Experimental

Arm Description

45 min of resistance training will be performed prior to a standard meal

Intervention Type

Other

Intervention Name(s)

No exercise

Other Intervention Name(s)

NoEX

Intervention Description

During the no exercise trial (NoEX), the participants will remain sedentary during testing.

Intervention Type

Other

Intervention Name(s)

Meal then exercise

Other Intervention Name(s)

M-EX

Intervention Description

During the post-meal exercise trial (M→EX), 45 min of resistance training will be performed

Intervention Type

Other

Intervention Name(s)

exercise then meal

Other Intervention Name(s)

EX-M

Intervention Description

During the exercise prior to the meal trial (EX→M), 45 min of resistance training will be performed

Primary Outcome Measure Information:

Title

glucose concentrations

Time Frame

Blood samples were taken every 5-10 min during the first 3.7 h of testing and every 30 min during the last 2 h

Secondary Outcome Measure Information:

Title

triglyceride concentrations

Time Frame

Blood samples were taken every 5-10 min during the first 3.7 h of testing and every 30 min during the last 2 h

Other Pre-specified Outcome Measures:

Title

GLP-1 concentrations

Time Frame

Blood samples were taken every 5-10 min during the first 3.7 h of testing and every 30 min during the last 2 h

10. Eligibility

Sex

All

Minimum Age & Unit of Time

25 Years

Maximum Age & Unit of Time

55 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Obese ( body mass index 30-45 kg/m2) Physician diagnosed with type 2 diabetes receiving standard medical care Non-smokers Pregnancy Lactating mothers Exclusion Criteria: Insulin Surgical weight loss Orthopedic limitations to exercise Weight loss in the previous 3 months

12. IPD Sharing Statement

Plan to Share IPD

Citations:

PubMed Identifier

28970202

Citation

Heden TD, Liu Y, Kanaley JA. A comparison of adipose tissue interstitial glucose and venous blood glucose during postprandial resistance exercise in patients with type 2 diabetes. J Appl Physiol (1985). 2018 Apr 1;124(4):1054-1061. doi: 10.1152/japplphysiol.00475.2017. Epub 2017 Sep 28.

Results Reference

derived

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Pre-dinner vs. Post-dinner Exercise on Glycemic Control

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