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Pre-eclampsia and Future Cardiovascular Health: An Underused Opportunity to Improve Family Health (FINNCARE)

Primary Purpose

Pre-Eclampsia, Cardiovascular Diseases, Cardiovascular Risk Factor

Status
Recruiting
Phase
Not Applicable
Locations
Finland
Study Type
Interventional
Intervention
Face-to-face and web-based lifestyle intervention
Sponsored by
Helsinki University Central Hospital
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Pre-Eclampsia

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

Families are recruited from the FINNPEC cohort. In FINNPEC, PE was defined as hypertension and proteinuria occurring after 20 weeks gestation (American College of Obstetricians and Gynecologists 2002 criteria). Hypertension was defined as systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg. Proteinuria was defined as urinary excretion of ≥0.3 g protein in a 24-hour specimen, or 0.3 g/L, or two ≥1+ readings on a dipstick in a random urine determination with no evidence of a urinary tract infection. Each PE diagnosis was ascertained based on hospital records and confirmed independently by a research nurse and a study physician in the original FINNPEC case-control study including 1450 nulliparous or multiparous women with a singleton pregnancy with PE and 1065 pregnant control women without PE (aged 18-47 years) from all 5 university hospitals in Finland during 2008-2011.

Exclusion criteria in the FINNPEC: multiple pregnancy, inability to speak Finnish or Swedish.

Exclusion Criteria in the FINNCARE:

  • Pregnancy and/or lactation (for all mothers)
  • Pre-eclampsia in any previous or subsequent pregnancies (for all non-PE mothers)

Sites / Locations

  • Helsinki University HospitalRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

No Intervention

No Intervention

Arm Label

PE intervention

PE control

Non-PE control

Arm Description

A 12-month lifestyle intervention program to improve mothers and their children blood pressure and CVD risk profile.

The control group continue habitual lifestyle but will perform the same baseline and follow-up measurements as the intervention group. They will be given general written information on healthy eating.

The control group continue habitual lifestyle but will perform the same baseline and follow-up measurements as the intervention group. They will be given general written information on healthy eating.

Outcomes

Primary Outcome Measures

Blood pressure (mothers)
mean 24 hour ambulatory systolic BP and diastolic BP; mmHg
Blood pressure (children)
mean 24 hour ambulatory systolic BP and diastolic BP; mmHg

Secondary Outcome Measures

Blood pressure 24 hour variability (mothers)
nocturnal systolic and diastolic BP dip; standard deviation of systolic and diastolic BP; weighted standard deviation of systolic and diastolic BP; mmHg
Arterial stiffness (mothers)
carotid-femoral pulse wave velocity; m/s
Adiposity (mothers)
BMI; kg/m2
Adiposity (mothers)
waist-hip-ratio (no unit)
Adiposity (mothers)
body fat percentage; %
Dietary intake (mothers)
food frequency questionnaire on quality of fat (SFA, MUFA and PUFA; E%/day)
Dietary intake (mothers)
food frequency questionnaire on fiber intake; g/day
Dietary intake (mothers)
food frequency questionnaire on salt intake; g/d
Physical activity and sedentary behavior (mothers)
questionnaire data: weekly number of sessions and minutes of moderate-to-vigorous-intensity physical activity and walking
Physical activity and sedentary behavior (mothers)
questionnaire data: meeting physical activity recommendations
Physical activity and sedentary behavior (mothers)
questionnaire data: daily minutes of sitting on a non-weekend and weekend day
Physical activity and sedentary behavior (mothers)
accelerometer data: daily number of steps
Physical activity and sedentary behavior (mothers)
accelerometer data: daily minutes of total and intensity-specific physical activity
Physical activity and sedentary behavior (mothers)
accelerometer data: daily minutes of stationary behavior
Physical activity and sedentary behavior (mothers)
accelerometer data: daily number of breaks in stationary behavior
Smoking (mothers)
questionnaire on status of smoking/use of snuf/use of electronic cigarettes/nicotine replacement therapy and number of cigarettes/day
Laboratory assessment of cardiovascular risk (mothers)
lipids (total cholesterol, LDL, HDL, triglycerides; mmol/l)
Laboratory assessment of cardiovascular risk (mothers)
hs-CRP; mg/l
Laboratory assessment of cardiovascular risk (mothers)
HOMA index calculated as glucose; mmol/l x insulin; mU/l / 22.5
Awareness of later life morbidity (mothers)
A brief questionnaire with true or false questions on pre-eclampsia and later life morbidity
Heart rate variability (mothers)
standard deviation of all R-R intervals; root mean square of successive R-R interval differences, ms; High frequency power of R-R intervals from spectral band 0.15-0.4 Hz, ms2 ;Low frequency power of R-R intervals from spectral band 0.04-0.15 Hz, ms2 ; and LF/HF ratio
Blood pressure 24 hour variability (children)
nocturnal systolic and diastolic BP dip; standard deviation of systolic and diastolic BP; weighted standard deviation of systolic and diastolic BP; mmHg
Arterial stiffness (children)
carotid-femoral pulse wave velocity; m/s
Adiposity (children)
BMI z-score
Adiposity (children)
waist-hip-ratio (no unit)
Adiposity (children)
body fat percentage; %
Dietary intake (children)
food frequency questionnaire derived data on SFA index, fiber index, salt index (sum of food items rich in SFA/fiber/salt used during the previous week)
Physical activity and sedentary behavior (children)
questionnaire data: weekly number of days and daily duration of active travel to school and hobbies, structured physical activity outside school hours, unstructured physical activity outside school hours, screen time sitting, non-screen time sitting Accelerometer data: daily number of steps; daily minutes of total and intensity-specific physical activity; daily minutes of and stationary behavior; meeting physical activity recommendations; daily number of breaks in stationary behavior
Physical activity and sedentary behavior (children)
questionnaire data: weekly number of days and daily duration of active travel to school and hobbies
Physical activity and sedentary behavior (children)
questionnaire data: structured physical activity outside school hours
Physical activity and sedentary behavior (children)
questionnaire data: unstructured physical activity outside school hours
Physical activity and sedentary behavior (children)
questionnaire data: screen time and non-screen time sitting
Physical activity and sedentary behavior (children)
accelerometer data: daily number of steps
Physical activity and sedentary behavior (children)
accelerometer data: daily minutes of total and intensity-specific physical activity
Physical activity and sedentary behavior (children)
accelerometer data: daily minutes of stationary behavior
Physical activity and sedentary behavior (children)
accelerometer data: meeting physical activity recommendations
Physical activity and sedentary behavior (children)
accelerometer data: daily number of breaks in stationary behavior
Laboratory assessment of cardiovascular risk (children)
lipids (total cholesterol, LDL, HDL, triglycerides; mmol/l)
Laboratory assessment of cardiovascular risk (children)
hs-CRP; mg/l
Laboratory assessment of cardiovascular risk (children)
HOMA index calculated as glucose; mmol/l x insulin; mU/l / 22.5
Process evaluation: reach
participation rate of the families recruited (research database on study visits)
Process evaluation: reach
representativeness of the families participating (parents' and children's age, questionnaire on socio-economics)
Process evaluation: compliance
participation rate in measurements (number of study visits and questionnaires completed)
Process evaluation: compliance
proportion of sessions completed in the web-based portal (data accumulated in the web-based portal)
Process evaluation: acceptability
usefulness and ease of use (questionnaire and proportion of webportal sessions completed by the families)
Process evaluation: acceptability
credibility and satisfaction of the web-based portal (questionnaire and proportion of webportal sessions completed by the families)
Process evaluation: acceptability
occurrence of technical problems (questionnaire)

Full Information

First Posted
December 7, 2020
Last Updated
December 14, 2020
Sponsor
Helsinki University Central Hospital
Collaborators
University of Helsinki
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1. Study Identification

Unique Protocol Identification Number
NCT04676295
Brief Title
Pre-eclampsia and Future Cardiovascular Health: An Underused Opportunity to Improve Family Health
Acronym
FINNCARE
Official Title
Pre-eclampsia and Future Cardiovascular Health: An Underused Opportunity to Improve Family Health
Study Type
Interventional

2. Study Status

Record Verification Date
December 2020
Overall Recruitment Status
Recruiting
Study Start Date
June 1, 2019 (Actual)
Primary Completion Date
December 2022 (Anticipated)
Study Completion Date
December 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Helsinki University Central Hospital
Collaborators
University of Helsinki

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No

5. Study Description

Brief Summary
Background: PE (pre-eclampsia) is a common pregnancy-specific vascular hypertensive disease affecting 3-5% of pregnancies. PE independently increases the risk for premature cardiovascular disease (CVD) in mothers and their offspring long-term. PE provides a unique window for early risk profiling and CVD prevention. However, the efficacy of a family oriented lifestyle intervention to lower CVD risk in families with history of PE has not previously been evaluated. Aim: This study will explore the impact of PE on CVD progression 8-12 years from delivery in mothers and their children, and assess whether a lifestyle intervention is useful for lowering mother and child blood pressure and improving the CVD risk profile overall in families with a history of PE. Hypothesis: PE is related with CVD progression mediated by elevated blood pressure. Blood pressure and the CVD risk profile overall is modifiable in mothers and children by a 12-month behavioral lifestyle intervention in families with a history of PE. Study design: Randomized controlled behavioral lifestyle intervention trial where families (mother, child and father from the FINNPEC study) are offered the opportunity to participate in a lifestyle intervention program 8-12 years after a PE pregnancy. 300 PE families will be randomized 1:1 to a 12-month lifestyle intervention program or to a control group. A parallel group of 100 non-PE control families will be assessed at baseline and follow-up. Main outcome: 24 hour mean blood pressure change between baseline and follow-up in mother and child. Significance: This study will provide information on CVD progression in mothers and children 8-12 years from a PE pregnancy. Furthermore, the study assess the effect of a 12-month lifestyle intervention on blood pressure and CVD risk profile overall following a PE pregnancy. Potentially, the study provides the opportunity to identify PE families at highest risk of CVD progression and families amenable to blood pressure and CVD risk profile improvement.
Detailed Description
Power analysis: Power calculations were performed in order to detect 5.5 mmHg reduction in maternal systolic blood pressure with a power of 80% and a 2-sided p-value of 0.05 for the difference between the groups (intervention and control PE) (NICE 2011). Accounting for a 20% loss to follow-up or missing data, a sample of 148 women in the PE intervention group and 148 women in the PE control group is needed. Specific objectives: To assess cardiovascular health and CVD progression in families (mother, child and father) 8-12 years following a PE pregnancy compared with non-PE control families. To assess the effectiveness of a behavioral 12-month lifestyle intervention in mothers and their children 8-12 years following a PE pregnancy to lower blood pressure and improve their CVD risk profile overall. To assess the effectiveness of a lifestyle intervention on the awareness of CVD risk after a PE pregnancy.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Pre-Eclampsia, Cardiovascular Diseases, Cardiovascular Risk Factor, Gestational Hypertension

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
400 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
PE intervention
Arm Type
Experimental
Arm Description
A 12-month lifestyle intervention program to improve mothers and their children blood pressure and CVD risk profile.
Arm Title
PE control
Arm Type
No Intervention
Arm Description
The control group continue habitual lifestyle but will perform the same baseline and follow-up measurements as the intervention group. They will be given general written information on healthy eating.
Arm Title
Non-PE control
Arm Type
No Intervention
Arm Description
The control group continue habitual lifestyle but will perform the same baseline and follow-up measurements as the intervention group. They will be given general written information on healthy eating.
Intervention Type
Behavioral
Intervention Name(s)
Face-to-face and web-based lifestyle intervention
Intervention Description
Families are provided at baseline with one 60 min face-to-face dietary counseling session with nutritionist using family-oriented motivational interviewing and solution focusing techniques. The intervention continues in an interactive web-based portal where different modules include assignments, activities, and tests and related videos targeting five cardiovascular health-linked behaviors: 1) improving quality of fat in the diet, 2) increasing the consumption of foods rich in fiber, 3) decreasing the use of salt, 4) increasing physical activity and 5) reducing smoking.
Primary Outcome Measure Information:
Title
Blood pressure (mothers)
Description
mean 24 hour ambulatory systolic BP and diastolic BP; mmHg
Time Frame
baseline -12 months
Title
Blood pressure (children)
Description
mean 24 hour ambulatory systolic BP and diastolic BP; mmHg
Time Frame
baseline -12 months
Secondary Outcome Measure Information:
Title
Blood pressure 24 hour variability (mothers)
Description
nocturnal systolic and diastolic BP dip; standard deviation of systolic and diastolic BP; weighted standard deviation of systolic and diastolic BP; mmHg
Time Frame
baseline -12 months
Title
Arterial stiffness (mothers)
Description
carotid-femoral pulse wave velocity; m/s
Time Frame
baseline -12 months
Title
Adiposity (mothers)
Description
BMI; kg/m2
Time Frame
baseline -12 months
Title
Adiposity (mothers)
Description
waist-hip-ratio (no unit)
Time Frame
baseline -12 months
Title
Adiposity (mothers)
Description
body fat percentage; %
Time Frame
baseline -12 months
Title
Dietary intake (mothers)
Description
food frequency questionnaire on quality of fat (SFA, MUFA and PUFA; E%/day)
Time Frame
baseline -12 months
Title
Dietary intake (mothers)
Description
food frequency questionnaire on fiber intake; g/day
Time Frame
baseline -12 months
Title
Dietary intake (mothers)
Description
food frequency questionnaire on salt intake; g/d
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (mothers)
Description
questionnaire data: weekly number of sessions and minutes of moderate-to-vigorous-intensity physical activity and walking
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (mothers)
Description
questionnaire data: meeting physical activity recommendations
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (mothers)
Description
questionnaire data: daily minutes of sitting on a non-weekend and weekend day
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (mothers)
Description
accelerometer data: daily number of steps
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (mothers)
Description
accelerometer data: daily minutes of total and intensity-specific physical activity
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (mothers)
Description
accelerometer data: daily minutes of stationary behavior
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (mothers)
Description
accelerometer data: daily number of breaks in stationary behavior
Time Frame
baseline -12 months
Title
Smoking (mothers)
Description
questionnaire on status of smoking/use of snuf/use of electronic cigarettes/nicotine replacement therapy and number of cigarettes/day
Time Frame
baseline -12 months
Title
Laboratory assessment of cardiovascular risk (mothers)
Description
lipids (total cholesterol, LDL, HDL, triglycerides; mmol/l)
Time Frame
baseline -12 months
Title
Laboratory assessment of cardiovascular risk (mothers)
Description
hs-CRP; mg/l
Time Frame
baseline -12 months
Title
Laboratory assessment of cardiovascular risk (mothers)
Description
HOMA index calculated as glucose; mmol/l x insulin; mU/l / 22.5
Time Frame
baseline -12 months
Title
Awareness of later life morbidity (mothers)
Description
A brief questionnaire with true or false questions on pre-eclampsia and later life morbidity
Time Frame
baseline -12 months
Title
Heart rate variability (mothers)
Description
standard deviation of all R-R intervals; root mean square of successive R-R interval differences, ms; High frequency power of R-R intervals from spectral band 0.15-0.4 Hz, ms2 ;Low frequency power of R-R intervals from spectral band 0.04-0.15 Hz, ms2 ; and LF/HF ratio
Time Frame
baseline -12 months
Title
Blood pressure 24 hour variability (children)
Description
nocturnal systolic and diastolic BP dip; standard deviation of systolic and diastolic BP; weighted standard deviation of systolic and diastolic BP; mmHg
Time Frame
baseline -12 months
Title
Arterial stiffness (children)
Description
carotid-femoral pulse wave velocity; m/s
Time Frame
baseline -12 months
Title
Adiposity (children)
Description
BMI z-score
Time Frame
baseline -12 months
Title
Adiposity (children)
Description
waist-hip-ratio (no unit)
Time Frame
baseline -12 months
Title
Adiposity (children)
Description
body fat percentage; %
Time Frame
baseline -12 months
Title
Dietary intake (children)
Description
food frequency questionnaire derived data on SFA index, fiber index, salt index (sum of food items rich in SFA/fiber/salt used during the previous week)
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (children)
Description
questionnaire data: weekly number of days and daily duration of active travel to school and hobbies, structured physical activity outside school hours, unstructured physical activity outside school hours, screen time sitting, non-screen time sitting Accelerometer data: daily number of steps; daily minutes of total and intensity-specific physical activity; daily minutes of and stationary behavior; meeting physical activity recommendations; daily number of breaks in stationary behavior
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (children)
Description
questionnaire data: weekly number of days and daily duration of active travel to school and hobbies
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (children)
Description
questionnaire data: structured physical activity outside school hours
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (children)
Description
questionnaire data: unstructured physical activity outside school hours
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (children)
Description
questionnaire data: screen time and non-screen time sitting
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (children)
Description
accelerometer data: daily number of steps
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (children)
Description
accelerometer data: daily minutes of total and intensity-specific physical activity
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (children)
Description
accelerometer data: daily minutes of stationary behavior
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (children)
Description
accelerometer data: meeting physical activity recommendations
Time Frame
baseline -12 months
Title
Physical activity and sedentary behavior (children)
Description
accelerometer data: daily number of breaks in stationary behavior
Time Frame
baseline -12 months
Title
Laboratory assessment of cardiovascular risk (children)
Description
lipids (total cholesterol, LDL, HDL, triglycerides; mmol/l)
Time Frame
baseline -12 months
Title
Laboratory assessment of cardiovascular risk (children)
Description
hs-CRP; mg/l
Time Frame
baseline -12 months
Title
Laboratory assessment of cardiovascular risk (children)
Description
HOMA index calculated as glucose; mmol/l x insulin; mU/l / 22.5
Time Frame
baseline -12 months
Title
Process evaluation: reach
Description
participation rate of the families recruited (research database on study visits)
Time Frame
baseline
Title
Process evaluation: reach
Description
representativeness of the families participating (parents' and children's age, questionnaire on socio-economics)
Time Frame
baseline
Title
Process evaluation: compliance
Description
participation rate in measurements (number of study visits and questionnaires completed)
Time Frame
baseline -12 months
Title
Process evaluation: compliance
Description
proportion of sessions completed in the web-based portal (data accumulated in the web-based portal)
Time Frame
baseline -12 months
Title
Process evaluation: acceptability
Description
usefulness and ease of use (questionnaire and proportion of webportal sessions completed by the families)
Time Frame
baseline -12 months
Title
Process evaluation: acceptability
Description
credibility and satisfaction of the web-based portal (questionnaire and proportion of webportal sessions completed by the families)
Time Frame
baseline -12 months
Title
Process evaluation: acceptability
Description
occurrence of technical problems (questionnaire)
Time Frame
baseline -12 months
Other Pre-specified Outcome Measures:
Title
Arterial wall thickness (mothers)
Description
intima-media thickness; common carotid, brachial and radial; mm
Time Frame
baseline
Title
Left ventricular mass (mothers)
Description
left ventricular mass; g
Time Frame
baseline
Title
Left ventricular systolic function (mothers)
Description
left ventricular global longitudinal strain; %
Time Frame
baseline
Title
Left ventricular diastolic function (mothers)
Description
left atrial volume; ml
Time Frame
baseline
Title
Left ventricular diastolic function (mothers)
Description
pulsed wave Doppler mitral early to late inflow velocity ratio (no unit)
Time Frame
baseline
Title
Left ventricular diastolic function (mothers)
Description
mitral lateral annular pulsed wave tissue Doppler early velocity; cm/s
Time Frame
baseline
Title
Left ventricular diastolic function (mothers)
Description
septal pulsed wave tissue Doppler early velocity; cm/s
Time Frame
baseline
Title
Arterial wall thickness (children)
Description
intima-media thickness; common carotid, brachial and radial; mm
Time Frame
baseline
Title
Left ventricular mass (children)
Description
left ventricular mass; g
Time Frame
baseline
Title
Left ventricular systolic function (children)
Description
left ventricular global longitudinal strain; %
Time Frame
baseline
Title
Left ventricular diastolic function (children)
Description
left atrial volume; ml
Time Frame
baseline
Title
Left ventricular diastolic function (children)
Description
pulsed wave Doppler mitral early to late inflow velocity ratio (no unit)
Time Frame
baseline
Title
Left ventricular diastolic function (children)
Description
mitral lateral annular pulsed wave tissue Doppler early velocity; cm/s
Time Frame
baseline
Title
Left ventricular diastolic function (children)
Description
septal pulsed wave tissue Doppler early velocity; cm/s
Time Frame
baseline

10. Eligibility

Sex
All
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Families are recruited from the FINNPEC cohort. In FINNPEC, PE was defined as hypertension and proteinuria occurring after 20 weeks gestation (American College of Obstetricians and Gynecologists 2002 criteria). Hypertension was defined as systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg. Proteinuria was defined as urinary excretion of ≥0.3 g protein in a 24-hour specimen, or 0.3 g/L, or two ≥1+ readings on a dipstick in a random urine determination with no evidence of a urinary tract infection. Each PE diagnosis was ascertained based on hospital records and confirmed independently by a research nurse and a study physician in the original FINNPEC case-control study including 1450 nulliparous or multiparous women with a singleton pregnancy with PE and 1065 pregnant control women without PE (aged 18-47 years) from all 5 university hospitals in Finland during 2008-2011. Exclusion criteria in the FINNPEC: multiple pregnancy, inability to speak Finnish or Swedish. Exclusion Criteria in the FINNCARE: Pregnancy and/or lactation (for all mothers) Pre-eclampsia in any previous or subsequent pregnancies (for all non-PE mothers)
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Tiina Jääskeläinen, PhD
Phone
+358 50 4150274
Email
tiina.j.jaaskelainen@helsinki.fi
First Name & Middle Initial & Last Name or Official Title & Degree
Taisto Sarkola, PhD, MD
Phone
+358504274971
Email
taisto.sarkola@hus.fi
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Tiina Jääskeläinen, PhD
Organizational Affiliation
University of Helsinki
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Hannele Laivuori, Prof, MD
Organizational Affiliation
University of Helsinki and University of Tampere
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Taisto Sarkola, PhD, MD
Organizational Affiliation
Helsinki University Central Hospital
Official's Role
Study Director
Facility Information:
Facility Name
Helsinki University Hospital
City
Helsinki
ZIP/Postal Code
00029
Country
Finland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Taisto Sarkola, PhD, MD
Phone
+358504274971
Email
taisto.sarkola@hus.fi

12. IPD Sharing Statement

Citations:
PubMed Identifier
28067621
Citation
Jaaskelainen T, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Laivuori H; FINNPEC Study Group. Cohort profile: the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC). BMJ Open. 2016 Nov 10;6(11):e013148. doi: 10.1136/bmjopen-2016-013148.
Results Reference
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Pre-eclampsia and Future Cardiovascular Health: An Underused Opportunity to Improve Family Health

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