Preemptive Analgesia With OxyContin Versus Placebo Before Surgery for Long Bone Fractures
Fractures
About this trial
This is an interventional treatment trial for Fractures focused on measuring long bone fracture, open fractures, closed fractures, trauma
Eligibility Criteria
Inclusion Criteria: Patient consent. Age 18 years to 60 years. Isolated limb bone fracture/s. Exclusion Criteria: Patient refusal. Age 61 years and older. Known allergy to study medication. Multiple bone fractures in different limbs. Multiple trauma. Oncological patients. Respiratory depression / respiratory insufficiency / hypercarbia. Acute bronchial asthma. CNS depression / hallucinations. Alzheimer / dementia. Known convulsive disorder. Prostate hypertrophy. Paralytic ileus. Renal dysfunction (plasma creatinine > 1.5). Liver dysfunction. Adrenocortical insufficiency. Hypothyroidism. Pancreatitis. Pregnancy and lactating. Drug abuse, current or in the past. Alcohol abuse on admission to operating room.
Sites / Locations
- RAMBAM Health Care Campus
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
study group
placebo group
pre operative medication with 20 mg oxycontine PO
pre operative medication with placebo tablet PO