Prefrontal Transcranial Random Noise Stimulation in Patients With Depression (tRNS-depr)
Depression

About this trial
This is an interventional treatment trial for Depression focused on measuring depression; trns
Eligibility Criteria
Inclusion Criteria:
- episode of depression (unipolar or bipolar) ( ICD-10)
- female or male between 18 and 70 years old
- skills to participate in all study procedures
- 18 or more points in the Hamilton rating scale or depression
- written informed consent
Exclusion Criteria:
- clinically relevant unstable internal or neurological comorbidity
- evidence of significant brain malformations or neoplasm, head injury
- cerebral vascular events
- neurodegenerative disorders affecting the brain or prior brain surgery
- metal objects in and around body that can not be removed
- pregnancy
- alcohol or drug abuse
- eczema on the head
- heart pacemaker
- high dose tranquillizers
Sites / Locations
- University of Regensburg
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Verum Prefrontal tRNS
Placebo Prefrontal tRNS
2mA of tRNS (DC-Stimulator, NeuroConn GmbH, Germany) with a zero offset will be applied to the left and right dorsolateral prefrontal cortex. Treatment will consist of 15 days with 20 minutes stimulation per day. Voltage will be ramped at the begin and end of a stimulation for 10 seconds.
2mA of tRNS (DC-Stimulator, NeuroConn GmbH, Germany) with a zero offset will be applied to the left and right dorsolateral prefrontal cortex. Treatment will consist of 15 days with 20 minutes stimulation per day. Voltage will be ramped at the begin and end of a stimulation for 10 seconds. Placebo stimulation will consist of just applying the ramps at the begin and end of the stimulation.