Prehabilitation Intervention to Maximize Early Recovery (PRIMER) in Liver Transplantation (PRIMER)

This is an interventional treatment trial for Liver Diseases focused on measuring liver transplantation, malnutrition, exercise, prehabilitation, nutrition, sarcopenia Read More

Inclusion Criteria:

1. Participants must be wait-listed, in transplant evaluation, or "Penn Ready" with a MELD-Na score less than or equal to 25;
2. Patients must be English speaking and own/use a smartphone and cognitively able to consent;
3. Patient and physician feel that individual can safely participate in an exercise program;
4. Meeting at least one 'at risk' criterion for impaired physical performance, frailty, or malnutrition (by SPPB, abPG-SG, dynamometer measured grip strength), or physical deconditioning as determined by physical therapist, or treating clinician.

Exclusion Criteria:

1. The patient is unable to provide informed consent;
2. The patient has been hospitalized within the last 30 days;
3. A score of 0-3 points on the SPPB assessment indicating inability to participate in a physical activity program or a score of 12 in the absence of frailty or malnutrition (indicating low risk for poor physical or performance or malnutrition);
4. The patient is at risk for falling as defined by clinician assessment results or if the patient states that he/she has a history of falling (record of a fall(s) in the past 30 days);
5. The patient is already enrolled in a financial incentive-based exercise program using a wearable device;
6. Any other medical conditions that would prohibit participation in a physical activity program as determined by transplant clinicians or severe vision, hearing, or mobility impairment precluding participation.