Preliminary Administration of EPO and Markers of Cardiac Ischemia Induced by CPB (EPOetCEC)
Myocardial Ischemia
About this trial
This is an interventional prevention trial for Myocardial Ischemia focused on measuring troponin T, CK-MB, protein S-100, Cardiopulmonary Bypass, Erythropoietin
Eligibility Criteria
Inclusion Criteria: Coronary bypass surgery. Surgery not urgent. Left ventricular ejection fraction (LVEF) > 40. Informed consent form signed. Exclusion Criteria: Valvular surgery. Surgery with beating heart, with or without cardiopulmonary bypass. Carotid bypass surgery. Myocardial infarction less than 30 days. Previous history of cardiac surgery. Kidney failure (creatinine > 200 µmol/l). Uncontrolled hypertension. Unstable angina. Risk of deep venous thrombosis. Vascular cerebral attack less than 30 days. Malignant tumour. Phenylketonuria. Allergy to erythropoietin. Previous programmed blood donation. Pregnancy and feeding.
Sites / Locations
- Cardiac Surgery Department - CHU de Grenoble
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
1
2
epoetin beta
placebo of NaCl