Preop CPET Testing and Exercise Training in Colorectal Patients
Colorectal Neoplasms
About this trial
This is an interventional treatment trial for Colorectal Neoplasms focused on measuring CPET test, Exercise training, Prehabilitation, Exercise Test
Eligibility Criteria
Inclusion Criteria:
- Written informed consent
- Colorectal malignancy suitable for curative resection, no metastatic disease
- Elective procedure, ability to undergo CPET testing
- American Society of Anaesthesiologists (ASA) physical status I-III
Exclusion Criteria:
- Emergency surgery
- Unable to participate due to any of the following absolute contraindications to CPET testing: acute MI in past 3 - 5 days; Unstable angina; Uncontrolled arrhythmias; Syncope; Active endocarditis; Symptomatic severe aortic stenosis; Acute PE; DVT; Uncontrolled asthma; Pulmonary oedema; Room air desaturation at rest <85%; Respiratory failure; Cognitive impairment leading to inability to cooperate
- Distant metastases on CT
- American Society of Anaesthesiologists (ASA) physical status IV
Sites / Locations
- University of East Anglia
- Norfolk and Norwich University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Exercise Training Arm
No Exercise Training Arm
Patients randomised to exercise training will be offered three sessions of aerobic interval exercise per week over the subsequent 4 weeks prior to their procedure. Each session will comprise 6 x 5 min repetitions at 60-80% peak VO2, with 2.5 min rest intervals. The aim will be to quickly progress patients to exercise intensities that correspond to and exceed the individual AT. Heart rate, clinical signs, blood pressure and perceived exertion will be recorded regularly throughout exercise. Repeat CPET testing will then take place 4 weeks from the baseline test in the exercise laboratory (on the day prior to surgery) to determine changes (if any) in AT, VO2, VE/VCO2.
The patients in the non-exercise arm of the study will not undergo any exercise intervention but will be CPET tested in the exercise laboratory at the same time points as the exercise arm patients.