Prescription Opioid Effects in Abusers Versus Non-Abusers

Inclusion Criteria: In good physical health Women reporting regular menstrual cycles lasting between 24 to 35 days Able to perform study procedures Normal body weight Use of opioids for medical purposes (cough, pain, or diarrhea) or recreational purposes at least twice in lifetime with no serious adverse effects Current opioid abuse, but not opioid dependence (drug abusers only) Exclusion Criteria: On parole or probation Recently convicted of a crime of violence History of significant violent behavior Current Axis I psychopathology Significant Axis II disorder Pregnancy Women who have irregular menstrual cycles, or who are dysmenorrheic, amenorrheic, or menopausal Women who have been pregnant or breastfeeding within the past 6 months Women who have had a miscarriage or abortion within the past 6 months Women who meet DSM-IV criteria for premenstrual dysphoric disorder Women who report suffering from moderate to severe premenstrual symptoms Women seeking treatment for premenstrual problems Taking prescription or over-the-counter psychotropic medication History of chronic pain, or routinely uses over-the-counter analgesics (more than 4 days per month) Blood pressure greater than 150/90 mm Hg Reports of sensitivity, allergy, or contraindication to opioids Non-drug abusers: Current or lifetime history of substance abuse or dependence according to DSM-IV criteria (those requiring detoxification) Consumes more than 500 mg caffeine daily Seeking treatment for substance use