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Preventing Language Decline in Dementia

Primary Purpose

Primary Progressive Aphasia

Status
Completed
Phase
Not Applicable
Locations
Canada
Study Type
Interventional
Intervention
Language therapy
Sponsored by
Baycrest
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Primary Progressive Aphasia

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • diagnosis of PPA
  • fluent in English
  • able to see and hear
  • able to participate in individual and group sessions
  • willing to travel to sessions
  • physically independent (if assistive devices needed, must be able to operate them)

Exclusion Criteria:

  • untreated mental conditions
  • neurodegenerative conditions (other than PPA)

Sites / Locations

  • Baycrest Health Sciences

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Active Comparator

Arm Label

Language therapy-Individual treatment

Language therapy-Group treatment

Arm Description

Participants will receive intervention for naming impairment based on either phonological or semantic cues.

Following the individual therapy, participants will be randomly assigned to either verbal or non-verbal group

Outcomes

Primary Outcome Measures

Naming accuracy measured with standard naming tests (e.g., BNT)

Secondary Outcome Measures

Full Information

First Posted
August 31, 2015
Last Updated
July 8, 2019
Sponsor
Baycrest
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1. Study Identification

Unique Protocol Identification Number
NCT02541097
Brief Title
Preventing Language Decline in Dementia
Official Title
Preventing Language Decline in Dementia
Study Type
Interventional

2. Study Status

Record Verification Date
July 2019
Overall Recruitment Status
Completed
Study Start Date
May 2016 (undefined)
Primary Completion Date
December 2018 (Actual)
Study Completion Date
January 31, 2019 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Baycrest

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
This study will establish factors fundamental to the improvement in communication and quality of life for people with dementia known as primary progressive aphasia (PPA). PPA is a type of dementia in which language declines but other cognitive skills (including memory) are preserved in the first several years after the onset. This makes those in the initial stages of PPA excellent candidates for treatment and creates a window of time (2-7 years) whereby they can lead independent lives with minimal support. However, currently, no communication therapy is available to people with PPA due to the progressive nature of the disorder and lack of awareness of available options for professionals willing to treat it. Participants with PPA in our study will receive two kinds of therapy for the words they cannot recall spontaneously, and will be trained to maintain them through social interaction. The type of training will be based on the most successful interventions the investigators provided to people with PPA in our previous work. The investigators expect that successful re-learning of forgotten words and practicing them in a group setting will facilitate retention of communication skills leading to greater personal independence and increased/maintained quality of life for people with PPA. Our study represents natural combination of two novel approaches for PPA that ultimately will lead to lower demands on the health care system.
Detailed Description
The study will establish factors fundamental to the improvement in communication and quality of life for people with dementia known as primary progressive aphasia (PPA). PPA is a type of dementia in which language declines but other cognitive skills (including memory) are preserved in the first several years after the onset (see Mesulam 1982). This makes those in the initial stages of PPA excellent candidates for treatment and creates a window of time (2-7 years) whereby PPA individuals can lead independent lives with minimal support. However, currently, no communication therapy is available to people with PPA due to the progressive nature of the disorder and lack of awareness of available options for professionals willing to treat it. Naming impairments are omnipresent in PPA. For this reason, anomia will be the focus of our intervention. Participants with PPA in our study will receive two kinds of therapy for the words they cannot recall spontaneously, and will be trained to maintain them through social interaction. The type of training will be based on the most successful interventions the investigators provided to people with PPA in our previous work (active encoding and errorless lerning). The investigators expect that successful re-learning of forgotten words and practicing them in a group setting will facilitate retention of communication skills leading to greater personal independence and increased/maintained quality of life for people with PPA. half of the cohort (randomly determined) will then participate in a communication group where conversations are encouraged and half will attend "non-verbal" group meetings when they will paint, watch movies and engage in other activities not requiring talking. To evaluate the benefits of practicing the re-learned words in a social setting naming skills will be tested for each participant before and after individual and group interventions.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Primary Progressive Aphasia

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
20 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Language therapy-Individual treatment
Arm Type
Active Comparator
Arm Description
Participants will receive intervention for naming impairment based on either phonological or semantic cues.
Arm Title
Language therapy-Group treatment
Arm Type
Active Comparator
Arm Description
Following the individual therapy, participants will be randomly assigned to either verbal or non-verbal group
Intervention Type
Behavioral
Intervention Name(s)
Language therapy
Intervention Description
Participants will receive semantic and phonological therapy for words they cannot retrieve spontaneously. They will be given an opportunity to practice the words in a group setting.
Primary Outcome Measure Information:
Title
Naming accuracy measured with standard naming tests (e.g., BNT)
Time Frame
4 months

10. Eligibility

Sex
All
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: diagnosis of PPA fluent in English able to see and hear able to participate in individual and group sessions willing to travel to sessions physically independent (if assistive devices needed, must be able to operate them) Exclusion Criteria: untreated mental conditions neurodegenerative conditions (other than PPA)
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Regina Jokel
Organizational Affiliation
Rotman Research Institute, Baycrest and University of Toronto
Official's Role
Principal Investigator
Facility Information:
Facility Name
Baycrest Health Sciences
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M6A 2E1
Country
Canada

12. IPD Sharing Statement

Plan to Share IPD
No
IPD Sharing Plan Description
Only de-identified group data will be published

Learn more about this trial

Preventing Language Decline in Dementia

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