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Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin (PEGASUS)

Primary Purpose

Myocardial Infarction, Cardiovascular Death, Atherothrombosis

Status

Completed

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Ticagrelor 90 mg

Ticagrelor 60 mg

Ticagrelor Placebo

About this trial

This is an interventional prevention trial for Myocardial Infarction focused on measuring Heart attack, Heart Disease, Acute coronary syndrome, ACS, Cardiovascular Disease

Eligibility Criteria

50 Years - 130 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age ≥ 65 years old, Diabetes requiring medication, Documented history of 2nd prior MI (>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic, non-end stage renal dysfunction.
Females of child-bearing potential must have a negative pregnancy test at enrollment
Persons who are currently taking aspirin between 75 and 150 mg once daily

Exclusion Criteria:

Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start
Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start
Persons with known bleeding disorders
Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin
Persons with a history of ischemic stroke
Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days.
Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker
Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery
Persons with known severe liver disease
Persons with kidney failure requiring dialysis
Persons with life expectancy < 1 year

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Placebo Comparator

Arm Label

Arm Description

Oral Treatment

Outcomes

Primary Outcome Measures

Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death), Myocardial Infarction (MI) or Stroke Within 3 Years From Randomization

Participants with CV death, MI or Stroke. If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent, non-CV death or at the last time point of complete clinical event assessment. Events were adjudicated by a blinded endpoint committee. The Kaplan-Meier estimate reports the percentage of patients who experienced CV Death, MI or stroke within 3 years from randomization

Kaplan-Meier Estimate of the Percentage of Patients Who Experienced a TIMI Major Bleeding Within 3 Years From First Dose of Study Drug Units: Percentage of Patients

A Thrombolysis in Myocardial Infarction (TIMI) study group major bleeding is defined as any fatal bleeding (leading directly to death within 7 days), any intrcranial bleeding or any clinically overt signs of haemorrhage associated with a drop in Haemoglobin of >= 5g/dL. Events were adjudicated by a clinical events committee. Censoring ocurrs at 7 days following last dose of study drug. The Kaplan-Meier estimate reports the percentage of patients who experienced a TIMI Major bleeding within 3 years from first dose of study drug

Secondary Outcome Measures

Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death) Within 3 Years From Randomization

Participants with CV death. If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent, non-CV death or at the last time point of complete clinical event assessment. Events were adjudicated by a blinded endpoint committee. The Kaplan-Meier estimate reports the percentage of patients who experienced CV Death within 3 years from randomization

Kaplan-Meier Estimate of the Percentage of Patients Who Died From Any Cause Within 3 Years From Randomization

Participants with death from any cause. If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent or the last time point the particapant was known to be alive. Events were adjudicated by a blinded endpoint committee. The Kaplan-Meier estimate reports the percentage of patients who died from any cause within 3 years from randomization

Full Information

NCT ID

NCT01225562

First Posted

July 9, 2010

Last Updated

December 18, 2015

Sponsor

AstraZeneca

1. Study Identification

Unique Protocol Identification Number

NCT01225562

Brief Title

Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin

Acronym

PEGASUS

Official Title

A Randomized, Double-Blind, Placebo Controlled, Parallel Group, Multinational Trial, to Assess the Prevention of Thrombotic Events With Ticagrelor Compared to Placebo on a Background of Acetyl Salicylic Acid (ASA) Therapy in Patients With History of Myocardial Infarction

Study Type

Interventional

2. Study Status

Record Verification Date

December 2015

Overall Recruitment Status

Completed

Study Start Date

October 2010 (undefined)

Primary Completion Date

December 2014 (Actual)

Study Completion Date

December 2014 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

AstraZeneca

4. Oversight

5. Study Description

Brief Summary

This study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Myocardial Infarction, Cardiovascular Death, Atherothrombosis, Stroke

Keywords

Heart attack, Heart Disease, Acute coronary syndrome, ACS, Cardiovascular Disease

7. Study Design

Primary Purpose

Prevention

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantCare ProviderInvestigatorOutcomes Assessor

Allocation

Randomized

Enrollment

21379 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Arm Type

Experimental

Arm Description

Oral Treatment

Arm Title

Arm Type

Experimental

Arm Description

Oral Treatment

Arm Title

Arm Type

Placebo Comparator

Arm Description

Oral Treatment

Intervention Type

Drug

Intervention Name(s)

Ticagrelor 90 mg

Intervention Description

Oral dose twice a day

Intervention Type

Drug

Intervention Name(s)

Ticagrelor 60 mg

Intervention Description

Oral dose twice a day

Intervention Type

Drug

Intervention Name(s)

Ticagrelor Placebo

Intervention Description

Oral dose twice a day

Primary Outcome Measure Information:

Title

Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death), Myocardial Infarction (MI) or Stroke Within 3 Years From Randomization

Description

Time Frame

Randomization up to 47 months

Title

Kaplan-Meier Estimate of the Percentage of Patients Who Experienced a TIMI Major Bleeding Within 3 Years From First Dose of Study Drug Units: Percentage of Patients

Description

Time Frame

First dosing up to 48 months

Secondary Outcome Measure Information:

Title

Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death) Within 3 Years From Randomization

Description

Time Frame

Randomization up to 47 months

Title

Kaplan-Meier Estimate of the Percentage of Patients Who Died From Any Cause Within 3 Years From Randomization

Description

Time Frame

Randomization up to 47 months

10. Eligibility

Sex

All

Minimum Age & Unit of Time

50 Years

Maximum Age & Unit of Time

130 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age ≥ 65 years old, Diabetes requiring medication, Documented history of 2nd prior MI (>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic, non-end stage renal dysfunction. Females of child-bearing potential must have a negative pregnancy test at enrollment Persons who are currently taking aspirin between 75 and 150 mg once daily Exclusion Criteria: Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start Persons with known bleeding disorders Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin Persons with a history of ischemic stroke Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days. Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery Persons with known severe liver disease Persons with kidney failure requiring dialysis Persons with life expectancy < 1 year

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Eugene Braunwald, MD

Organizational Affiliation

TIMI Study Group

Official's Role

Study Chair

First Name & Middle Initial & Last Name & Degree

Marc Sabatine, MD, MPh

Organizational Affiliation

TIMI Study Group

Official's Role

Principal Investigator

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Alexander City

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Alabama

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United States

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Athens

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Bronx

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Cortlandt Manor

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Cary

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Hickory

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United States

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Research Site

City

Sanford

State/Province

North Carolina

Country

United States

Facility Name

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City

Smithfield

State/Province

North Carolina

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United States

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City

Statesville

State/Province

North Carolina

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United States

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City

Wilmington

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North Carolina

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United States

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City

Grand Forks

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North Dakota

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United States

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City

Akron

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Ohio

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United States

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City

Canton

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Ohio

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United States

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City

Cincinnati

State/Province

Ohio

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United States

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City

Cleveland

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Ohio

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United States

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City

Columbus

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Ohio

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United States

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City

Dayton

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Ohio

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United States

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City

Fairfield

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Ohio

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United States

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City

Mansfield

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Ohio

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United States

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City

Sandusky

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Ohio

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United States

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City

Springfield

State/Province

Ohio

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United States

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City

Toledo

State/Province

Ohio

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United States

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City

Youngstown

State/Province

Ohio

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United States

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City

Zanesville

State/Province

Ohio

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United States

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City

Oklahoma City

State/Province

Oklahoma

Country

United States

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City

Tulsa

State/Province

Oklahoma

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United States

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City

Bend

State/Province

Oregon

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United States

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City

Portland

State/Province

Oregon

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United States

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City

Altoona

State/Province

Pennsylvania

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United States

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City

Beaver

State/Province

Pennsylvania

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United States

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City

Bethlehem

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Pennsylvania

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United States

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City

Chambersburg

State/Province

Pennsylvania

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United States

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City

Doylestown

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Pennsylvania

Country

United States

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City

Erie

State/Province

Pennsylvania

Country

United States

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City

Johnstown

State/Province

Pennsylvania

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United States

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City

Lancaster

State/Province

Pennsylvania

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United States

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City

Langhorne

State/Province

Pennsylvania

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United States

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City

Philadelphia

State/Province

Pennsylvania

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United States

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City

Pittsburgh

State/Province

Pennsylvania

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United States

Facility Name

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City

Scranton

State/Province

Pennsylvania

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United States

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City

Sellersville

State/Province

Pennsylvania

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United States

Facility Name

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City

West Chester

State/Province

Pennsylvania

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United States

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City

York

State/Province

Pennsylvania

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United States

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City

Providence

State/Province

Rhode Island

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United States

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City

Anderson

State/Province

South Carolina

Country

United States

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City

Charleston

State/Province

South Carolina

Country

United States

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City

Florence

State/Province

South Carolina

Country

United States

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City

Greenville

State/Province

South Carolina

Country

United States

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City

Rapid City

State/Province

South Dakota

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United States

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City

Watertown

State/Province

South Dakota

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United States

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City

Germantown

State/Province

Tennessee

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United States

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City

Jackson

State/Province

Tennessee

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United States

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City

Knoxville

State/Province

Tennessee

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United States

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City

Nashville

State/Province

Tennessee

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United States

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City

Oak Ridge

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Tennessee

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United States

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City

Tullahoma

State/Province

Tennessee

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United States

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City

Austin

State/Province

Texas

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United States

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City

Dallas

State/Province

Texas

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United States

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City

Fort Worth

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Texas

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United States

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City

Georgetown

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Texas

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United States

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City

Grapevine

State/Province

Texas

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United States

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City

Houston

State/Province

Texas

Country

United States

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City

Katy

State/Province

Texas

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United States

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City

Kingwood

State/Province

Texas

Country

United States

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City

MC Allen

State/Province

Texas

Country

United States

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City

McAllen

State/Province

Texas

Country

United States

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City

Plano

State/Province

Texas

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United States

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City

Round Rock

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Texas

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United States

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City

San Antonio

State/Province

Texas

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United States

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City

Tomball

State/Province

Texas

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United States

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City

Tyler

State/Province

Texas

Country

United States

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City

Victoria

State/Province

Texas

Country

United States

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City

Provo

State/Province

Utah

Country

United States

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City

Burlington

State/Province

Vermont

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United States

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City

Alexandria

State/Province

Virginia

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United States

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City

Charlottesville

State/Province

Virginia

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United States

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City

Danville

State/Province

Virginia

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United States

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City

Falls Church

State/Province

Virginia

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United States

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City

Lynchburg

State/Province

Virginia

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United States

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City

Manassas

State/Province

Virginia

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United States

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Norfolk

State/Province

Virginia

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United States

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Richmond

State/Province

Virginia

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United States

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City

Winchester

State/Province

Virginia

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United States

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City

Bellevue

State/Province

Washington

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United States

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City

Everett

State/Province

Washington

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United States

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City

Spokane

State/Province

Washington

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United States

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City

Tacoma

State/Province

Washington

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United States

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City

Green Bay

State/Province

Wisconsin

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United States

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City

Wausau

State/Province

Wisconsin

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United States

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City

Bahia Blanca

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Argentina

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Buenos Aires

Country

Argentina

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Ciudad Autonoma de BA

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Argentina

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Ciudad de Buenos Aires

Country

Argentina

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Ciudadela

Country

Argentina

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City

Cordoba

Country

Argentina

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City

Coronel Suarez

Country

Argentina

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Corrientes

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Argentina

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City

Córdoba

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Argentina

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Haedo

Country

Argentina

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La Plata

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Argentina

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City

Mar del Plata

Country

Argentina

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Ramos Mejía

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Argentina

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Rosario Santa Fe

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Argentina

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City

Rosario

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Argentina

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City

San Luis

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Argentina

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San Miguel de Tucuman

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Argentina

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San Nicolas

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Argentina

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City

San Salvador de Jujuy

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Argentina

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City

Santa Fe

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Argentina

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City

Santa Fé

Country

Argentina

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City

Tucuman

Country

Argentina

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City

Tucumán

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Argentina

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City

Zarate

Country

Argentina

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City

Adelaide

Country

Australia

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City

Ashford

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Australia

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City

Auchenflower

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Australia

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City

Ballarat

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Australia

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City

Bruce

Country

Australia

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City

Chermside

Country

Australia

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City

Clayton

Country

Australia

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City

Concord

Country

Australia

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City

East St Kilda

Country

Australia

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City

Elizabeth Vale

Country

Australia

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City

Epping

Country

Australia

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City

Fremantle

Country

Australia

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City

Geelong

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Australia

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City

Gosford

Country

Australia

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City

Greenslopes

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Australia

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City

Herston

Country

Australia

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City

Joondalup

Country

Australia

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City

Kingswood

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Australia

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City

Kogorah

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Australia

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City

Launceston

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Australia

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City

Melbourne

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Australia

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City

Nedlands

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Australia

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City

New Lambton Heights

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Australia

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City

Richmond

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Australia

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City

St Leonards

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Australia

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City

Wollongong

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Australia

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City

Woodville

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Australia

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Woolloongabba

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Australia

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City

Aalst

Country

Belgium

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Antwerpen

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Belgium

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Bonheiden

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Belgium

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City

Bouge

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Belgium

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City

Brasschaat

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Belgium

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City

Brussels (Anderlecht)

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Belgium

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City

Brussels (Jette)

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Belgium

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Brussels (Woluwé-St-Lambert)

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Belgium

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Brussels

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Belgium

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City

Charleroi

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Belgium

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City

Edegem

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Belgium

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City

Genk

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Belgium

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City

Gent

Country

Belgium

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City

Hasselt

Country

Belgium

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City

Huy

Country

Belgium

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City

La Louvière

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Belgium

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City

Leuven

Country

Belgium

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City

Liege

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Belgium

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City

Liège

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Belgium

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City

Mechelen

Country

Belgium

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City

Mol

Country

Belgium

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City

Ottignies

Country

Belgium

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City

Roeselare

Country

Belgium

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City

Tienen

Country

Belgium

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City

Turnhout

Country

Belgium

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City

Yvoir

Country

Belgium

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City

Zottegem

Country

Belgium

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City

Aracaju

Country

Brazil

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City

Belo Horizonte

Country

Brazil

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City

Blumenau

Country

Brazil

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Brasília

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Brazil

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City

Campina Grande do Sul

Country

Brazil

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City

Campinas

Country

Brazil

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City

Campo Grande

Country

Brazil

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City

Curitiba

Country

Brazil

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City

Goiânia

Country

Brazil

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City

Maceio

Country

Brazil

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City

Marilia

Country

Brazil

Facility Name

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City

Porto Alegre

Country

Brazil

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City

Ribeirão Preto

Country

Brazil

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City

Rio de Janeiro

Country

Brazil

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City

S.J.Rio Preto

Country

Brazil

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City

Salvador

Country

Brazil

Facility Name

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City

São José do Rio Preto

Country

Brazil

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City

São Paulo

Country

Brazil

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City

Uberlândia

Country

Brazil

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City

Votuporanga

Country

Brazil

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City

Dimitrovgrad

Country

Bulgaria

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City

Gotse Delchev

Country

Bulgaria

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City

Pernik

Country

Bulgaria

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City

Pleven

Country

Bulgaria

Facility Name

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City

Plovdiv

Country

Bulgaria

Facility Name

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City

Razlog

Country

Bulgaria

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City

Ruse

Country

Bulgaria

Facility Name

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City

Sevlievo

Country

Bulgaria

Facility Name

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City

Sofia

Country

Bulgaria

Facility Name

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City

Varna

Country

Bulgaria

Facility Name

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City

Veliko Tarnovo

Country

Bulgaria

Facility Name

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City

Edmonton

State/Province

Alberta

Country

Canada

Facility Name

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City

Kelowna

State/Province

British Columbia

Country

Canada

Facility Name

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City

New Westminster

State/Province

British Columbia

Country

Canada

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City

Penticton

State/Province

British Columbia

Country

Canada

Facility Name

Research Site

City

Surrey

State/Province

British Columbia

Country

Canada

Facility Name

Research Site

City

Vancouver

State/Province

British Columbia

Country

Canada

Facility Name

Research Site

City

Victoria

State/Province

British Columbia

Country

Canada

Facility Name

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City

Moncton

State/Province

New Brunswick

Country

Canada

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City

Saint John

State/Province

New Brunswick

Country

Canada

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City

St. John's

State/Province

Newfoundland and Labrador

Country

Canada

Facility Name

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City

Halifax

State/Province

Nova Scotia

Country

Canada

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City

Brampton

State/Province

Ontario

Country

Canada

Facility Name

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City

Burlington

State/Province

Ontario

Country

Canada

Facility Name

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City

Cambridge

State/Province

Ontario

Country

Canada

Facility Name

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City

Cornwall

State/Province

Ontario

Country

Canada

Facility Name

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City

Hamilton

State/Province

Ontario

Country

Canada

Facility Name

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City

Kitchener

State/Province

Ontario

Country

Canada

Facility Name

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City

London

State/Province

Ontario

Country

Canada

Facility Name

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City

Mississauga

State/Province

Ontario

Country

Canada

Facility Name

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City

Newmarket

State/Province

Ontario

Country

Canada

Facility Name

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City

North York

State/Province

Ontario

Country

Canada

Facility Name

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City

Oshawa

State/Province

Ontario

Country

Canada

Facility Name

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City

Ottawa

State/Province

Ontario

Country

Canada

Facility Name

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City

Sarnia

State/Province

Ontario

Country

Canada

Facility Name

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City

Scarborough

State/Province

Ontario

Country

Canada

Facility Name

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City

Sudbury

State/Province

Ontario

Country

Canada

Facility Name

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City

Thunder Bay

State/Province

Ontario

Country

Canada

Facility Name

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City

Toronto

State/Province

Ontario

Country

Canada

Facility Name

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City

Windsor

State/Province

Ontario

Country

Canada

Facility Name

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City

Chicoutimi

State/Province

Quebec

Country

Canada

Facility Name

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City

Gatineau

State/Province

Quebec

Country

Canada

Facility Name

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City

Greenfield Park

State/Province

Quebec

Country

Canada

Facility Name

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City

Laval

State/Province

Quebec

Country

Canada

Facility Name

Research Site

City

Levis

State/Province

Quebec

Country

Canada

Facility Name

Research Site

City

Longueuil

State/Province

Quebec

Country

Canada

Facility Name

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City

Montreal

State/Province

Quebec

Country

Canada

Facility Name

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City

Montréal

State/Province

Quebec

Country

Canada

Facility Name

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City

Saint-Charles-Borromee

State/Province

Quebec

Country

Canada

Facility Name

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City

Saint-Georges

State/Province

Quebec

Country

Canada

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City

Saint-Jerome

State/Province

Quebec

Country

Canada

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City

St-Lambert

State/Province

Quebec

Country

Canada

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City

Terrebonne

State/Province

Quebec

Country

Canada

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City

Thetford Mines

State/Province

Quebec

Country

Canada

Facility Name

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City

Val d'Or

State/Province

Quebec

Country

Canada

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City

Saskatoon

State/Province

Saskatchewan

Country

Canada

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City

Quebec

Country

Canada

Facility Name

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City

Concepcion

Country

Chile

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City

Osorno

Country

Chile

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Rancagua

Country

Chile

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Santiago Centro

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Chile

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Santiago

Country

Chile

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City

Temuco

Country

Chile

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Vina del Mar

Country

Chile

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Beijing

Country

China

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Changsha

Country

China

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City

Chongqing

Country

China

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City

Guang Zhou

Country

China

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City

Guangzhou

Country

China

Facility Name

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City

Hang Zhou

Country

China

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City

Lanzhou

Country

China

Facility Name

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City

Nanjing

Country

China

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City

Shanghai

Country

China

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City

Shengyang

Country

China

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City

Shenyang

Country

China

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City

Taiyuan

Country

China

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City

Wuhan

Country

China

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City

Xi'an

Country

China

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City

Armenia

Country

Colombia

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City

Barranquilla

Country

Colombia

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City

Bogota

Country

Colombia

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City

Bogotá D.C.

Country

Colombia

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City

Bucaramanga

Country

Colombia

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City

Cali

Country

Colombia

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City

Cartagena

Country

Colombia

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City

Manizales

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Colombia

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City

Medellin

Country

Colombia

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City

Medellín

Country

Colombia

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City

Medillin

Country

Colombia

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City

Brno

Country

Czech Republic

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City

Caslav

Country

Czech Republic

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City

Ceska Lipa

Country

Czech Republic

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City

Cesky Krumlov

Country

Czech Republic

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City

Chomutov

Country

Czech Republic

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City

Havirov

Country

Czech Republic

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City

Kromeriz

Country

Czech Republic

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City

Kyjov

Country

Czech Republic

Facility Name

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City

Liberec

Country

Czech Republic

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City

Marianske Lazne

Country

Czech Republic

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City

Ostrava-Poruba

Country

Czech Republic

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City

Ostrava-Zabreh

Country

Czech Republic

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City

Ostrava

Country

Czech Republic

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City

Pelhrimov

Country

Czech Republic

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City

Praha 2

Country

Czech Republic

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City

Praha 5

Country

Czech Republic

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City

Praha 6

Country

Czech Republic

Facility Name

Research Site

City

Pribram

Country

Czech Republic

Facility Name

Research Site

City

Slany

Country

Czech Republic

Facility Name

Research Site

City

Teplice

Country

Czech Republic

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Research Site

City

Usti nad Labem

Country

Czech Republic

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Research Site

City

Usti nad Orlici

Country

Czech Republic

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Research Site

City

Znojmo

Country

Czech Republic

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City

ABBEVILLE cedex

Country

France

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City

Albi

Country

France

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Research Site

City

ANGERS Cedex 9

Country

France

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City

Angers

Country

France

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City

Avignon Cedex

Country

France

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City

Bayonne

Country

France

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City

Cannes

Country

France

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City

Creteil

Country

France

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City

Dijon

Country

France

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City

Jossigny

Country

France

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La Rochelle Cedex

Country

France

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Le Chesnay

Country

France

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City

Le Coudray Cedex

Country

France

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City

Limoges Cedex

Country

France

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City

MARSEILLE Cedex 5

Country

France

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City

Metz Cedex 1

Country

France

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City

NICE Cedex 01

Country

France

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City

NIMES Cedex 9

Country

France

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City

Orléans Cedex 2

Country

France

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City

Paris

Country

France

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City

Pessac

Country

France

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City

Poitiers

Country

France

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City

Toulouse Cedex

Country

France

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TOURCOING cedex

Country

France

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City

Bad Krozingen

Country

Germany

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City

Bad Mergentheim

Country

Germany

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City

Bad Nauheim

Country

Germany

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City

Berlin

Country

Germany

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City

Bielefeld

Country

Germany

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City

Coburg

Country

Germany

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City

Deggingen

Country

Germany

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City

Dortmund

Country

Germany

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City

Dresden

Country

Germany

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City

Essen

Country

Germany

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City

Esslingen

Country

Germany

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City

Frankfurt

Country

Germany

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City

Hamburg

Country

Germany

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City

Heidelberg

Country

Germany

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City

Kassel

Country

Germany

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City

Kiel

Country

Germany

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City

Leipzig

Country

Germany

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City

Limburg

Country

Germany

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City

Ludwigshafen

Country

Germany

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City

Lübeck

Country

Germany

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City

Mainz

Country

Germany

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City

Mönchengladbach

Country

Germany

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City

Ulm

Country

Germany

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City

Warendorf

Country

Germany

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City

Witten

Country

Germany

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City

Ballasagyarmat

Country

Hungary

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City

Budapest

Country

Hungary

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City

Békéscsaba

Country

Hungary

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City

Cegléd

Country

Hungary

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City

Debrecen

Country

Hungary

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City

Eger

Country

Hungary

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City

Gyula

Country

Hungary

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City

Kalocsa

Country

Hungary

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City

Kecskemét

Country

Hungary

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City

Mosonmagyaróvár

Country

Hungary

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City

Nyíregyháza

Country

Hungary

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City

Pécs

Country

Hungary

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City

Sopron

Country

Hungary

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City

Szeged

Country

Hungary

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City

Szekszárd

Country

Hungary

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City

Szolnok

Country

Hungary

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City

Székesfehérvár

Country

Hungary

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City

Zalaegerszeg

Country

Hungary

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City

Albano Laziale

Country

Italy

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City

Bari

Country

Italy

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City

Benevento

Country

Italy

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City

Brescia

Country

Italy

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City

Carpi

Country

Italy

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City

Catania

Country

Italy

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City

Genova

Country

Italy

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City

Legnano

Country

Italy

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City

Lucca

Country

Italy

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City

Massa

Country

Italy

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City

Milano

Country

Italy

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City

Napoli

Country

Italy

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City

Osio Sotto frazione di Zingoni

Country

Italy

Facility Name

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City

Parma

Country

Italy

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City

Pavia

Country

Italy

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City

Perugia

Country

Italy

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City

Pescara

Country

Italy

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City

Pisa

Country

Italy

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City

Reggio Emilia

Country

Italy

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City

Roma

Country

Italy

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City

Rozzano

Country

Italy

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City

S Maria Capua Vetere

Country

Italy

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City

San Remo

Country

Italy

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City

Sassari

Country

Italy

Facility Name

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City

Sessa Aurunca

Country

Italy

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City

Siena

Country

Italy

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City

Sorrento NA

Country

Italy

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City

Vimercate

Country

Italy

Facility Name

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City

Akishima-shi

Country

Japan

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Research Site

City

Amagasaki-shi

Country

Japan

Facility Name

Research Site

City

Beppu-shi

Country

Japan

Facility Name

Research Site

City

Chuo-ku

Country

Japan

Facility Name

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City

Daito-shi

Country

Japan

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City

Fukui-shi

Country

Japan

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City

Funabashi-shi

Country

Japan

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City

Gifu-shi

Country

Japan

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Research Site

City

Hamamatsu-shi

Country

Japan

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Research Site

City

Himeji-shi

Country

Japan

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City

Imabari-shi

Country

Japan

Facility Name

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City

Isehara-shi

Country

Japan

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City

Kamogawa-shi

Country

Japan

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City

Kanazawa-shi

Country

Japan

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City

Kawachinagano-shi

Country

Japan

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Research Site

City

Kisarazu-shi

Country

Japan

Facility Name

Research Site

City

Komatsushima-shi

Country

Japan

Facility Name

Research Site

City

Koriyama-shi

Country

Japan

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City

Kumamoto-shi

Country

Japan

Facility Name

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City

Kure-shi

Country

Japan

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Research Site

City

Kusatsu-shi

Country

Japan

Facility Name

Research Site

City

Kyoto-shi

Country

Japan

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Research Site

City

Maebashi-shi

Country

Japan

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Research Site

City

Matsue-shi

Country

Japan

Facility Name

Research Site

City

Matsumoto-shi

Country

Japan

Facility Name

Research Site

City

Matsuyama-shi

Country

Japan

Facility Name

Research Site

City

Meguro-ku

Country

Japan

Facility Name

Research Site

City

Miyazaki-shi

Country

Japan

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Research Site

City

Osaka-shi

Country

Japan

Facility Name

Research Site

City

Saga-shi

Country

Japan

Facility Name

Research Site

City

Sagamihara-shi

Country

Japan

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Research Site

City

Saitama-shi

Country

Japan

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Research Site

City

Sakai-shi

Country

Japan

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Research Site

City

Sakaide-shi

Country

Japan

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Research Site

City

Sapporo-shi

Country

Japan

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City

Sayama-shi

Country

Japan

Facility Name

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City

Shimada-shi

Country

Japan

Facility Name

Research Site

City

Shinagawa-ku

Country

Japan

Facility Name

Research Site

City

Shizuoka-shi

Country

Japan

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Research Site

City

Suwa-shi

Country

Japan

Facility Name

Research Site

City

Takarazuka-shi

Country

Japan

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Research Site

City

Takasaki-shi

Country

Japan

Facility Name

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City

Takatsuki-shi

Country

Japan

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City

Tomakomai-shi

Country

Japan

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Research Site

City

Toyonaka-shi

Country

Japan

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City

Ueda-shi

Country

Japan

Facility Name

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City

Wakayama-shi

Country

Japan

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City

Wako-shi

Country

Japan

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Research Site

City

Yatsushiro-shi

Country

Japan

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Research Site

City

Yokohama-shi

Country

Japan

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City

Bucheon-si

Country

Korea, Republic of

Facility Name

Research Site

City

Busan

Country

Korea, Republic of

Facility Name

Research Site

City

Cheongju

Country

Korea, Republic of

Facility Name

Research Site

City

Daegu

Country

Korea, Republic of

Facility Name

Research Site

City

Daejeon

Country

Korea, Republic of

Facility Name

Research Site

City

Gwangju

Country

Korea, Republic of

Facility Name

Research Site

City

Jeonju

Country

Korea, Republic of

Facility Name

Research Site

City

Seongnam-si

Country

Korea, Republic of

Facility Name

Research Site

City

Seoul

Country

Korea, Republic of

Facility Name

Research Site

City

Suwon-si

Country

Korea, Republic of

Facility Name

Research Site

City

Uijeongbu

Country

Korea, Republic of

Facility Name

Research Site

City

Wonju-si

Country

Korea, Republic of

Facility Name

Research Site

City

Almere

Country

Netherlands

Facility Name

Research Site

City

Amersfoort

Country

Netherlands

Facility Name

Research Site

City

Amsterdam

Country

Netherlands

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City

Arnhem

Country

Netherlands

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City

Beverwijk

Country

Netherlands

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Research Site

City

Breda

Country

Netherlands

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Research Site

City

Delft

Country

Netherlands

Facility Name

Research Site

City

Den Haag

Country

Netherlands

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Research Site

City

Den Helder

Country

Netherlands

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Research Site

City

Deventer

Country

Netherlands

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Research Site

City

Drachten

Country

Netherlands

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Research Site

City

EDE

Country

Netherlands

Facility Name

Research Site

City

Eindhoven

Country

Netherlands

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Research Site

City

Goes

Country

Netherlands

Facility Name

Research Site

City

Groningen

Country

Netherlands

Facility Name

Research Site

City

Hardenberg

Country

Netherlands

Facility Name

Research Site

City

Heerenveen

Country

Netherlands

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Research Site

City

Heerlen

Country

Netherlands

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Research Site

City

Helmond

Country

Netherlands

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Research Site

City

Hilversum

Country

Netherlands

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City

Hoofddorp

Country

Netherlands

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Research Site

City

Hoogeveen

Country

Netherlands

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Research Site

City

Leiderdorp

Country

Netherlands

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Research Site

City

Maastricht

Country

Netherlands

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City

Nieuwegein

Country

Netherlands

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Research Site

City

Nijmegen

Country

Netherlands

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City

OSS

Country

Netherlands

Facility Name

Research Site

City

Roosendaal

Country

Netherlands

Facility Name

Research Site

City

Rotterdam

Country

Netherlands

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Research Site

City

Schiedam

Country

Netherlands

Facility Name

Research Site

City

Shertogenbosch

Country

Netherlands

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Research Site

City

Sittardgeleen

Country

Netherlands

Facility Name

Research Site

City

Sneek

Country

Netherlands

Facility Name

Research Site

City

Tiel

Country

Netherlands

Facility Name

Research Site

City

Tilburg

Country

Netherlands

Facility Name

Research Site

City

Veldhoven

Country

Netherlands

Facility Name

Research Site

City

Bergen

Country

Norway

Facility Name

Research Site

City

Bodo

Country

Norway

Facility Name

Research Site

City

Bodø

Country

Norway

Facility Name

Research Site

City

Flekkefjord

Country

Norway

Facility Name

Research Site

City

Hamar

Country

Norway

Facility Name

Research Site

City

Levanger

Country

Norway

Facility Name

Research Site

City

Lillehammer

Country

Norway

Facility Name

Research Site

City

Nesttun

Country

Norway

Facility Name

Research Site

City

Oslo

Country

Norway

Facility Name

Research Site

City

Skien

Country

Norway

Facility Name

Research Site

City

Tromsø

Country

Norway

Facility Name

Research Site

City

Tynset

Country

Norway

Facility Name

Research Site

City

Arequipa

Country

Peru

Facility Name

Research Site

City

Callao

Country

Peru

Facility Name

Research Site

City

Lima

Country

Peru

Facility Name

Research Site

City

San Borja

Country

Peru

Facility Name

Research Site

City

Trujillo

Country

Peru

Facility Name

Research Site

City

Cebu City

Country

Philippines

Facility Name

Research Site

City

Fuente Osmena Cebu City

Country

Philippines

Facility Name

Research Site

City

Iloilo City

Country

Philippines

Facility Name

Research Site

City

Las Pinas City

Country

Philippines

Facility Name

Research Site

City

Lipa City

Country

Philippines

Facility Name

Research Site

City

Mandaluyong City

Country

Philippines

Facility Name

Research Site

City

Manila

Country

Philippines

Facility Name

Research Site

City

Pasig City

Country

Philippines

Facility Name

Research Site

City

Quezon City

Country

Philippines

Facility Name

Research Site

City

Quezon

Country

Philippines

Facility Name

Research Site

City

San Juan

Country

Philippines

Facility Name

Research Site

City

Białystok

Country

Poland

Facility Name

Research Site

City

Bielsko Biala

Country

Poland

Facility Name

Research Site

City

Bydgoszcz

Country

Poland

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Research Site

City

Chorzow

Country

Poland

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Research Site

City

Gdańsk

Country

Poland

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Research Site

City

Gdynia

Country

Poland

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Research Site

City

Giżycko

Country

Poland

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Research Site

City

Kraków

Country

Poland

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City

Legnica

Country

Poland

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City

Lubin

Country

Poland

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City

Nowa Sól

Country

Poland

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City

Olsztyn

Country

Poland

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Research Site

City

Opole

Country

Poland

Facility Name

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City

Ostrów Mazowiecka

Country

Poland

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City

Oława

Country

Poland

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City

Piotrkow

Country

Poland

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City

Poznań

Country

Poland

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City

Płock

Country

Poland

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City

Skierniewice

Country

Poland

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City

Sobótka

Country

Poland

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City

Sokolka

Country

Poland

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City

Szczecin

Country

Poland

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City

Tarnów

Country

Poland

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City

Torun

Country

Poland

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City

Toruń

Country

Poland

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Warszawa

Country

Poland

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City

Wrocław

Country

Poland

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City

Włocławek

Country

Poland

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City

Łańcut

Country

Poland

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City

Łódź

Country

Poland

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City

Łęczna

Country

Poland

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City

Bacau

Country

Romania

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Research Site

City

Braila

Country

Romania

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City

Brasov

Country

Romania

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Research Site

City

Bucharest

Country

Romania

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City

Bucuresti

Country

Romania

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Research Site

City

Buzau

Country

Romania

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Research Site

City

Cluj Napoca

Country

Romania

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Research Site

City

Craiova

Country

Romania

Facility Name

Research Site

City

Deva

Country

Romania

Facility Name

Research Site

City

Focsani

Country

Romania

Facility Name

Research Site

City

Iasi

Country

Romania

Facility Name

Research Site

City

Pitesti

Country

Romania

Facility Name

Research Site

City

Sibiu

Country

Romania

Facility Name

Research Site

City

Suceava

Country

Romania

Facility Name

Research Site

City

Tg. Mures

Country

Romania

Facility Name

Research Site

City

Timisoara

Country

Romania

Facility Name

Research Site

City

Ekaterinburg

Country

Russian Federation

Facility Name

Research Site

City

Gatchina

Country

Russian Federation

Facility Name

Research Site

City

Kazan

Country

Russian Federation

Facility Name

Research Site

City

Krasnodar

Country

Russian Federation

Facility Name

Research Site

City

Moscow

Country

Russian Federation

Facility Name

Research Site

City

Nizhnii Novgorod

Country

Russian Federation

Facility Name

Research Site

City

Novosibirsk

Country

Russian Federation

Facility Name

Research Site

City

Perm

Country

Russian Federation

Facility Name

Research Site

City

Saint Petersburg

Country

Russian Federation

Facility Name

Research Site

City

Saint-Petersburg

Country

Russian Federation

Facility Name

Research Site

City

Saratov

Country

Russian Federation

Facility Name

Research Site

City

St.-Petersburg,

Country

Russian Federation

Facility Name

Research Site

City

St.-Petersburg

Country

Russian Federation

Facility Name

Research Site

City

St.Petersburg

Country

Russian Federation

Facility Name

Research Site

City

StPetersburg

Country

Russian Federation

Facility Name

Research Site

City

Vladikavkaz

Country

Russian Federation

Facility Name

Research Site

City

Volgograd

Country

Russian Federation

Facility Name

Research Site

City

Banska Bystrica

Country

Slovakia

Facility Name

Research Site

City

Bardejov

Country

Slovakia

Facility Name

Research Site

City

Bratislava

Country

Slovakia

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Research Site

City

Komarno

Country

Slovakia

Facility Name

Research Site

City

Kosice

Country

Slovakia

Facility Name

Research Site

City

Liptovsky Hradok

Country

Slovakia

Facility Name

Research Site

City

Liptovsky Mikulas

Country

Slovakia

Facility Name

Research Site

City

Martin

Country

Slovakia

Facility Name

Research Site

City

Nitra

Country

Slovakia

Facility Name

Research Site

City

Partizanske

Country

Slovakia

Facility Name

Research Site

City

Piestany

Country

Slovakia

Facility Name

Research Site

City

Povazska Bystrica

Country

Slovakia

Facility Name

Research Site

City

Presov

Country

Slovakia

Facility Name

Research Site

City

Ruzomberok

Country

Slovakia

Facility Name

Research Site

City

Trnava

Country

Slovakia

Facility Name

Research Site

City

Zilina

Country

Slovakia

Facility Name

Research Site

City

Alberton

Country

South Africa

Facility Name

Research Site

City

Bloemfontein

Country

South Africa

Facility Name

Research Site

City

Cape Town

Country

South Africa

Facility Name

Research Site

City

Centurion

Country

South Africa

Facility Name

Research Site

City

Durban

Country

South Africa

Facility Name

Research Site

City

Gatesville

Country

South Africa

Facility Name

Research Site

City

George

Country

South Africa

Facility Name

Research Site

City

Johannesburg

Country

South Africa

Facility Name

Research Site

City

Kempron Park

Country

South Africa

Facility Name

Research Site

City

Panorama

Country

South Africa

Facility Name

Research Site

City

Parow

Country

South Africa

Facility Name

Research Site

City

Pretoria

Country

South Africa

Facility Name

Research Site

City

Somerset West

Country

South Africa

Facility Name

Research Site

City

Soweto

Country

South Africa

Facility Name

Research Site

City

Worcester

Country

South Africa

Facility Name

Research Site

City

Almeria

Country

Spain

Facility Name

Research Site

City

Aviles

Country

Spain

Facility Name

Research Site

City

Barcelona

Country

Spain

Facility Name

Research Site

City

Bilbao

Country

Spain

Facility Name

Research Site

City

Don Benito (Badajoz)

Country

Spain

Facility Name

Research Site

City

Hospitalet de Llobregat(Barcel

Country

Spain

Facility Name

Research Site

City

Madrid

Country

Spain

Facility Name

Research Site

City

Majadahonda

Country

Spain

Facility Name

Research Site

City

Málaga

Country

Spain

Facility Name

Research Site

City

Oviedo

Country

Spain

Facility Name

Research Site

City

Palma de Mallorca

Country

Spain

Facility Name

Research Site

City

Sabadell

Country

Spain

Facility Name

Research Site

City

San Sebastian de los Reyes

Country

Spain

Facility Name

Research Site

City

Santiago(A Coruña)

Country

Spain

Facility Name

Research Site

City

Sevilla

Country

Spain

Facility Name

Research Site

City

Valencia

Country

Spain

Facility Name

Research Site

City

Eksjö

Country

Sweden

Facility Name

Research Site

City

Göteborg

Country

Sweden

Facility Name

Research Site

City

Jönköping

Country

Sweden

Facility Name

Research Site

City

Linkoping

Country

Sweden

Facility Name

Research Site

City

Ljungby

Country

Sweden

Facility Name

Research Site

City

Lund

Country

Sweden

Facility Name

Research Site

City

Molndal

Country

Sweden

Facility Name

Research Site

City

Stockholm

Country

Sweden

Facility Name

Research Site

City

Sundsvall

Country

Sweden

Facility Name

Research Site

City

Umea

Country

Sweden

Facility Name

Research Site

City

Västerås

Country

Sweden

Facility Name

Research Site

City

Örebro

Country

Sweden

Facility Name

Research Site

City

Östersund

Country

Sweden

Facility Name

Research Site

City

Adana

Country

Turkey

Facility Name

Research Site

City

Ankara

Country

Turkey

Facility Name

Research Site

City

Istanbul

Country

Turkey

Facility Name

Research Site

City

Izmir

Country

Turkey

Facility Name

Research Site

City

Malatya

Country

Turkey

Facility Name

Research Site

City

Mersin

Country

Turkey

Facility Name

Research Site

City

Dnepropetrovsk

Country

Ukraine

Facility Name

Research Site

City

Donetsk

Country

Ukraine

Facility Name

Research Site

City

Kharkiv

Country

Ukraine

Facility Name

Research Site

City

Kharkov

Country

Ukraine

Facility Name

Research Site

City

Kiev

Country

Ukraine

Facility Name

Research Site

City

Kyiv

Country

Ukraine

Facility Name

Research Site

City

Lviv

Country

Ukraine

Facility Name

Research Site

City

Uzhgorod

Country

Ukraine

Facility Name

Research Site

City

Vinnitsa

Country

Ukraine

Facility Name

Research Site

City

Zaporozye

Country

Ukraine

Facility Name

Research Site

City

Airdrie

Country

United Kingdom

Facility Name

Research Site

City

Antrim

Country

United Kingdom

Facility Name

Research Site

City

Belfast

Country

United Kingdom

Facility Name

Research Site

City

Blackpool

Country

United Kingdom

Facility Name

Research Site

City

Bournemouth

Country

United Kingdom

Facility Name

Research Site

City

Brighton

Country

United Kingdom

Facility Name

Research Site

City

Bristol

Country

United Kingdom

Facility Name

Research Site

City

Coventry

Country

United Kingdom

Facility Name

Research Site

City

Dundee

Country

United Kingdom

Facility Name

Research Site

City

East Kilbride

Country

United Kingdom

Facility Name

Research Site

City

Ely

Country

United Kingdom

Facility Name

Research Site

City

Hastings

Country

United Kingdom

Facility Name

Research Site

City

London

Country

United Kingdom

Facility Name

Research Site

City

Manchester

Country

United Kingdom

Facility Name

Research Site

City

Middlesborough

Country

United Kingdom

Facility Name

Research Site

City

Northampton

Country

United Kingdom

Facility Name

Research Site

City

Nottingham

Country

United Kingdom

Facility Name

Research Site

City

Peterborough

Country

United Kingdom

Facility Name

Research Site

City

Rotherham

Country

United Kingdom

Facility Name

Research Site

City

Sheffield

Country

United Kingdom

Facility Name

Research Site

City

Swansea

Country

United Kingdom

Facility Name

Research Site

City

Torquay

Country

United Kingdom

Facility Name

Research Site

City

York

Country

United Kingdom

12. IPD Sharing Statement

Citations:

PubMed Identifier

25773268

Citation

Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Oude Ophuis T, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS; PEGASUS-TIMI 54 Steering Committee and Investigators. Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med. 2015 May 7;372(19):1791-800. doi: 10.1056/NEJMoa1500857. Epub 2015 Mar 14.

Results Reference

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PubMed Identifier

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Citation

Bonaca MP, Im K, Magnani G, Bansilal S, Dellborg M, Storey RF, Bhatt DL, Steg PG, Cohen M, Johanson P, Braunwald E, Sabatine MS. Patient selection for long-term secondary prevention with ticagrelor: insights from PEGASUS-TIMI 54. Eur Heart J. 2022 Dec 21;43(48):5037-5044. doi: 10.1093/eurheartj/ehac402.

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derived

PubMed Identifier

35224730

Citation

Natale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4.

Results Reference

derived

PubMed Identifier

34423649

Citation

Bergmark BA, Bhatt DL, Steg PG, Budaj A, Storey RF, Gurmu Y, Kuder JF, Im K, Magnani G, Oude Ophuis T, Hamm C, Spinar J, Kiss RG, Van de Werf FJ, Montalescot G, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Long-Term Ticagrelor in Patients With Prior Coronary Stenting in the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2021 Sep 7;10(17):e020446. doi: 10.1161/JAHA.120.020446. Epub 2021 Aug 21.

Results Reference

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PubMed Identifier

33559485

Citation

Magnani G, Ardissino D, Im K, Budaj A, Storey RF, Steg PG, Bhatt DL, Cohen M, Oude Ophius T, Goudev A, Parkhomenko A, Kamensky G, Angiolillo DJ, Lopez-Sendon J, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Predictors, Type, and Impact of Bleeding on the Net Clinical Benefit of Long-Term Ticagrelor in Stable Patients With Prior Myocardial Infarction. J Am Heart Assoc. 2021 Feb 16;10(4):e017008. doi: 10.1161/JAHA.120.017008. Epub 2021 Feb 9.

Results Reference

derived

PubMed Identifier

32410485

Citation

Furtado RHM, Venkateswaran RV, Nicolau JC, Gurmu Y, Bhatt DL, Storey RF, Steg PG, Magnani G, Goto S, Dellborg M, Kamensky G, Isaza D, Aylward P, Johanson P, Bonaca MP. Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015785. doi: 10.1161/JAHA.119.015785. Epub 2020 May 15.

Results Reference

derived

PubMed Identifier

32366163

Citation

Gencer B, Li XS, Gurmu Y, Bonaca MP, Morrow DA, Cohen M, Bhatt DL, Steg PG, Storey RF, Johanson P, Wang Z, Hazen SL, Sabatine MS. Gut Microbiota-Dependent Trimethylamine N-oxide and Cardiovascular Outcomes in Patients With Prior Myocardial Infarction: A Nested Case Control Study From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015331. doi: 10.1161/JAHA.119.015331. Epub 2020 May 5.

Results Reference

derived

PubMed Identifier

31811715

Citation

Furtado RHM, Nicolau JC, Magnani G, Im K, Bhatt DL, Storey RF, Steg PG, Spinar J, Budaj A, Kontny F, Corbalan R, Kiss RG, Abola MT, Johanson P, Jensen EC, Braunwald E, Sabatine MS, Bonaca MP. Long-term ticagrelor for secondary prevention in patients with prior myocardial infarction and no history of coronary stenting: insights from PEGASUS-TIMI 54. Eur Heart J. 2020 May 1;41(17):1625-1632. doi: 10.1093/eurheartj/ehz821.

Results Reference

derived

PubMed Identifier

31218354

Citation

Dellborg M, Bonaca MP, Storey RF, Steg PG, Im KA, Cohen M, Bhatt DL, Oude Ophuis T, Budaj A, Hamm C, Spinar J, Kiss RG, Lopez-Sendon J, Kamensky G, Van de Werf F, Ardissino D, Kontny F, Montalescot G, Johanson P, Bengtsson O, Himmelmann A, Braunwald E, Sabatine MS. Efficacy and safety with ticagrelor in patients with prior myocardial infarction in the approved European label: insights from PEGASUS-TIMI 54. Eur Heart J Cardiovasc Pharmacother. 2019 Oct 1;5(4):200-206. doi: 10.1093/ehjcvp/pvz020.

Results Reference

derived

PubMed Identifier

30571502

Citation

Bonaca MP, Wiviott SD, Morrow DA, Steg PG, Hamm C, Bhatt DL, Storey RF, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Diaz R, Van de Werf F, Corbalan R, Goudev A, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Reduction in Subtypes and Sizes of Myocardial Infarction With Ticagrelor in PEGASUS-TIMI 54. J Am Heart Assoc. 2018 Nov 20;7(22):e009260. doi: 10.1161/JAHA.118.009260.

Results Reference

derived

PubMed Identifier

29406853

Citation

Bansilal S, Bonaca MP, Cornel JH, Storey RF, Bhatt DL, Steg PG, Im K, Murphy SA, Angiolillo DJ, Kiss RG, Parkhomenko AN, Lopez-Sendon J, Isaza D, Goudev A, Kontny F, Held P, Jensen EC, Braunwald E, Sabatine MS, Oude Ophuis AJ. Ticagrelor for Secondary Prevention of Atherothrombotic Events in Patients With Multivessel Coronary Disease. J Am Coll Cardiol. 2018 Feb 6;71(5):489-496. doi: 10.1016/j.jacc.2017.11.050.

Results Reference

derived

PubMed Identifier

29084737

Citation

Cavallari I, Morrow DA, Creager MA, Olin J, Bhatt DL, Steg PG, Storey RF, Cohen M, Scirica BS, Piazza G, Goodrich EL, Braunwald E, Sabatine MS, Bonaca MP. Frequency, Predictors, and Impact of Combined Antiplatelet Therapy on Venous Thromboembolism in Patients With Symptomatic Atherosclerosis. Circulation. 2018 Feb 13;137(7):684-692. doi: 10.1161/CIRCULATIONAHA.117.031062. Epub 2017 Oct 30.

Results Reference

derived

PubMed Identifier

28882235

Citation

Bonaca MP, Storey RF, Theroux P, Steg PG, Bhatt DL, Cohen MC, Im K, Murphy SA, Magnani G, Ophuis TO, Rudah M, Parkhomenko A, Isaza D, Kamensky G, Goudev A, Montalescot G, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Efficacy and Safety of Ticagrelor Over Time in Patients With Prior MI in PEGASUS-TIMI 54. J Am Coll Cardiol. 2017 Sep 12;70(11):1368-1375. doi: 10.1016/j.jacc.2017.07.768.

Results Reference

derived

PubMed Identifier

28750695

Citation

Magnuson EA, Li H, Wang K, Vilain K, Shafiq A, Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Braunwald E, Sabatine MS, Cohen DJ; PEGASUS-TIMI 54 Trial Investigators. Cost-Effectiveness of Long-Term Ticagrelor in Patients With Prior Myocardial Infarction: Results From the PEGASUS-TIMI 54 Trial. J Am Coll Cardiol. 2017 Aug 1;70(5):527-538. doi: 10.1016/j.jacc.2017.05.063.

Results Reference

derived

PubMed Identifier

28300867

Citation

Thomas MR, Angiolillo DJ, Bonaca MP, Ajjan RA, Judge HM, Rollini F, Franchi F, Ahsan AJ, Bhatt DL, Kuder JF, Steg PG, Cohen M, Muthusamy R, Sabatine MS, Storey RF. Consistent platelet inhibition with ticagrelor 60 mg twice-daily following myocardial infarction regardless of diabetes status. Thromb Haemost. 2017 May 3;117(5):940-947. doi: 10.1160/TH16-09-0703. Epub 2017 Mar 16.

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derived

PubMed Identifier

27576775

Citation

Bonaca MP, Goto S, Bhatt DL, Steg PG, Storey RF, Cohen M, Goodrich E, Mauri L, Ophuis TO, Ruda M, Spinar J, Seung KB, Hu D, Dalby AJ, Jensen E, Held P, Morrow DA, Braunwald E, Sabatine MS. Prevention of Stroke with Ticagrelor in Patients with Prior Myocardial Infarction: Insights from PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54). Circulation. 2016 Sep 20;134(12):861-71. doi: 10.1161/CIRCULATIONAHA.116.024637. Epub 2016 Aug 30.

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PubMed Identifier

27438319

Citation

Bonaca MP, Bhatt DL, Oude Ophuis T, Steg PG, Storey R, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Theroux P, Hamm C, Spinar J, Kiss RG, Dalby AJ, Medina FA, Kontny F, Aylward PE, Jensen EC, Held P, Braunwald E, Sabatine MS. Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events: A Secondary Analysis of the PEGASUS-TIMI 54 Trial. JAMA Cardiol. 2016 Jul 1;1(4):425-32. doi: 10.1001/jamacardio.2016.1017.

Results Reference

derived

PubMed Identifier

27160944

Citation

Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10.

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PubMed Identifier

27046162

Citation

Bonaca MP, Bhatt DL, Storey RF, Steg PG, Cohen M, Kuder J, Goodrich E, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Dalby A, Spinar J, Aylward P, Corbalan R, Abola MTB, Jensen EC, Held P, Braunwald E, Sabatine MS. Ticagrelor for Prevention of Ischemic Events After Myocardial Infarction in Patients With Peripheral Artery Disease. J Am Coll Cardiol. 2016 Jun 14;67(23):2719-2728. doi: 10.1016/j.jacc.2016.03.524. Epub 2016 Apr 1.

Results Reference

derived

PubMed Identifier

27046160

Citation

Bhatt DL, Bonaca MP, Bansilal S, Angiolillo DJ, Cohen M, Storey RF, Im K, Murphy SA, Held P, Braunwald E, Sabatine MS, Steg PG. Reduction in Ischemic Events With Ticagrelor in Diabetic Patients With Prior Myocardial Infarction in PEGASUS-TIMI 54. J Am Coll Cardiol. 2016 Jun 14;67(23):2732-2740. doi: 10.1016/j.jacc.2016.03.529. Epub 2016 Apr 1.

Results Reference

derived

PubMed Identifier

26491109

Citation

Bonaca MP, Bhatt DL, Steg PG, Storey RF, Cohen M, Im K, Oude Ophuis T, Budaj A, Goto S, Lopez-Sendon J, Diaz R, Dalby A, Van de Werf F, Ardissino D, Montalescot G, Aylward P, Magnani G, Jensen EC, Held P, Braunwald E, Sabatine MS. Ischaemic risk and efficacy of ticagrelor in relation to time from P2Y12 inhibitor withdrawal in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54. Eur Heart J. 2016 Apr 7;37(14):1133-42. doi: 10.1093/eurheartj/ehv531. Epub 2015 Oct 21.

Results Reference

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PubMed Identifier

24655690

Citation

Bonaca MP, Bhatt DL, Braunwald E, Cohen M, Steg PG, Storey RF, Held P, Jensen EC, Sabatine MS. Design and rationale for the Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54 (PEGASUS-TIMI 54) trial. Am Heart J. 2014 Apr;167(4):437-444.e5. doi: 10.1016/j.ahj.2013.12.020. Epub 2014 Jan 6.

Results Reference

derived

Links:

URL

http://filehosting.pharmacm.com/DownloadService.ashx?client=CTR_MED_7111&studyid=489&filename=D5132C00001_CSP1.pdf

Description

D5132C00001_Protocol

Learn more about this trial

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Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin (PEGASUS)

Myocardial Infarction, Cardiovascular Death, Atherothrombosis

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Arm 3

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial